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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1978 1
1979 4
1980 1
1981 2
1982 6
1983 13
1984 16
1985 20
1986 36
1987 71
1988 91
1989 136
1990 180
1991 200
1992 236
1993 258
1994 261
1995 278
1996 343
1997 411
1998 450
1999 492
2000 496
2001 514
2002 572
2003 545
2004 624
2005 690
2006 734
2007 798
2008 878
2009 913
2010 945
2011 1011
2012 1156
2013 1161
2014 1112
2015 1160
2016 1116
2017 1180
2018 1059
2019 488
2020 10
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18,686 results
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Page 1
Calcium-Binding Proteins as Determinants of Central Nervous System Neuronal Vulnerability to Disease.
Fairless R, et al. Int J Mol Sci 2019 - Review. PMID 31052285 Free PMC article.
Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding proteins providing an important first line of defense through their ability to buffer incoming calcium, allowing the neuron to quickly achieve homeostasis. ...In this review, we will summarize some of the evidence that expression of the EF-hand calcium-binding proteins, calbindin, calretinin and parvalbumin, may influence the susceptibility of distinct neuronal subpopulations to disease processes....
Toxic increases in intracellular calcium are a key factor in several neurodegenerative processes, with calcium-binding
Calcium-binding proteins of Entamoeba histolytica.
Bhattacharya A, et al. Arch Med Res 2006 - Review. PMID 16380322
Many of the calcium-mediated processes are carried out through the help of calcium-binding proteins (CaBPs). A few of these E. histolytica CaBPs have been described before. These proteins are unique to this organism and are thought to be essential. Availability of genome sequence has opened up the possibility of studying CaBPs at the whole genome level. ...
Many of the calcium-mediated processes are carried out through the help of calcium-binding proteins (CaBPs). A f …
Annexins: from structure to function
Gerke V and Moss SE. Physiol Rev 2002 - Review. PMID 11917092 Free article.
Annexins are Ca2+ and phospholipid binding proteins forming an evolutionary conserved multigene family with members of the family being expressed throughout animal and plant kingdoms. Structurally, annexins are characterized by a highly alpha-helical and tightly packed protein core domain considered to represent a Ca2+-regulated membrane binding module. ...
Annexins are Ca2+ and phospholipid binding proteins forming an evolutionary conserved multigene family with members of the fam …
Selective specificity of calcium-binding proteins calbindin and calretinin expression in the magnocellular neurosecretory hypothalamic nuclei of tortoises and turtles.
Belekhova MG, et al. Dokl Biol Sci 2017. PMID 28508199
We have studied the distribution of calcium-binding proteins in the magnocellular neurosecretory nuclei of nonapeptidergic neurosecretory nuclei of the preoptic-hypothalamic complex in a tortoise (Testudo horsfieldi) and a pond turtle (Emys orbicularis) using immunohistochemistry. ...
We have studied the distribution of calcium-binding proteins in the magnocellular neurosecretory nuclei of nonapeptider …
Irradiation of Epithelial Carcinoma Cells Upregulates Calcium-Binding Proteins That Promote Survival under Hypoxic Conditions.
Ren Y, et al. J Proteome Res 2016. PMID 27790916
When assessed using iTRAQ quantitative proteomics and Western blotting, irradiated tumor cells were observed to significantly up-regulate the expression of calcium-binding proteins CALM1, CALU, and RCN1, suggesting important roles for these mediators in promoting tumor cell survival during hypoxia. ...These data indicate that γ-irradiation of hypoxic tumor cells induces up-regulation of calcium-binding proteins that promote cancer cell survival and may limit the efficacy of radiotherapy in the clinic....
When assessed using iTRAQ quantitative proteomics and Western blotting, irradiated tumor cells were observed to significantly up-regulate th …
Calcium-binding proteins: basic concepts and clinical implications.
Heizmann CW. Gen Physiol Biophys 1992 - Review. PMID 1291444
Calcium ions exert their effects in part via interactions with a wide variety of intracellular calcium-binding proteins. One class of these proteins shares a common calcium-binding motif, the EF-hand. ...Since cellular degeneration is accompanied by impaired Ca2+ homeostasis, a protective role for Ca(2+)-binding proteins in certain neuron populations has been postulated. ...
Calcium ions exert their effects in part via interactions with a wide variety of intracellular calcium-binding prote
S100P, a peculiar member of S100 family of calcium-binding proteins implicated in cancer.
Tóthová V and Gibadulinová A. Acta Virol 2013 - Review. PMID 23600880
S100P belongs to several members of the S100 family of calcium-binding proteins, associated with malignant phenotype. Altered levels of S100P expression have been described at different stages and types of cancer. ...In addition, S100P interacts and modulates the activity of several targets with multiple binding modes and simultaneous coordination of further target proteins in larger multiprotein complexes, e.g. scaffolding proteins -IQGAP1 and ezrin, known to promote and regulate signal transduction pathways. ...
S100P belongs to several members of the S100 family of calcium-binding proteins, associated with malignant phenotype. A …
Ca(2+)-Binding Proteins of the EF-Hand Superfamily: Diagnostic and Prognostic Biomarkers and Novel Therapeutic Targets.
Heizmann CW. Methods Mol Biol 2019 - Review. PMID 30710273
A multitude of Ca(2+)-sensor proteins containing the specific Ca(2+)-binding motif (helix-loop-helix, called EF-hand) are of major clinical relevance in a many human diseases. ...S100 proteins, the largest subgroup with the EF-hand protein family, are closely associated with cardiovascular diseases, various types of cancer, inflammation, and autoimmune pathologies. ...
A multitude of Ca(2+)-sensor proteins containing the specific Ca(2+)-binding motif (helix-loop-helix, called EF-hand) are of m …
Fingerprints of Calcium-Binding Protein Conformational Dynamics Monitored by Surface Plasmon Resonance.
Dell'Orco D and Koch KW. ACS Chem Biol 2016 - Review. PMID 27380526
In past years, SPR-based experimental approaches were developed to monitor conformational changes induced by the binding of small analytes to proteins coupled to the surface of commercially available sensor chips. ...Structural and physicochemical analyses demonstrated that the SPR signal not only depends on the change in protein size upon Ca(2+)-binding but likely originates from variations in the hydration shell structure. ...
In past years, SPR-based experimental approaches were developed to monitor conformational changes induced by the binding of small ana …
Mechanism of direct coupling between binding and induced structural change in regulatory calcium binding proteins.
Gagné SM, et al. Biochemistry 1997. PMID 9109645
The structural transition in troponin C induced by the binding of two calcium ions involves an "opening" of the structure, an event that triggers skeletal muscle contraction. ...This structure remains "closed" upon calcium binding, indicating that the linkage between calcium binding and the induced conformational change has been broken. ...
The structural transition in troponin C induced by the binding of two calcium ions involves an "opening" of the structure, an …
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