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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1952 3
1953 1
1964 6
1965 38
1966 77
1967 26
1968 32
1969 29
1970 23
1971 15
1972 22
1973 22
1974 5
1975 8
1976 9
1977 8
1978 11
1979 3
1980 4
1981 8
1982 15
1983 9
1984 19
1985 13
1986 11
1987 12
1988 13
1989 28
1990 8
1991 12
1992 11
1993 20
1994 23
1995 19
1996 30
1997 36
1998 73
1999 58
2000 92
2001 135
2002 158
2003 164
2004 208
2005 236
2006 184
2007 238
2008 255
2009 283
2010 264
2011 273
2012 284
2013 282
2014 246
2015 248
2016 221
2017 231
2018 184
2019 71
2020 0
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4,474 results
Results by year
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Page 1
Simultaneous tracing of carbon and nitrogen isotopes in human cells.
Nilsson R and Jain M. Mol Biosyst 2016. PMID 27098229 Free PMC article.
Tracing stable isotopes of such elements may help shed light on poorly understood metabolic pathways. Here, we demonstrate the use of high-resolution mass spectrometry to simultaneously trace carbon and nitrogen metabolism in human cells cultured with (13)C- and (15)N-labeled glucose and glutamine. ...Whereas measured (13)C MIDs were informative for central carbon metabolism, (15)N isotopes provided evidence for nitrogen-carrying reactions in amino acid and nucleotide metabolism. ...
Tracing stable isotopes of such elements may help shed light on poorly understood metabolic pathways. Here, we demonstrate the use of …
Carbon isotopes and water use efficiency in C4 plants.
Ellsworth PZ and Cousins AB. Curr Opin Plant Biol 2016 - Review. PMID 27155062
The leaf carbon isotopic composition (δ(13)Cleaf) has been suggested to serve as a rapid and effective high throughput phenotyping method for WUE in both C3 and C4 species. This is because WUE, leaf carbon discrimination (Δ(13)Cleaf), and δ(13)Cleaf are correlated through their relationships with intercellular to ambient CO2 partial pressures (Ci/Ca). ...
The leaf carbon isotopic composition (δ(13)Cleaf) has been suggested to serve as a rapid and effective high throughput phenotyping me …
Learning from quantitative data to understand central carbon metabolism.
Matsuda F, et al. Biotechnol Adv 2017 - Review. PMID 28928003
We emphasize that metabolic flux analysis based on material balance is a critical method for quantitative investigations into cell metabolism. The absolute determination of metabolite concentration appears to be essential for evaluating the thermodynamic state of metabolism. ...
We emphasize that metabolic flux analysis based on material balance is a critical method for quantitative investigations into cell metabo
A roadmap for interpreting (13)C metabolite labeling patterns from cells
Buescher JM, et al. Curr Opin Biotechnol 2015 - Review. PMID 25731751 Free PMC article.
Measuring intracellular metabolism has increasingly led to important insights in biomedical research. (13)C tracer analysis, although less information-rich than quantitative (13)C flux analysis that requires computational data integration, has been established as a time-efficient method to unravel relative pathway activities, qualitative changes in pathway contributions, and nutrient contributions. ...
Measuring intracellular metabolism has increasingly led to important insights in biomedical research. (13)C tracer analysis, although …
Tracing metabolism from lignocellulosic biomass and gaseous substrates to products with stable-isotopes.
Gonzalez JE and Antoniewicz MR. Curr Opin Biotechnol 2017 - Review. PMID 27780112
To increase the economic feasibility of biological processes, microbial isolates are engineered to take up inexpensive feedstocks (including lignocellulosic biomass, syngas, methane, and carbon dioxide), and convert them into substrates of central metabolism and further into value-added products. To trace the metabolism of these feedstocks into products, isotopic tracers are applied together with isotopomer analysis techniques such as (13)C-metabolic flux analysis to provide a detailed picture of pathway utilization. ...
To increase the economic feasibility of biological processes, microbial isolates are engineered to take up inexpensive feedstocks (including …
Carbon isotopes in terrestrial ecosystem pools and CO2 fluxes.
Bowling DR, et al. New Phytol 2008 - Review. PMID 18179603 Free article.
Stable carbon isotopes are used extensively to examine physiological, ecological, and biogeochemical processes related to ecosystem, regional, and global carbon cycles and provide information at a variety of temporal and spatial scales. Much is known about the processes that regulate the carbon isotopic composition (delta(13)C) of leaf, plant, and ecosystem carbon pools and of photosynthetic and respiratory carbon dioxide (CO(2)) fluxes. ...
Stable carbon isotopes are used extensively to examine physiological, ecological, and biogeochemical processes related to ecos …
Fatty Acid 13C Isotopologue Profiling Provides Insight into Trophic Carbon Transfer and Lipid Metabolism of Invertebrate Consumers.
Menzel R, et al. J Vis Exp 2018. PMID 29733305 Free PMC article.
However, the FA trophic marker approach is still hampered by the limited knowledge in lipid metabolism of the soil fauna. This study used entirely labelled palmitic acid ((13)C16:0, 99 atom%) as a tracer in fatty acid metabolism pathways of two widespread soil Collembola, Protaphorura fimata and Heteromurus nitidus. ...The isotopologue profiling is suggested as a useful tool for evaluation of fatty acid metabolism in soil animals to disentangle trophic interactions....
However, the FA trophic marker approach is still hampered by the limited knowledge in lipid metabolism of the soil fauna. This study …
13C metabolic flux analysis
Wiechert W. Metab Eng 2001 - Review. PMID 11461141
It allows the detailed quantification of all intracellular fluxes in the central metabolism of a microorganism. The method has strongly evolved in recent years by the introduction of new experimental procedures, measurement techniques, and mathematical data evaluation methods. ...
It allows the detailed quantification of all intracellular fluxes in the central metabolism of a microorganism. The method has strong …
Experimental strategies for in vivo13C NMR spectroscopy
Valette J, et al. Anal Biochem 2017 - Review. PMID 27515993
In vivo carbon-13 ((13)C) MRS opens unique insights into the metabolism of intact organisms, and has led to major advancements in the understanding of cellular metabolism under normal and pathological conditions in various organs such as skeletal muscles, the heart, the liver and the brain. ...
In vivo carbon-13 ((13)C) MRS opens unique insights into the metabolism of intact organisms, and has led to major advancements …
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