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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1986 1
1987 1
1988 2
1989 4
1990 7
1991 8
1992 11
1993 27
1994 56
1995 86
1996 105
1997 105
1998 164
1999 165
2000 121
2001 116
2002 109
2003 92
2004 109
2005 82
2006 114
2007 116
2008 147
2009 164
2010 178
2011 194
2012 195
2013 207
2014 223
2015 203
2016 179
2017 171
2018 166
2019 67
2020 1
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3,392 results
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Page 1
Calcium/Calmodulin-Dependent Protein Kinase II and Eukaryotic Elongation Factor 2 Kinase Pathways Mediate the Antidepressant Action of Ketamine.
Adaikkan C, et al. Biol Psychiatry 2018. PMID 29395043
METHODS: To unravel the mechanism of action of ketamine, we treated wild-type C57BL/6 mice with calcium/calmodulin-dependent protein kinase II (CaMKII) specific inhibitor tatCN21 peptide. ...The inhibition phase of CaMKII, which lasted 10 to 20 minutes after administration of ketamine, occurred concurrently with eEF2K-dependent increased protein synthesis. ...
METHODS: To unravel the mechanism of action of ketamine, we treated wild-type C57BL/6 mice with calcium/calmodulin-dependen
Calcium/calmodulin-dependent protein kinase IV: A multifunctional enzyme and potential therapeutic target.
Naz H, et al. Prog Biophys Mol Biol 2016 - Review. PMID 26773169
The calcium/calmodulin-dependent protein kinase IV (CAMKIV) belongs to the serine/threonine protein kinase family, and is primarily involved in transcriptional regulation in lymphocytes, neurons and male germ cells. ...In this review, we tried to focus on different aspects of CAMKIV to understand the significance of this protein in the biological system. ...
The calcium/calmodulin-dependent protein kinase IV (CAMKIV) belongs to the serine/threonine protein kinas …
Ca(2+)/calmodulin-dependent protein kinases.
Swulius MT and Waxham MN. Cell Mol Life Sci 2008 - Review. PMID 18463790 Free PMC article.
In this article the calcium/calmodulin-dependent protein kinases are reviewed. The primary focus is on the structure and function of this diverse family of enzymes, and the elegant regulation of their activity. ...Finally, how the enzymes become activated in the intracellular setting is considered by exploring the reciprocal interactions that exist between calcium binding to calmodulin when interacting with the CaM-kinases....
In this article the calcium/calmodulin-dependent protein kinases are reviewed. The primary focus is on th …
Calcium/calmodulin-dependent protein kinase IV gene polymorphisms in Korean alcohol-dependent patients.
Jung WY, et al. Prog Neuropsychopharmacol Biol Psychiatry 2017. PMID 28734942
INTRODUCTION: A relationship between alcohol dependence (AD) and calcium/calmodulin-dependent protein kinase IV (CAMKIV) has been reported in a whole genome study of Korean AD patients. ...
INTRODUCTION: A relationship between alcohol dependence (AD) and calcium/calmodulin-dependent protein kinase IV …
Autophosphorylation of calcium/calmodulin-dependent protein kinase (CCaMK) at S343 or S344 generates an intramolecular interaction blocking the CaM-binding.
Jauregui E, et al. Plant Signal Behav 2017. PMID 28696815 Free PMC article.
The Ca(2+) and Ca(2+)/calmodulin-dependent protein kinase (CCaMK) is an important effector protein of Ca(2+)/calmodulin-mediated signaling, and in legumes, it is a critical regulator of plant-rhizobia and mycorrhizal symbioses. CCaMK contains a kinase domain, a calmodulin-binding/autoinhibitory domain and a visinin-like domain. Previous studies revealed the presence of 2 phosphorylation sites, S343 and S344, in the calmodulin-binding domain. ...
The Ca(2+) and Ca(2+)/calmodulin-dependent protein kinase (CCaMK) is an important effector protein of Ca(2+)/ …
Regulation of Multifunctional Calcium/Calmodulin Stimulated Protein Kinases by Molecular Targeting.
Skelding KA and Rostas JAP. Adv Exp Med Biol 2020 - Review. PMID 31646529
Multifunctional calcium/calmodulin-stimulated protein kinases control a broad range of cellular functions in a multitude of cell types. ...As these protein kinases are widely or ubiquitously expressed, and yet regulate a broad range of different cellular functions, additional levels of regulation exist that control these cell-specific functions. ...
Multifunctional calcium/calmodulin-stimulated protein kinases control a broad range of cellular functions in a m …
The Ca(2+)/Calmodulin/CaMKK2 Axis: Nature's Metabolic CaMshaft.
Marcelo KL, et al. Trends Endocrinol Metab 2016 - Review. PMID 27449752 Free PMC article.
Calcium (Ca(2+)) is an essential ligand that binds its primary intracellular receptor calmodulin (CaM) to trigger a variety of downstream processes and pathways. ...An appreciation of this information is critical to understanding the mechanisms by which Ca(2+)/CaM-dependent signaling contributes to metabolic homeostasis and disease....
Calcium (Ca(2+)) is an essential ligand that binds its primary intracellular receptor calmodulin (CaM) to trigger a variety of
Specificity of calcium/calmodulin-dependent protein kinases in mouse egg activation.
Medvedev S, et al. Cell Cycle 2014. PMID 24626179 Free PMC article.
Using exogenous expression of different cRNAs in Camk2g(-/-) eggs, we show that the other multifunctional CaM kinases, CaMKI, and CaMKIV, are not capable of substituting CaMKIIγ to initiate cell cycle resumption in response to a rise in intracellular Ca (2+). ...
Using exogenous expression of different cRNAs in Camk2g(-/-) eggs, we show that the other multifunctional CaM kinases, CaMKI, and CaM …
Calcium/Calmodulin-dependent protein kinase is negatively and positively regulated by calcium, providing a mechanism for decoding calcium responses during symbiosis signaling.
Miller JB, et al. Plant Cell 2013. PMID 24368786 Free PMC article.
In animal systems, comparable calcium oscillations are decoded by calmodulin (CaM)-dependent protein kinases, but symbiotic signaling involves a calcium/CaM-dependent protein kinase (CCaMK) that is unique to plants. CCaMK differs from the animal CaM kinases by its dual ability to bind free calcium, via calcium binding EF-hand domains on the protein, or to bind calcium complexed with CaM, via a CaM binding domain. ...
In animal systems, comparable calcium oscillations are decoded by calmodulin (CaM)-dependent protein kinases
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