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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1964 1
1980 2
1981 18
1982 16
1983 50
1984 59
1985 76
1986 83
1987 73
1988 79
1989 90
1990 95
1991 106
1992 99
1993 117
1994 112
1995 123
1996 136
1997 177
1998 180
1999 175
2000 219
2001 209
2002 239
2003 233
2004 236
2005 275
2006 318
2007 307
2008 317
2009 327
2010 316
2011 283
2012 330
2013 312
2014 276
2015 259
2016 258
2017 240
2018 204
2019 112
2020 3
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6,521 results
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Page 1
Calpain research for drug discovery: challenges and potential.
Ono Y, et al. Nat Rev Drug Discov 2016 - Review. PMID 27833121
Therapeutic strategies targeting malfunctions of calpains have been developed, driven primarily by improvements in the specificity and bioavailability of calpain inhibitors. Here, we review the calpain superfamily and calpain-related disorders, and discuss emerging calpain-targeted therapeutic strategies....
Therapeutic strategies targeting malfunctions of calpains have been developed, driven primarily by improvements in the specificity and bioav …
Presence of calpain-5 in mitochondria.
Iwamoto T, et al. Biochem Biophys Res Commun 2018. PMID 30195492
There are 15 members of the calpain family in mammals. In animal cells, there are three types of calpains, viz., calpain-1, calpain-2, and calpain-10 in the mitochondria. ...However, the distribution of calpain-5 in the retina has not been elucidated. Therefore, in the present study, we determined the localization of calpain-5 in the porcine retina. ...
There are 15 members of the calpain family in mammals. In animal cells, there are three types of calpains, viz., calpain-1, …
Calpain-2 as a therapeutic target for acute neuronal injury.
Wang Y, et al. Expert Opin Ther Targets 2018 - Review. PMID 29168923 Free PMC article.
In the CNS, where calpain-1 and calpain-2 are the main calpain isoforms, their activation has been linked to synaptic plasticity as well as to neurodegeneration. This review will focus on the role of calpain-2 in acute neuronal injury and discuss the possibility of developing selective calpain-2 inhibitors for therapeutic purposes. ...
In the CNS, where calpain-1 and calpain-2 are the main calpain isoforms, their activation has been linked to synaptic p …
Calpain-14 and its association with eosinophilic esophagitis.
Litosh VA, et al. J Allergy Clin Immunol 2017 - Review. PMID 28131390 Free PMC article.
These enzymes have been implicated in a number of disease processes, notably for this review involving eosinophilic tissue inflammation, such as eosinophilic esophagitis (EoE), a chronic inflammatory disorder triggered by allergic hypersensitivity to food and associated with genetic variants in calpain 14 (CAPN14). ...Structurally, CAPN14 has classical calpain motifs, including a cysteine protease core. In comparison with other human calpains, CAPN14 has a unique expression pattern, with the highest levels in the upper gastrointestinal tract, particularly in the squamous epithelium of the esophagus. ...
These enzymes have been implicated in a number of disease processes, notably for this review involving eosinophilic tissue inflammation, suc …
Calpain-1 deletion impairs mGluR-dependent LTD and fear memory extinction.
Zhu G, et al. Sci Rep 2017. PMID 28202907 Free PMC article.
Recent studies indicate that calpain-1 is required for the induction of long-term potentiation (LTP) elicited by theta-burst stimulation in field CA1 of hippocampus. ...Furthermore, calpain-1 KO mice exhibited impairment in fear memory extinction to tone presentation. These results indicate that calpain-1 plays a critical role in mGluR-LTD and is involved in many forms of synaptic plasticity and learning and memory....
Recent studies indicate that calpain-1 is required for the induction of long-term potentiation (LTP) elicited by theta-burst stimulat …
Calpain-6 controls the fate of sarcoma stem cells by promoting autophagy and preventing senescence.
Andrique C, et al. JCI Insight 2018. PMID 30185659 Free PMC article.
Here, we show that calpain-6 expression is associated with cancer stem cell features. In mouse models of bone sarcoma, calpain-6-expressing cells have unique tumor-initiating and metastatic capacities. ...We found that calpain-6 levels are increased by hypoxia in vitro and calpain-6 is detected within hypoxic areas in tumors. Furthermore, calpain-6 expression depends on the stem cell transcription network that involves Oct4, Nanog, and Sox2 and is activated by hypoxia. ...
Here, we show that calpain-6 expression is associated with cancer stem cell features. In mouse models of bone sarcoma, calpain
The Calcium-Dependent Protease Calpain-1 Links TRPC6 Activity to Podocyte Injury.
Verheijden KAT, et al. J Am Soc Nephrol 2018. PMID 29954830 Free PMC article.
Treatment with the calpain inhibitor calpeptin prevented these effects. In cultured podocytes, pharmacologic stimulation of TRPC6-dependent calcium influx increased calpain-1 and calcineurin activity and reduced Talin-1 expression, and knockdown of TRPC6 or calpain-1 prevented these effects. ...Therefore, calpain-1 and/or TRPC6 inhibition could be future therapeutic options to treat patients with FSGS or other podocytopathies....
Treatment with the calpain inhibitor calpeptin prevented these effects. In cultured podocytes, pharmacologic stimulation of TRPC6-dep …
Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation.
Davis MA, et al. Proc Natl Acad Sci U S A 2019. PMID 30796192 Free PMC article.
Cell analyses revealed that all major cytoskeleton components were disrupted during pyroptosis and that sensitivity to rupture was calpain-dependent and linked with cleavage of vimentin and loss of intermediate filaments. ...
Cell analyses revealed that all major cytoskeleton components were disrupted during pyroptosis and that sensitivity to rupture was calpai
Calpain system protein expression and activity in ovarian cancer.
Zhang S, et al. J Cancer Res Clin Oncol 2019. PMID 30448882 Free PMC article.
PURPOSE: Expression of members of the calpain system are associated with clinical outcome of patients with, amongst others, breast and ovarian cancers, with calpain-2 expression in ovarian cancer being implicated in chemo-resistance and survival. ...METHODS: Calpain-1, calpain-2, calpain-4 and calpastatin expression were evaluated in primary ovarian carcinomas (n = 575) by immunohistochemistry. ...
PURPOSE: Expression of members of the calpain system are associated with clinical outcome of patients with, amongst others, breast an …
Inhibition of calpain-1 stabilizes TCF11/Nrf1 but does not affect its activation in response to proteasome inhibition.
Nowak K, et al. Biosci Rep 2018. PMID 30177525 Free PMC article.
It was previously shown that the calcium-dependent protease calpain-1 interacts with TCF11/Nrf1 and the TCF11/Nrf1 cleavage site is a potential calpain target. Here, we tested the hypothesis that calpain-1 or -2 cleave TCF11/Nrf1. However, we did not find a role for calpain-1 or -2 in the activation of TCF11/Nrf1 after proteasome inhibition neither by using chemical inhibitors nor siRNA-mediated knockdown or overexpression of calpain subunits. ...
It was previously shown that the calcium-dependent protease calpain-1 interacts with TCF11/Nrf1 and the TCF11/Nrf1 cleavage site is a …
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