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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2004 8
2005 20
2006 16
2007 14
2008 19
2009 15
2010 31
2011 22
2012 27
2013 20
2014 17
2015 17
2016 14
2017 15
2018 6
2019 4
2020 0
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230 results
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Page 1
Transgenic Cdx2 induces endogenous Cdx1 in intestinal metaplasia of Cdx2-transgenic mouse stomach.
Mutoh H, et al. FEBS J 2009. PMID 19725873 Free article.
Cdx2 mRNA was expressed in the Cdx2-transgenic mouse stomach. However, endogenous Cdx2 mRNA was not expressed in the intestinal metaplasia of the Cdx2-transgenic mouse stomach. On the other hand, endogenous Cdx1 mRNA and protein were expressed in the intestinal metaplasia of the Cdx2-transgenic mouse stomach. ...
Cdx2 mRNA was expressed in the Cdx2-transgenic mouse stomach. However, endogenous Cdx2 mRNA was not expressed in
The lineage-specific transcription factor CDX2 navigates dynamic chromatin to control distinct stages of intestine development.
Kumar N, et al. Development 2019. PMID 30745430 Free PMC article.
Using primary and engineered human tissues, mouse genetics, and a multi-omics approach, we demonstrate that divergent CDX2 loss-of-function phenotypes in embryonic versus adult intestines correspond to divergent CDX2 chromatin-binding profiles in embryonic versus adult stages. CDX2 binds and activates distinct target genes in developing versus adult mouse and human intestinal cells. We find that temporal shifts in chromatin accessibility correspond to these context-specific CDX2 activities. ...
Using primary and engineered human tissues, mouse genetics, and a multi-omics approach, we demonstrate that divergent CDX2 los …
HIPPO signaling resolves embryonic cell fate conflicts during establishment of pluripotency in vivo
Frum T, et al. Elife 2018. PMID 30526858 Free PMC article.
Here, we unveil novel roles for the HIPPO signaling pathway in controlling cell positioning and expression of Sox2, the first marker of pluripotency in the mouse early embryo. We show that maternal and zygotic YAP1 and WWTR1 repress Sox2 while promoting expression of the trophectoderm gene Cdx2 in parallel. ...
Here, we unveil novel roles for the HIPPO signaling pathway in controlling cell positioning and expression of Sox2, the first marker of plur …
BRAF(V600E) cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis.
Sakamoto N, et al. Elife 2017. PMID 28072391 Free PMC article.
We studied 36 human serrated CRCs and found CDX2 loss or BRAF mutations in ~60% of cases and often together (p=0.04). CDX2(Null)/BRAF(V600E) expression in adult mouse intestinal epithelium led to serrated morphology tumors (including carcinomas) and BRAF(V600E) potently interacted with CDX2 silencing to alter gene expression. ...We present a novel mouse tumor model based on signature defects seen in many human serrated CRCs - CDX2 loss and BRAF(V600E). ...
We studied 36 human serrated CRCs and found CDX2 loss or BRAF mutations in ~60% of cases and often together (p=0.04). CDX2(Nul …
Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development
Banerjee KK, et al. Genes Dev 2018. PMID 30366903 Free PMC article.
We investigated the chromatin basis for these developmental milestones in mouse endoderm, a tissue with recognizable rostro-caudal patterning and transcription factor (TF)-dependent interim plasticity. ...Later in development, as the window of chromatin plasticity elapses, CDX2 depletion weakens intestinal, without strengthening foregut, enhancers. ...
We investigated the chromatin basis for these developmental milestones in mouse endoderm, a tissue with recognizable rostro-caudal pa …
Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos.
Goolam M, et al. Cell 2016. PMID 27015307 Free PMC article.
To address when and how this fundamental process is initiated in mammals, we characterize transcriptomes of all individual cells throughout mouse pre-implantation development. ...Consistently, decreasing Sox21 results in premature upregulation of the differentiation regulator Cdx2, suggesting that Sox21 helps safeguard pluripotency. ...
To address when and how this fundamental process is initiated in mammals, we characterize transcriptomes of all individual cells throughout …
cdx4/lacZ and cdx2/lacZ protein gradients formed by decay during gastrulation in the mouse.
Gaunt SJ, et al. Int J Dev Biol 2005. PMID 16281167 Free article.
Expression of the mouse caudal genes cdx4 and cdx2 is examined by use of lacZ reporter constructs expressed in transgenic mouse embryos. ...Our results indicate how cdx4 and cdx2 protein gradients might be generated by decay during normal development. The smoothness of the gradients that we detect shows that there cannot be extensive mixing of cells once they leave the tailbud to contribute to the growing axis. ...
Expression of the mouse caudal genes cdx4 and cdx2 is examined by use of lacZ reporter constructs expressed in transgenic m
Rbm46 regulates trophectoderm differentiation by stabilizing Cdx2 mRNA in early mouse embryos.
Wang C, et al. Stem Cells Dev 2015. PMID 25397698
However, post-transcriptional regulation of Cdx2 remains largely unknown. In this study, we report that RNA-binding protein motif 46 (Rbm46), an RNA-binding motif protein with unknown function, directly binds to and stabilizes Cdx2 mRNA in early mouse embryos. ...Our study revealed a novel mechanism by which Rbm46 regulates trophectoderm specification through stabilizing Cdx2 mRNA in early mouse embryos....
However, post-transcriptional regulation of Cdx2 remains largely unknown. In this study, we report that RNA-binding protein mo …
Cdx2 is required for correct cell fate specification and differentiation of trophectoderm in the mouse blastocyst.
Strumpf D, et al. Development 2005. PMID 15788452 Free article.
The T-box protein eomesodermin (Eomes) and the caudal-type homeodomain protein Cdx2 are expressed in the TE, and both Eomes and Cdx2 homozygous mutant embryos die around the time of implantation. ...However, Eomes mutant blastocysts implant, and Cdx2 and Oct4 expression are correctly restricted to the ICM TE. Blastocoel formation initiates in Cdx2 mutants but epithelial integrity is not maintained and embryos fail to implant. ...
The T-box protein eomesodermin (Eomes) and the caudal-type homeodomain protein Cdx2 are expressed in the TE, and both E …
The caudal-related protein cdx2 promotes trophoblast differentiation of mouse embryonic stem cells.
Tolkunova E, et al. Stem Cells 2006. PMID 16210407 Free article.
The caudal-related homeobox protein Cdx2 is a transcriptional regulator essential for trophoblast lineage, functioning as early as implantation. Using an inducible system, we show that gain of Cdx2 function in ES cells triggers trophoblast-like morphological differentiation, accompanied by ploidy increase, onset of expression of trophoblast-specific markers, and loss of pluripotency-associated gene expression. ...
The caudal-related homeobox protein Cdx2 is a transcriptional regulator essential for trophoblast lineage, functioning as earl …
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