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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 7
1946 27
1947 25
1948 23
1949 23
1950 45
1951 53
1952 68
1953 76
1954 93
1955 103
1956 108
1957 148
1958 184
1959 213
1960 239
1961 298
1962 325
1963 672
1964 889
1965 793
1966 927
1967 1146
1968 1322
1969 1588
1970 1665
1971 1865
1972 2198
1973 2224
1974 2290
1975 2323
1976 2268
1977 2682
1978 3211
1979 3877
1980 4725
1981 5330
1982 6154
1983 6539
1984 7360
1985 8336
1986 8852
1987 9234
1988 10641
1989 11578
1990 13284
1991 14413
1992 16208
1993 17686
1994 19972
1995 21203
1996 23205
1997 25033
1998 28060
1999 29721
2000 32853
2001 34519
2002 36100
2003 37687
2004 39540
2005 41195
2006 44259
2007 45489
2008 46855
2009 48407
2010 50486
2011 53160
2012 55492
2013 57339
2014 55879
2015 55710
2016 53444
2017 51942
2018 48537
2019 22837
2020 533
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1,135,282 results
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Page 1
MG53: Biological Function and Potential as a Therapeutic Target
Zhang Y, et al. Mol Pharmacol 2017 - Review. PMID 28432201
In summary, MG53 is a multifunctional protein involved in the vital physiologic and pathologic processes of multiple organs and is a promising therapeutic target for various human diseases. In this review, we comprehensively summarize current research progress on the biologic functions and therapeutic potential of MG53....
In summary, MG53 is a multifunctional protein involved in the vital physiologic and pathologic processes of multiple organs an …
Lipid transfer proteins: classification, nomenclature, structure, and function.
Salminen TA, et al. Planta 2016 - Review. PMID 27562524 Free PMC article.
The non-specific lipid transfer proteins (LTPs) constitute a large protein family found in all land plants. They are small proteins characterized by a tunnel-like hydrophobic cavity, which makes them suitable for binding and transporting various lipids. ...LTPs are considered as key proteins for the plant's survival and colonization of land. In this review, we aim to present an overview of the current status of LTP research and also to discuss potential future applications of these proteins. ...
The non-specific lipid transfer proteins (LTPs) constitute a large protein family found in all land plants. They are small …
TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review)
Mbimba T, et al. Int J Mol Med 2018 - Review. PMID 30272317
Trafficking protein particle complex 9 (TRAPPC9) is a protein subunit of the transport protein particle II (TRAPPII), which has been reported to be important in the trafficking of cargo from the endoplasmic reticulum (ER) to the Golgi, and in intra‑Golgi and endosome‑to‑Golgi transport in yeast cells. ...The present review highlights the most recent publications on the structure, expression and function of TRAPPC9, and its association with various human diseases....
Trafficking protein particle complex 9 (TRAPPC9) is a protein subunit of the transport protein particle II (TRAPPII), w …
Protein-protein interactions: methods for detection and analysis.
Phizicky EM and Fields S. Microbiol Rev 1995 - Review. PMID 7708014 Free PMC article.
The function and activity of a protein are often modulated by other proteins with which it interacts. This review is intended as a practical guide to the analysis of such protein-protein interactions. We discuss biochemical methods such as protein affinity chromatography, affinity blotting, coimmunoprecipitation, and cross-linking; molecular biological methods such as protein probing, the two-hybrid system, and phage display: and genetic methods such as the isolation of extragenic suppressors, synthetic mutants, and unlinked noncomplementing mutants. ...
The function and activity of a protein are often modulated by other proteins with which it interacts. This review is intended …
Inositol transport proteins.
Schneider S. FEBS Lett 2015 - Review. PMID 25819438 Free article.
They can be divided into two groups according to their transport mechanisms: (1) sodium ion coupled inositol transporters that belong to the Solute Carrier Families 5 and 6-like Superfamily and, (2) proton coupled inositol symporters that are members of the Major Facilitator Superfamily. Intriguingly members of both families offer promising targets for medical treatment of a variety of diseases....
They can be divided into two groups according to their transport mechanisms: (1) sodium ion coupled inositol transporters that belong to the …
Mitochondrial carrier proteins can reversibly change their transport mode: the cases of the aspartate/glutamate and the phosphate carrier.
Krämer R. Exp Physiol 1998 - Review. PMID 9568487 Free article.
In this transport mode a mixture of carrier- and channel-type properties is observed. To address this question on the molecular level, the phosphate carrier from yeast (S. cerevisiae) mitochondria was expressed in E. coli, solubilized, purified and functionally reconstituted. From three cysteine residues present in the yeast phosphate carrier at positions 28, 134 and 300, only one single cysteine residue (C28) was found responsible for the functional switch from antiport to uniport. ...
In this transport mode a mixture of carrier- and channel-type properties is observed. To address this question on the molecula …
Structure and elevator mechanism of the Na+-citrate transporter CitS
Lolkema JS and Slotboom DJ. Curr Opin Struct Biol 2017 - Review. PMID 27776291
The protein has a fold that has not been seen in other proteins, but the oligomeric state, domain organization and proposed transport mechanism strongly resemble those of the sodium-dicarboxylate symporter vcINDY, and the putative exporters YdaH and MtrF, thus hinting at convergence in structure and function. ...We propose a testable model for the coupling mechanism....
The protein has a fold that has not been seen in other proteins, but the oligomeric state, domain organization and proposed
The ubiquitous carrier protein--a window to metabolite biosynthesis.
Mercer AC and Burkart MD. Nat Prod Rep 2007 - Review. PMID 17653358
Common to both primary and secondary metabolic pathways, acyl-carrier proteins constitute a conserved protein architecture which mediate the biosynthesis of a variety of metabolic products. ...However, there is significantly more to the carrier protein than an attachment point. In this review, we aim to systematically characterize the role of carrier proteins in various metabolic pathways and outline their utility in biosynthesis and biotechnology; 185 references are cited....
Common to both primary and secondary metabolic pathways, acyl-carrier proteins constitute a conserved protein ar …
Renal Na/Pi-cotransporters
Biber J, et al. Kidney Int 1996 - Review. PMID 8691748 Free article.
Two non-homologous proximal tubular apical Na/Pi-cotransport systems (type I and type II) have been identified thus far by expression cloning. Subsequent studies provided evidence that the type II Na/Pi-cotransporter represents a target for the physiological and pathophysiological regulation of proximal reabsorption of phosphate. ...
Two non-homologous proximal tubular apical Na/Pi-cotransport systems (type I and type II) have been identified thus far by expression …
Folate receptors
Antony AC. Annu Rev Nutr 1996 - Review. PMID 8839936
Three FR isoforms with differing relative affinities for folates and expression patterns in normal and malignant cells/tissues are recognized, but the precise mechanism of cellular entry of folate via FR remains controversial. Although FR expression allows previously FR-deficient cells to survive a reduced folate milieu, an inverse relationship between FR expression and cell proliferation has been established in some cells. ...
Three FR isoforms with differing relative affinities for folates and expression patterns in normal and malignant cells/tissues are recognize …
1,135,282 results
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