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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1974 89
1975 135
1976 204
1977 275
1978 303
1979 310
1980 385
1981 398
1982 392
1983 433
1984 405
1985 411
1986 434
1987 443
1988 441
1989 502
1990 506
1991 498
1992 447
1993 495
1994 467
1995 486
1996 459
1997 460
1998 421
1999 349
2000 349
2001 359
2002 356
2003 356
2004 395
2005 449
2006 538
2007 545
2008 516
2009 543
2010 466
2011 470
2012 543
2013 565
2014 595
2015 618
2016 702
2017 562
2018 662
2019 597
2020 26
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20,274 results
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Page 1
Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.
van Galen P, et al. Cell 2019. PMID 30827681 Free PMC article.
Cell type compositions correlated with prototypic genetic lesions, including an association of FLT3-ITD with abundant progenitor-like cells. ...Differentiated monocyte-like AML cells expressed diverse immunomodulatory genes and suppressed T cell activity in vitro. In conclusion, we provide single-cell technologies and an atlas of AML cell states, regulators, and markers with implications for precision medicine and immune therapies. ...
Cell type compositions correlated with prototypic genetic lesions, including an association of FLT3-ITD with abundant progenitor-like cells. ...Differentiated monocyte-like AML cells expressed diverse immunomodulatory genes and suppressed T cell activity in vitro. In conclusion, we pro
The Coming Decade of Cell Death Research: Five Riddles.
Green DR. Cell 2019 - Review. PMID 31100266 Free PMC article.
Active cell death, in its many forms, is a fundamental biological process. Studies over the past several decades have explored the functions and consequences of cellular demise and elucidated several of the key cell death pathways. Here, I pose five questions, or riddles, that might provide a guide to the next decade of cell death research. Focusing mainly on four types of active cell death (apoptosis, necroptosis, pyroptosis, and ferroptosis) mainly in mammals, this Perspective explores the possible research directions that might answer these riddles, or at least prompt new ones....
Active cell death, in its many forms, is a fundamental biological process. Studies over the past several decades have explored the functions and consequences of cellular demise and elucidated several of the key cell death pathways. Here, I pose five questions, or riddles, that might pr …
Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence.
Neurohr GE, et al. Cell 2019. PMID 30739799 Free PMC article.
Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size is important remains poorly understood. Here we show that growing budding yeast and primary mammalian cells beyond a certain size impairs gene induction, cell-cycle progression, and cell signaling. ...
Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size is important remains poorly understood. Here we show that growing budding
Single-Cell Multi-omic Integration Compares and Contrasts Features of Brain Cell Identity.
Welch JD, et al. Cell 2019. PMID 31178122 Free PMC article.
Defining cell types requires integrating diverse single-cell measurements from multiple experiments and biological contexts. ...Finally, we jointly defined mouse cortical cell types using single-cell RNA-seq and DNA methylation profiles, revealing putative mechanisms of cell-type-specific epigenomic regulation. ...
Defining cell types requires integrating diverse single-cell measurements from multiple experiments and biological contexts. ...Finally, we jointly defined mouse cortical cell types using single-cell RNA-seq and DNA methylation profiles, revealing putative mechanisms of …
B Cell Responses: Cell Interaction Dynamics and Decisions.
Cyster JG and Allen CDC. Cell 2019 - Review. PMID 31002794 Free PMC article.
Here, we review current understanding of how B cell responses are initiated; the different paths to generate short- and long-lived plasma cells, germinal center cells, and memory cells; and how each path impacts antibody diversity, selectivity, and affinity. ...
Here, we review current understanding of how B cell responses are initiated; the different paths to generate short- and long-lived plasma cells, germinal center cells, and memory cells; and how each path impacts antibody diversity, selectivity, and affinity. ...
Comprehensive Integration of Single-Cell Data.
Stuart T, et al. Cell 2019. PMID 31178118 Free PMC article.
Single-cell transcriptomics has transformed our ability to characterize cell states, but deep biological understanding requires more than a taxonomic listing of clusters. ...Here, we develop a strategy to "anchor" diverse datasets together, enabling us to integrate single-cell measurements not only across scRNA-seq technologies, but also across different modalities. ...
Single-cell transcriptomics has transformed our ability to characterize cell states, but deep biological understanding requires more than a taxonomic listing of clusters. ...Here, we develop a strategy to "anchor" diverse datasets together, enabling us to integrate single-cell m …
FXR Regulates Intestinal Cancer Stem Cell Proliferation.
Fu T, et al. Cell 2019. PMID 30794774 Free PMC article.
Conversely, selective activation of intestinal FXR can restrict abnormal Lgr5(+) cell growth and curtail CRC progression. This unexpected role for FXR in coordinating intestinal self-renewal with BA levels implicates FXR as a potential therapeutic target for CRC....
Conversely, selective activation of intestinal FXR can restrict abnormal Lgr5(+) cell growth and curtail CRC progression. This unexpected role for FXR in coordinating intestinal self-renewal with BA levels implicates FXR as a potential therapeutic target for CRC....
Suppression of Exosomal PD-L1 Induces Systemic Anti-tumor Immunity and Memory
Poggio M, et al. Cell 2019. PMID 30951669 Free PMC article.
Exosomal PD-L1 from the tumor suppresses T cell activation in the draining lymph node. Systemically introduced exosomal PD-L1 rescues growth of tumors unable to secrete their own. ...
Exosomal PD-L1 from the tumor suppresses T cell activation in the draining lymph node. Systemically introduced exosomal PD-L1 rescues growth of tumors unable to secrete their own. ...
A Single-Cell Atlas of the Tumor and Immune Ecosystem of Human Breast Cancer.
Wagner J, et al. Cell 2019. PMID 30982598 Free PMC article.
The expression of 73 proteins in 26 million cells was evaluated using tumor and immune cell-centric antibody panels. Tumors displayed individuality in tumor cell composition, including phenotypic abnormalities and phenotype dominance. ...This large-scale, single-cell atlas deepens our understanding of breast tumor ecosystems and suggests that ecosystem-based patient classification will facilitate identification of individuals for precision medicine approaches targeting the tumor and its immunoenvironment....
The expression of 73 proteins in 26 million cells was evaluated using tumor and immune cell-centric antibody panels. Tumors displayed individuality in tumor cell composition, including phenotypic abnormalities and phenotype dominance. ...This large-scale, single-cell atlas deepe …
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