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Development of [18F]ACI-19626 as a first-in-class brain PET tracer for imaging TDP-43 pathology.
Vokali E, Chevalier E, Dreyfus N, Charmey D, Melly T, Kocher J, Ratnam M, Serra AM, Jaquier T, Delgado C, Ravache M, Scialò C, Cappelli S, Kroth H, Capotosti F, Luthi-Carter R, Afroz T, Derouazi M, Constantinescu CC, Seelaar H, Buratti E, Nelson PT, Polymenidou M, Pfeifer A, Kosco-Vilbois M, Seredenina T. Vokali E, et al. Among authors: capotosti f. Nat Commun. 2025 Oct 24;16(1):9358. doi: 10.1038/s41467-025-64540-6. Nat Commun. 2025. PMID: 41136425 Free PMC article.
The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases.
Smith R, Capotosti F, Schain M, Ohlsson T, Vokali E, Molette J, Touilloux T, Hliva V, Dimitrakopoulos IK, Puschmann A, Jögi J, Svenningsson P, Andréasson M, Sandiego C, Russell DS, Miranda-Azpiazu P, Halldin C, Stomrud E, Hall S, Bratteby K, Tampio L'Estrade E, Luthi-Carter R, Pfeifer A, Kosco-Vilbois M, Streffer J, Hansson O. Smith R, et al. Among authors: capotosti f. Nat Commun. 2023 Oct 27;14(1):6750. doi: 10.1038/s41467-023-42305-3. Nat Commun. 2023. PMID: 37891183 Free PMC article.
PI-2620 Lead Optimization Highlights the Importance of Off-Target Assays to Develop a PET Tracer for the Detection of Pathological Aggregated Tau in Alzheimer's Disease and Other Tauopathies.
Kroth H, Oden F, Molette J, Schieferstein H, Gabellieri E, Mueller A, Berndt M, Sreenivasachary N, Serra AM, Capotosti F, Schmitt-Willich H, Hickman D, Pfeifer A, Dinkelborg L, Stephens A. Kroth H, et al. Among authors: capotosti f. J Med Chem. 2021 Sep 9;64(17):12808-12830. doi: 10.1021/acs.jmedchem.1c00861. Epub 2021 Aug 29. J Med Chem. 2021. PMID: 34455780
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