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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 8
1948 9
1949 8
1950 24
1951 32
1952 11
1953 27
1954 18
1955 31
1956 22
1957 17
1958 27
1959 17
1960 31
1961 28
1962 45
1963 16
1964 27
1965 13
1966 3
1967 12
1968 5
1969 2
1970 12
1971 117
1972 171
1973 2966
1974 6282
1975 1428
1976 313
1977 394
1978 369
1979 433
1980 517
1981 583
1982 563
1983 659
1984 846
1985 825
1986 741
1987 519
1988 525
1989 452
1990 542
1991 551
1992 512
1993 519
1994 447
1995 477
1996 470
1997 494
1998 522
1999 453
2000 538
2001 527
2002 560
2003 519
2004 498
2005 517
2006 504
2007 547
2008 531
2009 492
2010 438
2011 447
2012 485
2013 501
2014 448
2015 438
2016 357
2017 367
2018 338
2019 128
2020 2
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Search Results

32,285 results
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Page 1
New radical methods for the potential synthesis of carbon-13 and carbon-14 labeled complex products.
Maxwell BD. J Labelled Comp Radiopharm 2018 - Review. PMID 30156329
Recently, there has been a surge in the use of radicals to form new carbon-carbon bonds and for the incorporation of functional groups which can be used to incorporate isotopically labeled carbons. This review will describe some potential new radical methods for incorporating isotopically labeled carbon into complex molecules or into substrates that can be attached to late stage intermediates to generate labeled products....
Recently, there has been a surge in the use of radicals to form new carbon-carbon bonds and for the incorporation of fu …
An Overview of PET Radiochemistry, Part 1: The Covalent Labels (18)F, (11)C, and (13)N.
Pichler V, et al. J Nucl Med 2018 - Review. PMID 30042159 Free article.
This continuing educational article introduces the radiochemistry of PET tracers that exhibit a covalently bound radiolabel with the nuclides (11)C, (13)N, and (18)F. The overall process of PET tracer production is explained, starting from the production of the radionuclide in a cyclotron; followed by the automatization process of the radiosynthesis, including the necessary steps for the respective synthesis; and finalized with the requirements for quality control....
This continuing educational article introduces the radiochemistry of PET tracers that exhibit a covalently bound radiolabel wi …
Recent developments in carbonylation chemistry using [13 C]CO, [11 C]CO, and [14 C]CO
Nielsen DU, et al. J Labelled Comp Radiopharm 2018 - Review. PMID 29858516
Recent years have nevertheless witnessed a considerable headway on the development of carbon monoxide surrogates and reactor systems, which provide an ideal setting for performing carbonylation chemistry with stoichiometric and substoichiometric carbon monoxide. Such setups are particularly ideal for the introduction of isotope labels such as carbon-11, carbon-13, and carbon-14 into bioactive compounds. ...
Recent years have nevertheless witnessed a considerable headway on the development of carbon monoxide surrogates and reactor systems, …
GMP synthesis of carbon-14 labelled substances.
Filer CN, et al. J Labelled Comp Radiopharm 2016 - Review. PMID 26695715
This review discusses the process of preparing and analyzing carbon-14 labelled substances under good manufacturing practice....
This review discusses the process of preparing and analyzing carbon-14 labelled substances under good manufacturing practice....
From Carbon-11-Labeled Amino Acids to Peptides in Positron Emission Tomography: the Synthesis and Clinical Application.
Pekošak A, et al. Mol Imaging Biol 2018 - Review. PMID 29411226
Radiolabeled amino acids, their derivatives and peptides have a broad scope of application and can be used as receptor ligands, as well as enzyme substrates for many different diseases as radiopharmaceutical tracers. ...This review provides a comprehensive overview of radiosynthetic and enzymatic approaches towards carbon-11 amino acids, their analogues and peptides, with focus on stereoselective reactions, and reflects upon their clinical application....
Radiolabeled amino acids, their derivatives and peptides have a broad scope of application and can be used as receptor ligands, as we
Did the Romans introduce the Egyptian mongoose (Herpestes ichneumon) into the Iberian Peninsula?
Detry C, et al. Naturwissenschaften 2018. PMID 30311012
Therefore, radiocarbon dating of new archaeological finds of bones of the Egyptian Mongoose (Herpestes ichneumon) in the Iberian Peninsula push back the confirmed presence of the species in the region by approximately eight centuries, as the previously oldest dated record is from the ninth century. ...
Therefore, radiocarbon dating of new archaeological finds of bones of the Egyptian Mongoose (Herpestes ichneumon) in the Iberian Peni …
Use of carbon-11 labelled tool compounds in support of drug development.
Boscutti G, et al. Drug Discov Today Technol 2017 - Review. PMID 29233265
Whereas fluorine-18 has probably gained wider use in the community, there are benefits to using carbon-11 given the greater flexibility the use of this isotope permits in adaptive clinical study design. This review explores the scope of available carbon-11 chemistries and provides clinical examples to highlight its value in PET studies in support of drug development....
Whereas fluorine-18 has probably gained wider use in the community, there are benefits to using carbon-11 given the greater flexibili …
Classics in Neuroimaging: Radioligands for the Vesicular Monoamine Transporter 2.
Kilbourn MR and Koeppe RA. ACS Chem Neurosci 2019 - Review. PMID 30198706
The development of in vivo imaging radiotracers for VMAT2 is a story of starting with a well-characterized clinically used drug (tetrabenazine) which had a pharmacologically active metabolite: that metabolite that was in stepwise fashion refined and modified to provide both carbon-11 and fluorine-18 labeled VMAT2 radiotracers that are now used for human PET studies of neurodegenerative and psychiatric diseases. The design approach taken, which involved understanding the metabolism of the radiotracers and identification of the optimal ligand stereochemistry, are representative of important steps in the general concepts behind successful in vivo radiotracer design for brain imaging agents....
The development of in vivo imaging radiotracers for VMAT2 is a story of starting with a well-characterized clinically used drug (tetr …
Aged dissolved organic carbon exported from rivers of the Tibetan Plateau.
Qu B, et al. PLoS One 2017. PMID 28552976 Free PMC article.
The role played by river networks in regional and global carbon cycle is receiving increasing attention. Despite the potential of radiocarbon measurements (14C) to elucidate sources and cycling of different riverine carbon pools, there remain large regions such as the climate-sensitive Tibetan Plateau for which no data are available. ...A positive correlation between radiocarbon age and permafrost watershed coverage was observed, indicating that 14C-deplted/old carbon is exported from permafrost regions of the Tibetan Plateau during periods of high flow. ...
The role played by river networks in regional and global carbon cycle is receiving increasing attention. Despite the potential of …
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