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Presumptive motor neuron degeneration in an adult cat.
Leger D, Bater S, Paulin MV, Linn K, Taylor S, Shelton GD. Leger D, et al. Can Vet J. 2024 Oct;65(10):1034-1040. Can Vet J. 2024. PMID: 39355693 Free PMC article.
Generalized paresis, diffuse muscle atrophy, and diminished spinal reflexes were present in all limbs, consistent with a generalized lower motor neuron disease. ...Key clinical message: In this case, an adult cat had a chronic, progressive history of lower motor neu …
Generalized paresis, diffuse muscle atrophy, and diminished spinal reflexes were present in all limbs, consistent with a gener …
X-linked myotubular myopathy associated with an MTM1 variant in a Maine coon cat.
Kopke MA, Shelton GD, Lyons LA, Wall MJ, Pemberton S, Gedye KR, Owen R, Guo LT, Buckley RM, Valencia JA; 99 Lives Consortium; Jones BR. Kopke MA, et al. J Vet Intern Med. 2022 Sep;36(5):1800-1805. doi: 10.1111/jvim.16509. Epub 2022 Aug 13. J Vet Intern Med. 2022. PMID: 35962713 Free PMC article.
Neurolocalization was to the neuromuscular system. Genetic testing for spinal muscular atrophy (LIX1) was negative. Given the progressive nature and suspected poor long-term prognosis, the owners elected euthanasia. ...Maine coon cat breeders may consider scr …
Neurolocalization was to the neuromuscular system. Genetic testing for spinal muscular atrophy (LIX1) was negative. Giv …
Medial gastrocnemius muscles fatigue but do not atrophy in paralyzed cat hindlimb after long-term spinal cord hemisection and unilateral deafferentation.
Gordon T, Tyreman N, Harris LR, Rafuse VF. Gordon T, et al. Exp Neurol. 2020 May;327:113201. doi: 10.1016/j.expneurol.2020.113201. Epub 2020 Jan 15. Exp Neurol. 2020. PMID: 31953040
This study of medial gastrocnemius (MG) muscle and motor units (MUs) after spinal cord hemisection and deafferentation (HSDA) in adult cats, asked 1) whether the absence of muscle atrophy and unaltered contractile speed demonstrated previously in HSDA-paralyz …
This study of medial gastrocnemius (MG) muscle and motor units (MUs) after spinal cord hemisection and deafferentation (HSDA) in adul …
Immunohistochemical analysis of canine and feline muscle disorders using formalin-fixed, paraffin-embedded tissues.
Shiga T, Uchida K, Chambers JK, Nakayama H. Shiga T, et al. J Vet Diagn Invest. 2017 Nov;29(6):805-813. doi: 10.1177/1040638717715287. Epub 2017 Jun 9. J Vet Diagn Invest. 2017. PMID: 28599613
Based on hematoxylin and eosin staining, we defined in dogs the histologic lesions in 4 neurogenic disorders (degenerative myelopathy and polyneuropathy) and 2 myogenic disorders (dystrophin-deficient muscular dystrophy). In cats, we defined the lesions in 2 neuroge …
Based on hematoxylin and eosin staining, we defined in dogs the histologic lesions in 4 neurogenic disorders (degenerative myelopathy and po …
Cytokine profiles in multifocal motor neuropathy and progressive muscular atrophy.
Vlam L, Stam M, de Jager W, Cats EA, van den Berg LH, van der Pol WL. Vlam L, et al. J Neuroimmunol. 2015 Sep 15;286:1-4. doi: 10.1016/j.jneuroim.2015.06.008. Epub 2015 Jun 20. J Neuroimmunol. 2015. PMID: 26298317 Free article.
Multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA) are associated with IgM monoclonal gammopathy or the presence IgM anti-GM1-antibodies. ...
Multifocal motor neuropathy (MMN) and progressive muscular atrophy (PMA) are associated with IgM monoclonal gammopathy or the …
Association of IgM monoclonal gammopathy with progressive muscular atrophy and multifocal motor neuropathy: a case-control study.
Vlam L, Piepers S, Sutedja NA, Jacobs BC, Tio-Gillen AP, Stam M, Franssen H, Veldink JH, Cats EA, Notermans NC, Bloem AC, Wadman RI, van der Pol WL, van den Berg LH. Vlam L, et al. J Neurol. 2015 Mar;262(3):666-73. doi: 10.1007/s00415-014-7612-4. Epub 2015 Jan 1. J Neurol. 2015. PMID: 25549972
Monoclonal gammopathy was determined by immunoelectrophoresis and immunofixation in serum from 445 patients with ALS, 158 patients with progressive muscular atrophy (PMA), 60 patients with primary lateral sclerosis (PLS), 88 patients with MMN and in 430 matched heal …
Monoclonal gammopathy was determined by immunoelectrophoresis and immunofixation in serum from 445 patients with ALS, 158 patients with prog …
Failure of lower motor neuron radial outgrowth precedes retrograde degeneration in a feline model of spinal muscular atrophy.
Wakeling EN, Joussemet B, Costiou P, Fanuel D, Moullier P, Barkats M, Fyfe JC. Wakeling EN, et al. J Comp Neurol. 2012 Jun 1;520(8):1737-50. doi: 10.1002/cne.23010. J Comp Neurol. 2012. PMID: 22120001 Free PMC article.
Feline spinal muscular atrophy (SMA) is a fully penetrant, autosomal recessive lower motor neuron disease in domestic cats that clinically resembles human SMA Type III. ...In affected cats, significant loss of L5 ventral root axons was observed …
Feline spinal muscular atrophy (SMA) is a fully penetrant, autosomal recessive lower motor neuron disease in domestic …
Lix1 knockout mouse does not exhibit spinal muscular atrophy phenotype.
Wakeling EN, Fyfe JC. Wakeling EN, et al. J Hered. 2011 Sep-Oct;102 Suppl 1:S32-9. doi: 10.1093/jhered/esr031. J Hered. 2011. PMID: 21846745
Feline spinal muscular atrophy (SMA) is an autosomal recessive juvenile onset lower motor neuron disease caused by an 140 kb deletion that disrupts expression of 2 genes, limb expression 1 (LIX1) and leucyl/cystinyl aminopeptidase (LNPEP). ...Reverse transcri …
Feline spinal muscular atrophy (SMA) is an autosomal recessive juvenile onset lower motor neuron disease caused by an 1 …
Acquired motor neuron loss causing severe pelvic limb contractures in a young cat.
Rohdin C, Karlstam E, Jäderlund KH, Shelton GD. Rohdin C, et al. J Feline Med Surg. 2010 Mar;12(3):237-40. doi: 10.1016/j.jfms.2010.01.007. J Feline Med Surg. 2010. PMID: 20193915 Free PMC article.
PRESENTATION: This report describes a kitten with paraplegia and extensor rigidity of the pelvic limbs associated with motor neuron loss and chronic denervation of skeletal muscle. Persistent skeletal muscle atrophy and degeneration had resulted in immobile stifle and hock …
PRESENTATION: This report describes a kitten with paraplegia and extensor rigidity of the pelvic limbs associated with motor neuron loss and …
Electrophysiologic evidence of polyneuropathy in a cat with signs of bilateral brachial plexus neuropathy.
Freeman PM, Harcourt-Brown TR, Jeffery ND, Granger N. Freeman PM, et al. J Am Vet Med Assoc. 2009 Jan 15;234(2):240-4. doi: 10.2460/javma.234.2.240. J Am Vet Med Assoc. 2009. PMID: 19210244 Free article.
CLINICAL FINDINGS: Clinical signs included muscle atrophy, paresis, depressed spinal reflexes, hyperesthesia of the thoracic limbs, and reduced jaw muscle tone. ...CONCLUSIONS AND CLINICAL RELEVANCE: Findings suggested that brachial plexus neuropathy can be a multif …
CLINICAL FINDINGS: Clinical signs included muscle atrophy, paresis, depressed spinal reflexes, hyperesthesia of the thoracic l …
35 results