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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 1
1959 1
1961 1
1966 3
1967 1
1969 3
1970 3
1971 3
1972 2
1973 6
1974 4
1975 2
1976 2
1977 2
1978 3
1979 3
1980 5
1981 5
1982 8
1983 9
1984 8
1985 4
1986 10
1987 8
1989 6
1990 8
1991 14
1992 9
1993 13
1994 12
1995 14
1996 13
1997 13
1998 15
1999 17
2000 30
2001 24
2002 45
2003 36
2004 35
2005 33
2006 35
2007 39
2008 55
2009 48
2010 37
2011 43
2012 36
2013 29
2014 52
2015 59
2016 34
2017 34
2018 39
2019 19
2020 1
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927 results
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Page 1
Genetics of celiac disease.
Ricaño-Ponce I, et al. Best Pract Res Clin Gastroenterol 2015 - Review. PMID 26060105
New insights into the underlying molecular pathophysiology of celiac disease (CeD) over the last few years have been guided by major advances in the fields of genetics and genomics. The development and use of the Immunochip genotyping platform paved the way for the discovery of 39 non-HLA loci associated to CeD, and for follow-up functional genomics studies that pinpointed new disease genes, biological pathways and regulatory elements. ...
New insights into the underlying molecular pathophysiology of celiac disease (CeD) over the last few years have been guided by …
Understanding Celiac Disease by Genomics.
Withoff S, et al. Trends Genet 2016 - Review. PMID 26972670
Celiac disease (CeD) is a complex immune-mediated disease. Genetic studies have implicated 43 predisposing loci that collectively explain some 50% of the genetic variance in CeD. ...
Celiac disease (CeD) is a complex immune-mediated disease. Genetic studies have implicated 43 predisposing loci that co
The genetics of celiac disease: A comprehensive review of clinical implications.
Dieli-Crimi R, et al. J Autoimmun 2015 - Review. PMID 26194613
Celiac disease (CD) is a complex immune-related disease with a very strong genetic component. Multiple genetic findings over the last decade have added to the already known MHC influence numerous genetic variants associated to CD susceptibility. ...Epigenetics and microbiota are emerging as potent factors modulating disease risk and putatively affecting disease manifestation, which are also being explored as therapeutic targets....
Celiac disease (CD) is a complex immune-related disease with a very strong genetic component. Multiple genetic findings
Genetics and celiac disease: the importance of screening.
Leonard MM, et al. Expert Rev Gastroenterol Hepatol 2015 - Review. PMID 25294637
The prevalence of celiac disease (CD) is increasing. Despite an increased awareness and an improvement in diagnostic testing, the majority of individuals with CD remain undiagnosed. ...
The prevalence of celiac disease (CD) is increasing. Despite an increased awareness and an improvement in diagnostic testing, …
PREVALENCE OF CELIAC DISEASE PREDISPOSING GENOTYPES, INCLUDING HLA-DQ2.2 VARIANT, IN BRAZILIAN CHILDREN.
Selleski N, et al. Arq Gastroenterol 2018. PMID 29561984 Free article.
We found significant differences between the distribution of some but not all of the analyzed alleles when comparing celiac and non-celiac children. ...No significant association was found between DQ2.2 variant and celiac disease in the studied population....
We found significant differences between the distribution of some but not all of the analyzed alleles when comparing celiac an …
Coeliac disease and autoimmune disease-genetic overlap and screening.
Lundin KE and Wijmenga C. Nat Rev Gastroenterol Hepatol 2015 - Review. PMID 26303674
Coeliac disease is a treatable, gluten-induced disease that often occurs concurrently with other autoimmune diseases. In genetic studies since 2007, a partial genetic overlap between these diseases has been revealed and further insights into the pathophysiology of coeliac disease and autoimmunity have been gained. ...Serological test results can also predict the probability of coeliac disease development, even if asymptomatic. In patients with autoimmune diseases known to occur alongside coeliac disease (particularly type 1 diabetes mellitus or thyroid disorders), disease screening-and subsequent treatment if coeliac disease is detected-could have beneficial effects on progression or potential complications of both diseases, owing to the effectiveness of gluten-free dietary interventions in coeliac disease. ...
Coeliac disease is a treatable, gluten-induced disease that often occurs concurrently with other autoimmune diseases. I …
Profiling Celiac Disease-Related Transcriptional Changes.
Castellanos-Rubio A and Bilbao JR. Int Rev Cell Mol Biol 2018 - Review. PMID 29413889
Celiac disease (CD) is a chronic, autoimmune disease of the small intestine with a strong but complex genetic component. The disease is triggered by the consumption of dietary gluten through the presentation of immunogenic gliadin peptides to T helper lymphocytes by HLA-DQ2 and DQ8 heterodimers, which are the major contributors to the genetic risk. Recent large-scale genotyping efforts have identified a large number of additional association signals, but the functional role of the underlying genes in the pathogenesis of the disease is still unclear. ...
Celiac disease (CD) is a chronic, autoimmune disease of the small intestine with a strong but complex genetic component
Genetic susceptibilty and celiac disease: what role do HLA haplotypes play?
Sciurti M, et al. Acta Biomed 2018 - Review. PMID 30561391 Free PMC article.
Celiac disease is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten in genetically predisposed individuals. ...However, since HLA-DQ2 and HLA-DQ8 heterodimers explain almost 40% of the disease heritability, HLA typing should not be applied in diagnosis, but exclusively to clarify uncertain diagnoses, considering its negative predictive value....
Celiac disease is a chronic immune-mediated enteropathy triggered by exposure to dietary gluten in genetically predisposed ind
A long noncoding RNA associated with susceptibility to celiac disease.
Castellanos-Rubio A, et al. Science 2016. PMID 27034373 Free PMC article.
Lnc13 levels are significantly decreased in small intestinal biopsy samples from patients with celiac disease, which suggests that down-regulation of lnc13 may contribute to the inflammation seen in this disease. Furthermore, the lnc13 disease-associated variant binds hnRNPD less efficiently than its wild-type counterpart, thus helping to explain how these single-nucleotide polymorphisms contribute to celiac disease....
Lnc13 levels are significantly decreased in small intestinal biopsy samples from patients with celiac disease, which suggests …
Functional implication of celiac disease associated lncRNAs in disease pathogenesis.
Olazagoitia-Garmendia A, et al. Comput Biol Med 2018 - Review. PMID 30126616
Celiac disease (CD) is a chronic immune-mediated disorder triggered by the consumption of dietary gluten that develops in genetically susceptible individuals. ...New evidences indicate that long non-coding RNAs (lncRNAs) play crucial roles in various biological processes and they have emerged as key regulatory molecules involved in the development of a wide range of diseases, including intestinal inflammatory disorders. ...
Celiac disease (CD) is a chronic immune-mediated disorder triggered by the consumption of dietary gluten that develops
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