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Quoted phrase not found in phrase index: "CORO1A deficiency"
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Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis.
Ho CT, Evans EB, Lukasik K, O'Shaughnessy EC, Shah A, Hsu CH, Temple B, Bear JE, Gupton SL. Ho CT, et al. J Cell Biol. 2025 Dec 1;224(12):e202503068. doi: 10.1083/jcb.202503068. Epub 2025 Oct 14. J Cell Biol. 2025. PMID: 41085995 Free PMC article.
Loss of Coro1A and loss of TRIM67 shared similar phenotypes, suggesting that they may function together in the same netrin pathway. A Coro1A mutant deficient in binding TRIM67 was unable to rescue loss of Coro1A phenotypes, indicating that the interact …
Loss of Coro1A and loss of TRIM67 shared similar phenotypes, suggesting that they may function together in the same netrin pathway. A …
Genome-wide gene by sleepiness interaction analysis for sleep apnea.
Nagarajan P, Kurniansyah N, Lee J, Gharib SA, Xu Y, Zhang Y, Spitzer B, Faquih T, Zhou H, Boerwinkle E, Chen H, Gottlieb DJ, Guo X, Heard-Costa NL, Hidalgo BA, Levy D, Liu PY, Mei H, Montalvan R, Mukherjee S, North KE, O'Connor GT, Palmer LJ, Patel SR, Psaty BM, Purcell SM, Raffield LM, Rich SS, Rotter JI, Saxena R, Smith AV, Stone KL, Zhu X; TOPMed Sleep Trait Working Group; Cade BE, Sofer T, Redline S, Wang H. Nagarajan P, et al. Sleep. 2026 Jan 13;49(1):zsaf212. doi: 10.1093/sleep/zsaf212. Sleep. 2026. PMID: 40736211 Free PMC article.
Meta-analysis revealed EDS interaction with 11 rare variant gene sets mapped to UBLCP1, MED31, RAP1GAP, CPNE5, MYMX, YY1, ZNF773, YBEY, IQCB1, PI4K2B, and CORO1A. CONCLUSION: Genetic loci reveal connections to cardiovascular risk, insulin resistance, thiamine deficiency …
Meta-analysis revealed EDS interaction with 11 rare variant gene sets mapped to UBLCP1, MED31, RAP1GAP, CPNE5, MYMX, YY1, ZNF773, YBEY, IQCB …
A rare case of coronin-1A deficiency with IgM dominant membranoproliferative glomerulonephritis.
Ural Z, Ogüt B, Kayhan G, Gönül II, Derici U. Ural Z, et al. CEN Case Rep. 2025 Oct;14(5):687-692. doi: 10.1007/s13730-025-01004-2. Epub 2025 Jun 4. CEN Case Rep. 2025. PMID: 40464874 Free PMC article.
Coronin-1A deficiency, caused by mutations in the CORO1A gene, is an autosomal recessive immunodeficiency characterized by T-cell dysfunction and is classified as severe combined immunodeficiency (SCID). ...This case report presents a 32-year-old female with Coronin …
Coronin-1A deficiency, caused by mutations in the CORO1A gene, is an autosomal recessive immunodeficiency characterized by T-c …
Coro1A and TRIM67 collaborate in netrin-dependent neuronal morphogenesis.
Ho CT, Evans EB, Lukasik K, O'Shaughnessy EC, Shah A, Hsu CH, Temple B, Bear JE, Gupton SL. Ho CT, et al. bioRxiv [Preprint]. 2025 Mar 21:2025.03.20.644333. doi: 10.1101/2025.03.20.644333. bioRxiv. 2025. Update in: J Cell Biol. 2025 Dec 1;224(12):e202503068. doi: 10.1083/jcb.202503068. PMID: 40166342 Free PMC article. Updated. Preprint.
Loss of Coro1A and loss of TRIM67 shared similar phenotypes, suggesting that they may function together in the same netrin pathway. A Coro1A mutant deficient in binding TRIM67 was not able to rescue loss of Coro1A phenotypes, indicating that the intera …
Loss of Coro1A and loss of TRIM67 shared similar phenotypes, suggesting that they may function together in the same netrin pathway. A …
Coronin 1a-mediated F-actin disassembly controls effector function in murine neutrophils.
Shaverskyi A, Hegermann J, Brand K, Lee KH, Föger N. Shaverskyi A, et al. Redox Biol. 2025 May;82:103618. doi: 10.1016/j.redox.2025.103618. Epub 2025 Mar 26. Redox Biol. 2025. PMID: 40158258 Free PMC article.
Utilizing neutrophils from Coronin 1a (Coro1a)-deficient mice, our data reveal that the actin-regulatory protein Coro1a controls this spatial F-actin deconstruction and concomitantly forms a signaling complex with Rac-GTPases, thereby promoting activation and …
Utilizing neutrophils from Coronin 1a (Coro1a)-deficient mice, our data reveal that the actin-regulatory protein Coro1a …
CFTR dictates monocyte adhesion by facilitating integrin clustering but not activation.
Younis DA, Marosvari M, Liu W, Pulikkot S, Cao Z, Zhou B, Vella AT, McArdle S, Hu L, Chen Y, Gan W, Yu J, Bruscia EM, Fan Z. Younis DA, et al. Proc Natl Acad Sci U S A. 2025 Jan 21;122(3):e2412717122. doi: 10.1073/pnas.2412717122. Epub 2025 Jan 15. Proc Natl Acad Sci U S A. 2025. PMID: 39813254 Free PMC article.
Herein, superresolution microscopy showed that an integrin clustering but not an integrin activation defect determines the adhesion defect in CFTR-deficient monocytes, challenging the existing paradigm emphasizing an integrin activation defect in CF patient monocytes. We f …
Herein, superresolution microscopy showed that an integrin clustering but not an integrin activation defect determines the adhesion defect i …
Kif15 regulates Coro1a(+) cell migration and phagocytosis in zebrafish after spinal cord injury.
Dong Z, Zhuo R, Wang Q, Sun Y, Zhou Z, Wu R, Liu Y, Liu M. Dong Z, et al. Int Immunopharmacol. 2025 Jan 27;146:113874. doi: 10.1016/j.intimp.2024.113874. Epub 2024 Dec 21. Int Immunopharmacol. 2025. PMID: 39709909
This study investigates the impact of Kif15 deficiency on immune cells in zebrafish with spinal cord injury. Using kif15 morphants in Tg(coro1a:EGFP) zebrafish, we observed increased recruitment of Coro1a(+) cells to the injury site, followed by a rapid decli …
This study investigates the impact of Kif15 deficiency on immune cells in zebrafish with spinal cord injury. Using kif15 morphants in …
Distinct roles of core autophagy-related genes in zebrafish definitive hematopoiesis.
Chen XK, Yi ZN, Lau JJ, Ma AC. Chen XK, et al. Autophagy. 2024 Apr;20(4):830-846. doi: 10.1080/15548627.2023.2274251. Epub 2023 Nov 3. Autophagy. 2024. PMID: 37921505 Free PMC article.
Zebrafish with various atg mutations showed autophagic deficiency and presented partially consistent hematopoietic abnormalities during early development. ...However, only becn1 mutation resulted in the expansion of myb(+) (v-myb avian myeloblastosis viral oncogene homolog …
Zebrafish with various atg mutations showed autophagic deficiency and presented partially consistent hematopoietic abnormalities duri …
Novel hemizygous CORO1A variant leads to combined immunodeficiency with defective platelet calcium signaling and cell mobility.
Khoreva A, Butov KR, Nikolaeva EI, Martyanov A, Kulakovskaya E, Pershin D, Alexenko M, Kurnikova M, Abasov R, Raykina E, Abramov D, Arnaudova K, Rodina Y, Trubina N, Skvortsova Y, Balashov D, Sveshnikova A, Maschan A, Novichkova G, Panteleev M, Shcherbina A. Khoreva A, et al. J Allergy Clin Immunol Glob. 2023 Sep 27;3(1):100172. doi: 10.1016/j.jacig.2023.100172. eCollection 2024 Feb. J Allergy Clin Immunol Glob. 2023. PMID: 37915722 Free PMC article.
However, the effects of CORO1A protein disruption on actin-dependent functions in primary cells have not been fully delineated. ...CONCLUSION: Collectively, we added new data about the CORO1A gene as a key player in actin cytoskeleton dynamics and cell signaling. Ou …
However, the effects of CORO1A protein disruption on actin-dependent functions in primary cells have not been fully delineated. ...CO …
CREBH promotes autophagy to ameliorate NASH by regulating Coro1a.
Deng X, Liu B, Jiang Q, Li G, Li J, Xu K. Deng X, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166914. doi: 10.1016/j.bbadis.2023.166914. Epub 2023 Oct 13. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37837948 Free article.
Moreover, we observed that CREBH inhibited the expression of Coronin 1a (Coro1a), an autophagosome-lysosome fusion-related gene, through transcriptional regulation. The overexpression of Coro1a in LO2 liver cells inhibited autophagic flux and elevated inflammatory c …
Moreover, we observed that CREBH inhibited the expression of Coronin 1a (Coro1a), an autophagosome-lysosome fusion-related gene, thro …
When to suspect inborn errors of immunity in Epstein-Barr virus-related lymphoproliferative disorders.
Sacco KA, Notarangelo LD, Delmonte OM. Sacco KA, et al. Clin Microbiol Infect. 2023 Apr;29(4):457-462. doi: 10.1016/j.cmi.2022.10.003. Epub 2022 Oct 6. Clin Microbiol Infect. 2023. PMID: 36209991 Free PMC article. Review.
This includes classic disorders such as X-linked lymphoproliferative disease 1 (due to SH2D1A mutations), X-linked lymphoproliferative disease 2 (XIAP), and other genetic diseases, such as ITK, MAGT1, CD27, CD70, CTPS1, RASGRP1, and CORO1A deficiencies. EBV-driven l …
This includes classic disorders such as X-linked lymphoproliferative disease 1 (due to SH2D1A mutations), X-linked lymphoproliferative disea …
Severe combined immunodeficiencies: Expanding the mutation spectrum in Turkey and identification of 12 novel variants.
Aykut A, Durmaz A, Karaca N, Gulez N, Genel F, Celmeli F, Ozturk G, Atay D, Aydogmus C, Kiykim A, Aksu G, Kutukculer N. Aykut A, et al. Scand J Immunol. 2022 Jun;95(6):e13163. doi: 10.1111/sji.13163. Epub 2022 Mar 23. Scand J Immunol. 2022. PMID: 35303369 Free article.
According to the most recent report by the International Union of Immunological Societies (IUIS), SCID is caused by mutations in IL2RG, JAK3, FOXN1, CORO1A, PTPRC, CD3D, CD3E, CD247, ADA, AK2, NHEJ1, LIG4, PRKDC, DCLRE1C, RAG1 and RAG2 genes. The targeted next-generation s …
According to the most recent report by the International Union of Immunological Societies (IUIS), SCID is caused by mutations in IL2RG, JAK3 …
CORO1A regulates lipoprotein uptake in Leydig cells exposed to cadmium.
Wang Y, Li T, Li H, Liang Y, Mai W, Liu C, Chen H, Huang Y, Zhang Q. Wang Y, et al. Ecotoxicol Environ Saf. 2022 Mar 1;232:113255. doi: 10.1016/j.ecoenv.2022.113255. Epub 2022 Feb 1. Ecotoxicol Environ Saf. 2022. PMID: 35121256 Free article.
This study was performed to explore the role of CORO1A in androgen deficiency caused by Cd exposure and its involvement of low-density lipoprotein (LDL) uptake and effects on LDs. ...These findings highlight the crucial role of CORO1A as a cytoskeleton regula …
This study was performed to explore the role of CORO1A in androgen deficiency caused by Cd exposure and its involvement of low …
Clinical, Immunological, and Molecular Features of Severe Combined Immune Deficiency: A Multi-Institutional Experience From India.
Vignesh P, Rawat A, Kumrah R, Singh A, Gummadi A, Sharma M, Kaur A, Nameirakpam J, Jindal A, Suri D, Gupta A, Khadwal A, Saikia B, Minz RW, Sharma K, Desai M, Taur P, Gowri V, Pandrowala A, Dalvi A, Jodhawat N, Kambli P, Madkaikar MR, Bhattad S, Ramprakash S, Cp R, Jayaram A, Sivasankaran M, Munirathnam D, Balaji S, Rajendran A, Aggarwal A, Singh K, Na F, George B, Mehta A, Lashkari HP, Uppuluri R, Raj R, Bartakke S, Gupta K, Sreedharanunni S, Ogura Y, Kato T, Imai K, Chan KW, Leung D, Ohara O, Nonoyama S, Hershfield M, Lau YL, Singh S. Vignesh P, et al. Front Immunol. 2021 Feb 8;11:619146. doi: 10.3389/fimmu.2020.619146. eCollection 2020. Front Immunol. 2021. PMID: 33628209 Free PMC article.
BACKGROUND: Severe Combined Immune Deficiency (SCID) is an inherited defect in lymphocyte development and function that results in life-threatening opportunistic infections in early infancy. ...Twelve (12) centers provided necessary details which were then compiled and ana …
BACKGROUND: Severe Combined Immune Deficiency (SCID) is an inherited defect in lymphocyte development and function that results in li …
The Actin Regulator Coronin-1A Modulates Platelet Shape Change and Consolidates Arterial Thrombosis.
Stocker TJ, Pircher J, Skenderi A, Ehrlich A, Eberle C, Megens RTA, Petzold T, Zhang Z, Walzog B, Müller-Taubenberger A, Weber C, Massberg S, Ishikawa-Ankerhold H, Schulz C. Stocker TJ, et al. Thromb Haemost. 2018 Dec;118(12):2098-2111. doi: 10.1055/s-0038-1675604. Epub 2018 Nov 19. Thromb Haemost. 2018. PMID: 30453345
The role of Coro1A in platelets has been previously unknown. Here, we identified Coro1A in human and mouse platelets. ...Furthermore, Coro1A-deficient mice displayed a defect in ferric chloride-induced arterial thrombosis with prolonged thrombus format …
The role of Coro1A in platelets has been previously unknown. Here, we identified Coro1A in human and mouse platelets. ...Furth …
Inherited Immunodeficiencies With High Predisposition to Epstein-Barr Virus-Driven Lymphoproliferative Diseases.
Latour S, Winter S. Latour S, et al. Front Immunol. 2018 Jun 4;9:1103. doi: 10.3389/fimmu.2018.01103. eCollection 2018. Front Immunol. 2018. PMID: 29942301 Free PMC article. Review.
Among them are SH2D1A (SAP), XIAP, ITK, MAGT1, CD27, CD70, CTPS1, RASGRP1, and CORO1A deficiencies. Penetrance of EBV infection ranges from 50 to 100% in those PIDs. ...SLAM-associated protein-dependent SLAM receptors and MAGT1-dependent NKG2D pathways are important …
Among them are SH2D1A (SAP), XIAP, ITK, MAGT1, CD27, CD70, CTPS1, RASGRP1, and CORO1A deficiencies. Penetrance of EBV infectio …
Irf8 regulates the progression of myeloproliferative neoplasm-like syndrome via Mertk signaling in zebrafish.
Zhao F, Shi Y, Huang Y, Zhan Y, Zhou L, Li Y, Wan Y, Li H, Huang H, Ruan H, Luo L, Li L. Zhao F, et al. Leukemia. 2018 Jan;32(1):149-158. doi: 10.1038/leu.2017.189. Epub 2017 Jun 19. Leukemia. 2018. PMID: 28626217
Multiple molecules presented notable alteration and Mertk signaling was aberrantly activated in the hematopoietic cells in irf8 mutants. Transgenic mertk overexpression in Tg(coro1a:mertk) zebrafish recapitulated the myeloid neoplasia-like syndrome in irf8 mutants. Moreove …
Multiple molecules presented notable alteration and Mertk signaling was aberrantly activated in the hematopoietic cells in irf8 mutants. Tra …
Re-evaluation of epidermodysplasia verruciformis: Reconciling more than 90 years of debate.
Przybyszewska J, Zlotogorski A, Ramot Y. Przybyszewska J, et al. J Am Acad Dermatol. 2017 Jun;76(6):1161-1175. doi: 10.1016/j.jaad.2016.12.035. Epub 2017 Feb 10. J Am Acad Dermatol. 2017. PMID: 28196644 Review.
A breakthrough in our understanding of EV was the discovery that homozygous inactivating mutations in TMC6 (EVER1) and TMC8 (EVER2) determine susceptibility to this disorder; however, they have not solved all EV cases fully. These deficiencies account for 75% of affected i …
A breakthrough in our understanding of EV was the discovery that homozygous inactivating mutations in TMC6 (EVER1) and TMC8 (EVER2) determin …
Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.
Siegmund K, Klepsch V, Hermann-Kleiter N, Baier G. Siegmund K, et al. J Biol Chem. 2016 Oct 14;291(42):22086-22092. doi: 10.1074/jbc.M116.748012. Epub 2016 Aug 26. J Biol Chem. 2016. PMID: 27566541 Free PMC article.
Studies analyzing complete Coronin 1a knock-out mice have shown that this molecule is an important regulator of naive T cell homeostasis and it has been linked to immune deficiencies as well as autoimmune disorders. Nevertheless, because Coronin 1A is strongly expressed in …
Studies analyzing complete Coronin 1a knock-out mice have shown that this molecule is an important regulator of naive T cell homeostasis and …
Recurrent viral infections associated with a homozygous CORO1A mutation that disrupts oligomerization and cytoskeletal association.
Yee CS, Massaad MJ, Bainter W, Ohsumi TK, Föger N, Chan AC, Akarsu NA, Aytekin C, Ayvaz DÇ, Tezcan I, Sanal Ö, Geha RS, Chou J. Yee CS, et al. J Allergy Clin Immunol. 2016 Mar;137(3):879-88.e2. doi: 10.1016/j.jaci.2015.08.020. Epub 2015 Oct 21. J Allergy Clin Immunol. 2016. PMID: 26476480 Free PMC article.
BACKGROUND: Coronin-1A (CORO1A) is a regulator of actin dynamics important for T-cell homeostasis. CORO1A deficiency causes T(-)B(+) natural killer-positive severe combined immunodeficiency or T-cell lymphopenia with severe viral infections. ...The CORO1A …
BACKGROUND: Coronin-1A (CORO1A) is a regulator of actin dynamics important for T-cell homeostasis. CORO1A deficiency ca …
Primary Immunodeficiencies Associated with EBV Disease.
Cohen JI. Cohen JI. Curr Top Microbiol Immunol. 2015;390(Pt 1):241-65. doi: 10.1007/978-3-319-22822-8_10. Curr Top Microbiol Immunol. 2015. PMID: 26424649 Free PMC article. Review.
These include mutations in SH2D1A, BIRC4, ITK, CD27, MAGT1, CORO1A, and LRBA. Since EBV is the only virus that induces proliferation of B cells, the study of these diseases has helped to identify proteins critical for interactions of T and/or NK cells with B cells. ...
These include mutations in SH2D1A, BIRC4, ITK, CD27, MAGT1, CORO1A, and LRBA. Since EBV is the only virus that induces proliferation …
The disease-linked Glu-26-Lys mutant version of Coronin 1A exhibits pleiotropic and pathway-specific signaling defects.
Ojeda V, Robles-Valero J, Barreira M, Bustelo XR. Ojeda V, et al. Mol Biol Cell. 2015 Aug 15;26(16):2895-912. doi: 10.1091/mbc.E15-01-0052. Epub 2015 Jun 24. Mol Biol Cell. 2015. PMID: 26108624 Free PMC article.
Mutations that generate truncated or unstable Coro1A proteins cause immunodeficiencies in both humans and rodents. However, in the case of the peripheral T-cell-deficient (Ptcd) mouse strain, the immunodeficiency is caused by a Glu-26-Lys mutation that targets a sur …
Mutations that generate truncated or unstable Coro1A proteins cause immunodeficiencies in both humans and rodents. However, in the ca …
Novel protein kinase C θ: coronin 1A complex in T lymphocytes.
Siegmund K, Thuille N, Posch N, Fresser F, Baier G. Siegmund K, et al. Cell Commun Signal. 2015 Mar 31;13:22. doi: 10.1186/s12964-015-0100-3. Cell Commun Signal. 2015. PMID: 25889880 Free PMC article.
FINDINGS: Employing a yeast two-hybrid screen and co-immunoprecipitation analyses, we here identify coronin 1A (Coro1A) as a novel PKCtheta-interacting protein. We show that the NH2-terminal WD40 domains of Coro1A and the C2-like domain of PKCtheta are sufficient fo …
FINDINGS: Employing a yeast two-hybrid screen and co-immunoprecipitation analyses, we here identify coronin 1A (Coro1A) as a novel PK …
Interleukin-2-inducible T-cell kinase (ITK) deficiency - clinical and molecular aspects.
Ghosh S, Bienemann K, Boztug K, Borkhardt A. Ghosh S, et al. J Clin Immunol. 2014 Nov;34(8):892-9. doi: 10.1007/s10875-014-0110-8. Epub 2014 Oct 24. J Clin Immunol. 2014. PMID: 25339095 Free PMC article. Review.
Several newly discovered primary immunodeficiencies (STK4, CD27, MAGT1, CORO1A) have been described in recent years; our group and collaborators were able to reveal the pathogenicity of mutations in the Interleukin-2-inducible T-cell Kinase (ITK) in a cohort of nine patien …
Several newly discovered primary immunodeficiencies (STK4, CD27, MAGT1, CORO1A) have been described in recent years; our group and co …
Compound heterozygous CORO1A mutations in siblings with a mucocutaneous-immunodeficiency syndrome of epidermodysplasia verruciformis-HPV, molluscum contagiosum and granulomatous tuberculoid leprosy.
Stray-Pedersen A, Jouanguy E, Crequer A, Bertuch AA, Brown BS, Jhangiani SN, Muzny DM, Gambin T, Sorte H, Sasa G, Metry D, Campbell J, Sockrider MM, Dishop MK, Scollard DM, Gibbs RA, Mace EM, Orange JS, Lupski JR, Casanova JL, Noroski LM. Stray-Pedersen A, et al. J Clin Immunol. 2014 Oct;34(7):871-90. doi: 10.1007/s10875-014-0074-8. Epub 2014 Jul 30. J Clin Immunol. 2014. PMID: 25073507 Free PMC article.
PURPOSE: Coronin-1A deficiency is a recently recognized autosomal recessive primary immunodeficiency caused by mutations in CORO1A (OMIM 605000) that results in T-cell lymphopenia and is classified as T(-)B(+)NK(+)severe combined immunodeficiency (SCID). ...Our find …
PURPOSE: Coronin-1A deficiency is a recently recognized autosomal recessive primary immunodeficiency caused by mutations in CORO1A …
Lytic immune synapse function requires filamentous actin deconstruction by Coronin 1A.
Mace EM, Orange JS. Mace EM, et al. Proc Natl Acad Sci U S A. 2014 May 6;111(18):6708-13. doi: 10.1073/pnas.1314975111. Epub 2014 Apr 23. Proc Natl Acad Sci U S A. 2014. PMID: 24760828 Free PMC article.
Here, we show that Coro1A is required for natural killer (NK) cell cytotoxic function in two human NK cell lines and ex vivo cells from a Coro1A-deficient patient. ...Thus, we show, for the first time to our knowledge, a critical role for F-actin deconstructi …
Here, we show that Coro1A is required for natural killer (NK) cell cytotoxic function in two human NK cell lines and ex vivo cells fr …
Coronin-1 is a neurotrophin endosomal effector that is required for developmental competition for survival.
Suo D, Park J, Harrington AW, Zweifel LS, Mihalas S, Deppmann CD. Suo D, et al. Nat Neurosci. 2014 Jan;17(1):36-45. doi: 10.1038/nn.3593. Epub 2013 Nov 24. Nat Neurosci. 2014. PMID: 24270184 Free PMC article.
Here we report that in mouse sympathetic neurons, the target-derived nerve growth factor (NGF)-tropomyosin-related kinase type 1 (TrkA, also called Ntrk1) signaling endosome, on arrival at the cell body, induces the expression and recruitment of a new effector protein known as Co …
Here we report that in mouse sympathetic neurons, the target-derived nerve growth factor (NGF)-tropomyosin-related kinase type 1 (TrkA, also …
Whole-exome sequencing identifies Coronin-1A deficiency in 3 siblings with immunodeficiency and EBV-associated B-cell lymphoproliferation.
Moshous D, Martin E, Carpentier W, Lim A, Callebaut I, Canioni D, Hauck F, Majewski J, Schwartzentruber J, Nitschke P, Sirvent N, Frange P, Picard C, Blanche S, Revy P, Fischer A, Latour S, Jabado N, de Villartay JP. Moshous D, et al. J Allergy Clin Immunol. 2013 Jun;131(6):1594-603. doi: 10.1016/j.jaci.2013.01.042. Epub 2013 Mar 21. J Allergy Clin Immunol. 2013. PMID: 23522482
RESULTS: We identified a homozygous inherited missense mutation in the gene encoding Coronin-1A (CORO1A) in the 3 siblings. This mutation, p. V134M, results in the substitution of an evolutionarily conserved amino acid within the beta-propeller domain, which abrogates almo …
RESULTS: We identified a homozygous inherited missense mutation in the gene encoding Coronin-1A (CORO1A) in the 3 siblings. This muta …
Endosomal actin remodeling by coronin-1A controls lipoprotein uptake and degradation in macrophages.
Hölttä-Vuori M, Vainio S, Kauppi M, Van Eck M, Jokitalo E, Ikonen E. Hölttä-Vuori M, et al. Circ Res. 2012 Feb 3;110(3):450-5. doi: 10.1161/CIRCRESAHA.111.256842. Epub 2012 Jan 5. Circ Res. 2012. PMID: 22223354 Free article.
METHODS AND RESULTS: In wild-type primary macrophages, filamentous actin transiently decorated AcLDL containing endosomes that also recruited Coro1A. This dynamic association of F-actin with endosomes was disturbed in Coro1A deficient macrophages. ...Overexpr …
METHODS AND RESULTS: In wild-type primary macrophages, filamentous actin transiently decorated AcLDL containing endosomes that also recruite …
Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells.
Kaminski S, Hermann-Kleiter N, Meisel M, Thuille N, Cronin S, Hara H, Fresser F, Penninger JM, Baier G. Kaminski S, et al. J Autoimmun. 2011 Nov;37(3):198-208. doi: 10.1016/j.jaut.2011.05.018. Epub 2011 Jun 22. J Autoimmun. 2011. PMID: 21700422
In this study, we describe an essential mechanism by which the actin regulatory protein Coronin 1A (Coro1A) ensures the proper response of Th17 CD4(+) T cells to TGFbeta. Coro1A has been established as a key player in T cell survival, migration, activation, and Ca(2 …
In this study, we describe an essential mechanism by which the actin regulatory protein Coronin 1A (Coro1A) ensures the proper respon …
Mast cell function is not altered by Coronin-1A deficiency.
Arandjelovic S, Wickramarachchi D, Hemmers S, Leming SS, Kono DH, Mowen KA. Arandjelovic S, et al. J Leukoc Biol. 2010 Oct;88(4):737-45. doi: 10.1189/jlb.0310131. Epub 2010 Jul 19. J Leukoc Biol. 2010. PMID: 20643816 Free PMC article.
In Coro1a(-/-) and Coro1a(Lmb3) mice, peripheral T cells exhibit impairments in survival, migration, activation, and Ca2+ flux. ...In Coro1a(Lmb3) mast cells, Ca2+ flux in response to physiological FcepsilonRI stimulation is unaffected. ...
In Coro1a(-/-) and Coro1a(Lmb3) mice, peripheral T cells exhibit impairments in survival, migration, activation, and Ca2+ flux …
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency.
Shiow LR, Roadcap DW, Paris K, Watson SR, Grigorova IL, Lebet T, An J, Xu Y, Jenne CN, Föger N, Sorensen RU, Goodnow CC, Bear JE, Puck JM, Cyster JG. Shiow LR, et al. Nat Immunol. 2008 Nov;9(11):1307-15. doi: 10.1038/ni.1662. Epub 2008 Oct 5. Nat Immunol. 2008. PMID: 18836449 Free PMC article.
Mice carrying the recessive locus for peripheral T cell deficiency (Ptcd) have a block in thymic egress, but the mechanism responsible is undefined. ...The discovery of another coronin 1A mutant during an N-ethyl-N-nitrosourea-mutagenesis screen for T cell-lymphopenic mice …
Mice carrying the recessive locus for peripheral T cell deficiency (Ptcd) have a block in thymic egress, but the mechanism responsibl …
Regulation of T cell survival through coronin-1-mediated generation of inositol-1,4,5-trisphosphate and calcium mobilization after T cell receptor triggering.
Mueller P, Massner J, Jayachandran R, Combaluzier B, Albrecht I, Gatfield J, Blum C, Ceredig R, Rodewald HR, Rolink AG, Pieters J. Mueller P, et al. Nat Immunol. 2008 Apr;9(4):424-31. doi: 10.1038/ni1570. Epub 2008 Mar 16. Nat Immunol. 2008. PMID: 18345003
We here report that the WD-repeat protein family member coronin-1, encoded by the gene Coro1a, is essential in the mouse for T cell survival through its promotion of Ca2+ mobilization from intracellular stores. ...
We here report that the WD-repeat protein family member coronin-1, encoded by the gene Coro1a, is essential in the mouse for T cell s …