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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 3
1952 9
1953 13
1954 3
1955 3
1956 5
1963 4
1964 1
1965 44
1966 74
1967 75
1968 101
1969 90
1970 87
1971 135
1972 142
1973 182
1974 155
1975 174
1976 168
1977 167
1978 190
1979 213
1980 222
1981 187
1982 233
1983 228
1984 190
1985 214
1986 276
1987 277
1988 341
1989 380
1990 345
1991 311
1992 326
1993 311
1994 298
1995 292
1996 285
1997 270
1998 234
1999 224
2000 326
2001 310
2002 350
2003 372
2004 434
2005 590
2006 651
2007 788
2008 915
2009 1046
2010 1181
2011 1305
2012 1298
2013 1357
2014 1352
2015 1447
2016 1551
2017 1485
2018 1431
2019 648
2020 15
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23,827 results
Results by year
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Page 1
Thrombopoiesis
Kaushansky K. Semin Hematol 2015 - Review. PMID 25578413
The production of platelets is a complex process that involves hematopoietic stem cells (HSCs), their differentiated progeny, the marrow microenvironment and hematopoietic cytokines. ...Since that time many of the molecular mechanisms of thrombopoiesis have been identified, including the effects of thrombopoietin on the survival, proliferation, and differentiation of hematopoietic stem and progenitor cells, the development of polyploidy and proplatelet formation, the final fragmentation of megakaryocyte cytoplasm to yield blood platelets, and the regulation of this process. ...
The production of platelets is a complex process that involves hematopoietic stem cells (HSCs), their differentiated progeny, the mar …
Ketogenesis contributes to intestinal cell differentiation.
Wang Q, et al. Cell Death Differ 2017. PMID 27935584 Free PMC article.
However, the downstream targets mediating the effects of mTOR in intestinal cells are not known. Here, we show that the ketone body β-hydroxybutyrate (βHB), an endogenous inhibitor of histone deacetylases (HDACs) induces intestinal cell differentiation as noted by the increased expression of differentiation markers (Mucin2 (MUC2), lysozyme, IAP, sucrase-isomaltase, KRT20, villin, Caudal-related homeobox transcription factor 2 (CDX2) and p21(Waf1)). ...In addition, mice fed a ketogenic diet demonstrated increased differentiation of intestinal cells as noted by an increase in the enterocyte, goblet and Paneth cell lineages. ...
However, the downstream targets mediating the effects of mTOR in intestinal cells are not known. Here, we show that the ketone body β …
Chemical compound-based direct reprogramming for future clinical applications
Takeda Y, et al. Biosci Rep 2018 - Review. PMID 29739872 Free PMC article.
The direct reprogramming is a promising alternative to rapidly prepare different cell types by bypassing the pluripotent state. ...This review summarizes up-to-date progress in each specific cell type and discusses prospects for future clinical application toward cell transplantation therapy....
The direct reprogramming is a promising alternative to rapidly prepare different cell types by bypassing the pluripotent state. ...Th …
Nanomaterials modulate stem cell differentiation: biological interaction and underlying mechanisms.
Wei M, et al. J Nanobiotechnology 2017 - Review. PMID 29065876 Free PMC article.
Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell types. ...Over the recent years, accumulating evidence has shown that nanomaterials can facilitate stem cell proliferation and differentiation, and great effort is undertaken to explore their possible modulating manners and mechanisms on stem cell differentiation. ...
Stem cells are unspecialized cells that have the potential for self-renewal and differentiation into more specialized cell typ …
Reprogramming and Stemness
Laplane L. Perspect Biol Med 2015. PMID 26750604
Reprogramming technologies show that cellular identity can be reprogrammed, challenging the classical conception of cell differentiation as an irreversible process. If non-stem cells can be reprogrammed into stem cells, then what is it to be a stem cell, and what kind of property is stemness? ...
Reprogramming technologies show that cellular identity can be reprogrammed, challenging the classical conception of cell different
Effects of differentiation inducers on cell phenotypes of cultured nontransformed and immortalized mammary epithelial cells: a comparative immunocytochemical analysis.
Grünberg E, et al. Tumour Biol 2000. PMID 10867614
We examined the effects of the differentiation-inducing agents 1, 25-dihydroxyvitamin D(3) (calcitriol), phorbol myristate acetate (PMA), the cytokine interferon-gamma (IFN-gamma), and the tumor necrosis factor-alpha (TNF-alpha) alone and in combination with calcitriol on cell growth and differentiation parameters of cultured nontransformed human mammary epithelial cell (HMEC) lines, the chemically transformed HMEC line H184 A1N4, and the human mammary carcinoma cell line CAL51. Cell differentiation was phenotyped by semiquantitative immunocytochemistry using a panel of 15 monoclonal antibodies against marker molecules representing epithelial cell differentiation, cell-cell adhesion processes and malignancy. ...
We examined the effects of the differentiation-inducing agents 1, 25-dihydroxyvitamin D(3) (calcitriol), phorbol myristate ace …
Comparative performance of cell life span and cell transit models for describing erythropoietic drug effects.
Budha NR, et al. AAPS J 2011. PMID 22005901 Free PMC article.
The objective of this study was to compare the performance of two competing modeling approaches for delayed drug effects, mechanistic cell life span models, and semi-mechanistic cell transit models. ...The cell transit model needed slightly longer time to converge compared to the cell life span model. The system and drug effect parameters were similar in both models indicating that the models can be interchangeably used to describe the current data. ...
The objective of this study was to compare the performance of two competing modeling approaches for delayed drug effects, mech …
Liraglutide suppresses proliferation and induces adipogenic differentiation of 3T3-L1 cells via the Hippo-YAP signaling pathway.
Li Y, et al. Mol Med Rep 2018. PMID 29344656 Free PMC article.
Previous findings have demonstrated the effects of liraglutide on adipogenesis; however, the underlying mechanism involved in this process remains to be elucidated. ...Cell proliferation was determined by a Cell Counting Kit-8 assay and cell immunofluorescence for Ki67, and apoptosis was assessed by flow cytometry. ...
Previous findings have demonstrated the effects of liraglutide on adipogenesis; however, the underlying mechanism involved in this pr …
Chemical modulation of cell fates: in situ regeneration.
Qin H, et al. Sci China Life Sci 2018 - Review. PMID 30099708
Chemical modulation of cell fates has been widely used to promote tissue and organ regeneration. Small molecules can target the self-renewal, expansion, differentiation, and survival of endogenous stem cells for enhancing their regenerative power or induce dedifferentiation or transdifferentiation of mature cells into proliferative progenitors or specialized cell types needed for regeneration. Here, we discuss current progress and potential using small molecules to promote in vivo regenerative processes by regulating the cell fate. ...
Chemical modulation of cell fates has been widely used to promote tissue and organ regeneration. Small molecules can target the self- …
Naturally occurring compounds in differentiation based therapy of cancer.
Mijatović S, et al. Biotechnol Adv 2018 - Review. PMID 29656090
Differentiation of cancer cells entails the reversion of phenotype from malignant to the original. The conversion to cell type characteristic for another tissue is named transdifferentiation. Differentiation/transdifferentiation of malignant cells in high grade tumor mass could serve as a nonaggressive approach that potentially limits tumor progression and augments chemosensitivity. ...
Differentiation of cancer cells entails the reversion of phenotype from malignant to the original. The conversion to cell type
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