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Kupffer cell receptor CLEC4F is important for the destruction of desialylated platelets in mice.
Jiang Y, Tang Y, Hoover C, Kondo Y, Huang D, Restagno D, Shao B, Gao L, Michael McDaniel J, Zhou M, Silasi-Mansat R, McGee S, Jiang M, Bai X, Lupu F, Ruan C, Marth JD, Wu D, Han Y, Xia L. Jiang Y, et al. Cell Death Differ. 2021 Nov;28(11):3009-3021. doi: 10.1038/s41418-021-00797-w. Epub 2021 May 15. Cell Death Differ. 2021. PMID: 33993195 Free PMC article.
Mucins Shed from the Laminated Layer in Cystic Echinococcosis Are Captured by Kupffer Cells via the Lectin Receptor Clec4F.
Barrios AA, Mouhape C, Schreiber L, Zhang L, Nell J, Suárez-Martins M, Schlapp G, Meikle MN, Mulet AP, Hsu TL, Hsieh SL, Mourglia-Ettlin G, González C, Crispo M, Barth TFE, Casaravilla C, Jenkins SJ, Díaz Á. Barrios AA, et al. Infect Immun. 2023 Jun 15;91(6):e0003123. doi: 10.1128/iai.00031-23. Epub 2023 May 10. Infect Immun. 2023. PMID: 37162364 Free PMC article.
Sialylation on O-glycans protects platelets from clearance by liver Kupffer cells.
Li Y, Fu J, Ling Y, Yago T, McDaniel JM, Song J, Bai X, Kondo Y, Qin Y, Hoover C, McGee S, Shao B, Liu Z, Sonon R, Azadi P, Marth JD, McEver RP, Ruan C, Xia L. Li Y, et al. Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8360-8365. doi: 10.1073/pnas.1707662114. Epub 2017 Jul 17. Proc Natl Acad Sci U S A. 2017. PMID: 28716912 Free PMC article.