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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 2
1981 9
1982 12
1983 17
1984 21
1985 8
1986 13
1987 26
1988 54
1989 70
1990 111
1991 166
1992 214
1993 312
1994 465
1995 703
1996 1002
1997 1299
1998 1816
1999 1694
2000 556
2001 500
2002 516
2003 344
2004 360
2005 380
2006 370
2007 278
2008 96
2009 134
2010 161
2011 120
2012 118
2013 73
2014 37
2015 28
2016 31
2017 23
2018 32
2019 9
2020 1
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11,892 results
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Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis.
Zhang X, et al. FASEB J 2017. PMID 28615325 Free PMC article.
Mitochondria also buffer Ca(2+), and their buffering capacity is dependent on Δ(Ψ) Here, we characterize a role for calcium/calmodulin-dependent protein kinase (CaMK) I in the regulation of these mechanisms. ...Calcium/calmodulin-dependent protein kinase regulates the PINK1/Parkin and DJ-1 pathways of mitophagy during sepsis....
Mitochondria also buffer Ca(2+), and their buffering capacity is dependent on Δ(Ψ) Here, we characterize a role for calcium/ …
Molecular mechanisms of protein kinase regulation by calcium/calmodulin.
Simon B, et al. Bioorg Med Chem 2015 - Review. PMID 25963826
Many human protein kinases are regulated by the calcium-sensor protein calmodulin, which binds to a short flexible segment C-terminal to the enzyme's catalytic kinase domain. Our understanding of the molecular mechanism of kinase activity regulation by calcium/calmodulin has been advanced by the structures of two protein kinases-calmodulin kinase II and death-associated protein kinase 1-bound to calcium/calmodulin. ...
Many human protein kinases are regulated by the calcium-sensor protein calmodulin, which binds to a short …
CALCIUM-DEPENDENT PROTEIN KINASE5 Associates with the Truncated NLR Protein TIR-NBS2 to Contribute to exo70B1-Mediated Immunity.
Liu N, et al. Plant Cell 2017. PMID 28351987 Free PMC article.
Calcium-dependent protein kinases (CPKs) function as calcium sensors and play important roles in plant immunity. Loss of function of the exocyst complex subunit EXO70B1 leads to autoimmunity caused by activation of TN2, a truncated Toll/interleukin-1 receptor-nucleotide binding sequence protein. ...Overexpressing CPK5 results in TN2-dependent autoimmunity and enhanced disease resistance, reminiscent of the exo70B1 phenotypes. ...
Calcium-dependent protein kinases (CPKs) function as calcium sensors and play important roles in plant im
Characterization and functional analysis of calcium/calmodulin-dependent protein kinases (CaMKs) in the nematode-trapping fungus Arthrobotrys oligospora.
Zhen Z, et al. Appl Microbiol Biotechnol 2019. PMID 30417308
Ca(2+)/calmodulin-dependent protein kinases (CaMKs) are unique second-messenger molecules that impact almost all cellular processes in eukaryotes. ...
Ca(2+)/calmodulin-dependent protein kinases (CaMKs) are unique second-messenger molecules that impact almost all …
Kinase activity-dependent stability of calcium/calmodulin-dependent protein kinase of Lotus japonicus.
Shimoda Y, et al. Planta 2019. PMID 31440828
Accumulation of calcium/calmodulin-dependent protein kinase (CCaMK) in root cell nucleus depends on its kinase activity but not on nuclear symbiotic components crucial for nodulation. Plant calcium/calmodulin-dependent protein kinase (CCaMK) is a key regulator of symbioses with rhizobia and arbuscular mycorrhizal fungi as it decodes symbiotic calcium signals induced by microsymbionts. ...
Accumulation of calcium/calmodulin-dependent protein kinase (CCaMK) in root cell nucleus depends on its kinase a …
Abscisic acid-induced degradation of Arabidopsis guanine nucleotide exchange factor requires calcium-dependent protein kinases.
Li Z, et al. Proc Natl Acad Sci U S A 2018. PMID 29686103 Free PMC article.
We have screened inhibitors followed by several protein kinase mutants and find that quadruple-mutant plants in the Arabidopsis calcium-dependent protein kinases (CPKs) cpk3/4/6/11 disrupt ABA-induced trafficking and degradation of RopGEF1. ...We further discuss that CPK-dependent RopGEF degradation during abiotic stress could provide a mechanism for down-regulation of RopGEF-dependent growth responses....
We have screened inhibitors followed by several protein kinase mutants and find that quadruple-mutant plants in the Arabidopsis ca
Characterization of CoPK02, a Ca(2+)/calmodulin-dependent protein kinase in mushroom Coprinopsis cinerea.
Yamashita M, et al. Biosci Biotechnol Biochem 2018. PMID 29673297
We surveyed genome sequences from the basidiomycetous mushroom Coprinopsis cinerea and isolated a cDNA homologous to CMKA, a calmodulin-dependent protein kinase (CaMK) in Aspergillus nidulans. ...CoPK02 possessed twelve subdomains specific to protein kinases and exhibited 43, 35, 40% identity with rat CaMKI, CaMKII, CaMKIV, respectively, and 40% identity with CoPK12, one of the CaMK orthologs in C. cinerea. ...
We surveyed genome sequences from the basidiomycetous mushroom Coprinopsis cinerea and isolated a cDNA homologous to CMKA, a calmodulin
Calcium-dependent protein kinase/NADPH oxidase activation circuit is required for rapid defense signal propagation.
Dubiella U, et al. Proc Natl Acad Sci U S A 2013. PMID 23650383 Free PMC article.
We identified that Arabidopsis thaliana isoform CPK5 of the plant calcium-dependent protein kinase family becomes rapidly biochemically activated in response to pathogen-associated molecular pattern (PAMP) stimulation. ...Remarkably, CPK5-dependent in vivo phosphorylation of RBOHD occurs on both PAMP- and ROS stimulation. Furthermore, rapid CPK5-dependent biochemical and transcriptional activation of defense reactions at distal sites is compromised in cpk5 and rbohd mutants. ...
We identified that Arabidopsis thaliana isoform CPK5 of the plant calcium-dependent protein kinase family becomes rapid …
Calmodulin kinases: essential regulators in health and disease.
Takemoto-Kimura S, et al. J Neurochem 2017 - Review. PMID 28295333 Free article.
Among these, the multifunctional Ca(2+) /calmodulin-dependent protein kinases (CaMKs, or calmodulin kinases) play key roles in neuronal transmission, synaptic plasticity, circuit development and cognition. ...Although they all necessitate the binding of Ca(2+) and calmodulin complex (Ca(2+) /CaM) for releasing autoinhibition, each member of CaMK has distinct activation mechanisms-autophosphorylation mediated autonomy of multimeric CaMKII and CaMKK-dependent phosphoswitch-induced activation of CaMKI or CaMKIV. ...
Among these, the multifunctional Ca(2+) /calmodulin-dependent protein kinases (CaMKs, or calmodulin ki
Focal adhesion kinases and calcium/calmodulin-dependent protein kinases regulate protein tyrosine phosphorylation in stallion sperm.
González-Fernández L, et al. Biol Reprod 2013. PMID 23595906
Treatment with inhibitors of calcium/calmodulin-dependent kinases, protein kinase A (PRKA), or Src family kinases suppressed the PY induced by the absence of added calcium, but not that induced by the Ca/W-7 treatment, indicating that PY in the absence of added calcium occurred via the canonical PRKA pathway, but that PY in the Ca/W-7 treatment did not. ...These results show for the first time a role for calcium/calmodulin-dependent kinases in PRKA-dependent sperm PY; a non-PRKA-dependent pathway regulating sperm PY; and the apparent involvement of the FAK family of protein tyrosine kinases downstream in both pathways....
Treatment with inhibitors of calcium/calmodulin-dependent kinases, protein kinase A (PRKA), or Src family …
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