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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1487
1843 1118
1844 1248
1845 1277
1846 1404
1847 1367
1848 1203
1849 1207
1850 1125
1851 1228
1852 1309
1853 1558
1854 1306
1855 1586
1856 1587
1857 1488
1858 1541
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1138
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1809
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2179
1878 2454
1879 2399
1880 2646
1881 3149
1882 2742
1883 3126
1884 3049
1885 3337
1886 3291
1887 3966
1888 4002
1889 4194
1890 4024
1891 3607
1892 4064
1893 4369
1894 3801
1895 4129
1896 4412
1897 4688
1898 4631
1899 4169
1900 3785
1901 3885
1902 3967
1903 3910
1904 4059
1905 4067
1906 3872
1907 4323
1908 4459
1909 4687
1910 4799
1911 5006
1912 4906
1913 5104
1914 5135
1915 4640
1916 4543
1917 4281
1918 4567
1919 4618
1920 4960
1921 4628
1922 4123
1923 4432
1924 4850
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5496
1932 5546
1933 5610
1934 5507
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4517
1944 4745
1945 20420
1946 53735
1947 64959
1948 70709
1949 62803
1950 85750
1951 103741
1952 108052
1953 108914
1954 105914
1955 108541
1956 107005
1957 111515
1958 109456
1959 109957
1960 112134
1961 120097
1962 125629
1963 141519
1964 162086
1965 176636
1966 179743
1967 191501
1968 207847
1969 215048
1970 218964
1971 222888
1972 227510
1973 230645
1974 234527
1975 248235
1976 250299
1977 249718
1978 258001
1979 265302
1980 266979
1981 271316
1982 282889
1983 294532
1984 302465
1985 318666
1986 331125
1987 347102
1988 363438
1989 377428
1990 382560
1991 380279
1992 381975
1993 390565
1994 401491
1995 410829
1996 421010
1997 418839
1998 436475
1999 453674
2000 490542
2001 503160
2002 520924
2003 548450
2004 592218
2005 650082
2006 695524
2007 733084
2008 779805
2009 818525
2010 880843
2011 955089
2012 1021086
2013 1072199
2014 1124500
2015 1165557
2016 1197528
2017 1217940
2018 1260258
2019 1317215
2020 1501629
2021 1640774
2022 1637568
2023 1546736
2024 1153894
2025 850

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35,323,390 results

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Quoted phrases not found in phrase index: "Priority Journal", "Agrobacterium Tumefaciens Genetics Metabolism", "Bacterial Proteins Chemistry Genetics Metabolism", "Dna Binding Proteins Chemistry Genetics Metabolism", "Metalloproteins Chemistry Genetics Metabolism"
Page 1
Microbial metallothioneins.
Robinson NJ, Whitehall SK, Cavet JS. Robinson NJ, et al. Adv Microb Physiol. 2001;44:183-213. doi: 10.1016/s0065-2911(01)44014-8. Adv Microb Physiol. 2001. PMID: 11407113 Review.
The imidazole groups of histidine residues, in addition to the thiol groups of cysteine residues, co-ordinate zinc in bacterial metallothioneins. The structure of bacterial metallothionein must facilitate some discrimination between 'adventitious' and 'adventageous' …
The imidazole groups of histidine residues, in addition to the thiol groups of cysteine residues, co-ordinate zinc in bacterial metal …
A single amino acid substitution alters ClpS2 binding specificity.
Bergonzo C, Dharmadhikari K, Samuels E, Christensen M, Tullman J. Bergonzo C, et al. Proteins. 2020 Sep;88(9):1189-1196. doi: 10.1002/prot.25890. Epub 2020 Mar 27. Proteins. 2020. PMID: 32181926
To understand the structural basis of ClpS2 specificity for an N-terminal amino acid, all atom molecular dynamics (MD) simulations were conducted using the sequence of a bench-stable mutant of ClpS2, called PROSS. ...Experimental validation of the mutant using a fluorescen …
To understand the structural basis of ClpS2 specificity for an N-terminal amino acid, all atom molecular dynamics (MD) simulations we …
The Mosaic Type IV Secretion Systems.
Christie PJ. Christie PJ. EcoSal Plus. 2016 Oct;7(1):10.1128/ecosalplus.ESP-0020-2015. doi: 10.1128/ecosalplus.ESP-0020-2015. EcoSal Plus. 2016. PMID: 27735785 Free PMC article. Review.
The conjugation systems are responsible for interbacterial transfer of antibiotic resistance genes, virulence determinants, and genes encoding other traits of potential benefit to the bacterial host. The effector translocators are used by many Gram-negative pathogens for d …
The conjugation systems are responsible for interbacterial transfer of antibiotic resistance genes, virulence determinants, and genes encodi …
Structure and function of bacterial H-NS protein.
Grainger DC. Grainger DC. Biochem Soc Trans. 2016 Dec 15;44(6):1561-1569. doi: 10.1042/BST20160190. Biochem Soc Trans. 2016. PMID: 27913665 Review.
Functions attributed to H-NS include management of genome evolution, DNA condensation, and transcription. The wide-ranging influence of H-NS is remarkable given the simplicity of the protein, a small peptide, possessing rudimentary determinants for self-association, hetero …
Functions attributed to H-NS include management of genome evolution, DNA condensation, and transcription. The wide-ranging influence …
Evolution of networks of protein domain organization.
Aziz MF, Caetano-Anollés G. Aziz MF, et al. Sci Rep. 2021 Jun 8;11(1):12075. doi: 10.1038/s41598-021-90498-8. Sci Rep. 2021. PMID: 34103558 Free PMC article.
Remarkably, the evolving networks highlighted a central evolutionary role of cofactor-supporting structures of non-ribosomal peptide synthesis pathways, likely crucial to the early development of the genetic code. Some highly modular domains featured dual response regulati …
Remarkably, the evolving networks highlighted a central evolutionary role of cofactor-supporting structures of non-ribosomal peptide synthes …
Deciphering Sequence-Specific DNA Binding by H-NS Using Molecular Simulation.
van Heesch T, van de Lagemaat EM, Vreede J. van Heesch T, et al. Methods Mol Biol. 2024;2819:585-609. doi: 10.1007/978-1-0716-3930-6_27. Methods Mol Biol. 2024. PMID: 39028525
Using molecular dynamics simulations and steered molecular dynamics, we are able to determine the free energy of formation and dissociation of a protein-DNA complex comprising an H-NS DNA-binding domain and a specific nucleotide sequence. …
Using molecular dynamics simulations and steered molecular dynamics, we are able to determine the free energy of formation and …
Biological and Structural Diversity of Type IV Secretion Systems.
Li YG, Hu B, Christie PJ. Li YG, et al. Microbiol Spectr. 2019 Mar;7(2):10.1128/microbiolspec.PSIB-0012-2018. doi: 10.1128/microbiolspec.PSIB-0012-2018. Microbiol Spectr. 2019. PMID: 30953428 Free PMC article. Review.
Collectively, the T4SSs translocate DNA and monomeric and multimeric protein substrates to bacterial and eukaryotic cell types. ...Advances in definition of T4SS machine structures now allow for detailed comparisons of nanomachines closely related to the Agrobact …
Collectively, the T4SSs translocate DNA and monomeric and multimeric protein substrates to bacterial and eukaryotic cell types …
SSB-DNA binding monitored by fluorescence intensity and anisotropy.
Kozlov AG, Galletto R, Lohman TM. Kozlov AG, et al. Methods Mol Biol. 2012;922:55-83. doi: 10.1007/978-1-62703-032-8_4. Methods Mol Biol. 2012. PMID: 22976177 Free PMC article. Review.
Such equilibrium studies can provide important quantitative information on stoichiometries (occluded site size, number of binding sites) and energetics (affinities and cooperativities) of the interactions. ...Here we describe procedures for using fluorescence approa …
Such equilibrium studies can provide important quantitative information on stoichiometries (occluded site size, number of binding …
DNA-binding proteins from marine bacteria expand the known sequence diversity of TALE-like repeats.
de Lange O, Wolf C, Thiel P, Krüger J, Kleusch C, Kohlbacher O, Lahaye T. de Lange O, et al. Nucleic Acids Res. 2015 Nov 16;43(20):10065-80. doi: 10.1093/nar/gkv1053. Epub 2015 Oct 19. Nucleic Acids Res. 2015. PMID: 26481363 Free PMC article.
Transcription Activator-Like Effectors (TALEs) of Xanthomonas bacteria are programmable DNA binding proteins with unprecedented target specificity. Comparative studies into TALE repeat structure and function are hindered by the limited sequence variation amon …
Transcription Activator-Like Effectors (TALEs) of Xanthomonas bacteria are programmable DNA binding proteins with unpre …
Role of Dps (DNA-binding proteins from starved cells) aggregation on DNA.
Chiancone E, Ceci P. Chiancone E, et al. Front Biosci (Landmark Ed). 2010 Jan 1;15(1):122-31. doi: 10.2741/3610. Front Biosci (Landmark Ed). 2010. PMID: 20036810 Free article. Review.
The review outlines the experimental studies that have led to the current understanding at a molecular level of the protective role exerted by Dps proteins under stress conditions. After a brief description of the structural signatures and of the ferroxidase activit …
The review outlines the experimental studies that have led to the current understanding at a molecular level of the protective role e …
35,323,390 results
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