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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 2
1995 2
1996 6
1997 11
1998 6
1999 14
2000 13
2001 15
2002 26
2003 33
2004 46
2005 73
2006 64
2007 82
2008 87
2009 101
2010 97
2011 89
2012 105
2013 84
2014 72
2015 81
2016 88
2017 66
2018 61
2019 27
2020 0
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1,201 results
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The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development.
Kumar N, et al. Development 2019. PMID 30745430 Free PMC article.
Lineage-restricted transcription factors, such as the intestine-specifying factor CDX2, often have dual requirements across developmental time. ...CDX2 binds and activates distinct target genes in developing versus adult mouse and human intestinal cells. We find that temporal shifts in chromatin accessibility correspond to these context-specific CDX2 activities. ...
Lineage-restricted transcription factors, such as the intestine-specifying factor CDX2, often have dual requirements ac …
Intestinal regulation of suppression of tumorigenicity 14 (ST14) and serine peptidase inhibitor, Kunitz type -1 (SPINT1) by transcription factor CDX2.
Danielsen ET, et al. Sci Rep 2018. PMID 30087389 Free PMC article.
The intestinal cell lineage is regulated by a transcriptional regulatory network where the tumor suppressor, Caudal homeobox 2 (CDX2) is considered to be an intestinal master transcription factor. ...We show that CDX2 displays both repressive and enhancing regulatory abilities in a cell specific manner. Together, these data reveal new insight into transcriptional mechanisms controlling the intestinal matriptase/inhibitor balance....
The intestinal cell lineage is regulated by a transcriptional regulatory network where the tumor suppressor, Caudal homeobox 2 (CD
Nuclear transcription factor CDX2 inhibits gastric cancer‑cell growth and reverses epithelial‑to‑mesenchymal transition in vitro and in vivo.
Zhang JF, et al. Mol Med Rep 2015. PMID 26238762
Recent studies showed that nuclear transcription factor caudal type homeobox transcription factor 2 (CDX2) is a prognostic factor, which acts as a marker of good outcome in gastric cancer (GC) patients. However, the association between CDX2 expression and EMT has remained to be fully elucidated. The present study reported that forced overexpression of CDX2 in MKN45/CDX2 cells inhibited GC‑cell growth and proliferation, and attenuated migration and invasion in vitro. ...
Recent studies showed that nuclear transcription factor caudal type homeobox transcription factor 2 (CDX2
Expression of CDX2 and Thyroid Transcription Factor-1 in Oropharyngeal Undifferentiated Carcinomas: A Potential Diagnostic Pitfall.
Chernock RD, et al. Appl Immunohistochem Mol Morphol 2018. PMID 27389559
We recently reviewed a case in consultation that strongly and diffusely expressed both thyroid transcription factor-1 (TTF-1, SPT24 clone) and CDX2, 2 widely used markers that are considered relatively lineage specific for lung/thyroid and intestinal differentiation, respectively. ...Thus, CDX2 immunoreactivity is common, whereas TTF-1 expression is rare in oropharyngeal undifferentiated carcinomas. As a result, one should not rely on CDX2 as evidence of intestinal differentiation or origin in metastatic undifferentiated carcinomas in the neck, particularly when staining is not strong and diffuse. ...
We recently reviewed a case in consultation that strongly and diffusely expressed both thyroid transcription factor-1 (TTF-1, …
Transcription factor AP-2γ induces early Cdx2 expression and represses HIPPO signaling to specify the trophectoderm lineage.
Cao Z, et al. Development 2015. PMID 25858457 Free PMC article.
Here we report that transcription factor AP-2γ (TFAP2C) functions as a novel upstream regulator of Cdx2 expression and position-dependent HIPPO signaling in mice. ...Altogether, these results demonstrate that TFAP2C facilitates trophectoderm lineage specification by functioning as a key regulator of Cdx2 transcription, cell polarity and position-dependent HIPPO signaling....
Here we report that transcription factor AP-2γ (TFAP2C) functions as a novel upstream regulator of Cdx2 expression and …
Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities.
Freund JN, et al. World J Gastroenterol 2015 - Review. PMID 25663763 Free PMC article.
At the molecular level, structure/function studies have demonstrated that the Cdx2 protein is a transcription factor containing a conserved homeotic DNA-binding domain made of three alpha helixes arranged in a helix-turn-helix motif, preceded by a transcriptional domain and followed by a regulatory domain. ...Yet, this transcription factor also acts trough original nontranscriptional mechanisms. Indeed, the identification of novel protein partners of Cdx2 and also of a splicing variant revealed unexpected functions in the control of signaling pathways like the Wnt and NF-κB pathways, in double-strand break DNA repair and in premessenger RNA splicing. ...
At the molecular level, structure/function studies have demonstrated that the Cdx2 protein is a transcription factor co …
CDX2 in colorectal cancer is an independent prognostic factor and regulated by promoter methylation and histone deacetylation in tumors of the serrated pathway.
Graule J, et al. Clin Epigenetics 2018. PMID 30257705 Free PMC article.
BACKGROUND: In colorectal cancer, CDX2 expression is lost in approximately 20% of cases and associated with poor outcome. Here, we aim to validate the clinical impact of CDX2 and investigate the role of promoter methylation and histone deacetylation in CDX2 repression and restoration. ...Lastly, decitabine co-treatment was more effective than LMK-235 alone at restoring CDX2. CONCLUSION: CDX2 loss is an adverse prognostic factor and linked to molecular features of the serrated pathway. ...
BACKGROUND: In colorectal cancer, CDX2 expression is lost in approximately 20% of cases and associated with poor outcome. Here, we ai …
Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains.
Saxena M, et al. Genes Dev 2017. PMID 29321178 Free PMC article.
Compacted chromatin and nucleosomes are known barriers to gene expression; the nature and relative importance of other transcriptional constraints remain unclear, especially at distant enhancers. ...In primary intestinal villus cells, we identified hundreds of tissue-restricted enhancers that require the transcription factor (TF) CDX2 to prevent the incursion of H3K27me3 from adjoining areas of elevated basal marking into large well-demarcated genome domains. ...
Compacted chromatin and nucleosomes are known barriers to gene expression; the nature and relative importance of other transcriptional
CDX2 as a Prognostic Biomarker in Stage II and Stage III Colon Cancer.
Dalerba P, et al. N Engl J Med 2016. PMID 26789870 Free PMC article.
Results The transcription factor CDX2 ranked first in our screening test. A group of 87 of 2115 tumor samples (4.1%) lacked CDX2 expression. ...Among patients with stage II cancer, the difference in 5-year disease-free survival was significant both in the discovery data set (49% among 15 patients with CDX2-negative tumors vs. 87% among 191 patients with CDX2-positive tumors, P=0.003) and in the validation data set (51% among 15 patients with CDX2-negative tumors vs. 80% among 106 patients with CDX2-positive tumors, P=0.004). ...
Results The transcription factor CDX2 ranked first in our screening test. A group of 87 of 2115 tumor samples (4.1%) la …
Thyroid Transcription Factor-1 Expression in Adenocarcinomas of the Bile Duct.
Lino-Silva LS, et al. Int J Surg Pathol 2016. PMID 26316052
BACKGROUND: The immunoreactivity of thyroid transcription factor-1 (TTF-1) is a very specific marker for lung and thyroid neoplasms; the expression of TTF-1 has also been demonstrated in extrapulmonary carcinomas. ...We then compared the expression to TTF-1 staining with other immunohistochemical markers including cytokeratin (CK) 7, CK20, caudal-type homeobox transcription factor 2 (CDX2), Napsin A, and MUC2. ...
BACKGROUND: The immunoreactivity of thyroid transcription factor-1 (TTF-1) is a very specific marker for lung and thyroid neop …
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