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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 8
1946 14
1947 24
1948 31
1949 21
1950 46
1951 37
1952 51
1953 65
1954 71
1955 59
1956 84
1957 63
1958 46
1959 69
1960 71
1961 66
1962 77
1963 67
1964 77
1965 22
1970 1
1972 4
1973 2
1974 1
1975 1
1977 1
1982 1
1984 2
1986 8
1987 1
1988 1
1989 11
1990 15
1991 318
1992 951
1993 1369
1994 1993
1995 2915
1996 3961
1997 5147
1998 6437
1999 7549
2000 9065
2001 9738
2002 10533
2003 11736
2004 12559
2005 13636
2006 14041
2007 14635
2008 15180
2009 15630
2010 16660
2011 17222
2012 18480
2013 19467
2014 20009
2015 20439
2016 20023
2017 19647
2018 19600
2019 10291
2020 254
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Search Results

306,339 results
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Page 1
Cell death: a review of the major forms of apoptosis, necrosis and autophagy.
D'Arcy MS. Cell Biol Int 2019 - Review. PMID 30958602
Cell death was once believed to be the result of one of two distinct processes, apoptosis (also known as programmed cell death) or necrosis (uncontrolled cell death); in recent years, however, several other forms of cell death have been discovered highlighting that a cell can die via a number of differing pathways. ...This will provide researchers with a summary of the major forms of cell death and allow them to compare and contrast between them....
Cell death was once believed to be the result of one of two distinct processes, apoptosis (also known as programmed cell
Cell Death Mechanisms in Stroke and Novel Molecular and Cellular Treatment Options.
Sekerdag E, et al. Curr Neuropharmacol 2018 - Review. PMID 29512465 Free PMC article.
However, if the acute time window is exceeded, neuronal loss starts due to the activation of cell death pathways. This review will explore the most updated cellular death mechanisms leading to neuronal loss in stroke. Ischemic and hemorrhagic stroke as well as subarachnoid hemorrhage will be debated in the light of cell death mechanisms and possible novel molecular and cellular treatment options will be discussed....
However, if the acute time window is exceeded, neuronal loss starts due to the activation of cell death pathways. This review …
Apoptosis, oncosis, and necrosis. An overview of cell death.
Majno G and Joris I. Am J Pathol 1995 - Review. PMID 7856735 Free PMC article.
The historical development of the cell death concept is reviewed, with special attention to the origin of the terms necrosis, coagulation necrosis, autolysis, physiological cell death, programmed cell death, chromatolysis (the first name of apoptosis in 1914), karyorhexis, karyolysis, and cell suicide, of which there are three forms: by lysosomes, by free radicals, and by a genetic mechanism (apoptosis). ...For cell death not by apoptosis the most satisfactory term is accidental cell death. Necrosis is commonly used but it is not appropriate, because it does not indicate a form of cell death but refers to changes secondary to cell death by any mechanism, including apoptosis. ...
The historical development of the cell death concept is reviewed, with special attention to the origin of the terms necrosis, …
Autophagy-dependent cell death - where, how and why a cell eats itself to death.
Bialik S, et al. J Cell Sci 2018 - Review. PMID 30237248 Free article.
Autophagy as a means of cell killing was first advanced by Clark's phenotypic description of 'Type II autophagic cell death' in 1990. ...Resolution of this issue comes from a more careful definition of autophagy-dependent cell death (ADCD) as a regulated cell death that is shown experimentally to require different components of the autophagy machinery without involvement of alternative cell death pathways. ...
Autophagy as a means of cell killing was first advanced by Clark's phenotypic description of 'Type II autophagic cell death
Cell death.
Hotchkiss RS, et al. N Engl J Med 2009 - Review. PMID 19828534 Free PMC article.
The inducers of immunogenic cell death for tumor immunotherapy.
Li X. Tumori 2018 - Review. PMID 28967094
Immunogenic cell death is a manner of cell death that can induce the emission of immunogenic damage-associated molecular patterns (DAMPs). ...
Immunogenic cell death is a manner of cell death that can induce the emission of immunogenic damage-associated m …
STING Signaling Promotes Apoptosis, Necrosis, and Cell Death: An Overview and Update.
Liu S and Guan W. Mediators Inflamm 2018 - Review. PMID 30595664 Free PMC article.
Recent studies have revealed that the outcome of STING activation could vary between distinct cell types and scenarios. STING activation in certain cell types triggered cell death including apoptosis and necrosis. ...Besides canonical immune responses represented by IFN and TNF productions, STING signaling can also induce cell death events in a variety of cell types. ...
Recent studies have revealed that the outcome of STING activation could vary between distinct cell types and scenarios. STING activat …
Non-Canonical Cell Death Induced by p53.
Ranjan A and Iwakuma T. Int J Mol Sci 2016 - Review. PMID 27941671 Free PMC article.
Programmed cell death is a vital biological process for multicellular organisms to maintain cellular homeostasis, which is regulated in a complex manner. Over the past several years, apart from apoptosis, which is the principal mechanism of caspase-dependent cell death, research on non-apoptotic forms of programmed cell death has gained momentum. p53 is a well characterized tumor suppressor that controls cell proliferation and apoptosis and has also been linked to non-apoptotic, non-canonical cell death mechanisms. p53 impacts these non-canonical forms of cell death through transcriptional regulation of its downstream targets, as well as direct interactions with key players involved in these mechanisms, in a cell type- or tissue context-dependent manner. ...
Programmed cell death is a vital biological process for multicellular organisms to maintain cellular homeostasis, which is reg …
Programmed cell death in aging.
Tower J. Ageing Res Rev 2015 - Review. PMID 25862945 Free PMC article.
Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are required for normal cell turnover and tissue homeostasis. ...During aging the cell turnover rate declines for several highly-mitotic tissues. Aging-associated disruptions in systemic and inter-cell signaling combined with cell-autonomous damage and mitochondrial malfunction result in increased PCD in some cell types, and decreased PCD in other cell types. ...
Programmed cell death (PCD) pathways, including apoptosis and regulated necrosis, are required for normal cell turnover …
Cell death pathologies: targeting death pathways and the immune system for cancer therapy.
Pentimalli F, et al. Genes Immun 2019 - Review. PMID 30563970 Free PMC article.
Alterations in the molecular mechanisms of cell death are a common feature of cancer. These alterations enable malignant cells to survive intrinsic death signalling leading to accumulation of genetic aberrations and helping them to cope with adverse conditions. Regulated cell death has historically been exclusively associated with classical apoptosis; however, increasing evidence indicates that several alternative mechanisms orchestrate multiple death pathways, such as ferroptosis, entosis, necroptosis and immunogenic cell death, each with distinct underlying molecular mechanisms. ...
Alterations in the molecular mechanisms of cell death are a common feature of cancer. These alterations enable malignant cells …
306,339 results
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