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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 2
1961 2
1962 2
1963 1
1995 1
1996 4
1997 20
1998 57
1999 96
2000 204
2001 251
2002 292
2003 324
2004 325
2005 338
2006 321
2007 344
2008 336
2009 371
2010 340
2011 407
2012 376
2013 393
2014 376
2015 331
2016 288
2017 235
2018 223
2019 88
2020 5
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5,714 results
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Page 1
Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
Mandal P, et al. Immunity 2018. PMID 30021146 Free PMC article.
Hematopoietic cells produced MyD88- and TRIF-dependent inflammatory cytokines sufficient to initiate shock without any contribution from caspase-8 or caspase-11. ...Caspase-11 enhanced the activation of caspase-8 and extrinsic cell death machinery within the lower small intestine. Neither caspase-8 nor caspase-11 was individually sufficient for shock. ...
Hematopoietic cells produced MyD88- and TRIF-dependent inflammatory cytokines sufficient to initiate shock without any contribution from …
Caspase-8: regulating life and death.
Tummers B and Green DR. Immunol Rev 2017 - Review. PMID 28462525 Free PMC article.
This review describes the role of caspase-8 in the initiation of extrinsic apoptosis execution and the mechanism by which caspase-8 inhibits necroptosis. The importance of caspase-8 in the development and homeostasis and the way that dysfunctional caspase-8 may contribute to the development of malignancies in mice and humans are also explored....
This review describes the role of caspase-8 in the initiation of extrinsic apoptosis execution and the mechanism by which c
Inhibition of caspase-1 or gasdermin-D enable caspase-8 activation in the Naip5/NLRC4/ASC inflammasome.
Mascarenhas DPA, et al. PLoS Pathog 2017. PMID 28771586 Free PMC article.
Mechanistically, we found that caspase-8 activation triggers gasdermin-D-independent pore formation and cell death. Interestingly, caspase-8 is recruited to the Naip5/NLRC4/ASC inflammasome in wild-type macrophages, but it is only activated when caspase-1 or gasdermin-D is inhibited. Our data suggest that caspase-8 activation in the Naip5/NLRC4/ASC inflammasome enable induction of cell death when caspase-1 or gasdermin-D is suppressed....
Mechanistically, we found that caspase-8 activation triggers gasdermin-D-independent pore formation and cell death. Interestin …
Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death.
Orning P, et al. Science 2018. PMID 30361383 Free PMC article.
The inhibition of TAK1 or IκB kinase (IKK) by the Yersinia effector protein YopJ elicits RIPK1- and caspase-8-dependent cleavage of GSDMD, which subsequently results in cell death. ...Thus, caspase-8 acts as a regulator of GSDMD-driven cell death. Furthermore, this study establishes the importance of TAK1 and IKK activity in the control of GSDMD cleavage and cytotoxicity....
The inhibition of TAK1 or IκB kinase (IKK) by the Yersinia effector protein YopJ elicits RIPK1- and caspase-8-dependent cleava …
Caspase-8 induces cleavage of gasdermin D to elicit pyroptosis during Yersinia infection.
Sarhan J, et al. Proc Natl Acad Sci U S A 2018. PMID 30381458 Free PMC article.
Pathogenic Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ, thereby silencing cytokine expression while activating caspase-8-mediated cell death. ...Our results uncover a form of caspase-8-mediated pyroptosis and suggest a hypothesis for the increased sensitivity of humans to Yersinia infection compared with the rodent reservoir....
Pathogenic Yersinia inhibits the MAP kinase TGFβ-activated kinase 1 (TAK1) via the effector YopJ, thereby silencing cytokine expression whil …
TLR-stimulated IRAKM activates caspase-8 inflammasome in microglia and promotes neuroinflammation.
Zhang CJ, et al. J Clin Invest 2018. PMID 30372424 Free PMC article.
Mechanistically, TLR stimulation led to IRAKM-caspase-8-ASC complex formation, resulting in the activation of caspase-8 and IL-1β release in microglia. ...Furthermore, active caspase-8 was markedly increased in the microglia in the brain tissue from patients with multiple sclerosis. ...
Mechanistically, TLR stimulation led to IRAKM-caspase-8-ASC complex formation, resulting in the activation of caspase- …
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation.
Vince JE, et al. Cell Rep 2018. PMID 30485804 Free article.
We show here that in macrophages, BAX/BAK activation results in inhibitor of apoptosis (IAP) protein degradation to promote caspase-8-mediated activation of IL-1β. ...Remarkably, following BAX/BAK activation, the apoptotic executioner caspases, caspase-3 and -7, act upstream of both caspase-8 and NLRP3-induced IL-1β maturation and secretion. ...
We show here that in macrophages, BAX/BAK activation results in inhibitor of apoptosis (IAP) protein degradation to promote caspase- …
Caspase-1 Engagement and TLR-Induced c-FLIP Expression Suppress ASC/Caspase-8-Dependent Apoptosis by Inflammasome Sensors NLRP1b and NLRC4.
Van Opdenbosch N, et al. Cell Rep 2017. PMID 29262324 Free PMC article.
The caspase-8 adaptor FADD was recruited to ASC specks, which served as cytosolic platforms for caspase-8 activation and NLRP1b/NLRC4-induced apoptosis. We further found that caspase-1 protease activity dominated over scaffolding functions in suppressing caspase-8 activation and induction of apoptosis of macrophages and IECs. ...
The caspase-8 adaptor FADD was recruited to ASC specks, which served as cytosolic platforms for caspase-8 activa …
Caspase-8 function, and phosphorylation, in cell migration.
Keller N, et al. Semin Cell Dev Biol 2018 - Review. PMID 29410361
Caspase-8 is involved in a number of cellular functions, with the most well established being the control of cell death. Yet caspase-8 is unique among the caspases in that it acts as an environmental sensor, transducing a range of signals to cells, modulating responses that extend far beyond simple survival. ...This is facilitated by caspase-8 interaction with a host of cell proteins ranging from the proteases caspase-3 and calpain-2 to adaptor proteins such as p85 and Crk, to the Src family of tyrosine kinases....
Caspase-8 is involved in a number of cellular functions, with the most well established being the control of cell death. Yet
A Dual Role of Caspase-8 in Triggering and Sensing Proliferation-Associated DNA Damage, a Key Determinant of Liver Cancer Development.
Boege Y, et al. Cancer Cell 2017. PMID 28898696 Free PMC article.
Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated DNA damage. ...This platform requires a non-apoptotic function of caspase-8, but no caspase-3 or caspase-8 cleavage. It may represent a DNA damage-sensing mechanism in hepatocytes that can act via JNK and subsequent phosphorylation of the histone variant H2AX....
Here, we mechanistically link caspase-8-dependent apoptosis to HCC development via proliferation- and replication-associated D …
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