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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1948 1
1951 1
1953 1
1956 1
1961 3
1984 1
1985 5
1986 4
1987 4
1988 8
1989 22
1990 43
1991 91
1992 125
1993 193
1994 265
1995 529
1996 757
1997 979
1998 1263
1999 1543
2000 1688
2001 1865
2002 1988
2003 2219
2004 2590
2005 2688
2006 2260
2007 2295
2008 2275
2009 2261
2010 2264
2011 2490
2012 2498
2013 2373
2014 2071
2015 2124
2016 2042
2017 2048
2018 1860
2019 844
2020 12
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44,968 results
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Page 1
MYC Oncogene Contributions to Release of Cell Cycle Brakes.
García-Gutiérrez L, et al. Genes (Basel) 2019 - Review. PMID 30909496 Free PMC article.
Promotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC). MYC promotes the cell cycle by not only activating or inducing cyclins and CDKs but also through the downregulation or the impairment of the activity of a set of proteins that act as cell-cycle brakes. This review is focused on the role of MYC as a cell-cycle brake releaser i.e., how MYC stimulates the cell cycle mainly through the functional inactivation of cell cycle inhibitors. ...
Promotion of the cell cycle is a major oncogenic mechanism of the oncogene c-MYC (MYC). MYC promotes the cell cycle
Self-organization and symmetry breaking in intestinal organoid development
Serra D, et al. Nature 2019. PMID 31019299 Free PMC article.
Intestinal organoids are complex three-dimensional structures that mimic the cell-type composition and tissue organization of the intestine by recapitulating the self-organizing ability of cell populations derived from a single intestinal stem cell. ...Cell-to-cell variability in YAP1, emerging in symmetrical spheres, initiates Notch and DLL1 activation, and drives the symmetry-breaking event and formation of the first Paneth cell. ...
Intestinal organoids are complex three-dimensional structures that mimic the cell-type composition and tissue organization of the int …
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma.
Bandopadhayay P, et al. Nat Commun 2019. PMID 31160565 Free PMC article.
Here, using a combination of expression profiling, genome-scale CRISPR/Cas9-mediated loss of function and ORF/cDNA driven rescue screens, and cell-based models of spontaneous resistance, we identify bHLH/homeobox transcription factors and cell-cycle regulators as key genes mediating BETi's response and resistance. ...Therefore, our data provide insights about the mechanisms underlying BETi effects and the appearance of resistance and support the therapeutic use of combined cell-cycle inhibitors with BETi in MYC-amplified medulloblastoma....
Here, using a combination of expression profiling, genome-scale CRISPR/Cas9-mediated loss of function and ORF/cDNA driven rescue screens, an …
The Dream of a Mycobacterium
Baranowski C, et al. Microbiol Spectr 2019 - Review. PMID 31025625
Cell division has been studied extensively in the model rod-shaped bacteria Escherichia coli and Bacillus subtilis, but much less is understood about cell division in mycobacteria, a genus that includes the major human pathogens M. tuberculosis and M. leprae. In general, bacterial cell division requires the concerted effort of many proteins in both space and time to elongate the cell, replicate and segregate the chromosome, and construct and destruct the septum - processes which result in the creation of two new daughter cells. ...
Cell division has been studied extensively in the model rod-shaped bacteria Escherichia coli and Bacillus subtilis, but much less is
Cell cycle arrest in replicative senescence is not an immediate consequence of telomere dysfunction.
Nassrally MS, et al. Mech Ageing Dev 2019. PMID 30710559
In replicative senescence, cells with critically-short telomeres activate a DNA-damage response leading to cell-cycle arrest, while those without telomere dysfunction would be expected to cycle normally. ...Cell cycle checkpoint engagement in response to DNA damage is thus weaker than generally supposed, explaining why an accumulation of dysfunctional telomeres is needed before marked cell cycle elongation or permanent arrest is achieved....
In replicative senescence, cells with critically-short telomeres activate a DNA-damage response leading to cell-cycle arrest, …
A polyherbal formulation, HC9 regulated cell growth and expression of cell cycle and chromatin modulatory proteins in breast cancer cell lines.
Suryavanshi S, et al. J Ethnopharmacol 2019. PMID 31201865
Cell cycle arrest was determined by propidium iodide (PI) staining and analyzed by flowcytometer. Scratch wound assay was used for studying cell migration. ...RESULTS: HC9 significantly altered growth of breast cancer cell lines, MCF-7 and MDA MB-231. It blocked the cell cycle progression at S phase in MCF-7 by up regulating the expression of p53, p21 and p16 proteins. ...
Cell cycle arrest was determined by propidium iodide (PI) staining and analyzed by flowcytometer. Scratch wound assay was used
RNA-sequencing Profiles of Cell Cycle-Related Genes Upregulated during the G2-Phase in Giardia lamblia.
Kim J, et al. Korean J Parasitol 2019. PMID 31104412 Free PMC article.
RNA-sequencing analysis of the 2 stages of Giardia cell cycle identified several cell cycle genes that were up-regulated at the G2-phase. Transcriptome analysis of cells in 2 distinct cell cycle stages of G. lamblia confirmed previously reported components of cell cycle (PcnA, cyclin B, and CDK) and identified additional cell cycle components (NEKs, Mad2, spindle pole protein, and CDC14A). ...
RNA-sequencing analysis of the 2 stages of Giardia cell cycle identified several cell cycle genes that were up-r …
Centriole assembly at a glance
Gönczy P and Hatzopoulos GN. J Cell Sci 2019 - Review. PMID 30787112 Free article.
Centrioles play fundamental roles across eukaryotes, notably in cell signaling, motility and division. In this Cell Science at a Glance article and accompanying poster, we cover the cellular life cycle of this organelle - from assembly to disappearance - focusing on human centrioles. The journey begins at the end of mitosis when centriole pairs disengage and the newly formed centrioles mature to begin a new duplication cycle. ...
Centrioles play fundamental roles across eukaryotes, notably in cell signaling, motility and division. In this Cell Science at …
APC/C(CDH1) synchronizes ribose-5-phosphate levels and DNA synthesis to cell cycle progression.
Li Y, et al. Nat Commun 2019. PMID 31175280 Free PMC article.
Herein, we find that the anaphase-promoting complex/cyclosome (APC/C) synchronizes ribose-5-phosphate levels and DNA synthesis during the cell cycle. ...Here we reveal that the cell cycle control machinery regulates DNA synthesis by mediating ribose-5-phosphate sufficiency....
Herein, we find that the anaphase-promoting complex/cyclosome (APC/C) synchronizes ribose-5-phosphate levels and DNA synthesis during the …
Cell cycle-dependent association of polo kinase Cdc5 with CENP-A contributes to faithful chromosome segregation in budding yeast.
Mishra PK, et al. Mol Biol Cell 2019. PMID 30726152 Free PMC article.
Here we report that evolutionarily conserved CEN histone H3 variant, Cse4 (CENP-A in humans), is a substrate of Cdc5, and that the cell cycle-regulated association of Cse4 with Cdc5 is required for cell growth. ...The cell cycle-regulated association of Cdc5 with Cse4 is essential for cell viability as constitutive association of Cdc5 with Cse4 at the kinetochore leads to growth defects. ...
Here we report that evolutionarily conserved CEN histone H3 variant, Cse4 (CENP-A in humans), is a substrate of Cdc5, and that the cell
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