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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 2
1946 22
1947 25
1948 21
1949 13
1950 31
1951 37
1952 34
1953 47
1954 32
1955 55
1956 40
1957 45
1958 47
1959 69
1960 69
1961 68
1962 59
1963 64
1964 84
1965 68
1966 51
1967 83
1968 77
1969 87
1970 79
1971 103
1972 97
1973 111
1974 83
1975 79
1976 66
1977 67
1978 58
1979 66
1980 83
1981 89
1982 91
1983 104
1984 106
1985 106
1986 112
1987 109
1988 109
1989 129
1990 112
1991 142
1992 127
1993 139
1994 131
1995 126
1996 96
1997 108
1998 96
1999 124
2000 138
2001 139
2002 139
2003 148
2004 162
2005 196
2006 220
2007 228
2008 245
2009 229
2010 242
2011 315
2012 328
2013 295
2014 316
2015 251
2016 298
2017 320
2018 271
2019 150
2020 2
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8,365 results
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Page 1
A simple diet- and chemical-induced murine NASH model with rapid progression of steatohepatitis, fibrosis and liver cancer
Tsuchida T, et al. J Hepatol 2018. PMID 29572095 Free PMC article.
METHODS: We have sought to establish a murine NASH model with rapid progression of extensive fibrosis and HCC by using a western diet (WD), which is high-fat, high-fructose and high-cholesterol, combined with low weekly dose of intraperitoneal carbon tetrachloride (CCl(4)), which serves as an accelerator. ...
METHODS: We have sought to establish a murine NASH model with rapid progression of extensive fibrosis and HCC by using a western diet (WD), …
Chloroquine ameliorates carbon tetrachloride-induced acute liver injury in mice via the concomitant inhibition of inflammation and induction of apoptosis.
Dai C, et al. Cell Death Dis 2018. PMID 30478280 Free PMC article.
This is the first study to investigate the hepatoprotective effect of CQ on acute liver injury caused by carbon tetrachloride (CCl(4)) in a murine model and the underlying molecular mechanisms. ...
This is the first study to investigate the hepatoprotective effect of CQ on acute liver injury caused by carbon tetrachloride
Polydatin protects against carbon tetrachloride-induced liver fibrosis in mice.
Zhao X, et al. Arch Biochem Biophys 2017. PMID 28666738
Recent study showed that polydatin prevented acute liver injury after carbon tetrachloride (CCl(4)) induction. However, the protective effects of polydatin on chronic liver injury and fibrosis has not been understood. ...
Recent study showed that polydatin prevented acute liver injury after carbon tetrachloride (CCl(4)) induction. However, the pr …
Docosahexaenoic acid attenuates carbon tetrachloride-induced hepatic fibrosis in rats.
He J, et al. Int Immunopharmacol 2017. PMID 29035816
In the present study, we reported the protective effect of DHA on carbon tetrachloride (CCl(4)) induced hepatic fibrosis. Compared with the control group, the CCl(4) group showed hepatic damage as evidenced by histological changes and elevation in serum transaminase activity, fibrosis, inflammation and oxidative stress levels. ...
In the present study, we reported the protective effect of DHA on carbon tetrachloride (CCl(4)) induced hepatic fibrosis. Comp …
Mesenchymal Stem Cell/Red Blood Cell-Inspired Nanoparticle Therapy in Mice with Carbon Tetrachloride-Induced Acute Liver Failure.
Liang H, et al. ACS Nano 2018. PMID 29943967 Free PMC article.
After intravenous delivery, these artificial stem cell analogs are able to remain in the liver and mitigate carbon tetrachloride-induced liver failure in a mouse model, as gauged by histology and liver function test. ...
After intravenous delivery, these artificial stem cell analogs are able to remain in the liver and mitigate carbon tetrachloride
Dimethylthiourea ameliorates carbon tetrachloride-induced acute liver injury in ovariectomized mice.
Mitazaki S, et al. Biomed Pharmacother 2018. PMID 29787990
AIMS: In order to clarify hepato-protective actions of estrogen, we examined the progress of carbon tetrachloride (CCl(4))-induced acute liver injury (ALI) in sham and ovariectomized (ovx) mice and the effects of dimethylthiourea (DMTU), a hydroxyl radical scavenger, and meloxicam (Melo), a selective cox-2 inhibitor, on the development of CCl(4)-induced ALI. ...
AIMS: In order to clarify hepato-protective actions of estrogen, we examined the progress of carbon tetrachloride (CCl(4))-ind …
GDF15 deficiency exacerbates chronic alcohol- and carbon tetrachloride-induced liver injury.
Chung HK, et al. Sci Rep 2017. PMID 29222479 Free PMC article.
In this study, we demonstrate that alcohol- or carbon tetrachloride (CCl(4))-mediated hepatic GDF15 production ameliorates liver inflammation and fibrosis. ...
In this study, we demonstrate that alcohol- or carbon tetrachloride (CCl(4))-mediated hepatic GDF15 production ameliorates liv …
ECM1 Prevents Activation of Transforming Growth Factor β, Hepatic Stellate Cells, and Fibrogenesis in Mice
Fan W, et al. Gastroenterology 2019. PMID 31362006 Free article.
Liver fibrosis was induced by carbon tetrachloride (CCl(4)) administration. Livers were collected from mice and analyzed by histology, immunohistochemistry, in situ hybridization, and immunofluorescence analyses. ...
Liver fibrosis was induced by carbon tetrachloride (CCl(4)) administration. Livers were collected from mice and analyzed by hi …
Single Cell RNA Sequencing Identifies Subsets of Hepatic Stellate Cells and Myofibroblasts in Liver Fibrosis
Krenkel O, et al. Cells 2019. PMID 31137713 Free PMC article.
In vivo resting HSCs or activated MFB were isolated from C57BL6/J mice challenged by carbon tetrachloride (CCl(4)) intraperitoneally for 3 weeks to induce liver fibrosis and compared to in vitro cultivated MFB. ...
In vivo resting HSCs or activated MFB were isolated from C57BL6/J mice challenged by carbon tetrachloride (CCl(4)) intraperito …
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