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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2013 20
2014 57
2015 200
2016 296
2017 324
2018 468
2019 322
2020 9
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1,508 results
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An updated evolutionary classification of CRISPR-Cas systems.
Makarova KS, Wolf YI, Alkhnbashi OS, Costa F, Shah SA, Saunders SJ, Barrangou R, Brouns SJ, Charpentier E, Haft DH, Horvath P, Moineau S, Mojica FJ, Terns RM, Terns MP, White MF, Yakunin AF, Garrett RA, van der Oost J, Backofen R, Koonin EV. Makarova KS, et al. Nat Rev Microbiol. 2015 Nov;13(11):722-36. doi: 10.1038/nrmicro3569. Epub 2015 Sep 28. Nat Rev Microbiol. 2015. PMID: 26411297 Free PMC article. Review.
CRISPR-Cas systems in multicellular cyanobacteria.
Hou S, Brenes-Álvarez M, Reimann V, Alkhnbashi OS, Backofen R, Muro-Pastor AM, Hess WR. Hou S, et al. RNA Biol. 2019 Apr;16(4):518-529. doi: 10.1080/15476286.2018.1493330. Epub 2018 Aug 15. RNA Biol. 2019. PMID: 29995583 Free PMC article.
The structural biology of CRISPR-Cas systems.
Jiang F, Doudna JA. Jiang F, et al. Curr Opin Struct Biol. 2015 Feb;30:100-111. doi: 10.1016/j.sbi.2015.02.002. Epub 2015 Feb 24. Curr Opin Struct Biol. 2015. PMID: 25723899 Free PMC article. Review.
CRISPR-Based Technologies: Impact of RNA-Targeting Systems.
Terns MP. Terns MP. Mol Cell. 2018 Nov 1;72(3):404-412. doi: 10.1016/j.molcel.2018.09.018. Mol Cell. 2018. PMID: 30388409 Free PMC article. Review.
Targeted transcriptional modulation with type I CRISPR-Cas systems in human cells.
Pickar-Oliver A, Black JB, Lewis MM, Mutchnick KJ, Klann TS, Gilcrest KA, Sitton MJ, Nelson CE, Barrera A, Bartelt LC, Reddy TE, Beisel CL, Barrangou R, Gersbach CA. Pickar-Oliver A, et al. Nat Biotechnol. 2019 Dec;37(12):1493-1501. doi: 10.1038/s41587-019-0235-7. Epub 2019 Sep 23. Nat Biotechnol. 2019. PMID: 31548729 Free PMC article.
Gene Editing With CRISPR/Cas9 RNA-Directed Nuclease.
Doetschman T, Georgieva T. Doetschman T, et al. Circ Res. 2017 Mar 3;120(5):876-894. doi: 10.1161/CIRCRESAHA.116.309727. Circ Res. 2017. PMID: 28254804 Review.
Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.
Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM, Migliardi G, Santos R, Rao Y, Sassi F, Pinnelli M, Ansari R, Harper S, Jackson DA, McRae R, Pooley R, Wilkinson P, van der Meer D, Dow D, Buser-Doepner C, Bertotti A, Trusolino L, Stronach EA, Saez-Rodriguez J, Yusa K, Garnett MJ. Behan FM, et al. Nature. 2019 Apr;568(7753):511-516. doi: 10.1038/s41586-019-1103-9. Epub 2019 Apr 10. Nature. 2019. PMID: 30971826
Type II-C CRISPR-Cas9 Biology, Mechanism, and Application.
Mir A, Edraki A, Lee J, Sontheimer EJ. Mir A, et al. ACS Chem Biol. 2018 Feb 16;13(2):357-365. doi: 10.1021/acschembio.7b00855. Epub 2017 Dec 20. ACS Chem Biol. 2018. PMID: 29202216 Free PMC article. Review.
Genome-scale CRISPR-Cas9 knockout and transcriptional activation screening.
Joung J, Konermann S, Gootenberg JS, Abudayyeh OO, Platt RJ, Brigham MD, Sanjana NE, Zhang F. Joung J, et al. Nat Protoc. 2017 Apr;12(4):828-863. doi: 10.1038/nprot.2017.016. Epub 2017 Mar 23. Nat Protoc. 2017. PMID: 28333914 Free PMC article.
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