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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1964 3
1965 7
1966 9
1967 25
1968 20
1969 16
1970 35
1971 27
1972 33
1973 34
1974 33
1975 39
1976 38
1977 48
1978 69
1979 62
1980 73
1981 72
1982 81
1983 88
1984 93
1985 114
1986 125
1987 125
1988 123
1989 126
1990 166
1991 112
1992 121
1993 103
1994 106
1995 128
1996 106
1997 108
1998 116
1999 116
2000 111
2001 113
2002 112
2003 113
2004 113
2005 137
2006 147
2007 146
2008 120
2009 137
2010 161
2011 137
2012 177
2013 192
2014 165
2015 184
2016 188
2017 171
2018 185
2019 99
2020 0
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5,264 results
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Page 1
Kinetics, pharmacokinetics, and regulation of L-carnitine and acetyl-L-carnitine metabolism.
Rebouche CJ. Ann N Y Acad Sci 2004 - Review. PMID 15591001
In mammals, the carnitine pool consists of nonesterified L-carnitine and many acylcarnitine esters. Of these esters, acetyl-L-carnitine is quantitatively and functionally the most significant. ...Elimination kinetics for acetyl-L-carnitine are similar to those for L-carnitine. There is evidence for renal tubular secretion of both L-carnitine and acetyl-L-carnitine. ...
In mammals, the carnitine pool consists of nonesterified L-carnitine and many acylcarnitine esters. Of these esters, acetyl-L- …
Disorders of carnitine biosynthesis and transport.
El-Hattab AW and Scaglia F. Mol Genet Metab 2015 - Review. PMID 26385306
Carnitine is a hydrophilic quaternary amine that plays a number of essential roles in metabolism with the main function being the transport of long-chain fatty acids from the cytosol to the mitochondrial matrix for β-oxidation. ...Diseases occurring due to primary defects in carnitine metabolism and homeostasis are comprised in two groups: disorders of carnitine biosynthesis and carnitine transport defect. ...
Carnitine is a hydrophilic quaternary amine that plays a number of essential roles in metabolism with the main function being
The role of carnitine in normal and altered fatty acid metabolism.
Hoppel C. Am J Kidney Dis 2003 - Review. PMID 12751049
The growing body of evidence about carnitine function has led to increased understanding and identification of disorders associated with altered carnitine metabolism. Disorders of fatty acid oxidation and metabolism typically are associated with primary and secondary forms of carnitine deficiency. ...
The growing body of evidence about carnitine function has led to increased understanding and identification of disorders associated w …
Acetyl-l-carnitine deficiency in patients with major depressive disorder.
Nasca C, et al. Proc Natl Acad Sci U S A 2018 - Clinical Trial. PMID 30061399 Free PMC article.
The endogenously produced molecule acetyl-l-carnitine (LAC) is critical for hippocampal function and several behavioral domains. ...We found that LAC levels, and not those of free carnitine, were decreased in patients with MDD compared with age- and sex-matched healthy controls in two independent study centers. ...
The endogenously produced molecule acetyl-l-carnitine (LAC) is critical for hippocampal function and several behavioral domains. ...W …
Carnitine.
Borum PR. Annu Rev Nutr 1983 - Review. PMID 6357236
Carnitine has a critical role in energy metabolism. Many of the functions of carnitine are not clearly elucidated and many of the regulatory mechanisms governing carnitine metabolism are ill-defined. Carnitine deficiency can be life threatening but may be resolved with carnitine supplementation. Various groups of individuals in addition to those with the classical carnitine deficiency syndrome may require exogenous carnitine. ...
Carnitine has a critical role in energy metabolism. Many of the functions of carnitine are not clearly elucidated and m
Carnitine and acylcarnitine metabolism during exercise in humans. Dependence on skeletal muscle metabolic state.
Hiatt WR, et al. J Clin Invest 1989. PMID 2794054 Free PMC article.
Carnitine metabolism has been previously shown to change with exercise in normal subjects, and in patients with ischemic muscle diseases. To characterize carnitine metabolism further during exercise, six normal male subjects performed constant-load exercise on a bicycle ergometer on two separate occasions. ...
Carnitine metabolism has been previously shown to change with exercise in normal subjects, and in patients with ischemic muscl
Carnitine: metabolism and clinical chemistry.
Siliprandi N, et al. Clin Chim Acta 1989 - Review. PMID 2670337
In man carnitine is synthesized from proteic trimethyllysine in liver, brain and kidney. Muscles which contain approximately 98% of carnitine must take it up from the blood in an exchange process with endogenous deoxycarnitine, the immediate precursor of carnitine. ...Assay of physiological and unphysiological carnitine esters in urine is necessary for the diagnosis of carnitine insufficiencies....
In man carnitine is synthesized from proteic trimethyllysine in liver, brain and kidney. Muscles which contain approximately 98% of …
Carnitine metabolism and deficit--when supplementation is necessary?
Evangeliou A and Vlassopoulos D. Curr Pharm Biotechnol 2003 - Review. PMID 12769764
It is essential for the intermediary metabolism of fatty acids. Carnitine is indispensable for beta-oxidation of long-chain fatty acids in the mitochondria but also regulates CoA concentration and removal of the produced acyl groups. ...Primary carnitine deficiency is caused by a defect in plasma membrane carnitine transporter in muscle and kidneys. Secondary carnitine deficiency is associated with several inborn errors of metabolism and acquired medical or iatrogenic conditions, for example in patients under valproate and zidovuline treatment. ...
It is essential for the intermediary metabolism of fatty acids. Carnitine is indispensable for beta-oxidation of long-chain fa …
Kinetics of carnitine concentration after switching from oral administration to intravenous injection in hemodialysis patients.
Suzuki A, et al. Ren Fail 2018 - Clinical Trial. PMID 29616582 Free PMC article.
Carnitine has high dialyzability and is often deficient in dialysis patients. This deficiency is treated by either intravenous (IV) or oral supplementation of carnitine. ...We found that the levels of total carnitine (TC), free-carnitine (FC), and acyl-carnitine (AC) significantly increased after 3 months of switching to IV administration (p < .05). ...
Carnitine has high dialyzability and is often deficient in dialysis patients. This deficiency is treated by either intravenous (IV) o
Carnitine supplementation alleviates lipid metabolism derangements and protects against oxidative stress in non-obese hereditary hypertriglyceridemic rats.
Cahova M, et al. Appl Physiol Nutr Metab 2015. PMID 25723909
Male HHTg rats were fed a standard diet, and half of them received daily doses of carnitine (500 mg·kg(-1) body weight) for 8 weeks. ...HHTg rats exhibited increased urinary excretion of free carnitine and reduced carnitine content in the liver and blood. Carnitine supplementation compensated for this shortage and promoted urinary excretion of acetylcarnitine without any signs of (acyl)carnitine accumulation in skeletal muscle. ...
Male HHTg rats were fed a standard diet, and half of them received daily doses of carnitine (500 mg·kg(-1) body weight) for 8 weeks. …
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