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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges.
Lai CC, Shih TP, Ko WC, Tang HJ, Hsueh PR. Lai CC, et al. Int J Antimicrob Agents. 2020 Mar;55(3):105924. doi: 10.1016/j.ijantimicag.2020.105924. Epub 2020 Feb 17. Int J Antimicrob Agents. 2020. PMID: 32081636
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; previously provisionally named 2019 novel coronavirus or 2019-nCoV) disease (COVID-19) in China at the end of 2019 has caused a large global outbreak and is a major public health issue. ...Among patients with pneumonia caused by SARS-CoV-2 (novel coronavirus pneumonia or Wuhan pneumonia), fever was the most common symptom, followed by cough. ...
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; previously provisionally named 2019 novel
The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status.
Guo YR, Cao QD, Hong ZS, Tan YY, Chen SD, Jin HJ, Tan KS, Wang DY, Yan Y. Guo YR, et al. Mil Med Res. 2020 Mar 13;7(1):11. doi: 10.1186/s40779-020-00240-0. Mil Med Res. 2020. PMID: 32169119 Free PMC article. Review.
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the coronavirus disease 2019 (COVID-19) has spread throughout China and received worldwide attention. ...In this review, we summarized the latest research progress of the epidemiology, pathogenesis, and clinical characteristics of COVID-19, and discussed the current treatment and scientific advancements to combat the epidemic novel coronavirus....
An acute respiratory disease, caused by a novel coronavirus (SARS-CoV-2, previously known as 2019-nCoV), the …
Of chloroquine and COVID-19.
Touret F, de Lamballerie X. Touret F, et al. Antiviral Res. 2020 Mar 5;177:104762. doi: 10.1016/j.antiviral.2020.104762. Online ahead of print. Antiviral Res. 2020. PMID: 32147496 Review.
Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of patients infected by the novel emerged coronavirus (SARS-CoV-2). ...
Recent publications have brought attention to the possible benefit of chloroquine, a broadly used antimalarial drug, in the treatment of pat …
A Review of Coronavirus Disease-2019 (COVID-19).
Singhal T. Singhal T. Indian J Pediatr. 2020 Apr;87(4):281-286. doi: 10.1007/s12098-020-03263-6. Epub 2020 Mar 13. Indian J Pediatr. 2020. PMID: 32166607 Free PMC article. Review.
There is a new public health crises threatening the world with the emergence and spread of 2019 novel coronavirus (2019-nCoV) or the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The virus originated in bats and was transmitted to humans through yet unknown intermediary animals in Wuhan, Hubei province, China in December 2019. ...
There is a new public health crises threatening the world with the emergence and spread of 2019 novel coronavirus
[The epidemiological characteristics of an outbreak of 2019 novel coronavirus diseases (COVID-19) in China].
Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. Novel Coronavirus Pneumonia Emergency Response Epidemiology Team. Zhonghua Liu Xing Bing Xue Za Zhi. 2020 Feb 17;41(2):145-151. doi: 10.3760/cma.j.issn.0254-6450.2020.02.003. Online ahead of print. Zhonghua Liu Xing Bing Xue Za Zhi. 2020. PMID: 32064853 Chinese.
Objective: An outbreak of 2019 novel coronavirus diseases (COVID-19) in Wuhan, China has spread quickly nationwide. Here, we report results of a descriptive, exploratory analysis of all cases diagnosed as of February 11, 2020. ...The COVID-19 spread outward from Hubei sometime after December 2019 and by February 11, 2020, 1 386 counties across all 31 provinces were affected. ...
Objective: An outbreak of 2019 novel coronavirus diseases (COVID-19) in Wuhan, China has spread qu …
The epidemiology and pathogenesis of coronavirus disease (COVID-19) outbreak.
Rothan HA, Byrareddy SN. Rothan HA, et al. J Autoimmun. 2020 Feb 26:102433. doi: 10.1016/j.jaut.2020.102433. Online ahead of print. J Autoimmun. 2020. PMID: 32113704 Review.
Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease that is of great global public health concern. Based on the large number of infected people that were exposed to the wet animal market in Wuhan City, China, it is suggested that this is likely the zoonotic origin of COVID-19. ...
Coronavirus disease (COVID-19) is caused by SARS-COV2 and represents the causative agent of a potentially fatal disease
Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding.
Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, Wang W, Song H, Huang B, Zhu N, Bi Y, Ma X, Zhan F, Wang L, Hu T, Zhou H, Hu Z, Zhou W, Zhao L, Chen J, Meng Y, Wang J, Lin Y, Yuan J, Xie Z, Ma J, Liu WJ, Wang D, Xu W, Holmes EC, Gao GF, Wu G, Chen W, Shi W, Tan W. Lu R, et al. Lancet. 2020 Feb 22;395(10224):565-574. doi: 10.1016/S0140-6736(20)30251-8. Epub 2020 Jan 30. Lancet. 2020. PMID: 32007145
A novel coronavirus was subsequently identified as the causative pathogen, provisionally named 2019 novel coronavirus (2019-nCoV). ...INTERPRETATION: 2019-nCoV is sufficiently divergent from SARS-CoV to be considered a new human-infecting betacoronavirus. Although our phylogenetic analysis suggests that bats might be the original host of this virus, an animal sold at the seafood market in Wuhan might represent an intermediate host facilitating the emergence of the virus in humans. ...
A novel coronavirus was subsequently identified as the causative pathogen, provisionally named 2019 novel cor
Understanding of COVID-19 based on current evidence.
Sun P, Lu X, Xu C, Sun W, Pan B. Sun P, et al. J Med Virol. 2020 Feb 25. doi: 10.1002/jmv.25722. Online ahead of print. J Med Virol. 2020. PMID: 32096567 Review.
Since December 2019, a series of unexplained pneumonia cases have been reported in Wuhan, China. On 12 January 2020, the World Health Organization (WHO) temporarily named this new virus as the 2019 novel coronavirus (2019-nCoV). On 11 February 2020, the WHO officially named the disease caused by the 2019-nCoV as coronavirus disease (COVID-19). The COVID-19 epidemic is spreading all over the world, especially in China. ...
Since December 2019, a series of unexplained pneumonia cases have been reported in Wuhan, China. On 12 January 2020, the World …
Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study.
Chen N, Zhou M, Dong X, Qu J, Gong F, Han Y, Qiu Y, Wang J, Liu Y, Wei Y, Xia J, Yu T, Zhang X, Zhang L. Chen N, et al. Lancet. 2020 Feb 15;395(10223):507-513. doi: 10.1016/S0140-6736(20)30211-7. Epub 2020 Jan 30. Lancet. 2020. PMID: 32007143
BACKGROUND: In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) emerged in Wuhan, China. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia. METHODS: In this retrospective, single-centre study, we included all confirmed cases of 2019-nCoV in Wuhan Jinyintan Hospital from Jan 1 to Jan 20, 2020. ...
BACKGROUND: In December, 2019, a pneumonia associated with the 2019 novel coronavirus (2019-nCoV) …
Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR.
Corman VM, Landt O, Kaiser M, Molenkamp R, Meijer A, Chu DKW, Bleicker T, Brünink S, Schneider J, Schmidt ML, Mulders DGJC, Haagmans BL, van der Veer B, van den Brink S, Wijsman L, Goderski G, Romette JL, Ellis J, Zambon M, Peiris M, Goossens H, Reusken C, Koopmans MPG, Drosten C. Corman VM, et al. Euro Surveill. 2020 Jan;25(3):2000045. doi: 10.2807/1560-7917.ES.2020.25.3.2000045. Euro Surveill. 2020. PMID: 31992387 Free PMC article.
BACKGROUND: The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for public health laboratories as virus isolates are unavailable while there is growing evidence that the outbreak is more widespread than initially thought, and international spread through travellers does already occur. ...METHODS: Here we present a validated diagnostic workflow for 2019-nCoV, its design relying on close genetic relatedness of 2019-nCoV with SARS coronavirus, making use of synthetic nucleic acid technology. ...
BACKGROUND: The ongoing outbreak of the recently emerged novel coronavirus (2019-nCoV) poses a challenge for pub …
The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients.
Li YC, Bai WZ, Hashikawa T. Li YC, et al. J Med Virol. 2020 Feb 27. doi: 10.1002/jmv.25728. Online ahead of print. J Med Virol. 2020. PMID: 32104915 Review.
Following the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), another highly pathogenic coronavirus named SARS-CoV-2 (previously known as 2019-nCoV) emerged in December 2019 in Wuhan, China, and rapidly spreads around the world. This virus shares highly homological sequence with SARS-CoV, and causes acute, highly lethal pneumonia coronavirus disease 2019 (COVID-19) with clinical symptoms similar to those reported for SARS-CoV and MERS-CoV. ...
Following the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS- …
Coronavirus Disease 2019 (COVID-19) and Pregnancy: What obstetricians need to know.
Rasmussen SA, Smulian JC, Lednicky JA, Wen TS, Jamieson DJ. Rasmussen SA, et al. Am J Obstet Gynecol. 2020 Feb 24. doi: 10.1016/j.ajog.2020.02.017. Online ahead of print. Am J Obstet Gynecol. 2020. PMID: 32105680 Free PMC article. Review.
Coronavirus Disease 2019 (COVID-19) is an emerging disease with a rapid increase in cases and deaths since its first identification in Wuhan, China, in December 2019. Limited data are available about COVID-19 during pregnancy; however, information on illnesses associated with other highly pathogenic coronaviruses (i.e., severe acute respiratory syndrome (SARS) and the Middle East respiratory syndrome (MERS)) might provide insights into COVID-19's effects during pregnancy....
Coronavirus Disease 2019 (COVID-19) is an emerging disease with a rapid increase in cases and deaths since its f
Unique epidemiological and clinical features of the emerging 2019 novel coronavirus pneumonia (COVID-19) implicate special control measures.
Wang Y, Wang Y, Chen Y, Qin Q. Wang Y, et al. J Med Virol. 2020 Mar 5. doi: 10.1002/jmv.25748. Online ahead of print. J Med Virol. 2020. PMID: 32134116 Review.
COVID-19 has spread to 46 countries internationally. Total fatality rate of COVID-19 is estimated at 3.46% by far based on published data from Chinese Center for Disease Control and Prevention (China CDC). Average incubation period of COVID-19 is around 6.4 days, ranges from 0-24 days. The basic reproductive number (R(0) ) of COVID-19 ranges from 2-3.5 at the early phase regardless of different prediction models, which is higher than SARS and MERS. ...
COVID-19 has spread to 46 countries internationally. Total fatality rate of COVID-19 is estimated at 3.46% by fa
Asymptomatic carrier state, acute respiratory disease, and pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2): Facts and myths.
Lai CC, Liu YH, Wang CY, Wang YH, Hsueh SC, Yen MY, Ko WC, Hsueh PR. Lai CC, et al. J Microbiol Immunol Infect. 2020 Mar 4:S1684-1182(20)30040-2. doi: 10.1016/j.jmii.2020.02.012. Online ahead of print. J Microbiol Immunol Infect. 2020. PMID: 32173241 Free article. Review.
Since the emergence of coronavirus disease 2019 (COVID-19) (formerly known as the 2019 novel coronavirus [2019-nCoV]) in Wuhan, China in December 2019, which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more than 75,000 cases have been reported in 32 countries/regions, resulting in more than 2000 deaths worldwide. Despite the fact that most COVID-19 cases and mortalities were reported in China, the WHO has declared this outbreak as the sixth public health emergency of international concern. ...
Since the emergence of coronavirus disease 2019 (COVID-19) (formerly known as the 2019 novel co
What we know so far: COVID-19 current clinical knowledge and research.
Lake MA. Lake MA. Clin Med (Lond). 2020 Mar;20(2):124-127. doi: 10.7861/clinmed.2019-coron. Epub 2020 Mar 5. Clin Med (Lond). 2020. PMID: 32139372 Free PMC article. Review.
Subsequent investigations revealed a novel coronavirus, SARS-CoV-2, as the causative agent now at the heart of a major outbreak. ...This article will review the new knowledge of SARS-CoV-2 COVID-19 acute respiratory disease, and summarise its clinical features....
Subsequent investigations revealed a novel coronavirus, SARS-CoV-2, as the causative agent now at the heart of a major outbrea …
Coronavirus Disease 2019 (COVID-19): A Perspective from China.
Zu ZY, Jiang MD, Xu PP, Chen W, Ni QQ, Lu GM, Zhang LJ. Zu ZY, et al. Radiology. 2020 Feb 21:200490. doi: 10.1148/radiol.2020200490. Online ahead of print. Radiology. 2020. PMID: 32083985
In December 2019, an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection occurred in Wuhan, Hubei Province, China and spread across China and beyond. On February 12, 2020, WHO officially named the disease caused by the novel coronavirus as Coronavirus Disease 2019 (COVID-19). ...
In December 2019, an outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection occurred in Wuhan
A new coronavirus associated with human respiratory disease in China.
Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY, Yuan ML, Zhang YL, Dai FH, Liu Y, Wang QM, Zheng JJ, Xu L, Holmes EC, Zhang YZ. Wu F, et al. Nature. 2020 Mar;579(7798):265-269. doi: 10.1038/s41586-020-2008-3. Epub 2020 Feb 3. Nature. 2020. PMID: 32015508 Free PMC article.
Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe respiratory disease was recently reported in Wuhan, Hubei province, China. ...Metagenomic RNA sequencing(4) of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae, which is designated here 'WH-Human 1' coronavirus (and has also been referred to as '2019-nCoV'). ...
Despite intense research efforts, how, when and where new diseases appear are still a source of considerable uncertainty. A severe re …
Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV.
Liu J, Zheng X, Tong Q, Li W, Wang B, Sutter K, Trilling M, Lu M, Dittmer U, Yang D. Liu J, et al. J Med Virol. 2020 May;92(5):491-494. doi: 10.1002/jmv.25709. Epub 2020 Feb 21. J Med Virol. 2020. PMID: 32056249 Review.
First reported from Wuhan, The People's Republic of China, on 31 December 2019, the ongoing outbreak of a novel coronavirus (2019-nCoV) causes great global concerns. ...Together with the other two highly pathogenic coronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), 2019-nCov and other yet to be identified coronaviruses pose a global threat to public health. ...
First reported from Wuhan, The People's Republic of China, on 31 December 2019, the ongoing outbreak of a novel coro
A pneumonia outbreak associated with a new coronavirus of probable bat origin.
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL. Zhou P, et al. Nature. 2020 Mar;579(7798):270-273. doi: 10.1038/s41586-020-2012-7. Epub 2020 Feb 3. Nature. 2020. PMID: 32015507 Free PMC article.
Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. ...Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. ...
Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemi …
The Novel Coronavirus: A Bird's Eye View.
Habibzadeh P, Stoneman EK. Habibzadeh P, et al. Int J Occup Environ Med. 2020 Feb 5;11(2):65-71. doi: 10.15171/ijoem.2020.1921. Online ahead of print. Int J Occup Environ Med. 2020. PMID: 32020915 Free article. Review.
The novel coronavirus (2019-nCoV) outbreak, which initially began in China, has spread to many countries around the globe, with the number of confirmed cases increasing every day. With a death toll exceeding that of the SARS-CoV outbreak back in 2002 and 2003 in China, 2019-nCoV has led to a public health emergency of international concern, putting all health organizations on high alert. ...
The novel coronavirus (2019-nCoV) outbreak, which initially began in China, has spread to many countries around …
A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version).
Jin YH, Cai L, Cheng ZS, Cheng H, Deng T, Fan YP, Fang C, Huang D, Huang LQ, Huang Q, Han Y, Hu B, Hu F, Li BH, Li YR, Liang K, Lin LK, Luo LS, Ma J, Ma LL, Peng ZY, Pan YB, Pan ZY, Ren XQ, Sun HM, Wang Y, Wang YY, Weng H, Wei CJ, Wu DF, Xia J, Xiong Y, Xu HB, Yao XM, Yuan YF, Ye TS, Zhang XC, Zhang YW, Zhang YG, Zhang HM, Zhao Y, Zhao MJ, Zi H, Zeng XT, Wang YY, Wang XH; , for the Zhongnan Hospital of Wuhan University Novel Coronavirus Management and Research Team, Evidence-Based Medicine Chapter of China International Exchange and Promotive Association for Medical and Health Care (CPAM). Jin YH, et al. Mil Med Res. 2020 Feb 6;7(1):4. doi: 10.1186/s40779-020-0233-6. Mil Med Res. 2020. PMID: 32029004 Free PMC article.
In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named "2019 novel coronavirus (2019-nCoV)" by the World Health Organization (WHO) on 12 January 2020. ...Moreover, we also provide a whole process of a successful treatment case of the severe 2019-nCoV infected pneumonia and experience and lessons of hospital rescue for 2019-nCoV infections. ...
In December 2019, a new type viral pneumonia cases occurred in Wuhan, Hubei Province; and then named "2019 no
Coronavirus Disease 2019: Coronaviruses and Blood Safety.
Chang L, Yan Y, Wang L. Chang L, et al. Transfus Med Rev. 2020 Feb 21:S0887-7963(20)30014-6. doi: 10.1016/j.tmrv.2020.02.003. Online ahead of print. Transfus Med Rev. 2020. PMID: 32107119 Review.
With the outbreak of unknown pneumonia in Wuhan, China, in December 2019, a new coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), aroused the attention of the entire world. The current outbreak of infections with SARS-CoV-2 is termed Coronavirus Disease 2019 (COVID-19). The World Health Organization declared COVID-19 in China as a Public Health Emergency of International Concern. ...
With the outbreak of unknown pneumonia in Wuhan, China, in December 2019, a new coronavirus, Severe Acute Respir …
Drug treatment options for the 2019-new coronavirus (2019-nCoV).
Lu H. Lu H. Biosci Trends. 2020 Mar 16;14(1):69-71. doi: 10.5582/bst.2020.01020. Epub 2020 Jan 28. Biosci Trends. 2020. PMID: 31996494 Free article.
As of January 22, 2020, a total of 571 cases of the 2019-new coronavirus (2019-nCoV) have been reported in 25 provinces (districts and cities) in China. At present, there is no vaccine or antiviral treatment for human and animal coronavirus, so that identifying the drug treatment options as soon as possible is critical for the response to the 2019-nCoV outbreak. ...
As of January 22, 2020, a total of 571 cases of the 2019-new coronavirus (2019-nCoV) have been reported i …
2019 novel coronavirus patients' clinical characteristics, discharge rate, and fatality rate of meta-analysis.
Li LQ, Huang T, Wang YQ, Wang ZP, Liang Y, Huang TB, Zhang HY, Sun W, Wang Y. Li LQ, et al. J Med Virol. 2020 Mar 12. doi: 10.1002/jmv.25757. Online ahead of print. J Med Virol. 2020. PMID: 32162702 Review.
The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical help. The clinical data of COVID-19 patients from December 2019 to February 2020 were retrieved from four databases. We statistically analyzed the clinical symptoms and laboratory results of COVID-19 patients and explained the discharge rate and fatality rate with a single-arm meta-analysis. ...
The aim of this study was to analyze the clinical data, discharge rate, and fatality rate of COVID-19 patients for clinical he …
SARS-CoV-2 and COVID-19: The most important research questions.
Yuen KS, Ye ZW, Fung SY, Chan CP, Jin DY. Yuen KS, et al. Cell Biosci. 2020 Mar 16;10:40. doi: 10.1186/s13578-020-00404-4. eCollection 2020. Cell Biosci. 2020. PMID: 32190290 Free PMC article.
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an ongoing global health emergency. ...
Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2
First Case of 2019 Novel Coronavirus in the United States.
Holshue ML, DeBolt C, Lindquist S, Lofy KH, Wiesman J, Bruce H, Spitters C, Ericson K, Wilkerson S, Tural A, Diaz G, Cohn A, Fox L, Patel A, Gerber SI, Kim L, Tong S, Lu X, Lindstrom S, Pallansch MA, Weldon WC, Biggs HM, Uyeki TM, Pillai SK; Washington State 2019-nCoV Case Investigation Team. Holshue ML, et al. N Engl J Med. 2020 Mar 5;382(10):929-936. doi: 10.1056/NEJMoa2001191. Epub 2020 Jan 31. N Engl J Med. 2020. PMID: 32004427
An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases now confirmed in multiple countries. We report the first case of 2019-nCoV infection confirmed in the United States and describe the identification, diagnosis, clinical course, and management of the case, including the patient's initial mild symptoms at presentation with progression to pneumonia on day 9 of illness. ...
An outbreak of novel coronavirus (2019-nCoV) that began in Wuhan, China, has spread rapidly, with cases n …
World Health Organization declares global emergency: A review of the 2019 novel coronavirus (COVID-19).
Sohrabi C, Alsafi Z, O'Neill N, Khan M, Kerwan A, Al-Jabir A, Iosifidis C, Agha R. Sohrabi C, et al. Int J Surg. 2020 Feb 26;76:71-76. doi: 10.1016/j.ijsu.2020.02.034. Online ahead of print. Int J Surg. 2020. PMID: 32112977 Review.
An unprecedented outbreak of pneumonia of unknown aetiology in Wuhan City, Hubei province in China emerged in December 2019. A novel coronavirus was identified as the causative agent and was subsequently termed COVID-19 by the World Health Organization (WHO). ...
An unprecedented outbreak of pneumonia of unknown aetiology in Wuhan City, Hubei province in China emerged in December 2019. A …
The COVID-19 epidemic.
Velavan TP, Meyer CG. Velavan TP, et al. Trop Med Int Health. 2020 Mar;25(3):278-280. doi: 10.1111/tmi.13383. Epub 2020 Feb 16. Trop Med Int Health. 2020. PMID: 32052514 Free article. No abstract available.
Novel Wuhan (2019-nCoV) Coronavirus.
Carlos WG, Dela Cruz CS, Cao B, Pasnick S, Jamil S. Carlos WG, et al. Am J Respir Crit Care Med. 2020 Feb 15;201(4):P7-P8. doi: 10.1164/rccm.2014P7. Am J Respir Crit Care Med. 2020. PMID: 32004066 No abstract available.
Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus.
Wan Y, Shang J, Graham R, Baric RS, Li F. Wan Y, et al. J Virol. 2020 Mar 17;94(7):e00127-20. doi: 10.1128/JVI.00127-20. Print 2020 Mar 17. J Virol. 2020. PMID: 31996437
Recently, a novel coronavirus (2019-nCoV) has emerged from Wuhan, China, causing symptoms in humans similar to those caused by severe acute respiratory syndrome coronavirus (SARS-CoV). ...These analyses provide insights into the receptor usage, cell entry, host cell infectivity and animal origin of 2019-nCoV and may help epidemic surveillance and preventive measures against 2019-nCoV.IMPORTANCE The recent emergence of Wuhan coronavirus (2019-nCoV) puts the world on alert. 2019-nCoV is reminiscent of the SARS-CoV outbreak in 2002 to 2003. ...
Recently, a novel coronavirus (2019-nCoV) has emerged from Wuhan, China, causing symptoms in humans simil …
The continuing 2019-nCoV epidemic threat of novel coronaviruses to global health - The latest 2019 novel coronavirus outbreak in Wuhan, China.
Hui DS, I Azhar E, Madani TA, Ntoumi F, Kock R, Dar O, Ippolito G, Mchugh TD, Memish ZA, Drosten C, Zumla A, Petersen E. Hui DS, et al. Int J Infect Dis. 2020 Feb;91:264-266. doi: 10.1016/j.ijid.2020.01.009. Epub 2020 Jan 14. Int J Infect Dis. 2020. PMID: 31953166 Free article. No abstract available.
2019 Novel coronavirus: where we are and what we know.
Cheng ZJ, Shan J. Cheng ZJ, et al. Infection. 2020 Feb 18. doi: 10.1007/s15010-020-01401-y. Online ahead of print. Infection. 2020. PMID: 32072569 Review.
There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan in China and has now spread to 17 other countries. ...
There is a current worldwide outbreak of a new type of coronavirus (2019-nCoV), which originated from Wuhan
Presumed Asymptomatic Carrier Transmission of COVID-19.
Bai Y, Yao L, Wei T, Tian F, Jin DY, Chen L, Wang M. Bai Y, et al. JAMA. 2020 Feb 21:e202565. doi: 10.1001/jama.2020.2565. Online ahead of print. JAMA. 2020. PMID: 32083643
This study describes possible transmission of novel coronavirus disease 2019 (COVID-19) from an asymptomatic Wuhan resident to 5 family members in Anyang, a Chinese city in the neighboring province of Hubei....
This study describes possible transmission of novel coronavirus disease 2019 (COVID-19) from an asymptoma …
Insights into the Recent 2019 Novel Coronavirus (SARS-CoV-2) in Light of Past Human Coronavirus Outbreaks.
Ashour HM, Elkhatib WF, Rahman MM, Elshabrawy HA. Ashour HM, et al. Pathogens. 2020 Mar 4;9(3):E186. doi: 10.3390/pathogens9030186. Pathogens. 2020. PMID: 32143502 Free article. Review.
Currently, the world is concerned about the 2019 novel CoV (SARS-CoV-2) that was initially identified in the city of Wuhan, China in December 2019. ...
Currently, the world is concerned about the 2019 novel CoV (SARS-CoV-2) that was initially identified in the city of Wuhan
Coronavirus Disease 2019 (COVID-19): What we know?
He F, Deng Y, Li W. He F, et al. J Med Virol. 2020 Mar 14. doi: 10.1002/jmv.25766. Online ahead of print. J Med Virol. 2020. PMID: 32170865 Review.
In late December 2019, a cluster of unexplained pneumonia cases has been reported in Wuhan, China. A few days later, the causative agent of this mysterious pneumonia was identified as a novel coronavirus. This causative virus has been temporarily named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the relevant infected disease has been named as coronavirus disease 2019 (COVID-19) by the World Health Organization respectively. ...
In late December 2019, a cluster of unexplained pneumonia cases has been reported in Wuhan, China. A few days later, the causa …
Practical recommendations for critical care and anesthesiology teams caring for novel coronavirus (2019-nCoV) patients.
Wax RS, Christian MD. Wax RS, et al. Can J Anaesth. 2020 Feb 12:1-9. doi: 10.1007/s12630-020-01591-x. Online ahead of print. Can J Anaesth. 2020. PMID: 32052373 Free PMC article. Review.
Patients infected with 2019-nCoV are at risk for developing respiratory failure and requiring admission to critical care units. ...This paper summarizes important considerations regarding patient screening, environmental controls, personal protective equipment, resuscitation measures (including intubation), and critical care unit operations planning as we prepare for the possibility of new imported cases or local outbreaks of 2019-nCoV. ...
Patients infected with 2019-nCoV are at risk for developing respiratory failure and requiring admission to critical care units …
Genomic characterization of the 2019 novel human-pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan.
Chan JF, Kok KH, Zhu Z, Chu H, To KK, Yuan S, Yuen KY. Chan JF, et al. Emerg Microbes Infect. 2020 Jan 28;9(1):221-236. doi: 10.1080/22221751.2020.1719902. eCollection 2020. Emerg Microbes Infect. 2020. PMID: 31987001 Free PMC article.
A mysterious outbreak of atypical pneumonia in late 2019 was traced to a seafood wholesale market in Wuhan of China. Within a few weeks, a novel coronavirus tentatively named as 2019 novel coronavirus (2019-nCoV) was announced by the World Health Organization. We performed bioinformatics analysis on a virus genome from a patient with 2019-nCoV infection and compared it with other related coronavirus genomes. ...
A mysterious outbreak of atypical pneumonia in late 2019 was traced to a seafood wholesale market in Wuhan of China. Within a …
Emerging coronaviruses: Genome structure, replication, and pathogenesis.
Chen Y, Liu Q, Guo D. Chen Y, et al. J Med Virol. 2020 Apr;92(4):418-423. doi: 10.1002/jmv.25681. Epub 2020 Feb 7. J Med Virol. 2020. PMID: 31967327 Review.
The recent emergence of a novel coronavirus (2019-nCoV), which is causing an outbreak of unusual viral pneumonia in patients in Wuhan, a central city in China, is another warning of the risk of CoVs posed to public health. ...
The recent emergence of a novel coronavirus (2019-nCoV), which is causing an outbreak of unusual viral pneumonia …
An interim review of the epidemiological characteristics of 2019 novel coronavirus.
Ryu S, Chun BC; Korean Society of Epidemiology 2019-nCoV Task Force Team. Ryu S, et al. Epidemiol Health. 2020;42:e2020006. doi: 10.4178/epih.e2020006. Epub 2020 Feb 6. Epidemiol Health. 2020. PMID: 32023775 Free PMC article. Review.
OBJECTIVES: The 2019 novel coronavirus (2019-nCoV) from Wuhan, China is currently recognized as a public health emergency of global concern. ...RESULTS: Some of the epidemiological characteristics of 2019-nCoV have been identified. However, there remain considerable uncertainties, which should be considered when providing guidance to public health authorities on control measures. ...
OBJECTIVES: The 2019 novel coronavirus (2019-nCoV) from Wuhan, China is currently recognized as a …
Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak.
Zhao S, Lin Q, Ran J, Musa SS, Yang G, Wang W, Lou Y, Gao D, Yang L, He D, Wang MH. Zhao S, et al. Int J Infect Dis. 2020 Mar;92:214-217. doi: 10.1016/j.ijid.2020.01.050. Epub 2020 Jan 30. Int J Infect Dis. 2020. PMID: 32007643 Free article.
BACKGROUNDS: An ongoing outbreak of a novel coronavirus (2019-nCoV) pneumonia hit a major city in China, Wuhan, December 2019 and subsequently reached other provinces/regions of China and other countries. ...CONCLUSION: The mean estimate of R(0) for the 2019-nCoV ranges from 2.24 to 3.58, and is significantly larger than 1. Our findings indicate the potential of 2019-nCoV to cause outbreaks....
BACKGROUNDS: An ongoing outbreak of a novel coronavirus (2019-nCoV) pneumonia hit a major city in China, Wuha
Chloroquine and hydroxychloroquine as available weapons to fight COVID-19.
Colson P, Rolain JM, Lagier JC, Brouqui P, Raoult D. Colson P, et al. Int J Antimicrob Agents. 2020 Mar 4:105932. doi: 10.1016/j.ijantimicag.2020.105932. Online ahead of print. Int J Antimicrob Agents. 2020. PMID: 32145363 No abstract available.
Review and Prospect of Pathological Features of Corona Virus Disease.
Wang HJ, Du SH, Yue X, Chen CX. Wang HJ, et al. Fa Yi Xue Za Zhi. 2020 Feb 25;36(1):16-20. doi: 10.12116/j.issn.1004-5619.2020.01.004. Online ahead of print. Fa Yi Xue Za Zhi. 2020. PMID: 32198986 Free article. Review. Chinese, English.
Since 2003, coronavirus has caused multiple major public health events that resulted in global epidemics such as, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome (MERS) and corona virus disease 2019 (COVID-19). Especially since COVID-19 has outbroken in Wuhan, Hubei, in December 2019, coronavirus has had a significant impact on people's health and lives. ...
Since 2003, coronavirus has caused multiple major public health events that resulted in global epidemics such as, severe acute respir …
2019-nCoV (Wuhan virus), a novel Coronavirus: human-to-human transmission, travel-related cases, and vaccine readiness.
Ralph R, Lew J, Zeng T, Francis M, Xue B, Roux M, Toloue Ostadgavahi A, Rubino S, Dawe NJ, Al-Ahdal MN, Kelvin DJ, Richardson CD, Kindrachuk J, Falzarano D, Kelvin AA. Ralph R, et al. J Infect Dev Ctries. 2020 Jan 31;14(1):3-17. doi: 10.3855/jidc.12425. J Infect Dev Ctries. 2020. PMID: 32088679 Free article.
The first patients began experiencing symptoms of illness in mid-December 2019. Clinical isolates were found to contain a novel coronavirus with similarity to bat coronaviruses. ...Diagnostic PCR protocols can be found at https://www.who.int/health-topics/coronavirus/laboratory-diagnostics-for-novel-coronavirus....
The first patients began experiencing symptoms of illness in mid-December 2019. Clinical isolates were found to contain a novel
[Expert consensus on chloroquine phosphate for the treatment of novel coronavirus pneumonia].
multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia. multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia. Zhonghua Jie He He Hu Xi Za Zhi. 2020 Feb 20;43(0):E019. doi: 10.3760/cma.j.issn.1001-0939.2020.0019. Online ahead of print. Zhonghua Jie He He Hu Xi Za Zhi. 2020. PMID: 32075365 Chinese.
At the end of December 2019, a novel coronavirus (COVID-19) caused an outbreak in Wuhan, and has quickly spread to all provinces in China and 26 other countries around the world, leading to a serious situation for epidemic prevention. ...In order to guide and regulate the use of chloroquine in patients with novel coronavirus pneumonia, the multicenter collaboration group of Department of Science and Technology of Guangdong Province and Health Commission of Guangdong Province for chloroquine in the treatment of novel coronavirus pneumonia developed this expert consensus after extensive discussion. ...
At the end of December 2019, a novel coronavirus (COVID-19) caused an outbreak in Wuhan, and has q …
The epidemic of 2019-novel-coronavirus (2019-nCoV) pneumonia and insights for emerging infectious diseases in the future.
Li JY, You Z, Wang Q, Zhou ZJ, Qiu Y, Luo R, Ge XY. Li JY, et al. Microbes Infect. 2020 Mar;22(2):80-85. doi: 10.1016/j.micinf.2020.02.002. Epub 2020 Feb 20. Microbes Infect. 2020. PMID: 32087334 Free PMC article. Review.
At the end of December 2019, a novel coronavirus, 2019-nCoV, caused an outbreak of pneumonia spreading from Wuhan, Hubei province, to the whole country of China, which has posed great threats to public health and attracted enormous attention around the world. ...Herein, we describe the epidemic and etiological characteristics of 2019-nCoV, discuss its essential biological features, including tropism and receptor usage, summarize approaches for disease prevention and treatment, and speculate on the transmission route of 2019-nCoV....
At the end of December 2019, a novel coronavirus, 2019-nCoV, caused an outbreak of pneumonia spreading fr …
Transmission routes of 2019-nCoV and controls in dental practice.
Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Peng X, et al. Int J Oral Sci. 2020 Mar 3;12(1):9. doi: 10.1038/s41368-020-0075-9. Int J Oral Sci. 2020. PMID: 32127517 Free PMC article. Review.
A novel β-coronavirus (2019-nCoV) caused severe and even fetal pneumonia explored in a seafood market of Wuhan city, Hubei province, China, and rapidly spread to other provinces of China and other countries. ...The natural host of 2019-nCoV may be the bat Rhinolophus affinis as 2019-nCoV showed 96.2% of whole-genome identity to BatCoV RaTG13. ...
A novel β-coronavirus (2019-nCoV) caused severe and even fetal pneumonia explored in a seafood market of Wuha
Return of the Coronavirus: 2019-nCoV.
Gralinski LE, Menachery VD. Gralinski LE, et al. Viruses. 2020 Jan 24;12(2):135. doi: 10.3390/v12020135. Viruses. 2020. PMID: 31991541 Free PMC article.
The emergence of a novel coronavirus (2019-nCoV) has awakened the echoes of SARS-CoV from nearly two decades ago. Yet, with technological advances and important lessons gained from previous outbreaks, perhaps the world is better equipped to deal with the most recent emergent group 2B coronavirus....
The emergence of a novel coronavirus (2019-nCoV) has awakened the echoes of SARS-CoV from nearly two decades ago …
Potential Maternal and Infant Outcomes from (Wuhan) Coronavirus 2019-nCoV Infecting Pregnant Women: Lessons from SARS, MERS, and Other Human Coronavirus Infections.
Schwartz DA, Graham AL. Schwartz DA, et al. Viruses. 2020 Feb 10;12(2):194. doi: 10.3390/v12020194. Viruses. 2020. PMID: 32050635 Free PMC article.
Further investigation revealed these cases to result from infection with a newly identified coronavirus, termed the 2019-nCoV. ...In order to assess the potential of the Wuhan 2019-nCoV to cause maternal, fetal and neonatal morbidity and other poor obstetrical outcomes, this communication reviews the published data addressing the epidemiological and clinical effects of SARS, MERS, and other coronavirus infections on pregnant women and their infants. ...
Further investigation revealed these cases to result from infection with a newly identified coronavirus, termed the 2019-nC
A systematic review of lopinavir therapy for SARS coronavirus and MERS coronavirus-A possible reference for coronavirus disease-19 treatment option.
Yao TT, Qian JD, Zhu WY, Wang Y, Wang GQ. Yao TT, et al. J Med Virol. 2020 Feb 27. doi: 10.1002/jmv.25729. Online ahead of print. J Med Virol. 2020. PMID: 32104907 Review.
Currently, the outbreak of coronavirus disease-19 (COVID-19) from Wuhan caused a worldwide panic. There are no specific antiviral therapies for COVID-19. ...Lopinavir (LPV) is an effective agent that inhibits the protease activity of coronavirus. In this review, we discuss the literature on the efficacy of LPV in vitro and in vivo, especially in patients with SARS and MERS, so that we might clarify the potential for the use of LPV in patients with COVID-19....
Currently, the outbreak of coronavirus disease-19 (COVID-19) from Wuhan caused a worldwide panic. There are no s …
[Potential antiviral therapeutics for 2019 Novel Coronavirus].
Li H, Wang YM, Xu JY, Cao B. Li H, et al. Zhonghua Jie He He Hu Xi Za Zhi. 2020 Feb 5;43(0):E002. doi: 10.3760/cma.j.issn.1001-0939.2020.0002. Online ahead of print. Zhonghua Jie He He Hu Xi Za Zhi. 2020. PMID: 32023685 Chinese.
The recent outbreak of respiratory illness in Wuhan, China is caused by a novel coronavirus, named 2019-nCoV, which is genetically close to a bat-derived coronavirus. 2019-nCoV is categorized as beta genus coronavirus, same as the two other strains - severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). ...But the efficacy and safety of these drugs for 2019-nCoV pneumonia patients need to be assessed by further clinical trials....
The recent outbreak of respiratory illness in Wuhan, China is caused by a novel coronavirus, named 2019-nCoV
Therapeutic options for the 2019 novel coronavirus (2019-nCoV).
Li G, De Clercq E. Li G, et al. Nat Rev Drug Discov. 2020 Mar;19(3):149-150. doi: 10.1038/d41573-020-00016-0. Nat Rev Drug Discov. 2020. PMID: 32127666 No abstract available.
2019 novel coronavirus of pneumonia in Wuhan, China: emerging attack and management strategies.
She J, Jiang J, Ye L, Hu L, Bai C, Song Y. She J, et al. Clin Transl Med. 2020 Feb 20;9(1):19. doi: 10.1186/s40169-020-00271-z. Clin Transl Med. 2020. PMID: 32078069 Free PMC article. Review.
An ongoing outbreak of 2019-nCoV pneumonia was first identified in Wuhan, Hubei province, China at the end of 2019. With the spread of the new coronavirus accelerating, person-to-person transmission in family homes or hospitals, and intercity spread of 2019-nCoV occurred. ...At present, the mortality of 2019-nCoV in China is 2.3%, compared with 9.6% of SARS and 34.4% of MERS reported by WHO. It seems the new virus is not as fatal as many people thought. ...
An ongoing outbreak of 2019-nCoV pneumonia was first identified in Wuhan, Hubei province, China at the end of 2019
Characteristics of and Public Health Responses to the Coronavirus Disease 2019 Outbreak in China.
Deng SQ, Peng HJ. Deng SQ, et al. J Clin Med. 2020 Feb 20;9(2):575. doi: 10.3390/jcm9020575. J Clin Med. 2020. PMID: 32093211 Free PMC article. Review.
In December 2019, cases of unidentified pneumonia with a history of exposure in the Huanan Seafood Market were reported in Wuhan, Hubei Province. A novel coronavirus, SARS-CoV-2, was identified to be accountable for this disease. Human-to-human transmission is confirmed, and this disease (named COVID-19 by World Health Organization (WHO)) spread rapidly around the country and the world. ...
In December 2019, cases of unidentified pneumonia with a history of exposure in the Huanan Seafood Market were reported in Wuhan
The SARS-CoV-2 outbreak: what we know.
Wu D, Wu T, Liu Q, Yang Z. Wu D, et al. Int J Infect Dis. 2020 Mar 11:S1201-9712(20)30123-5. doi: 10.1016/j.ijid.2020.03.004. Online ahead of print. Int J Infect Dis. 2020. PMID: 32171952 Free article. Review.
There is a current worldwide outbreak of the novel coronavirus Covid-19 (coronavirus disease 2019; the pathogen called SARS-CoV-2; previously 2019-nCoV), which originated from Wuhan in China and has now spread to 6 continents including 66 countries, as of 24:00 on March 2, 2020. ...This paper aggregates and consolidates the epidemiology, clinical manifestations, diagnosis, treatments and preventions of this new type of coronavirus....
There is a current worldwide outbreak of the novel coronavirus Covid-19 (coronavirus disease 2019; …
Emerging 2019 Novel Coronavirus (2019-nCoV) Pneumonia.
Song F, Shi N, Shan F, Zhang Z, Shen J, Lu H, Ling Y, Jiang Y, Shi Y. Song F, et al. Radiology. 2020 Apr;295(1):210-217. doi: 10.1148/radiol.2020200274. Epub 2020 Feb 6. Radiology. 2020. PMID: 32027573
BackgroundThe chest CT findings of patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia have not previously been described in detail.PurposeTo investigate the clinical, laboratory, and imaging findings of emerging 2019-nCoV pneumonia in humans.Materials and MethodsFifty-one patients (25 men and 26 women; age range 16-76 years) with laboratory-confirmed 2019-nCoV infection by using real-time reverse transcription polymerase chain reaction underwent thin-section CT. ...Follow-up CT in 13 patients showed improvement in seven (54%) patients and progression in four (31%) patients.ConclusionPatients with fever and/or cough and with conspicuous ground-glass opacity lesions in the peripheral and posterior lungs on CT images, combined with normal or decreased white blood cells and a history of epidemic exposure, are highly suspected of having 2019 Novel Coronavirus (2019-nCoV) pneumonia.© RSNA, 2020....
BackgroundThe chest CT findings of patients with 2019 Novel Coronavirus (2019-nCoV) pneumonia have not pr …
Full-genome evolutionary analysis of the novel corona virus (2019-nCoV) rejects the hypothesis of emergence as a result of a recent recombination event.
Paraskevis D, Kostaki EG, Magiorkinis G, Panayiotakopoulos G, Sourvinos G, Tsiodras S. Paraskevis D, et al. Infect Genet Evol. 2020 Apr;79:104212. doi: 10.1016/j.meegid.2020.104212. Epub 2020 Jan 29. Infect Genet Evol. 2020. PMID: 32004758
BACKGROUND: A novel coronavirus (2019-nCoV) associated with human to human transmission and severe human infection has been recently reported from the city of Wuhan in China. ...We show evidence that the novel coronavirus (2019-nCov) is not-mosaic consisting in almost half of its genome of a distinct lineage within the betacoronavirus. ...
BACKGROUND: A novel coronavirus (2019-nCoV) associated with human to human transmission and severe human infecti …
COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese-Western Medicine for the Management of 2019 Novel Coronavirus Disease.
Chan KW, Wong VT, Tang SCW. Chan KW, et al. Am J Chin Med. 2020 Mar 13:1-26. doi: 10.1142/S0192415X20500378. Online ahead of print. Am J Chin Med. 2020. PMID: 32164424
We reviewed the latest national and provincial clinical guidelines, retrospective cohort studies, and case series regarding the treatment of COVID-19 by add-on Chinese medicine. ...Given the paucity of strongly evidence-based regimens, the available data suggest that Chinese medicine could be considered as an adjunctive therapeutic option in the management of COVID-19....
We reviewed the latest national and provincial clinical guidelines, retrospective cohort studies, and case series regarding the treatment of …
Coronavirus 2019-nCoV: A brief perspective from the front line.
Han Q, Lin Q, Jin S, You L. Han Q, et al. J Infect. 2020 Apr;80(4):373-377. doi: 10.1016/j.jinf.2020.02.010. Epub 2020 Feb 25. J Infect. 2020. PMID: 32109444 Review.
A novel coronavirus, designated as 2019-nCoV, hit the central Chinese city of Wuhan in late December 2019, and subsequently spread rapidly to all provinces of China and multiple countries. ...At present, there is no vaccine or specific drugs for the human coronavirus. Therefore, it is critical to understand the nature of the virus and its clinical characteristics, in order to respond to the 2019-nCoV outbreak. ...
A novel coronavirus, designated as 2019-nCoV, hit the central Chinese city of Wuhan in late December 2
Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China.
Yu F, Du L, Ojcius DM, Pan C, Jiang S. Yu F, et al. Microbes Infect. 2020 Mar;22(2):74-79. doi: 10.1016/j.micinf.2020.01.003. Epub 2020 Feb 1. Microbes Infect. 2020. PMID: 32017984 Review.
On 10 January 2020, a new coronavirus causing a pneumonia outbreak in Wuhan City in central China was denoted as 2019-nCoV by the World Health Organization (WHO). ...Therefore, combating this new virus and stopping the epidemic is a matter of urgency. Here, we focus on advances in research and development of fast diagnosis methods, as well as potential prophylactics and therapeutics to prevent or treat 2019-nCoV infection....
On 10 January 2020, a new coronavirus causing a pneumonia outbreak in Wuhan City in central China was denoted as 201
Autopsy in suspected COVID-19 cases.
Hanley B, Lucas SB, Youd E, Swift B, Osborn M. Hanley B, et al. J Clin Pathol. 2020 Mar 20:jclinpath-2020-206522. doi: 10.1136/jclinpath-2020-206522. Online ahead of print. J Clin Pathol. 2020. PMID: 32198191 Review.
The severe acute respiratory syndrome (SARS)-coronavirus-2 (CoV-2) outbreak in Wuhan, China, has now spread to many countries across the world including the UK with over 3000 deaths as of early March 2020. This will inevitably lead to an increase in the number of suspected coronavirus disease 2019 (COVID-19)-related deaths at autopsy. ...
The severe acute respiratory syndrome (SARS)-coronavirus-2 (CoV-2) outbreak in Wuhan, China, has now spread to many countries …
Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China.
Li B, Yang J, Zhao F, Zhi L, Wang X, Liu L, Bi Z, Zhao Y. Li B, et al. Clin Res Cardiol. 2020 Mar 11. doi: 10.1007/s00392-020-01626-9. Online ahead of print. Clin Res Cardiol. 2020. PMID: 32161990 Review.
BACKGROUND: Studies have reminded that cardiovascular metabolic comorbidities made patients more susceptible to suffer 2019 novel corona virus (2019-nCoV) disease (COVID-19), and exacerbated the infection. ...On the other hand, COVID-19 can, in turn, aggravate the damage to the heart....
BACKGROUND: Studies have reminded that cardiovascular metabolic comorbidities made patients more susceptible to suffer 2019 novel
The outbreak of COVID-19: An overview.
Wu YC, Chen CS, Chan YJ. Wu YC, et al. J Chin Med Assoc. 2020 Mar;83(3):217-220. doi: 10.1097/JCMA.0000000000000270. J Chin Med Assoc. 2020. PMID: 32134861
In late December 2019, a previous unidentified coronavirus, currently named as the 2019 novel coronavirus#, emerged from Wuhan, China, and resulted in a formidable outbreak in many cities in China and expanded globally, including Thailand, Republic of Korea, Japan, United States, Philippines, Viet Nam, and our country (as of 2/6/2020 at least 25 countries). The disease is officially named as Coronavirus Disease-2019 (COVID-19, by WHO on February 11, 2020). It is also named as Severe Pneumonia with Novel Pathogens on January 15, 2019 by the Taiwan CDC, the Ministry of Health and is a notifiable communicable disease of the fifth category. ...
In late December 2019, a previous unidentified coronavirus, currently named as the 2019 novel coronavirus
Perspectives on monoclonal antibody therapy as potential therapeutic intervention for Coronavirus disease-19 (COVID-19).
Shanmugaraj B, Siriwattananon K, Wangkanont K, Phoolcharoen W. Shanmugaraj B, et al. Asian Pac J Allergy Immunol. 2020 Mar;38(1):10-18. doi: 10.12932/AP-200220-0773. Asian Pac J Allergy Immunol. 2020. PMID: 32134278 Free article. Review.
Last decade witnessed the outbreak of many life-threatening human pathogens including Nipah, Ebola, Chikungunya, Zika, Middle East respiratory syndrome coronavirus (MERS-CoV), Severe Acute respiratory syndrome coronavirus (SARS-CoV) and more recently novel coronavirus (2019-nCoV or SARS-CoV-2). The disease condition associated with novel coronavirus, referred to as Coronavirus disease (COVID-19). The emergence of novel coronavirus in 2019 in Wuhan, China marked the third highly pathogenic coronavirus infecting humans in the 21st century. ...
Last decade witnessed the outbreak of many life-threatening human pathogens including Nipah, Ebola, Chikungunya, Zika, Middle East respirato …
Genomic variance of the 2019-nCoV coronavirus.
Ceraolo C, Giorgi FM. Ceraolo C, et al. J Med Virol. 2020 May;92(5):522-528. doi: 10.1002/jmv.25700. Epub 2020 Feb 19. J Med Virol. 2020. PMID: 32027036
There is a rising global concern for the recently emerged novel coronavirus (2019-nCoV). Full genomic sequences have been released by the worldwide scientific community in the last few weeks to understand the evolutionary origin and molecular characteristics of this virus. ...We confirm high sequence similarity (>99%) between all sequenced 2019-nCoVs genomes available, with the closest BCoV sequence sharing 96.2% sequence identity, confirming the notion of a zoonotic origin of 2019-nCoV. ...
There is a rising global concern for the recently emerged novel coronavirus (2019-nCoV). Full genomic sequences …
Novel coronavirus: From discovery to clinical diagnostics.
Phan T. Phan T. Infect Genet Evol. 2020 Apr;79:104211. doi: 10.1016/j.meegid.2020.104211. Epub 2020 Jan 30. Infect Genet Evol. 2020. PMID: 32007627
A novel coronavirus designated as 2019-nCoV first appeared in Wuhan, China in late December 2019. Dozens of people died in China, and thousands of people infected as 2019-nCoV continues to spread around the world. We have described the discovery, emergence, genomic characteristics, and clinical diagnostics of 2019-nCoV....
A novel coronavirus designated as 2019-nCoV first appeared in Wuhan, China in late December 2019. …
CT Imaging Features of 2019 Novel Coronavirus (2019-nCoV).
Chung M, Bernheim A, Mei X, Zhang N, Huang M, Zeng X, Cui J, Xu W, Yang Y, Fayad ZA, Jacobi A, Li K, Li S, Shan H. Chung M, et al. Radiology. 2020 Apr;295(1):202-207. doi: 10.1148/radiol.2020200230. Epub 2020 Feb 4. Radiology. 2020. PMID: 32017661
In this retrospective case series, chest CT scans of 21 symptomatic patients from China infected with the 2019 novel coronavirus (2019-nCoV) were reviewed, with emphasis on identifying and characterizing the most common findings. ...
In this retrospective case series, chest CT scans of 21 symptomatic patients from China infected with the 2019 novel corona
Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes.
Zhang W, Du RH, Li B, Zheng XS, Yang XL, Hu B, Wang YY, Xiao GF, Yan B, Shi ZL, Zhou P. Zhang W, et al. Emerg Microbes Infect. 2020 Feb 17;9(1):386-389. doi: 10.1080/22221751.2020.1729071. eCollection 2020. Emerg Microbes Infect. 2020. PMID: 32065057 Free PMC article.
In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spread to other parts of the world. ...Our report provides a cautionary warning that 2019-nCoV may be shed through multiple routes....
In December 2019, a novel coronavirus (2019-nCoV) caused an outbreak in Wuhan, China, and soon spr …
Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China.
Wang W, Tang J, Wei F. Wang W, et al. J Med Virol. 2020 Apr;92(4):441-447. doi: 10.1002/jmv.25689. Epub 2020 Feb 12. J Med Virol. 2020. PMID: 31994742
To help health workers and the public recognize and deal with the 2019 novel coronavirus (2019-nCoV) quickly, effectively, and calmly with an updated understanding. ...A latest summary of 2019-nCoV and the current outbreak was drawn. Up to 24 pm, 25 January 2020, a total of 1975 cases of 2019-nCoV infection were confirmed in mainland China with a total of 56 deaths having occurred. ...
To help health workers and the public recognize and deal with the 2019 novel coronavirus (2019-nCoV) quic …
Correlation of Chest CT and RT-PCR Testing in Coronavirus Disease 2019 (COVID-19) in China: A Report of 1014 Cases.
Ai T, Yang Z, Hou H, Zhan C, Chen C, Lv W, Tao Q, Sun Z, Xia L. Ai T, et al. Radiology. 2020 Feb 26:200642. doi: 10.1148/radiol.2020200642. Online ahead of print. Radiology. 2020. PMID: 32101510
Background Chest CT is used for diagnosis of 2019 novel coronavirus disease (COVID-19), as an important complement to the reverse-transcription polymerase chain reaction (RT-PCR) tests. ...Conclusion Chest CT has a high sensitivity for diagnosis of COVID-19. Chest CT may be considered as a primary tool for the current COVID-19 detection in epidemic areas....
Background Chest CT is used for diagnosis of 2019 novel coronavirus disease (COVID-19), as an important c …
Transmission of 2019-nCoV Infection from an Asymptomatic Contact in Germany.
Rothe C, Schunk M, Sothmann P, Bretzel G, Froeschl G, Wallrauch C, Zimmer T, Thiel V, Janke C, Guggemos W, Seilmaier M, Drosten C, Vollmar P, Zwirglmaier K, Zange S, Wölfel R, Hoelscher M. Rothe C, et al. N Engl J Med. 2020 Mar 5;382(10):970-971. doi: 10.1056/NEJMc2001468. Epub 2020 Jan 30. N Engl J Med. 2020. PMID: 32003551 No abstract available.
Genome Composition and Divergence of the Novel Coronavirus (2019-nCoV) Originating in China.
Wu A, Peng Y, Huang B, Ding X, Wang X, Niu P, Meng J, Zhu Z, Zhang Z, Wang J, Sheng J, Quan L, Xia Z, Tan W, Cheng G, Jiang T. Wu A, et al. Cell Host Microbe. 2020 Mar 11;27(3):325-328. doi: 10.1016/j.chom.2020.02.001. Epub 2020 Feb 7. Cell Host Microbe. 2020. PMID: 32035028 Free article.
An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019-nCoV and severe acute respiratory syndrome (SARS) or SARS-like coronaviruses. A systematic comparison identified 380 amino acid substitutions between these coronaviruses, which may have caused functional and pathogenic divergence of 2019-nCoV....
An in-depth annotation of the newly discovered coronavirus (2019-nCoV) genome has revealed differences between 2019
Discovering drugs to treat coronavirus disease 2019 (COVID-19).
Dong L, Hu S, Gao J. Dong L, et al. Drug Discov Ther. 2020;14(1):58-60. doi: 10.5582/ddt.2020.01012. Drug Discov Ther. 2020. PMID: 32147628 Free article.
The SARS-CoV-2 virus emerged in December 2019 and then spread rapidly worldwide, particularly to China, Japan, and South Korea. ...Several drugs such as chloroquine, arbidol, remdesivir, and favipiravir are currently undergoing clinical studies to test their efficacy and safety in the treatment of coronavirus disease 2019 (COVID-19) in China; some promising results have been achieved thus far. ...
The SARS-CoV-2 virus emerged in December 2019 and then spread rapidly worldwide, particularly to China, Japan, and South Korea. ...Se …
Therapeutic strategies in an outbreak scenario to treat the novel coronavirus originating in Wuhan, China.
Kruse RL. Kruse RL. F1000Res. 2020 Jan 31;9:72. doi: 10.12688/f1000research.22211.2. eCollection 2020. F1000Res. 2020. PMID: 32117569 Free PMC article. Review.
A novel coronavirus (2019-nCoV) originating in Wuhan, China presents a potential respiratory viral pandemic to the world population. ...Herein, I review the potential options to treat 2019-nCoV in patients, with an emphasis on the necessity for speed and timeliness in developing new and effective therapies in this outbreak. ...
A novel coronavirus (2019-nCoV) originating in Wuhan, China presents a potential respiratory viral pandem …
First cases of coronavirus disease 2019 (COVID-19) in France: surveillance, investigations and control measures, January 2020.
Bernard Stoecklin S, Rolland P, Silue Y, Mailles A, Campese C, Simondon A, Mechain M, Meurice L, Nguyen M, Bassi C, Yamani E, Behillil S, Ismael S, Nguyen D, Malvy D, Lescure FX, Georges S, Lazarus C, Tabaï A, Stempfelet M, Enouf V, Coignard B, Levy-Bruhl D, Investigation Team. Bernard Stoecklin S, et al. Euro Surveill. 2020 Feb;25(6):2000094. doi: 10.2807/1560-7917.ES.2020.25.6.2000094. Euro Surveill. 2020. PMID: 32070465 Free PMC article.
A novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) causing a cluster of respiratory infections (coronavirus disease 2019, COVID-19) in Wuhan, China, was identified on 7 January 2020. ...Three cases of COVID-19 were confirmed on 24 January, the first cases in Europe. Contact tracing was immediately initiated. Five contacts were evaluated as at low risk of exposure and 18 at moderate/high risk. ...
A novel coronavirus (severe acute respiratory syndrome coronavirus 2, SARS-CoV-2) causing a cluster of respiratory infe …
Preliminary Identification of Potential Vaccine Targets for the COVID-19 Coronavirus (SARS-CoV-2) Based on SARS-CoV Immunological Studies.
Ahmed SF, Quadeer AA, McKay MR. Ahmed SF, et al. Viruses. 2020 Feb 25;12(3):E254. doi: 10.3390/v12030254. Viruses. 2020. PMID: 32106567 Free article.
The beginning of 2020 has seen the emergence of COVID-19 outbreak caused by a novel coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). ...As no mutation has been observed in these identified epitopes among the 120 available SARS-CoV-2 sequences (as of 21 February 2020), immune targeting of these epitopes may potentially offer protection against this novel virus. ...
The beginning of 2020 has seen the emergence of COVID-19 outbreak caused by a novel coronavirus, Severe Acute Re …
[Potential antiviral therapeutics for 2019 Novel Coronavirus].
Li H, Wang YM, Xu JY, Cao B. Li H, et al. Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 12;43(3):170-172. doi: 10.3760/cma.j.issn.1001-0939.2020.03.004. Zhonghua Jie He He Hu Xi Za Zhi. 2020. PMID: 32164080 Chinese.
The recent outbreak of respiratory illness in Wuhan, China is caused by a novel coronavirus, named 2019-nCoV, which is genetically close to a bat-derived coronavirus. 2019-nCoV is categorized as beta genus coronavirus, same as the two other strains-severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). ...But the efficacy and safety of these drugs for 2019-nCoV pneumonia patients need to be assessed by further clinical trials....
The recent outbreak of respiratory illness in Wuhan, China is caused by a novel coronavirus, named 2019-nCoV
Epidemiologic characteristics of early cases with 2019 novel coronavirus (2019-nCoV) disease in Korea.
Ki M; Task Force for 2019-nCoV. Ki M, et al. Epidemiol Health. 2020;42:e2020007. doi: 10.4178/epih.e2020007. Epub 2020 Feb 9. Epidemiol Health. 2020. PMID: 32035431 Free article.
In about 20 days since the diagnosis of the first case of the 2019 novel coronavirus (2019-nCoV) in Korea on January 20, 2020, 28 cases have been confirmed. ...Sharing epidemiological information among researchers worldwide is essential for efficient preparation and response in tackling this new infectious disease....
In about 20 days since the diagnosis of the first case of the 2019 novel coronavirus (2019-nCoV) in Korea …
Clinical characteristics and therapeutic procedure for four cases with 2019 novel coronavirus pneumonia receiving combined Chinese and Western medicine treatment.
Wang Z, Chen X, Lu Y, Chen F, Zhang W. Wang Z, et al. Biosci Trends. 2020 Mar 16;14(1):64-68. doi: 10.5582/bst.2020.01030. Epub 2020 Feb 9. Biosci Trends. 2020. PMID: 32037389 Free article.
Pneumonia associated with the 2019 novel coronavirus (2019-nCoV) is continuously and rapidly circulating at present. No effective antiviral treatment has been verified thus far. We report here the clinical characteristics and therapeutic procedure for four patients with mild or severe 2019-nCoV pneumonia admitted to Shanghai Public Health Clinical Center. ...
Pneumonia associated with the 2019 novel coronavirus (2019-nCoV) is continuously and rapidly circulating …
Clinical and biochemical indexes from 2019-nCoV infected patients linked to viral loads and lung injury.
Liu Y, Yang Y, Zhang C, Huang F, Wang F, Yuan J, Wang Z, Li J, Li J, Feng C, Zhang Z, Wang L, Peng L, Chen L, Qin Y, Zhao D, Tan S, Yin L, Xu J, Zhou C, Jiang C, Liu L. Liu Y, et al. Sci China Life Sci. 2020 Mar;63(3):364-374. doi: 10.1007/s11427-020-1643-8. Epub 2020 Feb 9. Sci China Life Sci. 2020. PMID: 32048163 Free PMC article.
The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to many provinces in China as well as other countries. ...All 12 cases of the 2019-nCoV-infected patients developed pneumonia and half of them developed acute respiratory distress syndrome (ARDS). ...
The outbreak of the 2019-nCoV infection began in December 2019 in Wuhan, Hubei province, and rapidly spread to m …
Dysregulation of immune response in patients with COVID-19 in Wuhan, China.
Qin C, Zhou L, Hu Z, Zhang S, Yang S, Tao Y, Xie C, Ma K, Shang K, Wang W, Tian DS. Qin C, et al. Clin Infect Dis. 2020 Mar 12:ciaa248. doi: 10.1093/cid/ciaa248. Online ahead of print. Clin Infect Dis. 2020. PMID: 32161940
BACKGROUND: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spread throughout China. METHODS: Demographic and clinical data of all confirmed cases with COVID-19 on admission at Tongji Hospital from January 10 to February 12, 2020, were collected and analyzed. ...Patients with COVID-19 also have lower level of regulatory T cells, and more obviously damaged in severe cases. CONCLUSIONS: The novel coronavirus might mainly act on lymphocytes, especially T lymphocytes. ...
BACKGROUND: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan and rapidly spr …
Pulmonary Pathology of Early-Phase 2019 Novel Coronavirus (COVID-19) Pneumonia in Two Patients With Lung Cancer.
Tian S, Hu W, Niu L, Liu H, Xu H, Xiao SY. Tian S, et al. J Thorac Oncol. 2020 Feb 28:S1556-0864(20)30132-5. doi: 10.1016/j.jtho.2020.02.010. Online ahead of print. J Thorac Oncol. 2020. PMID: 32114094
There is currently a lack of pathologic data on the novel coronavirus (severe acute respiratory syndrome coronavirus 2) pneumonia, or coronavirus disease 2019 (COVID-19), from autopsy or biopsy. Two patients who recently underwent lung lobectomies for adenocarcinoma were retrospectively found to have had COVID-19 at the time of the operation. ...
There is currently a lack of pathologic data on the novel coronavirus (severe acute respiratory syndrome coronavirus 2) …
Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine.
Meng L, Hua F, Bian Z. Meng L, et al. J Dent Res. 2020 Mar 12:22034520914246. doi: 10.1177/0022034520914246. Online ahead of print. J Dent Res. 2020. PMID: 32162995
The epidemic of coronavirus disease 2019 (COVID-19), originating in Wuhan, China, has become a major public health challenge for not only China but also countries around the world. The World Health Organization announced that the outbreaks of the novel coronavirus have constituted a public health emergency of international concern. ...
The epidemic of coronavirus disease 2019 (COVID-19), originating in Wuhan, China, has become a major publ …
Radiology Perspective of Coronavirus Disease 2019 (COVID-19): Lessons From Severe Acute Respiratory Syndrome and Middle East Respiratory Syndrome.
Hosseiny M, Kooraki S, Gholamrezanezhad A, Reddy S, Myers L. Hosseiny M, et al. AJR Am J Roentgenol. 2020 Feb 28:1-5. doi: 10.2214/AJR.20.22969. Online ahead of print. AJR Am J Roentgenol. 2020. PMID: 32108495
Since the outbreak of the novel coronavirus pulmonary illness coronavirus disease 2019 (COVID-19) in China, more than 79,000 people have contracted the virus worldwide. ...The known imaging manifestations of the novel coronavirus and the possible unknowns will also be discussed....
Since the outbreak of the novel coronavirus pulmonary illness coronavirus disease 2019 (COVID-19) …
Prevalence of comorbidities in the novel Wuhan coronavirus (COVID-19) infection: a systematic review and meta-analysis.
Yang J, Zheng Y, Gou X, Pu K, Chen Z, Guo Q, Ji R, Wang H, Wang Y, Zhou Y. Yang J, et al. Int J Infect Dis. 2020 Mar 12:S1201-9712(20)30136-3. doi: 10.1016/j.ijid.2020.03.017. Online ahead of print. Int J Infect Dis. 2020. PMID: 32173574 Free article.
BACKGROUND: An outbreak of Novel Coronavirus (COVID -19) in Wuhan, China, the epidemic is more widespread than initially estimated, with cases now confirmed in multiple countries. AIMS: The aim of the meta-analysis was to assess the prevalence of comorbidities in the COVID-19 infection patients and the risk of underlying diseases in severe patients compared to non-severe patients. ...
BACKGROUND: An outbreak of Novel Coronavirus (COVID -19) in Wuhan, China, the epidemic is more widespread …
Potent binding of 2019 novel coronavirus spike protein by a SARS coronavirus-specific human monoclonal antibody.
Tian X, Li C, Huang A, Xia S, Lu S, Shi Z, Lu L, Jiang S, Yang Z, Wu Y, Ying T. Tian X, et al. Emerg Microbes Infect. 2020 Feb 17;9(1):382-385. doi: 10.1080/22221751.2020.1729069. eCollection 2020. Emerg Microbes Infect. 2020. PMID: 32065055 Free PMC article.
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed human infections, including 259 deaths, posing a serious threat to human health. ...Interestingly, some of the most potent SARS-CoV-specific neutralizing antibodies (e.g. m396, CR3014) that target the ACE2 binding site of SARS-CoV failed to bind 2019-nCoV spike protein, implying that the difference in the RBD of SARS-CoV and 2019-nCoV has a critical impact for the cross-reactivity of neutralizing antibodies, and that it is still necessary to develop novel monoclonal antibodies that could bind specifically to 2019-nCoV RBD....
The newly identified 2019 novel coronavirus (2019-nCoV) has caused more than 11,900 laboratory-confirmed …
[2019-nCoV: new challenges from coronavirus].
Tian HY. Tian HY. Zhonghua Yu Fang Yi Xue Za Zhi. 2020 Feb 3;54(0):E001. doi: 10.3760/cma.j.issn.0253-9624.2020.0001. Online ahead of print. Zhonghua Yu Fang Yi Xue Za Zhi. 2020. PMID: 32023682 Chinese.
The outbreak of pneumonia caused by the novel coronavirus 2019-nCoV in Wuhan, Hubei province of China, at the end of 2019 shaped tremendous challenges to China's public health and clinical treatment. ...The emergence of 2019-nCoV reminds us once again of the importance of establishing a systematic coronavirus surveillance network. ...
The outbreak of pneumonia caused by the novel coronavirus 2019-nCoV in Wuhan, Hubei province of China, at …
Imaging and clinical features of patients with 2019 novel coronavirus SARS-CoV-2.
Xu X, Yu C, Qu J, Zhang L, Jiang S, Huang D, Chen B, Zhang Z, Guan W, Ling Z, Jiang R, Hu T, Ding Y, Lin L, Gan Q, Luo L, Tang X, Liu J. Xu X, et al. Eur J Nucl Med Mol Imaging. 2020 Feb 28:1-6. doi: 10.1007/s00259-020-04735-9. Online ahead of print. Eur J Nucl Med Mol Imaging. 2020. PMID: 32107577 Free PMC article.
BACKGROUND: The pneumonia caused by the 2019 novel coronavirus (SARS-CoV-2, also called 2019-nCoV) recently break out in Wuhan, China, and was named as COVID-19. ...Chest CT examination plays an important role in the initial diagnosis of the novel coronavirus pneumonia. Multiple patchy ground glass opacities in bilateral multiple lobular with periphery distribution are typical chest CT imaging features of the COVID-19 pneumonia....
BACKGROUND: The pneumonia caused by the 2019 novel coronavirus (SARS-CoV-2, also called 2019-nCoV) recent …
Teicoplanin: an alternative drug for the treatment of coronavirus COVID-19?
Baron SA, Devaux C, Colson P, Raoult D, Rolain JM. Baron SA, et al. Int J Antimicrob Agents. 2020 Mar 13:105944. doi: 10.1016/j.ijantimicag.2020.105944. Online ahead of print. Int J Antimicrob Agents. 2020. PMID: 32179150
In December 2019, a new coronavirus, named SARS-CoV-2, has emerged from China causing pneumonia outbreaks first in the Wuhan region and have now spread worldwide because of its probable high transmission efficiency. ...Chloroquine, remdesivir, lopinavir, ribavirin or ritonavir have shown efficacy to inhibit coronavirus in vitro. Teicoplanin, an antibiotic used to treat staphylococci infection, previously showed efficacy to inhibit the first stage of MERS-coronarivus viral cycle in human cells. ...
In December 2019, a new coronavirus, named SARS-CoV-2, has emerged from China causing pneumonia outbreaks first in the …
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade.
Coutard B, Valle C, de Lamballerie X, Canard B, Seidah NG, Decroly E. Coutard B, et al. Antiviral Res. 2020 Apr;176:104742. doi: 10.1016/j.antiviral.2020.104742. Epub 2020 Feb 10. Antiviral Res. 2020. PMID: 32057769
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome has been sequenced and the genomic information promptly released. Despite a high similarity with the genome sequence of SARS-CoV and SARS-like CoVs, we identified a peculiar furin-like cleavage site in the Spike protein of the 2019-nCoV, lacking in the other SARS-like CoVs. ...
In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China. Its genome ha …
COVID-19, an emerging coronavirus infection: advances and prospects in designing and developing vaccines, immunotherapeutics, and therapeutics.
Dhama K, Sharun K, Tiwari R, Dadar M, Malik YS, Singh KP, Chaicumpa W. Dhama K, et al. Hum Vaccin Immunother. 2020 Mar 18:1-7. doi: 10.1080/21645515.2020.1735227. Online ahead of print. Hum Vaccin Immunother. 2020. PMID: 32186952
The novel coronavirus infection (COVID-19 or Coronavirus disease 2019) that emerged from Wuhan, Hubei province of China has spread to many countries worldwide. ...Although a few candidates have shown efficacy in in vitro studies, not many have progressed to randomized animal or human trials, hence may have limited use to counter COVID-19 infection. ...
The novel coronavirus infection (COVID-19 or Coronavirus disease 2019) that emerged from Wuhan
A Novel Coronavirus from Patients with Pneumonia in China, 2019.
Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, Zhao X, Huang B, Shi W, Lu R, Niu P, Zhan F, Ma X, Wang D, Xu W, Wu G, Gao GF, Tan W; China Novel Coronavirus Investigating and Research Team. Zhu N, et al. N Engl J Med. 2020 Feb 20;382(8):727-733. doi: 10.1056/NEJMoa2001017. Epub 2020 Jan 24. N Engl J Med. 2020. PMID: 31978945 Free article.
In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, China. ...Human airway epithelial cells were used to isolate a novel coronavirus, named 2019-nCoV, which formed a clade within the subgenus sarbecovirus, Orthocoronavirinae subfamily. ...
In December 2019, a cluster of patients with pneumonia of unknown cause was linked to a seafood wholesale market in Wuhan, Chi …
Geographical tracking and mapping of coronavirus disease COVID-19/severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) epidemic and associated events around the world: how 21st century GIS technologies are supporting the global fight against outbreaks and epidemics.
Kamel Boulos MN, Geraghty EM. Kamel Boulos MN, et al. Int J Health Geogr. 2020 Mar 11;19(1):8. doi: 10.1186/s12942-020-00202-8. Int J Health Geogr. 2020. PMID: 32160889 Free PMC article.
In December 2019, a new virus (initially called 'Novel Coronavirus 2019-nCoV' and later renamed to SARS-CoV-2) causing severe acute respiratory syndrome (coronavirus disease COVID-19) emerged in Wuhan, Hubei Province, China, and rapidly spread to other parts of China and other countries around the world, despite China's massive efforts to contain the disease within Hubei. ...This paper offers pointers to, and describes, a range of practical online/mobile GIS and mapping dashboards and applications for tracking the 2019/2020 coronavirus epidemic and associated events as they unfold around the world. ...
In December 2019, a new virus (initially called 'Novel Coronavirus 2019-nCoV' and later renamed to …
2019 novel coronavirus (2019-nCoV) outbreak: A new challenge.
Lupia T, Scabini S, Mornese Pinna S, Di Perri G, De Rosa FG, Corcione S. Lupia T, et al. J Glob Antimicrob Resist. 2020 Mar 7;21:22-27. doi: 10.1016/j.jgar.2020.02.021. Online ahead of print. J Glob Antimicrob Resist. 2020. PMID: 32156648 Free article.
METHODS: The currently available literature was reviewed for microbiologically confirmed infections by 2019-nCoV or COVID-19 at the time of writing (13 February 2020). ...Search terms included 'novel coronavirus' or '2019-nCoV' or 'COVID-19'. RESULTS: Published cases occurred mostly in males (age range, 8-92 years). ...
METHODS: The currently available literature was reviewed for microbiologically confirmed infections by 2019-nCoV or COVID
Learning from the Past: Possible Urgent Prevention and Treatment Options for Severe Acute Respiratory Infections Caused by 2019-nCoV.
Morse JS, Lalonde T, Xu S, Liu WR. Morse JS, et al. Chembiochem. 2020 Mar 2;21(5):730-738. doi: 10.1002/cbic.202000047. Epub 2020 Feb 25. Chembiochem. 2020. PMID: 32022370
With the current trajectory of the 2019-nCoV outbreak unknown, public health and medicinal measures will both be needed to contain spreading of the virus and to optimize patient outcomes. ...Herein, we suggest four potential drug candidates (an ACE2-based peptide, remdesivir, 3CLpro-1 and a novel vinylsulfone protease inhibitor) that could be used to treat patients suffering with the 2019-nCoV. ...
With the current trajectory of the 2019-nCoV outbreak unknown, public health and medicinal measures will both be needed to con …
CT Imaging of the 2019 Novel Coronavirus (2019-nCoV) Pneumonia.
Lei J, Li J, Li X, Qi X. Lei J, et al. Radiology. 2020 Apr;295(1):18. doi: 10.1148/radiol.2020200236. Epub 2020 Jan 31. Radiology. 2020. PMID: 32003646 No abstract available.
New insights on the antiviral effects of chloroquine against coronavirus: what to expect for COVID-19?
Devaux CA, Rolain JM, Colson P, Raoult D. Devaux CA, et al. Int J Antimicrob Agents. 2020 Mar 11:105938. doi: 10.1016/j.ijantimicag.2020.105938. Online ahead of print. Int J Antimicrob Agents. 2020. PMID: 32171740 Free article.
Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), emerged in China. ...Preliminary trials of chloroquine repurposing in the treatment of COVID-19 in China have been encouraging, leading to several new trials. ...
Recently, a novel coronavirus (2019-nCoV), officially known as severe acute respiratory syndrome coronavirus
Pattern of early human-to-human transmission of Wuhan 2019 novel coronavirus (2019-nCoV), December 2019 to January 2020.
Riou J, Althaus CL. Riou J, et al. Euro Surveill. 2020 Jan;25(4):2000058. doi: 10.2807/1560-7917.ES.2020.25.4.2000058. Euro Surveill. 2020. PMID: 32019669 Free PMC article.
Since December 2019, China has been experiencing a large outbreak of a novel coronavirus (2019-nCoV) which can cause respiratory disease and severe pneumonia. We estimated the basic reproduction number R0 of 2019-nCoV to be around 2.2 (90% high density interval: 1.4-3.8), indicating the potential for sustained human-to-human transmission. ...
Since December 2019, China has been experiencing a large outbreak of a novel coronavirus (2019-nCoV) whic …
Chest CT manifestations of new coronavirus disease 2019 (COVID-19): a pictorial review.
Ye Z, Zhang Y, Wang Y, Huang Z, Song B. Ye Z, et al. Eur Radiol. 2020 Mar 19. doi: 10.1007/s00330-020-06801-0. Online ahead of print. Eur Radiol. 2020. PMID: 32193638 Review.
Coronavirus disease 2019 (COVID-19) outbreak, first reported in Wuhan, China, has rapidly swept around the world just within a month, causing global public health emergency. ...Based on a comprehensive literature review and the experience in the frontline, we aim to review the typical and relatively atypical CT manifestations with representative COVID-19 cases at our hospital, and hope to strengthen the recognition of these features with radiologists and help them make a quick and accurate diagnosis.Key Points • Ground glass opacities, consolidation, reticular pattern, and crazy paving pattern are typical CT manifestations of COVID-19. • Emerging atypical CT manifestations, including airway changes, pleural changes, fibrosis, nodules, etc., were demonstrated in COVID-19 patients. • CT manifestations may associate with the progression and prognosis of COVID-19....
Coronavirus disease 2019 (COVID-19) outbreak, first reported in Wuhan, China, has rapidly swept around th
Estimating Risk for Death from 2019 Novel Coronavirus Disease, China, January-February 2020.
Mizumoto K, Chowell G. Mizumoto K, et al. Emerg Infect Dis. 2020 Mar 13;26(6). doi: 10.3201/eid2606.200233. Online ahead of print. Emerg Infect Dis. 2020. PMID: 32168464 Free article.
Since December 2019, when the first case of 2019 novel coronavirus disease (COVID-19) was identified in the city of Wuhan in the Hubei Province of China, the epidemic has generated tens of thousands of cases throughout China. ...We estimated the time-delay adjusted risk for death from COVID-19 in Wuhan, as well as for China excluding Wuhan, to assess the severity of the epidemic in the country. ...
Since December 2019, when the first case of 2019 novel coronavirus disease (COVID-19) was identifi …
COVID-19 Therapeutic and Prevention.
Raoult D, Hsueh PR, Stefani S, Rolain JM. Raoult D, et al. Int J Antimicrob Agents. 2020 Mar 7:105937. doi: 10.1016/j.ijantimicag.2020.105937. Online ahead of print. Int J Antimicrob Agents. 2020. PMID: 32151714 No abstract available.
Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19).
Jiang F, Deng L, Zhang L, Cai Y, Cheung CW, Xia Z. Jiang F, et al. J Gen Intern Med. 2020 Mar 4. doi: 10.1007/s11606-020-05762-w. Online ahead of print. J Gen Intern Med. 2020. PMID: 32133578
In late December 2019, a cluster of cases with 2019 Novel Coronavirus pneumonia (SARS-CoV-2) in Wuhan, China, aroused worldwide concern. Previous studies have reported epidemiological and clinical characteristics of coronavirus disease 2019 (COVID-19). The purpose of this brief review is to summarize those published studies as of late February 2020 on the clinical features, symptoms, complications, and treatments of COVID-19 and help provide guidance for frontline medical staff in the clinical management of this outbreak....
In late December 2019, a cluster of cases with 2019 Novel Coronavirus pneumonia (SARS-CoV-2) in Wuhan, Ch …
Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20-28 January 2020.
Backer JA, Klinkenberg D, Wallinga J. Backer JA, et al. Euro Surveill. 2020 Feb;25(5):2000062. doi: 10.2807/1560-7917.ES.2020.25.5.2000062. Euro Surveill. 2020. PMID: 32046819 Free PMC article.
A novel coronavirus (2019-nCoV) is causing an outbreak of viral pneumonia that started in Wuhan, China. Using the travel history and symptom onset of 88 confirmed cases that were detected outside Wuhan in the early outbreak phase, we estimate the mean incubation period to be 6.4 days (95% credible interval: 5.6-7.7), ranging from 2.1 to 11.1 days (2.5th to 97.5th percentile). These values should help inform 2019-nCoV case definitions and appropriate quarantine durations....
A novel coronavirus (2019-nCoV) is causing an outbreak of viral pneumonia that started in Wuhan, China. U …
Pathogenicity and transmissibility of 2019-nCoV-A quick overview and comparison with other emerging viruses.
Chen J. Chen J. Microbes Infect. 2020 Mar;22(2):69-71. doi: 10.1016/j.micinf.2020.01.004. Epub 2020 Feb 4. Microbes Infect. 2020. PMID: 32032682 Free article.
A zoonotic coronavirus, tentatively labeled as 2019-nCoV by the World Health Organization (WHO), has been identified as the causative agent of the viral pneumonia outbreak in Wuhan, China, at the end of 2019. Although 2019-nCoV can cause a severe respiratory illness like SARS and MERS, evidence from clinics suggested that 2019-nCoV is generally less pathogenic than SARS-CoV, and much less than MERS-CoV. ...
A zoonotic coronavirus, tentatively labeled as 2019-nCoV by the World Health Organization (WHO), has been identified as …
COVID-19 and the cardiovascular system.
Zheng YY, Ma YT, Zhang JY, Xie X. Zheng YY, et al. Nat Rev Cardiol. 2020 Mar 5. doi: 10.1038/s41569-020-0360-5. Online ahead of print. Nat Rev Cardiol. 2020. PMID: 32139904 No abstract available.
Medical Journals and the 2019-nCoV Outbreak.
Rubin EJ, Baden LR, Morrissey S, Campion EW. Rubin EJ, et al. N Engl J Med. 2020 Feb 27;382(9):866. doi: 10.1056/NEJMe2001329. Epub 2020 Jan 27. N Engl J Med. 2020. PMID: 31986242 Free article. No abstract available.
False-Negative Results of Real-Time Reverse-Transcriptase Polymerase Chain Reaction for Severe Acute Respiratory Syndrome Coronavirus 2: Role of Deep-Learning-Based CT Diagnosis and Insights from Two Cases.
Li D, Wang D, Dong J, Wang N, Huang H, Xu H, Xia C. Li D, et al. Korean J Radiol. 2020 Apr;21(4):505-508. doi: 10.3348/kjr.2020.0146. Epub 2020 Mar 5. Korean J Radiol. 2020. PMID: 32174053 Free article.
The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still gradually spreading worldwide. ...
The epidemic of 2019 novel coronavirus, later named as severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Potential Factors Influencing Repeated SARS Outbreaks in China.
Sun Z, Thilakavathy K, Kumar SS, He G, Liu SV. Sun Z, et al. Int J Environ Res Public Health. 2020 Mar 3;17(5):1633. doi: 10.3390/ijerph17051633. Int J Environ Res Public Health. 2020. PMID: 32138266 Free PMC article. Review.
However, some unique factors might also contribute to the origination of SARS in Wuhan. These factors are discussed in different scenarios in order to promote more research for achieving final validation....
However, some unique factors might also contribute to the origination of SARS in Wuhan. These factors are discussed in different scen …
Real-time tentative assessment of the epidemiological characteristics of novel coronavirus infections in Wuhan, China, as at 22 January 2020.
Wu P, Hao X, Lau EHY, Wong JY, Leung KSM, Wu JT, Cowling BJ, Leung GM. Wu P, et al. Euro Surveill. 2020 Jan;25(3):2000044. doi: 10.2807/1560-7917.ES.2020.25.3.2000044. Euro Surveill. 2020. PMID: 31992388 Free PMC article.
A novel coronavirus (2019-nCoV) causing severe acute respiratory disease emerged recently in Wuhan, China. Information on reported cases strongly indicates human-to-human spread, and the most recent information is increasingly indicative of sustained human-to-human transmission. ...
A novel coronavirus (2019-nCoV) causing severe acute respiratory disease emerged recently in Wuhan, China …
Genetic evolution analysis of 2019 novel coronavirus and coronavirus from other species.
Li C, Yang Y, Ren L. Li C, et al. Infect Genet Evol. 2020 Mar 10;82:104285. doi: 10.1016/j.meegid.2020.104285. Online ahead of print. Infect Genet Evol. 2020. PMID: 32169673
The Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a Public Health Emergency of International Concern. ...Here, we found the novel coronavirus was closely related to coronaviruses derived from five wild animals, including Paguma larvata, Paradoxurus hermaphroditus, Civet, Aselliscus stoliczkanus and Rhinolophus sinicus, and was in the same branch of the phylogenetic tree. ...
The Corona Virus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Clinical Features and Treatment of COVID-19 Patients in Northeast Chongqing.
Wan S, Xiang Y, Fang W, Zheng Y, Li B, Hu Y, Lang C, Huang D, Sun Q, Xiong Y, Huang X, Lv J, Luo Y, Shen L, Yang H, Huang G, Yang R. Wan S, et al. J Med Virol. 2020 Mar 21. doi: 10.1002/jmv.25783. Online ahead of print. J Med Virol. 2020. PMID: 32198776
BACKGROUND: The outbreak of the novel coronavirus in China (SARS CoV-2) that began in December 2019 presents a significant and urgent threat to global health. ...Further studies are required to explore the role of Kaletra and traditional Chinese medicine in the treatment of COVID-19. This article is protected by copyright. ...
BACKGROUND: The outbreak of the novel coronavirus in China (SARS CoV-2) that began in December 2019 presents a signific …
Cross-species transmission of the newly identified coronavirus 2019-nCoV.
Ji W, Wang W, Zhao X, Zai J, Li X. Ji W, et al. J Med Virol. 2020 Apr;92(4):433-440. doi: 10.1002/jmv.25682. J Med Virol. 2020. PMID: 31967321
The current outbreak of viral pneumonia in the city of Wuhan, China, was caused by a novel coronavirus designated 2019-nCoV by the World Health Organization, as determined by sequencing the viral RNA genome. ...Results obtained from our analyses suggest that the 2019-nCoV may appear to be a recombinant virus between the bat coronavirus and an origin-unknown coronavirus. ...
The current outbreak of viral pneumonia in the city of Wuhan, China, was caused by a novel coronavirus designated 20
Development of Genetic Diagnostic Methods for Novel Coronavirus 2019 (nCoV-2019) in Japan.
Shirato K, Nao N, Katano H, Takayama I, Saito S, Kato F, Katoh H, Sakata M, Nakatsu Y, Mori Y, Kageyama T, Matsuyama S, Takeda M. Shirato K, et al. Jpn J Infect Dis. 2020 Feb 18. doi: 10.7883/yoken.JJID.2020.061. Online ahead of print. Jpn J Infect Dis. 2020. PMID: 32074516 Free article.
At the end of 2019, pneumonia caused by novel coronavirus 2019 (nCoV) emerged in Wuhan city, China. Many airline travelers moved between Wuhan and Japan at that time, suggesting that Japan is at high risk of invasion by the virus. Diagnostic systems for 2019-nCoV were developed with urgency. Two nested RT-PCR assays and two real-time RT-PCR assays were adapted to local Japanese conditions. ...
At the end of 2019, pneumonia caused by novel coronavirus 2019 (nCoV) emerged in Wuhan city, China …
COVID-19: Real-time dissemination of scientific information to fight a public health emergency of international concern.
Song P, Karako T. Song P, et al. Biosci Trends. 2020 Mar 16;14(1):1-2. doi: 10.5582/bst.2020.01056. Epub 2020 Feb 25. Biosci Trends. 2020. PMID: 32092748 Free article.
This issue has rapidly reviewed and published articles describing COVID-19, including the drug treatment options for SARS-CoV-2, its clinical characteristics, and therapies involving a combination of Chinese and Western medicine, the efficacy of chloroquine phosphate in the treatment of COVID-19 associated pneumonia according to clinical studies, and reflections on the system of reserve medical supplies for public health emergencies. As an academic journal, we will continue to quickly and transparently share data with frontline healthcare workers who need to know the epidemiological and clinical features of COVID-19....
This issue has rapidly reviewed and published articles describing COVID-19, including the drug treatment options for SARS-CoV- …
Incubation Period and Other Epidemiological Characteristics of 2019 Novel Coronavirus Infections with Right Truncation: A Statistical Analysis of Publicly Available Case Data.
Linton NM, Kobayashi T, Yang Y, Hayashi K, Akhmetzhanov AR, Jung SM, Yuan B, Kinoshita R, Nishiura H. Linton NM, et al. J Clin Med. 2020 Feb 17;9(2):538. doi: 10.3390/jcm9020538. J Clin Med. 2020. PMID: 32079150 Free PMC article.
The geographic spread of 2019 novel coronavirus (COVID-19) infections from the epicenter of Wuhan, China, has provided an opportunity to study the natural history of the recently emerged virus. ...The median time delay of 13 days from illness onset to death (17 days with right truncation) should be considered when estimating the COVID-19 case fatality risk....
The geographic spread of 2019 novel coronavirus (COVID-19) infections from the epicenter of Wuhan, …
Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia.
Chu DKW, Pan Y, Cheng SMS, Hui KPY, Krishnan P, Liu Y, Ng DYM, Wan CKC, Yang P, Wang Q, Peiris M, Poon LLM. Chu DKW, et al. Clin Chem. 2020 Jan 31:hvaa029. doi: 10.1093/clinchem/hvaa029. Online ahead of print. Clin Chem. 2020. PMID: 32031583
BACKGROUND: A novel coronavirus of zoonotic origin (2019-nCoV) has recently been identified in patients with acute respiratory disease. ...The primer and probe sets were designed to react with this novel coronavirus and its closely related viruses, such as SARS coronavirus. ...
BACKGROUND: A novel coronavirus of zoonotic origin (2019-nCoV) has recently been identified in patients with acu …
Recent advances in the detection of respiratory virus infection in humans.
Zhang N, Wang L, Deng X, Liang R, Su M, He C, Hu L, Su Y, Ren J, Yu F, Du L, Jiang S. Zhang N, et al. J Med Virol. 2020 Apr;92(4):408-417. doi: 10.1002/jmv.25674. Epub 2020 Feb 4. J Med Virol. 2020. PMID: 31944312 Review.
Respiratory tract viral infection caused by viruses or bacteria is one of the most common diseases in human worldwide, while those caused by emerging viruses, such as the novel coronavirus, 2019-nCoV that caused the pneumonia outbreak in Wuhan, China most recently, have posed great threats to global public health. ...This review summarizes currently available and novel emerging diagnostic methods for the detection of common respiratory viruses, such as influenza virus, human respiratory syncytial virus, coronavirus, human adenovirus, and human rhinovirus. ...
Respiratory tract viral infection caused by viruses or bacteria is one of the most common diseases in human worldwide, while those caused by …
[Cause analysis and treatment strategies of "recurrence" with novel coronavirus pneumonia (covid-19) patients after discharge from hospital].
Zhou L, Liu K, Liu HG. Zhou L, et al. Zhonghua Jie He He Hu Xi Za Zhi. 2020 Mar 2;43(0):E028. doi: 10.3760/cma.j.cn112147-20200229-00219. Online ahead of print. Zhonghua Jie He He Hu Xi Za Zhi. 2020. PMID: 32118391 Chinese.
With a large number of COVID-19 patients discharging from hospital, some had showed re-fever and positive nucleic acid test after discharge from hospital. This might be due to the biological characteristics of 2019-nCoV, and might also be related to the basic disease, clinical status, glucocorticoid using, sample sampling, processing and detecting of patients, and some even related to the re-infection or secondary bacterial virus infection. ...
With a large number of COVID-19 patients discharging from hospital, some had showed re-fever and positive nucleic acid test af …
Epidemiology of 2019 Novel Coronavirus Disease-19 in Gansu Province, China, 2020.
Fan J, Liu X, Pan W, Douglas MW, Bao S. Fan J, et al. Emerg Infect Dis. 2020 Mar 13;26(6). doi: 10.3201/eid2606.200251. Online ahead of print. Emerg Infect Dis. 2020. PMID: 32168465 Free article.
To determine the epidemiology of 2019 novel coronavirus disease (COVID-19) in a remote region of China, far from Wuhan, we analyzed the epidemiology of COVID-19 in Gansu Province. ...As a result of adequate interventions, transmission of the COVID-19 virus in Gansu Province is decreasing....
To determine the epidemiology of 2019 novel coronavirus disease (COVID-19) in a remote region of China, f …
Risk for Transportation of 2019 Novel Coronavirus Disease from Wuhan to Other Cities in China.
Du Z, Wang L, Cauchemez S, Xu X, Wang X, Cowling BJ, Meyers LA. Du Z, et al. Emerg Infect Dis. 2020 May 17;26(5). doi: 10.3201/eid2605.200146. Online ahead of print. Emerg Infect Dis. 2020. PMID: 32053479 Free article.
On January 23, 2020, China quarantined Wuhan to contain 2019 novel coronavirus disease (COVID-19). We estimated the probability of transportation of COVID-19 from Wuhan to 369 other cities in China before the quarantine. Expected COVID-19 risk is >50% in 130 (95% CI 89-190) cities and >99% in the 4 largest metropolitan areas....
On January 23, 2020, China quarantined Wuhan to contain 2019 novel coronavirus disease (COVID-19). …
Repurposing of clinically approved drugs for treatment of coronavirus disease 2019 in a 2019-novel coronavirus (2019-nCoV) related coronavirus model.
Fan HH, Wang LQ, Liu WL, An XP, Liu ZD, He XQ, Song LH, Tong YG. Fan HH, et al. Chin Med J (Engl). 2020 Mar 6. doi: 10.1097/CM9.0000000000000797. Online ahead of print. Chin Med J (Engl). 2020. PMID: 32149769
BACKGROUND: Medicines for the treatment of 2019-novel coronavirus (2019-nCoV) infections are urgently needed. However, drug screening using live 2019-nCoV requires high-level biosafety facilities, which imposes an obstacle for those without such facilities or 2019-novel coronavirus (2019-nCoV). This study aims to repurpose the clinically approved drugs for the treatment of coronavirus disease 2019 (COVID-19) in a 2019-nCoV related coronavirus model. ...
BACKGROUND: Medicines for the treatment of 2019-novel coronavirus (2019-nCoV) infections are urgently nee …
Lack of Vertical Transmission of Severe Acute Respiratory Syndrome Coronavirus 2, China.
Li Y, Zhao R, Zheng S, Chen X, Wang J, Sheng X, Zhou J, Cai H, Fang Q, Yu F, Fan J, Xu K, Chen Y, Sheng J. Li Y, et al. Emerg Infect Dis. 2020 Jun 17;26(6). doi: 10.3201/eid2606.200287. Online ahead of print. Emerg Infect Dis. 2020. PMID: 32134381 Free article.
A woman with 2019 novel coronavirus disease in her 35th week of pregnancy delivered an infant by cesarean section in a negative-pressure operating room. The infant was negative for severe acute respiratory coronavirus 2. This case suggests that mother-to-child transmission is unlikely for this virus....
A woman with 2019 novel coronavirus disease in her 35th week of pregnancy delivered an infant by cesarean section in a …
Note from the editors: novel coronavirus (2019-nCoV).
Eurosurveillance Editorial Team. Eurosurveillance Editorial Team. Euro Surveill. 2020 Jan;25(3):2001231. doi: 10.2807/1560-7917.ES.2020.25.3.2001231. Euro Surveill. 2020. PMID: 31992390 Free PMC article. No abstract available.
The reproductive number of COVID-19 is higher compared to SARS coronavirus.
Liu Y, Gayle AA, Wilder-Smith A, Rocklöv J. Liu Y, et al. J Travel Med. 2020 Mar 13;27(2):taaa021. doi: 10.1093/jtm/taaa021. J Travel Med. 2020. PMID: 32052846 Free PMC article. Review. No abstract available.
Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China.
Yuan M, Yin W, Tao Z, Tan W, Hu Y. Yuan M, et al. PLoS One. 2020 Mar 19;15(3):e0230548. doi: 10.1371/journal.pone.0230548. eCollection 2020. PLoS One. 2020. PMID: 32191764 Free PMC article.
Radiologic characteristics of 2019 novel coronavirus (2019-nCoV) infected pneumonia (NCIP) which had not been fully understood are especially important for diagnosing and predicting prognosis. ...An optimal cutoff value of a CT score of 24.5 had a sensitivity of 85.6% and a specificity of 84.5% for the prediction of mortality. 2019-nCoV was more likely to infect elderly people with chronic comorbidities. ...
Radiologic characteristics of 2019 novel coronavirus (2019-nCoV) infected pneumonia (NCIP) which had not …
Overview of The 2019 Novel Coronavirus (2019-nCoV): The Pathogen of Severe Specific Contagious Pneumonia (SSCP).
Wu YC, Chen CS, Chan YJ. Wu YC, et al. J Chin Med Assoc. 2020 Feb 11. doi: 10.1097/JCMA.0000000000000270. Online ahead of print. J Chin Med Assoc. 2020. PMID: 32049687
In late December 2019 a previous unidentified coronavirus, currently named as the 2019 novel coronavirus (2019-nCoV), emerged from Wuhan, China and resulted in a formidable outbreak in many cities in China and expanding globally, including Thailand, Republic of Korea, Japan, USA, Philippines, Viet Nam, and our country (as of 2/6/2020 at least 25 countries). The disease is officially named as the Severe Specific Contagious Pneumonia (SSCP) in 1/15/2019 and is a notifiable communicable disease of the 5 category by the Taiwan CDC, the Ministry of Health. ...
In late December 2019 a previous unidentified coronavirus, currently named as the 2019 novel coronavirus
[Clinical Management of Lung Cancer Patients during the Outbreak of 2019 Novel Coronavirus Disease (COVID-19)].
Xu Y, Liu H, Hu K, Wang M. Xu Y, et al. Zhongguo Fei Ai Za Zhi. 2020 Mar 20;23(3):136-141. doi: 10.3779/j.issn.1009-3419.2020.03.02. Epub 2020 Feb 20. Zhongguo Fei Ai Za Zhi. 2020. PMID: 32077441 Free article. Chinese.
Since late December 2019, an outbreak of 2019 novel coronavirus diseases (COVID-19) in Wuhan, China has spread quickly nationwide. ...Lung cancer patients should be the priority group for COVID-19 prevention. The protection provisions and control measures aiming to protect lung cancer patients from COVID-19 have been increasingly concerned. ...
Since late December 2019, an outbreak of 2019 novel coronavirus diseases (COVID-19) in Wuhan
The transmission and diagnosis of 2019 novel coronavirus infection disease (COVID-19): A Chinese perspective.
Han Y, Yang H. Han Y, et al. J Med Virol. 2020 Mar 6. doi: 10.1002/jmv.25749. Online ahead of print. J Med Virol. 2020. PMID: 32141619
2019 novel coronavirus (SARS-CoV-2), which originated in Wuhan, China, has attracted the world's attention over the last month. The Chinese government has taken emergency measures to control the outbreak and has undertaken initial steps in the diagnosis and treatment of 2019 novel coronavirus infection disease (COVID-19). ...
2019 novel coronavirus (SARS-CoV-2), which originated in Wuhan, China, has attracted the world's attention over
Severe Acute Respiratory Syndrome Coronavirus 2 from Patient with 2019 Novel Coronavirus Disease, United States.
Harcourt J, Tamin A, Lu X, Kamili S, Sakthivel SK, Murray J, Queen K, Tao Y, Paden CR, Zhang J, Li Y, Uehara A, Wang H, Goldsmith C, Bullock HA, Wang L, Whitaker B, Lynch B, Gautam R, Schindewolf C, Lokugamage KG, Scharton D, Plante JA, Mirchandani D, Widen SG, Narayanan K, Makino S, Ksiazek TG, Plante KS, Weaver SC, Lindstrom S, Tong S, Menachery VD, Thornburg NJ. Harcourt J, et al. Emerg Infect Dis. 2020 Mar 11;26(6). doi: 10.3201/eid2606.200516. Online ahead of print. Emerg Infect Dis. 2020. PMID: 32160149 Free article.
The etiologic agent of an outbreak of pneumonia in Wuhan, China, was identified as severe acute respiratory syndrome coronavirus 2 in January 2020. ...
The etiologic agent of an outbreak of pneumonia in Wuhan, China, was identified as severe acute respiratory syndrome coronavirus
Consistent detection of 2019 novel coronavirus in saliva.
To KK, Tsang OT, Chik-Yan Yip C, Chan KH, Wu TC, Chan JMC, Leung WS, Chik TS, Choi CY, Kandamby DH, Lung DC, Tam AR, Poon RW, Fung AY, Hung IF, Cheng VC, Chan JF, Yuen KY. To KK, et al. Clin Infect Dis. 2020 Feb 12:ciaa149. doi: 10.1093/cid/ciaa149. Online ahead of print. Clin Infect Dis. 2020. PMID: 32047895
The 2019-novel-coronavirus (2019-nCoV) was detected in the self-collected saliva of 91.7% (11/12) of patients. Serial saliva viral load monitoring generally showed a declining trend. ...Saliva is a promising non-invasive specimen for diagnosis, monitoring, and infection control in patients with 2019-nCoV infection....
The 2019-novel-coronavirus (2019-nCoV) was detected in the self-collected saliva of 91.7% (11/12) of pati …
RNA based mNGS approach identifies a novel human coronavirus from two individual pneumonia cases in 2019 Wuhan outbreak.
Chen L, Liu W, Zhang Q, Xu K, Ye G, Wu W, Sun Z, Liu F, Wu K, Zhong B, Mei Y, Zhang W, Chen Y, Li Y, Shi M, Lan K, Liu Y. Chen L, et al. Emerg Microbes Infect. 2020 Feb 5;9(1):313-319. doi: 10.1080/22221751.2020.1725399. eCollection 2020. Emerg Microbes Infect. 2020. PMID: 32020836 Free PMC article.
It rapidly identified a novel coronavirus (named 2019-nCoV according to World Health Organization announcement) which was the sole pathogens in the sample with very high abundance level (1.5% and 0.62% of total RNA sequenced). ...Evolutionary analysis based on ORF1a/1b, S, and N genes also suggests 2019-nCoV is more likely a novel CoV independently introduced from animals to humans....
It rapidly identified a novel coronavirus (named 2019-nCoV according to World Health Organization announcement) …
Misguided drug advice for COVID-19.
FitzGerald GA. FitzGerald GA. Science. 2020 Mar 27;367(6485):1434. doi: 10.1126/science.abb8034. Epub 2020 Mar 20. Science. 2020. PMID: 32198292 No abstract available.
2019-novel Coronavirus severe adult respiratory distress syndrome in two cases in Italy: An uncommon radiological presentation.
Albarello F, Pianura E, Di Stefano F, Cristofaro M, Petrone A, Marchioni L, Palazzolo C, Schininà V, Nicastri E, Petrosillo N, Campioni P, Eskild P, Zumla A, Ippolito G; COVID 19 INMI Study Group. Albarello F, et al. Int J Infect Dis. 2020 Feb 26;93:192-197. doi: 10.1016/j.ijid.2020.02.043. Online ahead of print. Int J Infect Dis. 2020. PMID: 32112966 Free article.
INTRODUCTION: Several recent case reports have described common early chest imaging findings of lung pathology caused by 2019 novel Coronavirus (SARS-COV2) which appear to be similar to those seen previously in SARS-CoV and MERS-CoV infected patients. OBJECTIVE: We present some remarkable imaging findings of the first two patients identified in Italy with COVID-19 infection travelling from Wuhan, China. ...
INTRODUCTION: Several recent case reports have described common early chest imaging findings of lung pathology caused by 2019 nove
Characteristics of COVID-19 infection in Beijing.
Tian S, Hu N, Lou J, Chen K, Kang X, Xiang Z, Chen H, Wang D, Liu N, Liu D, Chen G, Zhang Y, Li D, Li J, Lian H, Niu S, Zhang L, Zhang J. Tian S, et al. J Infect. 2020 Apr;80(4):401-406. doi: 10.1016/j.jinf.2020.02.018. Epub 2020 Feb 27. J Infect. 2020. PMID: 32112886
BACKGROUND: Since the first case of a novel coronavirus (COVID-19) infection pneumonia was detected in Wuhan, China, a series of confirmed cases of the COVID-19 were found in Beijing. We analyzed the data of 262 confirmed cases to determine the clinical and epidemiological characteristics of COVID-19 in Beijing. ...
BACKGROUND: Since the first case of a novel coronavirus (COVID-19) infection pneumonia was detected in Wuhan
The deadly coronaviruses: The 2003 SARS pandemic and the 2020 novel coronavirus epidemic in China.
Yang Y, Peng F, Wang R, Guan K, Jiang T, Xu G, Sun J, Chang C. Yang Y, et al. J Autoimmun. 2020 Mar 3:102434. doi: 10.1016/j.jaut.2020.102434. Online ahead of print. J Autoimmun. 2020. PMID: 32143990 Review.
The 2019-nCoV is officially called SARS-CoV-2 and the disease is named COVID-19. This viral epidemic in China has led to the deaths of over 1800 people, mostly elderly or those with an underlying chronic disease or immunosuppressed state. ...It is currently believed that this deadly Coronavirus strain originated from wild animals at the Huanan market in Wuhan, a city in Hubei province. ...
The 2019-nCoV is officially called SARS-CoV-2 and the disease is named COVID-19. This viral epidemic in China ha …
[Pulmonary rehabilitation guidelines in the principle of 4S for patients infected with 2019 novel coronavirus (2019-nCoV)].
Yang F, Liu N, Wu JY, Hu LL, Su GS, Zheng NS. Yang F, et al. Zhonghua Jie He He Hu Xi Za Zhi. 2020 Feb 5;43(0):E004. doi: 10.3760/cma.j.issn.1001-0939.2020.0004. Online ahead of print. Zhonghua Jie He He Hu Xi Za Zhi. 2020. PMID: 32023687 Chinese.
A recent epidemic of pneumonia cases in Wuhan China was caused by a novel coronavirus with strong infectivity, the 2019 novel coronavirus (2019-nCoV). The article provides the pulmonary rehabilitation (PR) methods in the principle of 4S (simple, safe, satisfy, save) for patients with pneumonia caused by the novel coronavirus, shows how to establish a ventilative and convectional PR environment to prevent the spread of virus through droplets, how to guide the patients to carry out PR, how to carry out respiratory muscle training, effective cough, expectoration, sneeze, general exercise, digestive function rehabilitation and psychological rehabilitation, and how to clean and disinfect the PR environment....
A recent epidemic of pneumonia cases in Wuhan China was caused by a novel coronavirus with strong infectivity, the 2
A comparative study on the clinical features of COVID-19 pneumonia to other pneumonias.
Zhao D, Yao F, Wang L, Zheng L, Gao Y, Ye J, Guo F, Zhao H, Gao R. Zhao D, et al. Clin Infect Dis. 2020 Mar 12:ciaa247. doi: 10.1093/cid/ciaa247. Online ahead of print. Clin Infect Dis. 2020. PMID: 32161968
BACKGROUND: A novel coronavirus (2019-nCoV) has raised world concern since it emerged in Wuhan Hubei China in December, 2019. ...CONCLUSION: The 2019-nCoV infection caused similar onsets to other pneumonias. CT scan may be a reliable test for screening NCOVID-19 cases. ...
BACKGROUND: A novel coronavirus (2019-nCoV) has raised world concern since it emerged in Wuhan Hubei Chin …
[Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV].
Peng YD, Meng K, Guan HQ, Leng L, Zhu RR, Wang BY, He MA, Cheng LX, Huang K, Zeng QT. Peng YD, et al. Zhonghua Xin Xue Guan Bing Za Zhi. 2020 Mar 2;48(0):E004. doi: 10.3760/cma.j.cn112148-20200220-00105. Online ahead of print. Zhonghua Xin Xue Guan Bing Za Zhi. 2020. PMID: 32120458 Chinese.
Objective: To explore the clinical characteristics and prognosis of the new coronavirus 2019-nCoV patients combined with cardiovascular disease (CVD). Methods: A retrospective analysis was performed on 112 COVID-19 patients with CVD admitted to the western district of Union Hospital in Wuhan, from January 20, 2020 to February 15, 2020. ...
Objective: To explore the clinical characteristics and prognosis of the new coronavirus 2019-nCoV patients combi …
The establishment of reference sequence for SARS-CoV-2 and variation analysis.
Wang C, Liu Z, Chen Z, Huang X, Xu M, He T, Zhang Z. Wang C, et al. J Med Virol. 2020 Mar 13. doi: 10.1002/jmv.25762. Online ahead of print. J Med Virol. 2020. PMID: 32167180
Starting around December 2019, an epidemic of pneumonia, which was named COVID-19 by the World Health Organization, broke out in Wuhan, China, and is spreading throughout the world. A new coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by the Coronavirus Study Group of the International Committee on Taxonomy of Viruses was soon found to be the cause. ...
Starting around December 2019, an epidemic of pneumonia, which was named COVID-19 by the World Health Organization, bro …
The first two cases of 2019-nCoV in Italy: Where they come from?
Giovanetti M, Benvenuto D, Angeletti S, Ciccozzi M. Giovanetti M, et al. J Med Virol. 2020 May;92(5):518-521. doi: 10.1002/jmv.25699. Epub 2020 Feb 12. J Med Virol. 2020. PMID: 32022275
A novel Coronavirus, 2019-nCoV, has been identified as the causal pathogen of an ongoing epidemic, with the first cases reported in Wuhan, China, last December 2019, and has since spread to other countries worldwide, included Europe and very recently Italy. ...A maximum clade credibility tree has been built using a dataset of 54 genome sequences of 2019-nCoV plus two closely related bat strains (SARS-like CoV) available in GenBank. ...
A novel Coronavirus, 2019-nCoV, has been identified as the causal pathogen of an ongoing epidemic, with the firs …
Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China.
Mo P, Xing Y, Xiao Y, Deng L, Zhao Q, Wang H, Xiong Y, Cheng Z, Gao S, Liang K, Luo M, Chen T, Song S, Ma Z, Chen X, Zheng R, Cao Q, Wang F, Zhang Y. Mo P, et al. Clin Infect Dis. 2020 Mar 16:ciaa270. doi: 10.1093/cid/ciaa270. Online ahead of print. Clin Infect Dis. 2020. PMID: 32173725
BACKGROUND: Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in Wuhan, and rapidly spread throughout China. This study aimed to clarify the characteristics of patients with refractory COVID-19. METHODS: In this retrospective single-center study, we included 155 consecutive patients with confirmed COVID-19 in Zhongnan Hospital of Wuhan University from January 1st to February 5th. ...
BACKGROUND: Since December 2019, novel coronavirus (SARS-CoV-2)-infected pneumonia (COVID-19) occurred in …
Soluble angiotensin-converting enzyme 2: a potential approach for coronavirus infection therapy?
Batlle D, Wysocki J, Satchell K. Batlle D, et al. Clin Sci (Lond). 2020 Mar 13;134(5):543-545. doi: 10.1042/CS20200163. Clin Sci (Lond). 2020. PMID: 32167153
A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbreak first detected in Wuhan, China in December 2019, has spread to other regions of China and to 25 other countries as of January, 2020. ...
A new coronavirus, referred to as SARS-CoV-2, is responsible for the recent outbreak of severe respiratory disease. This outbr …
The emotional impact of Coronavirus 2019-nCoV (new Coronavirus disease).
Lima CKT, Carvalho PMM, Lima IAAS, Nunes JVAO, Saraiva JS, de Souza RI, da Silva CGL, Neto MLR. Lima CKT, et al. Psychiatry Res. 2020 Mar 12;287:112915. doi: 10.1016/j.psychres.2020.112915. Online ahead of print. Psychiatry Res. 2020. PMID: 32199182
BACKGROUND: A novel form of Coronavirus (2019-nCoV) in Wuhan has created a confused and rapidly evolving situation. In this situational framework, patients and front-line healthcare workers are vulnerable. ...The COVID-19 epidemic has underscored potential gaps in mental health services during emergencies. CONCLUSIONS: Most health professionals working in isolation units and hospitals do not receive any training for providing mental health care. ...
BACKGROUND: A novel form of Coronavirus (2019-nCoV) in Wuhan has created a confused and rapidly evolving …