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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1992 4
1993 2
1994 10
1995 8
1996 19
1997 29
1998 36
1999 82
2000 85
2001 96
2002 143
2003 162
2004 164
2005 139
2006 13
2007 31
2008 38
2009 49
2010 54
2011 80
2012 70
2013 74
2014 116
2015 113
2016 115
2017 95
2018 98
2019 45
2020 0
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1,806 results
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Wnt/β-Catenin Signaling Pathway Governs a Full Program for Dopaminergic Neuron Survival, Neurorescue and Regeneration in the MPTP Mouse Model of Parkinson's Disease.
Marchetti B. Int J Mol Sci 2018 - Review. PMID 30477246 Free PMC article.
Wingless-type mouse mammary tumor virus (MMTV) integration site (Wnt) signaling is one of the most critical pathways in developing and adult tissues. ...Canonical Wnt signaling is mediated mainly by the multifunctional β-catenin protein which is a potent co-activator of transcription factors such as lymphoid enhancer factor (LEF) and T-cell factor (TCF). ...
Wingless-type mouse mammary tumor virus (MMTV) integration site (Wnt) signaling is one of the most critical pathways in developing an …
Applying the proximity ligation assay (PLA) to mouse preimplantation embryos for identifying protein-protein interactions in situ.
Bedzhov I and Stemmler MP. Methods Mol Biol 2015. PMID 25319889
Analysis of protein-protein interactions in mouse preimplantation embryos is hindered by the low cell number of the embryo. Here we describe the use of the proximity ligation assay to overcome these limitations and outline how protein-protein interactions can be visualized in situ. ...In contrast to normal immunofluorescence labeling, here detection of red fluorescent dots reflects protein-protein interaction....
Analysis of protein-protein interactions in mouse preimplantation embryos is hindered by the low cell number of the emb …
β-Catenin maintains lung epithelial progenitors after lung specification
Ostrin EJ, et al. Development 2018. PMID 29440304 Free PMC article.
Using inducible, progenitor-specific genetic mosaic mouse models, we showed that β-catenin (CTNNB1) maintains lung progenitors by promoting a hierarchical lung progenitor gene signature, suppressing gastrointestinal (GI) genes, and regulating NK2 homeobox 1 (NKX2.1) and SRY box 2 (SOX2) in a developmental stage-dependent manner. At the early, but not later, stage post-lung specification, CTNNB1 cell-autonomously maintained normal NKX2.1 expression levels and suppressed ectopic SOX2 expression. ...
Using inducible, progenitor-specific genetic mosaic mouse models, we showed that β-catenin (CTNNB1) maintains lung progenitors …
AXIN deficiency in human and mouse hepatocytes induces hepatocellular carcinoma in the absence of β-catenin activation.
Abitbol S, et al. J Hepatol 2018. PMID 29525529
We aimed to elucidate the relationship between CTNNB1 mutations, AXIN1 mutations and the activation level of the Wnt/β-catenin program. ...We defined a 329-gene signature common in human and mouse AXIN1 mutated HCC that is highly enriched in Notch and YAP oncogenic signatures. ...
We aimed to elucidate the relationship between CTNNB1 mutations, AXIN1 mutations and the activation level of the Wnt/β-catenin progra …
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