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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2004 1
2005 18
2006 104
2007 266
2008 290
2009 329
2010 345
2011 367
2012 384
2013 409
2014 365
2015 370
2016 344
2017 320
2018 213
2019 110
2020 2
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3,634 results
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Page 1
Caspase-9: structure, mechanisms and clinical application.
Li P, et al. Oncotarget 2017 - Review. PMID 28177918 Free PMC article.
As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which is involved in various stimuli, including chemotherapies, stress agents and radiation. ...Therefore, this review is to summarize recent pertinent literature on the comprehensive description of the molecular events implicated in caspase-9 activation and inhibition, as well as the clinical trials in progress to give deep insight into caspase-9 for suppressing cancer. ...
As the most intensively studied initiator caspase, caspase-9 is a key player in the intrinsic or mitochondrial pathway which i …
Caspase-9 as a therapeutic target for treating cancer.
Kim B, et al. Expert Opin Ther Targets 2015 - Review. PMID 25256701
In this article, we elucidate the regulators of caspase-9 including microRNAs, natural compounds that are related to caspase-9 and ongoing clinical trials with caspase-9 to better understand the caspase-9 in suppressing cancer. ...Since caspase-9 is an initiator caspase of apoptosis, it is an important therapeutic target of various diseases related to apoptosis. ...
In this article, we elucidate the regulators of caspase-9 including microRNAs, natural compounds that are related to caspase-9 …
Caspase-8 and Caspase-9 Functioned Differently at Different Stages of the Cyclic Stretch-Induced Apoptosis in Human Periodontal Ligament Cells.
Wu Y, et al. PLoS One 2016. PMID 27942018 Free PMC article.
Subsequently, the influences of caspase-8 and caspase-9 inhibitors on the apoptotic rate and the protein level of the activated caspase-3 were assessed as well. ...Caspase-3, -7, -8 and -9 were all activated after stretch loading. The stretch-induced apoptosis and the protein level of the activated caspase-3 were inhibited after inhibiting both caspase-8 and caspase-9 in both 6 and 24 h stretched cells and after inhibiting caspase-9 in 24 h stretched cells. ...
Subsequently, the influences of caspase-8 and caspase-9 inhibitors on the apoptotic rate and the protein level of the activate …
Contributions of caspase-8 and -9 to liver injury from CYP2E1-produced metabolites of halogenated hydrocarbons.
Ijiri Y, et al. Xenobiotica 2018. PMID 28081667
Halothane increased AST/ALT levels, caspase-3 and -8 activities (but not malondialdehyde) concomitant with widespread hepatotoxicity. In vitro, CCl(4) treatment increased caspase-9 activity and decreased both mitochondrial membrane potential (MMP) and cell viability. ...
Halothane increased AST/ALT levels, caspase-3 and -8 activities (but not malondialdehyde) concomitant with widespread hepatotoxicity. …
Caspase-9 has a nonapoptotic function in Xenopus embryonic primitive blood formation.
Tran HT, et al. J Cell Sci 2017. PMID 28576973 Free article.
These studies uncovered a nonapoptotic role for the initiator caspase-9 in primitive blood formation. Functional experiments further corroborated that caspase-9, but possibly not the executioners caspase-3 and caspase-7, are required for primitive erythropoiesis in the early embryo. These data reveal a novel nonapoptotic function for the initiator caspase-9 and, for the first time, implicate nonapoptotic caspase activity in primitive blood formation....
These studies uncovered a nonapoptotic role for the initiator caspase-9 in primitive blood formation. Functional experiments further …
Active site-adjacent phosphorylation at Tyr-397 by c-Abl kinase inactivates caspase-9.
Serrano BP, et al. J Biol Chem 2017. PMID 29066624 Free PMC article.
Caspase-9 (casp-9) is an initiator caspase and plays a central role in activating apoptotic cell death. Control of all caspases is tightly regulated by a series of phosphorylation events enacted by several different kinases. Caspase-9 is the most heavily phosphorylated of all caspases, with phosphorylation of at least 11 distinct residues in all three caspase-9 domains by nine kinases. ...
Caspase-9 (casp-9) is an initiator caspase and plays a central role in activating apoptotic cell death. Control of all caspase
Caspase-9 activation and Apaf-1 cleavage by MMP-3.
Kim EM, et al. Biochem Biophys Res Commun 2014. PMID 25285627
However, the mechanism by which MMP-3 activity leads to caspase-3 activation in apoptotic signaling was not known. In the present study, we found that MMP-3 acts upstream of caspase-9. Overexpression of wild type MMP-3, but not mutant MMP-3, generated the enzymatically active 35kD caspase-9. The caspase-9 activation was absent in MMP-3 knockout cells, but was present when these cells were transfected with wild type MMP-3 cDNA. ...
However, the mechanism by which MMP-3 activity leads to caspase-3 activation in apoptotic signaling was not known. In the present stu …
Berberine activates caspase-9/cytochrome c-mediated apoptosis to suppress triple-negative breast cancer cells in vitro and in vivo.
Zhao Y, et al. Biomed Pharmacother 2017. PMID 28826092
The expressions of caspase-3, caspase-9, Bcl-2 and Bax were detected by western blot, which showed BBR activated caspase-3, 9 and Bax, but down-regulated Bcl-2 expression. ...BBR suppressed tumor growth and increased caspase-9 levels in xenograft tumors through immunohistochemistry analysis (P<0.01). ...
The expressions of caspase-3, caspase-9, Bcl-2 and Bax were detected by western blot, which showed BBR activated caspase
Caspase-9 mediates photoreceptor death after blunt ocular trauma.
Blanch RJ, et al. Invest Ophthalmol Vis Sci 2014. PMID 25190658 Free PMC article.
We assessed the role of caspase-9 as a mediator of photoreceptor death in a rat model of ballistic ocular trauma causing commotio retinae. ...RESULTS: Increased levels of cleaved caspase-9 were shown in photoreceptors 5 hours after injury, and catalytically active full-length caspase-9 was isolated from retinas. ...
We assessed the role of caspase-9 as a mediator of photoreceptor death in a rat model of ballistic ocular trauma causing commotio ret …
Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome.
Hu Q, et al. Proc Natl Acad Sci U S A 2014. PMID 25313070 Free PMC article.
The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely unknown. Here we demonstrate that the previously reported 1:1 interaction between Apaf-1 caspase recruitment domain (CARD) and caspase-9 CARD is insufficient for the activation of caspase-9. Rather, formation of a multimeric CARD:CARD assembly between Apaf-1 and caspase-9, which requires three types of distinct interfaces, underlies caspase-9 activation. ...
The molecular mechanism by which caspase-9 is activated by the Apaf-1 apoptosome remains largely unknown. Here we demonstrate that th …
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