"Caspase Inhibitors"[nm] - Search Results

Year	Number of Results
1998	75
1999	283
2000	409
2001	446
2002	419
2003	427
2004	439
2005	438
2006	394
2007	383
2008	301
2009	273
2010	277
2011	251
2012	193
2013	174
2014	153
2015	115
2016	119
2017	98
2018	105
2019	87
2020	88
2021	56
2022	30
2023	7
2024	2

1

Caspase inhibitors: a review of recently patented compounds (2013-2015).

Lee H, Shin EA, Lee JH, Ahn D, Kim CG, Kim JH, Kim SH. Lee H, et al. Expert Opin Ther Pat. 2018 Jan;28(1):47-59. doi: 10.1080/13543776.2017.1378426. Epub 2017 Sep 18. Expert Opin Ther Pat. 2018. PMID: 28885866 Review.

2

FDA-approved disulfiram inhibits pyroptosis by blocking gasdermin D pore formation.

Hu JJ, Liu X, Xia S, Zhang Z, Zhang Y, Zhao J, Ruan J, Luo X, Lou X, Bai Y, Wang J, Hollingsworth LR, Magupalli VG, Zhao L, Luo HR, Kim J, Lieberman J, Wu H. Hu JJ, et al. Nat Immunol. 2020 Jul;21(7):736-745. doi: 10.1038/s41590-020-0669-6. Epub 2020 May 4. Nat Immunol. 2020. PMID: 32367036 Free PMC article.

3

An AMPK-caspase-6 axis controls liver damage in nonalcoholic steatohepatitis.

Zhao P, Sun X, Chaggan C, Liao Z, In Wong K, He F, Singh S, Loomba R, Karin M, Witztum JL, Saltiel AR. Zhao P, et al. Science. 2020 Feb 7;367(6478):652-660. doi: 10.1126/science.aay0542. Science. 2020. PMID: 32029622 Free PMC article.

4

Caspase inhibitors for the treatment of liver disease: friend or foe?

Woolbright BL, Ding WX, Jaeschke H. Woolbright BL, et al. Expert Rev Gastroenterol Hepatol. 2017 May;11(5):397-399. doi: 10.1080/17474124.2017.1300060. Epub 2017 Mar 4. Expert Rev Gastroenterol Hepatol. 2017. PMID: 28276808 Free PMC article. No abstract available.

5

A long way to go: caspase inhibitors in clinical use.

Dhani S, Zhao Y, Zhivotovsky B. Dhani S, et al. Cell Death Dis. 2021 Oct 15;12(10):949. doi: 10.1038/s41419-021-04240-3. Cell Death Dis. 2021. PMID: 34654807 Free PMC article. Review.

6

Identification of Allosteric Inhibitors against Active Caspase-6.

Tubeleviciute-Aydin A, Beautrait A, Lynham J, Sharma G, Gorelik A, Deny LJ, Soya N, Lukacs GL, Nagar B, Marinier A, LeBlanc AC. Tubeleviciute-Aydin A, et al. Sci Rep. 2019 Apr 2;9(1):5504. doi: 10.1038/s41598-019-41930-7. Sci Rep. 2019. PMID: 30940883 Free PMC article.

7

Caspase-1 inhibitor exerts brain-protective effects against sepsis-associated encephalopathy and cognitive impairments in a mouse model of sepsis.

Xu XE, Liu L, Wang YC, Wang CT, Zheng Q, Liu QX, Li ZF, Bai XJ, Liu XH. Xu XE, et al. Brain Behav Immun. 2019 Aug;80:859-870. doi: 10.1016/j.bbi.2019.05.038. Epub 2019 May 27. Brain Behav Immun. 2019. PMID: 31145977

8

Characterization of caspase-2 inhibitors based on specific sites of caspase-2-mediated proteolysis.

Bresinsky M, Strasser JM, Hubmann A, Vallaster B, McCue WM, Fuller J, Singh G, Nelson KM, Cuellar ME, Finzel BC, Ashe KH, Walters MA, Pockes S. Bresinsky M, et al. Arch Pharm (Weinheim). 2022 Sep;355(9):e2200095. doi: 10.1002/ardp.202200095. Epub 2022 May 31. Arch Pharm (Weinheim). 2022. PMID: 35642311 Free PMC article.

9

Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis.

Wu X, Zhang H, Qi W, Zhang Y, Li J, Li Z, Lin Y, Bai X, Liu X, Chen X, Yang H, Xu C, Zhang Y, Yang B. Wu X, et al. Cell Death Dis. 2018 Feb 7;9(2):171. doi: 10.1038/s41419-017-0257-3. Cell Death Dis. 2018. PMID: 29416034 Free PMC article.

10

Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis.

Jin Y, Liu Y, Xu L, Xu J, Xiong Y, Peng Y, Ding K, Zheng S, Yang N, Zhang Z, Li L, Tan L, Song H, Fu J. Jin Y, et al. Cell Death Dis. 2022 May 31;13(5):512. doi: 10.1038/s41419-022-04966-8. Cell Death Dis. 2022. PMID: 35641492 Free PMC article.

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