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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1993 5
1994 29
1995 127
1996 186
1997 305
1998 370
1999 429
2000 432
2001 477
2002 492
2003 417
2004 472
2005 422
2006 280
2007 273
2008 273
2009 286
2010 283
2011 272
2012 270
2013 247
2014 255
2015 248
2016 226
2017 197
2018 187
2019 73
2020 2
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6,999 results
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Page 1
Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes.
Collier AE, et al. Mol Biol Cell 2018. PMID 29118075 Free PMC article.
Genome-wide analysis of translation revealed that the mechanism for these critical adaptive responses by eIF2α-P involved induced expression of CDKN1A encoding the p21 (CIP1/WAF1) protein. We further show that human CDKN1A mRNA splice variant 4 is preferentially translated following stress-induced eIF2α-P by a mechanism mediated in part by upstream ORFs situated in the 5'-leader of CDKN1A mRNA. ...
Genome-wide analysis of translation revealed that the mechanism for these critical adaptive responses by eIF2α-P involved induced expression …
High speed of fork progression induces DNA replication stress and genomic instability.
Maya-Mendoza A, et al. Nature 2018. PMID 29950726
Aberrant acceleration of fork progression by 40% above the normal velocity leads to DNA damage. Depletion of the treslin or MTBP proteins, which are involved in origin firing, also increases fork speed above the tolerated threshold, and induces the DNA damage response pathway. ...PARylation and p21 act as suppressors of fork speed in a coordinated regulatory network that is orchestrated by the PARP1 and p53 proteins. ...
Aberrant acceleration of fork progression by 40% above the normal velocity leads to DNA damage. Depletion of the treslin or MTBP p
Clinical significance and functions of microRNA-93/CDKN1A axis in human cervical cancer.
Zhang X, et al. Life Sci 2018. PMID 30098344
The multivariate analysis identified miR-93 and/or CDKN1A expression as independent prognostic factors of cervical cancer. Functionally, miR-93 promoted cell proliferation and invasion of cervical cancer cells via inhibiting CDKN1A. CONCLUSION: miR-93 upregulation and CDKN1A downregulation may be both associated with the development, progression and patients' prognosis of cervical cancer. miR-93/CDKN1A axis may also play an important role in the malignancy of cervical cancer cells, suggesting its potential as a therapeutic target for this cancer....
The multivariate analysis identified miR-93 and/or CDKN1A expression as independent prognostic factors of cervical cancer. Fun …
The tumor suppressor protein p53 and the ferroptosis network.
Kang R, et al. Free Radic Biol Med 2019 - Review. PMID 29800655 Free PMC article.
On the other hand, p53 suppresses ferroptosis through the direct inhibition of DPP4 (dipeptidyl peptidase 4) activity or by the induction of CDKN1A/p21 (cyclin dependent kinase inhibitor 1 A) expression. ...
On the other hand, p53 suppresses ferroptosis through the direct inhibition of DPP4 (dipeptidyl peptidase 4) activity or by the induction of …
Dual Role of p21 in the Progression of Cancer and Its Treatment.
Parveen A, et al. Crit Rev Eukaryot Gene Expr 2016 - Review. PMID 27278885
Cancer develops due to an imbalance between cell proliferation and cell death. Various mechanisms of carcinogenesis as well as of novel anticancer agents that could be targeted for the treatment of cancer have been proposed by different studies. Among these, p21 is recognized as a potent cyclin-dependent kinase inhibitor that facilitates cell-cycle arrest by interacting with different stimuli such as p53, DNA repair process, CDK, E2F1, MYC, PCNA, STAT3 AP4, proteasomes, K1F, CDX2, and ER-α. p21 acts both as a tumor-suppressor gene and an inhibitor of apoptosis by interacting with various molecules and transition factors. ...
Cancer develops due to an imbalance between cell proliferation and cell death. Various mechanisms of carcinogenesis as well as of nov …
NSUN2-Mediated m5C Methylation and METTL3/METTL14-Mediated m6A Methylation Cooperatively Enhance p21 Translation
Li Q, et al. J Cell Biochem 2017. PMID 28247949 Free PMC article.
Our findings on p21 mRNA methylation and expression reveal that joint m6A and m5C modification of the same RNA may influence each other, coordinately affecting protein expression patterns. ...
Our findings on p21 mRNA methylation and expression reveal that joint m6A and m5C modification of the same RNA may influence each other, coo …
IPF lung fibroblasts have a senescent phenotype
Álvarez D, et al. Am J Physiol Lung Cell Mol Physiol 2017. PMID 28860144 Free PMC article.
Although it has been hypothesized that the proliferation and activation of human lung fibroblasts (hLFs) are essential in IPF, no studies have assessed how this process works in an aging lung. ...Our data suggest that IPF hLFs develop senescence resulting in a decreased apoptosis and that the development of SASP may be an important contributor to the fibrotic process observed in IPF. ...
Although it has been hypothesized that the proliferation and activation of human lung fibroblasts (hLFs) are essential in IPF, no stu …
Long noncoding RNA PANDAR blocks CDKN1A gene transcription by competitive interaction with p53 protein in gastric cancer.
Liu J, et al. Cell Death Dis 2018. PMID 29416011 Free PMC article.
A Kaplan-Meier survival analysis and univariate and multivariate Cox proportional hazards models were performed to evaluate the clinical and prognostic significance of PANDAR (promoter of CDKN1A antisense DNA damage activated RNA) in GC patients. ...As a target, the CDKN1A gene was successfully downregulated by PANDAR. PANDAR controlled the transcription of the CDKN1A gene by competitively binding with p53 protein. ...
A Kaplan-Meier survival analysis and univariate and multivariate Cox proportional hazards models were performed to evaluate the clini …
Telomere length-dependent transcription and epigenetic modifications in promoters remote from telomere ends.
Mukherjee AK, et al. PLoS Genet 2018. PMID 30439955 Free PMC article.
This raises a key question-do telomeres impact binding of shelterin proteins at distal non-telomeric sites? Here we show that binding of the telomere-repeat-binding-factor-2 (TRF2) at promoters ~60 Mb from telomeres depends on telomere length in human cells. ...These demonstrate that transcription, and the epigenetic state, of telomere-distal promoters can be influenced by telomere length. ...
This raises a key question-do telomeres impact binding of shelterin proteins at distal non-telomeric sites? Here we show that binding …
Hyper-Editing of Cell-Cycle Regulatory and Tumor Suppressor RNA Promotes Malignant Progenitor Propagation.
Jiang Q, et al. Cancer Cell 2019. PMID 30612940 Free PMC article.
Here we show that ADAR1-induced hyper-editing in normal human hematopoietic progenitors impairs miR-26a maturation, which represses CDKN1A expression indirectly via EZH2, thereby accelerating cell-cycle transit. However, in blast crisis chronic myeloid leukemia progenitors, loss of EZH2 expression and increased CDKN1A oppose cell-cycle transit. ...
Here we show that ADAR1-induced hyper-editing in normal human hematopoietic progenitors impairs miR-26a maturation, which represses …
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