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Year Number of Results
1842 1
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1847 1
1848 3
1850 2
1851 4
1852 6
1853 10
1854 6
1855 10
1856 6
1857 8
1858 5
1859 9
1860 7
1861 2
1862 1
1863 4
1864 3
1865 2
1866 4
1867 5
1868 3
1869 3
1870 9
1871 5
1872 1
1873 1
1874 5
1875 3
1876 3
1877 9
1878 7
1879 2
1880 2
1881 9
1882 4
1883 6
1884 8
1885 5
1886 5
1887 5
1888 8
1889 4
1890 4
1891 6
1892 13
1893 18
1894 8
1895 11
1896 12
1897 7
1898 10
1899 6
1900 6
1901 3
1902 9
1903 9
1904 10
1905 8
1906 15
1907 16
1908 7
1909 10
1910 6
1911 23
1912 14
1913 22
1914 19
1915 13
1916 24
1917 21
1918 15
1919 7
1920 22
1921 11
1922 29
1923 19
1924 34
1925 25
1926 36
1927 25
1928 37
1929 33
1930 28
1931 29
1932 33
1933 28
1934 43
1935 47
1936 46
1937 37
1938 27
1939 40
1940 42
1941 54
1942 48
1943 44
1944 47
1945 185
1946 492
1947 675
1948 742
1949 617
1950 845
1951 1031
1952 1153
1953 1200
1954 1276
1955 1385
1956 1332
1957 1535
1958 1581
1959 1537
1960 1745
1961 1905
1962 2065
1963 2609
1964 4875
1965 19182
1966 16742
1967 8649
1968 7740
1969 8940
1970 9259
1971 10329
1972 11412
1973 12570
1974 12994
1975 17592
1976 18052
1977 18556
1978 19434
1979 19826
1980 21258
1981 22088
1982 23781
1983 26439
1984 29249
1985 31256
1986 31927
1987 33413
1988 34660
1989 38954
1990 40650
1991 41080
1992 42042
1993 43148
1994 43714
1995 45184
1996 45546
1997 45857
1998 47607
1999 49589
2000 52224
2001 53855
2002 55882
2003 59066
2004 63982
2005 69609
2006 73434
2007 77148
2008 81933
2009 85318
2010 93723
2011 100157
2012 106912
2013 112362
2014 117547
2015 122517
2016 123490
2017 127214
2018 132076
2019 138467
2020 151852
2021 158028
2022 156058
2023 148457
2024 153723
2025 12967

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3,316,930 results

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Page 1
All-atom simulations to studying metallodrugs/target interactions.
Janoš P, Spinello A, Magistrato A. Janoš P, et al. Curr Opin Chem Biol. 2021 Apr;61:1-8. doi: 10.1016/j.cbpa.2020.07.005. Epub 2020 Aug 8. Curr Opin Chem Biol. 2021. PMID: 32781390 Review.
In this scenario, the complementary use of accurate computational methods allows uncovering the minutiae of metallodrugs/targets interactions and their underlying mechanism of action at an atomic-level of detail. This knowledge is increasingly perceived as an invaluable re …
In this scenario, the complementary use of accurate computational methods allows uncovering the minutiae of metallodrugs/targets inte …
Stimuli-Responsive Therapeutic Metallodrugs.
Wang X, Wang X, Jin S, Muhammad N, Guo Z. Wang X, et al. Chem Rev. 2019 Jan 23;119(2):1138-1192. doi: 10.1021/acs.chemrev.8b00209. Epub 2018 Oct 9. Chem Rev. 2019. PMID: 30299085 Review.
The success of platinum-based anticancer agents has motivated the exploration of novel metal-based drugs for several decades, whereas problems such as drug-resistance and systemic toxicity hampered their clinical applications and efficacy. ...The compounds are class …
The success of platinum-based anticancer agents has motivated the exploration of novel metal-based drugs for several decades, …
Methods to identify protein targets of metal-based drugs.
Skos L, Borutzki Y, Gerner C, Meier-Menches SM. Skos L, et al. Curr Opin Chem Biol. 2023 Apr;73:102257. doi: 10.1016/j.cbpa.2022.102257. Epub 2023 Jan 2. Curr Opin Chem Biol. 2023. PMID: 36599256 Free article. Review.
Metal-based anticancer agents occupy a distinct chemical space due to their particular coordination geometry and reactivity. ...Here, such experimental approaches are discussed, which showed that metallodrugs based on ruthenium, gold, rhenium and even …
Metal-based anticancer agents occupy a distinct chemical space due to their particular coordination geometry and reactivity. . …
Continuous Flow Synthesis of Metal-NHC Complexes*.
Simoens A, Scattolin T, Cauwenbergh T, Pisanò G, Cazin CSJ, Stevens CV, Nolan SP. Simoens A, et al. Chemistry. 2021 Mar 26;27(18):5653-5657. doi: 10.1002/chem.202100190. Epub 2021 Mar 3. Chemistry. 2021. PMID: 33528078
Herein, the use of cuprate, aurate or palladate species for a continuous flow preparation of Cu(I) , Au(I) and Pd(II) -NHC complexes is reported. All reactions examined proceed under extremely mild conditions and make use of technical grade acetone as solvent. ...
Herein, the use of cuprate, aurate or palladate species for a continuous flow preparation of Cu(I) , Au(I) and Pd(II) -NHC com …
Ultrafast Au(III)-Mediated Arylation of Cysteine.
Doud EA, Tilden JAR, Treacy JW, Chao EY, Montgomery HR, Kunkel GE, Olivares EJ, Adhami N, Kerr TA, Chen Y, Rheingold AL, Loo JA, Frost CG, Houk KN, Maynard HD, Spokoyny AM. Doud EA, et al. J Am Chem Soc. 2024 May 8;146(18):12365-12374. doi: 10.1021/jacs.3c12170. Epub 2024 Apr 24. J Am Chem Soc. 2024. PMID: 38656163
Through mechanistic work and rational design, we have developed the fastest organometallic abiotic Cys bioconjugation. As a result, the developed organometallic Au(III) bioconjugation reagents enable selective labeling of Cys moieties down to picomolar …
Through mechanistic work and rational design, we have developed the fastest organometallic abiotic Cys bioconjugation. …
Medicinal Chemistry of Gold Anticancer Metallodrugs.
Casini A, Sun RW, Ott I. Casini A, et al. Met Ions Life Sci. 2018 Feb 5;18:/books/9783110470734/9783110470734-007/9783110470734-013.xml. doi: 10.1515/9783110470734-013. Met Ions Life Sci. 2018. PMID: 29394026 Free article. Review.
Since ancient times gold and its complexes have been used as therapeutics against different diseases. In modern medicine gold drugs have been applied for the treatment of rheumatoid arthritis, however, recently other medical applications have come into the focus of …
Since ancient times gold and its complexes have been used as therapeutics against different diseases. In modern medicine gold …
Computational Studies of Au(I) and Au(III) Anticancer MetalLodrugs: A Survey.
Tolbatov I, Marrone A, Coletti C, Re N. Tolbatov I, et al. Molecules. 2021 Dec 15;26(24):7600. doi: 10.3390/molecules26247600. Molecules. 2021. PMID: 34946684 Free PMC article. Review.
Among them, Au(I)- and Au(III)-based compounds are promising candidates due to the strong affinity of Au(I) cations to cysteine and selenocysteine side chains of the protein residues and to Au(III) complexes being more labile and prone to the reduction …
Among them, Au(I)- and Au(III)-based compounds are promising candidates due to the strong affinity of Au(I) cati …
Multi-Target Metal-Based Anticancer Agents.
Chen ZF, Orvig C, Liang H. Chen ZF, et al. Curr Top Med Chem. 2017 Nov 20;17(28):3131-3145. doi: 10.2174/1568026617666171004155437. Curr Top Med Chem. 2017. PMID: 28982336 Review.
In this review, we focus on the multi-targeted metal-based anticancer agents, which include platinum, ruthenium, rhodium, gold, silver, copper, cobalt, zinc, and nickel complexes. Future directions for the development of multi-targeted metal-based anticanc …
In this review, we focus on the multi-targeted metal-based anticancer agents, which include platinum, ruthenium, rhodium, g …
Polyoxometalates as Potential Next-Generation Metallodrugs in the Combat Against Cancer.
Bijelic A, Aureliano M, Rompel A. Bijelic A, et al. Angew Chem Int Ed Engl. 2019 Mar 4;58(10):2980-2999. doi: 10.1002/anie.201803868. Epub 2018 Oct 12. Angew Chem Int Ed Engl. 2019. PMID: 29893459 Free PMC article. Review.
Polyoxometalates (POMs) are an emerging class of inorganic metal oxides, which over the last decades demonstrated promising biological activities by the virtue of their great diversity in structures and properties. They possess high potential for the inhibition of various …
Polyoxometalates (POMs) are an emerging class of inorganic metal oxides, which over the last decades demonstrated promising biological activ …
3,316,930 results
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