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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 2
1998 233
1999 843
2000 1272
2001 1587
2002 1703
2003 2135
2004 2296
2005 2427
2006 2728
2007 2901
2008 2925
2009 3067
2010 3096
2011 3301
2012 3542
2013 3629
2014 3403
2015 3253
2016 3104
2017 2791
2018 2462
2019 1104
2020 36
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47,686 results
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Page 1
Pyroptotic cell death defends against intracellular pathogens
Jorgensen I and Miao EA. Immunol Rev 2015 - Review. PMID 25879289 Free PMC article.
Inflammatory caspases play a central role in innate immunity by responding to cytosolic signals and initiating a twofold response. ...
Inflammatory caspases play a central role in innate immunity by responding to cytosolic signals and initiating a twofold response. .. …
The biochemistry of apoptosis
Hengartner MO. Nature 2000 - Review. PMID 11048727
The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation
Vince JE, et al. Cell Rep 2018. PMID 30485804 Free article.
Remarkably, following BAX/BAK activation, the apoptotic executioner caspases, caspase-3 and -7, act upstream of both caspase-8 and NLRP3-induced IL-1β maturation and secretion. ...
Remarkably, following BAX/BAK activation, the apoptotic executioner caspases, caspase-3 and -7, act upstream of both caspase-8 and NL …
A primer on caspase mechanisms
Ramirez MLG and Salvesen GS. Semin Cell Dev Biol 2018 - Review. PMID 29329946 Free PMC article.
Caspases belong to a diverse clan of proteolytic enzymes known as clan CD with highly disparate functions in cell signaling. ...This review looks at the mechanistic distinctions between the activity and activation mechanisms of mammalian caspases compared to other members of clan CD. ...
Caspases belong to a diverse clan of proteolytic enzymes known as clan CD with highly disparate functions in cell signaling. ...This
When dying is not the end: Apoptotic caspases as drivers of proliferation.
Pérez-Garijo A. Semin Cell Dev Biol 2018 - Review. PMID 29199139 Free article.
Furthermore, the emerging properties of apoptotic caspases as drivers of carcinogenesis are discussed, as well as their involvement in other diseases. Finally, I examine further effects of caspases regulating death and survival in a non-autonomous manner....
Furthermore, the emerging properties of apoptotic caspases as drivers of carcinogenesis are discussed, as well as their involvement i …
Apoptosis regulation by subcellular relocation of caspases.
Prokhorova EA, et al. Sci Rep 2018. PMID 30111833 Free PMC article.
The cleavage of nuclear proteins by caspases promotes nuclear breakdown and, therefore, plays a key role in apoptosis execution. ...The entry of initiator caspases to the nucleus was independent of caspase-3. Given that all three initiator caspases had catalytic activity in the nuclei, our findings indicate that initiator caspases might participate in the proteolysis of nuclear components during apoptosis, promoting its disintegration and apoptotic cell death....
The cleavage of nuclear proteins by caspases promotes nuclear breakdown and, therefore, plays a key role in apoptosis execution. ...T …
Physiological functions of non-apoptotic caspase activity in the nervous system
Hollville E and Deshmukh M. Semin Cell Dev Biol 2018 - Review. PMID 29199140 Free PMC article.
Caspases are cysteine proteases that play important and well-defined roles in apoptosis and inflammation. Increasing evidence point to alternative functions of caspases where restricted and localized caspase activation within neurons allows for a variety of non-apoptotic and non-inflammatory processes required for brain development and function. ...Importantly, as non-apoptotic activity of caspases is often confined in space and time in neurons, we also discuss the mechanisms that restrict caspase activity in order to maintain the neuronal networks in a healthy and functional state....
Caspases are cysteine proteases that play important and well-defined roles in apoptosis and inflammation. Increasing evidence point t
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