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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1969 1
1970 5
1971 34
1972 107
1973 176
1974 162
1975 126
1976 151
1977 159
1978 162
1979 124
1980 133
1981 132
1982 84
1983 87
1984 85
1985 75
1986 88
1987 93
1988 60
1989 61
1990 75
1991 108
1992 61
1993 74
1994 75
1995 113
1996 98
1997 112
1998 178
1999 151
2000 163
2001 202
2002 241
2003 238
2004 244
2005 288
2006 301
2007 336
2008 364
2009 314
2010 353
2011 395
2012 414
2013 364
2014 393
2015 431
2016 436
2017 455
2018 499
2019 270
2020 5
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8,981 results
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Page 1
The pharmacokinetics and the pharmacodynamics of cannabinoids.
Lucas CJ, et al. Br J Clin Pharmacol 2018 - Review. PMID 30001569 Free PMC article.
There is increasing interest in the use of cannabinoids for disease and symptom management, but limited information available regarding their pharmacokinetics and pharmacodynamics to guide prescribers. ...The pharmacokinetics of cannabinoids and the effects observed depend on the formulation and route of administration, which should be tailored to individual patient requirements. ...
There is increasing interest in the use of cannabinoids for disease and symptom management, but limited information available regardi …
Pharmacokinetics and pharmacodynamics of cannabinoids.
Grotenhermen F. Clin Pharmacokinet 2003 - Review. PMID 12648025
Delta(9)-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects caused by the consumption of cannabis, both the marijuana-like action and the medicinal benefits of the plant. ...Cannabinoids exert many effects through activation of G-protein-coupled cannabinoid receptors in the brain and peripheral tissues. ...
Delta(9)-Tetrahydrocannabinol (THC) is the main source of the pharmacological effects caused by the consumption of cannabis, both the …
Practical considerations in medical cannabis administration and dosing
MacCallum CA and Russo EB. Eur J Intern Med 2018 - Review. PMID 29307505
With the advent of pharmaceutical cannabis-based medicines (Sativex/nabiximols and Epidiolex), and liberalisation of access in certain nations, this ignorance of cannabis pharmacology and therapeutics has become untenable. In this article, the authors endeavour to present concise data on cannabis pharmacology related to tetrahydrocannabinol (THC), cannabidiol (CBD) et al., methods of administration (smoking, vaporisation, oral), and dosing recommendations. ...
With the advent of pharmaceutical cannabis-based medicines (Sativex/nabiximols and Epidiolex), and liberalisation of access in certain natio …
Spicing Up Pharmacology: A Review of Synthetic Cannabinoids From Structure to Adverse Events.
Davidson C, et al. Adv Pharmacol 2017 - Review. PMID 28826533
Recreational use of synthetic cannabinoids (SCB), a class of novel psychoactive substances is an increasing public health problem specifically in Western societies, with teenagers, young adults, and the prison population being the most affected. ...SCB are highly potent CB(1) cannabinoid receptor agonists falsely marketed and sold as safe and legal drugs. Here, we present an overview of the endocannabinoid system, CB, and SCB chemical structures and activity at CB receptors. ...
Recreational use of synthetic cannabinoids (SCB), a class of novel psychoactive substances is an increasing public health problem spe …
Toxicology of Marijuana, Synthetic Cannabinoids, and Cannabidiol in Dogs and Cats.
Brutlag A and Hommerding H. Vet Clin North Am Small Anim Pract 2018 - Review. PMID 30342565
In addition, exposure to illegal synthetic cannabinoids remains concerning. Veterinarians need to be able to recognize associated clinical signs and understand when cases have the potential for severity. ...
In addition, exposure to illegal synthetic cannabinoids remains concerning. Veterinarians need to be able to recognize associated cli …
Cannabis, from plant to pill
Grof CPL. Br J Clin Pharmacol 2018 - Review. PMID 29701252 Free PMC article.
Following supercritical CO(2) extraction of the inflorescence (and possibly bracts), the secondary metabolites can be blended to provide a specific ratio of major cannabinoids (THC : CBD) or individual cannabinoids can be isolated, purified and supplied as the pharmaceutical. Intensive breeding strategies will provide novel cultivars of cannabis possessing elevated levels of specific cannabinoids or other secondary metabolites....
Following supercritical CO(2) extraction of the inflorescence (and possibly bracts), the secondary metabolites can be blended to provide a s …
Clinical and Preclinical Evidence for Functional Interactions of Cannabidiol and Δ9-Tetrahydrocannabinol
Boggs DL, et al. Neuropsychopharmacology 2018 - Review. PMID 28875990 Free PMC article.
In this article, we review the available evidence on the pharmacology and behavioral interactions of THC and CBD from preclinical and human studies, particularly with reference to anxiety and psychosis-like symptoms. Both THC and CBD, as well as other cannabinoid molecules, are currently being evaluated for medicinal purposes, separately and in combination. ...
In this article, we review the available evidence on the pharmacology and behavioral interactions of THC and CBD from preclinical and …
Drug-drug interactions as a result of co-administering Δ9-THC and CBD with other psychotropic agents
Rong C, et al. Expert Opin Drug Saf 2018 - Review. PMID 29082802
The search term cannabis was cross-referenced with the terms drug interactions, cytochrome, cannabinoids, cannabidiol, and medical marijuana. Pharmacological, molecular, and physiologic studies evaluating the pharmacokinetics of Δ(9)-tetrahydrocannabinol (Δ(9)-THC) and cannabidiol (CBD), both in vitro and in vivo, were included. ...
The search term cannabis was cross-referenced with the terms drug interactions, cytochrome, cannabinoids, cannabidiol, and medical ma …
Cannabinoids for Symptom Management and Cancer Therapy: The Evidence.
Davis MP. J Natl Compr Canc Netw 2016 - Review. PMID 27407130
Cannabinoids are known to modulate a multitude of monoamine receptors. Structurally, there are 3 groups of cannabinoids. Multiple studies, most of which are of moderate to low quality, demonstrate that tetrahydrocannabinol (THC) and oromucosal cannabinoid combinations of THC and cannabidiol (CBD) modestly reduce cancer pain. ...Multiple cancers express cannabinoid receptors directly related to the degree of anaplasia and grade of tumor. Preclinical in vitro and in vivo studies suggest that cannabinoids may have anticancer activity. ...
Cannabinoids are known to modulate a multitude of monoamine receptors. Structurally, there are 3 groups of cannabinoids. Multi
Designer Drugs 2.0
Huestis MA and Tyndale RF. Clin Pharmacol Ther 2017. PMID 28084644
This "Designer Drugs 2.0" issue of Clinical Pharmacology & Therapeutics focuses on novel psychoactive substances, primarily cannabinoids and cathinones, and the repurposing of established psychoactive compounds (e.g., modafinil, psilocybin, lysergic acid diethylamide, and 3,4-methylenedioxymethamphetamine) that simultaneously offer new pharmacotherapies and pose serious health problems. Novel psychoactive substances were initially used as potent tools to investigate endogenous neurotransmitter systems; for example, synthetic cannabinoids have much higher potency than Δ9-tetrahydrocannabinol at the cannabinoid receptors. ...
This "Designer Drugs 2.0" issue of Clinical Pharmacology & Therapeutics focuses on novel psychoactive substances, primarily ca
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