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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1951 1
1953 1
1956 1
1961 3
1980 2
1981 6
1982 10
1983 6
1984 11
1985 13
1986 15
1987 14
1988 34
1989 91
1990 159
1991 338
1992 422
1993 568
1994 781
1995 1315
1996 1715
1997 2150
1998 2564
1999 2996
2000 3328
2001 3761
2002 3941
2003 4253
2004 4732
2005 4990
2006 5237
2007 5328
2008 5385
2009 5452
2010 5700
2011 5955
2012 6247
2013 6240
2014 5855
2015 5854
2016 5488
2017 5199
2018 4841
2019 2273
2020 44
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103,680 results
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Page 1
Cell cycle regulation by the NEK family of protein kinases.
Fry AM, et al. J Cell Sci 2012 - Review. PMID 23132929 Free PMC article.
Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus nidulans led to the discovery of never-in-mitosis A (NIMA), a serine/threonine kinase that is required for mitotic entry. ...Although there is no evidence that human NEKs are essential for mitotic entry, it is clear that several NEK family members have important roles in cell cycle control. ...
Genetic screens for cell division cycle mutants in the filamentous fungus Aspergillus nidulans led to the discovery of never-i …
Role of cell cycle regulators in adipose tissue and whole body energy homeostasis.
Lopez-Mejia IC, et al. Cell Mol Life Sci 2018 - Review. PMID 28988292
Recent data suggest that adipocyte differentiation, adipose tissue browning and mitochondrial function, lipogenesis and lipolysis are strongly modulated by the cell division machinery. This review will focus on the function of cell cycle regulators in adipocyte differentiation, adipose tissue function and whole body energy homeostasis; with particular attention in mouse studies....
Recent data suggest that adipocyte differentiation, adipose tissue browning and mitochondrial function, lipogenesis and lipolysis are strong …
Visualizing the complex functions and mechanisms of the anaphase promoting complex/cyclosome (APC/C)
Alfieri C, et al. Open Biol 2017 - Review. PMID 29167309 Free PMC article.
The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle progression by mediating the degradation of important cell cycle regulators. During the two decades since its discovery, much has been learnt concerning its role in recognizing and ubiquitinating specific proteins in a cell-cycle-dependent manner, the mechanisms governing substrate specificity, the catalytic process of assembling polyubiquitin chains on its target proteins, and its regulation by phosphorylation and the spindle assembly checkpoint. ...
The anaphase promoting complex or cyclosome (APC/C) is a large multi-subunit E3 ubiquitin ligase that orchestrates cell cycle
Cell cycle regulatory proteins--an overview with relevance to oral cancer.
Goodger NM, et al. Oral Oncol 1997 - Review. PMID 9231162
The cell cycle is controlled by a number of highly conserved proteins, found in species as diverse as yeast and mammals. The study of these proteins is a rapidly advancing field that is increasing our understanding of normal and abnormal cell division. Disruption of the cell cycle has been demonstrated in several different types of neoplasm, and there is increasing evidence that, in head and neck tumours, there is aberrant control of cyclins, cell cycle protein kinases and their inhibitors. ...
The cell cycle is controlled by a number of highly conserved proteins, found in species as diverse as yeast and mammals. The s …
Role of cell cycle proteins in CNS injury.
Byrnes KR and Faden AI. Neurochem Res 2007 - Review. PMID 17404835
Following trauma or ischemia to the central nervous system (CNS), there is a marked increase in the expression of cell cycle-related proteins. ...Here we critically review the role of cell cycle pathways in the pathophysiology of experimental stroke, traumatic brain injury and spinal cord injury, and discuss the potential of cell cycle inhibitors as neuroprotective agents....
Following trauma or ischemia to the central nervous system (CNS), there is a marked increase in the expression of cell cycle-r …
Recent patents on cell cycle regulatory proteins.
Chulu JL and Liu HJ. Recent Pat Biotechnol 2009 - Review. PMID 19149717
Cell cycle progression and cell division are driven by the sequential activation of a group of serine-threonine kinases called cyclin-dependent kinases (Cdks). ...This review, describes some of the most recent and important US patents related to cell cycle regulation and those on viral proteins involved in cell cycle modulation particularly the G2/M phase transition and cancer therapy....
Cell cycle progression and cell division are driven by the sequential activation of a group of serine-threonine kinases
Coupling the cell cycle to cell growth.
Boye E and Nordström K. EMBO Rep 2003. PMID 12897798 Free PMC article.
However, DNA replication, mitosis and cell division may also be viewed as having their own, in principle independent, cycles, which are tied together by mechanisms extrinsic to the cell cycle--the checkpoints--that maintain the order of events. ...The nature of the parameters that regulate cell-cycle events is discussed and, in particular, we argue that cell mass is not such a parameter....
However, DNA replication, mitosis and cell division may also be viewed as having their own, in principle independent, cycles, …
The mammalian cell cycle: an overview.
Harper JV and Brooks G. Methods Mol Biol 2005 - Review. PMID 15576929
In recent years, we have witnessed major advances in our understanding of the mammalian cell cycle and how it is regulated. Normal mammalian cellular proliferation is tightly regulated at each phase of the cell cycle by the activation and deactivation of a series of proteins that constitute the cell cycle machinery. This review article describes the various phases of the mammalian cell cycle and focuses on the cell cycle regulatory molecules that act at each stage to ensure normal cellular progression....
In recent years, we have witnessed major advances in our understanding of the mammalian cell cycle and how it is regulated. No …
Modeling epigenetic regulation of PRC1 protein accumulation in the cell cycle.
Dolbniak M, et al. Biol Direct 2015. PMID 26458878 Free PMC article.
Data set 2 seems qualitatively different, with more variation in cell cycle duration. CONCLUSIONS: The main question we address is whether the regulatory feedbacks deduced from single cell cycle data provide epigenetic regulation of cell characteristics in long run. ...Findings of the current paper include tight regulation of the cell cycle (particularly the timing of the cell cycle) even that PRC1 is only one of the players in cell dynamics. ...
Data set 2 seems qualitatively different, with more variation in cell cycle duration. CONCLUSIONS: The main question we addres …
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