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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1975 1
1981 1
1982 2
1983 5
1985 1
1988 6
1989 46
1990 134
1991 224
1992 363
1993 357
1994 393
1995 467
1996 474
1997 568
1998 616
1999 624
2000 656
2001 598
2002 846
2003 876
2004 1036
2005 1020
2006 1177
2007 1330
2008 1495
2009 1612
2010 2150
2011 2237
2012 2404
2013 2720
2014 2609
2015 2535
2016 2702
2017 2730
2018 2647
2019 1044
2020 14
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35,318 results
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Page 1
Epigenetic control of myeloid cell differentiation, identity and function.
Álvarez-Errico D, et al. Nat Rev Immunol 2015 - Review. PMID 25534619
The differentiation and activation of myeloid cells requires the timely regulation of gene expression; this depends on the interplay of a variety of elements, including transcription factors and epigenetic mechanisms. ...In this Review, we highlight key epigenetic events controlling myeloid cell biology, focusing on those related to myeloid cell differentiation, the acquisition of myeloid identity and innate immune memory....
The differentiation and activation of myeloid cells requires the timely regulation of gene expression; this depends on the interplay …
Alternative splicing switches: Important players in cell differentiation.
Fiszbein A and Kornblihtt AR. Bioessays 2017 - Review. PMID 28452057
Although the massive switch in AS profiles that often accompanies variations in gene expression patterns occurring during cell differentiation has been characterized for a variety of models, their causes and mechanisms remain largely unknown. Here, we integrate foundational and recent studies indicating the AS switches that govern the processes of cell fate determination. ...
Although the massive switch in AS profiles that often accompanies variations in gene expression patterns occurring during cell dif
Spermatogenesis in humans and its affecting factors
Neto FT, et al. Semin Cell Dev Biol 2016 - Review. PMID 27143445
The differentiation of spermatogonia into spermatozoa requires the participation of several cell types, hormones, paracrine factors, genes and epigenetic regulators. Recent researches in animals and humans have furthered our understanding of the male gamete differentiation, and led to clinical tools for the better management of male infertility. ...
The differentiation of spermatogonia into spermatozoa requires the participation of several cell types, hormones, paracrine fa …
Clonal hematopoiesis
Jan M, et al. Semin Hematol 2017 - Review. PMID 28088988
These somatic mutations drive the expansion from a single founding cell to a detectable hematopoietic clone. Owing to the admixed nature of blood that provides a sampling of blood cell production throughout the body, clonal hematopoiesis is a rare view into the biology of pre-malignancy and the direct effects of pre-cancerous lesions on organ dysfunction. ...
These somatic mutations drive the expansion from a single founding cell to a detectable hematopoietic clone. Owing to the admixed nat …
Characterization of cell fate probabilities in single-cell data with Palantir.
Setty M, et al. Nat Biotechnol 2019. PMID 30899105
Single-cell RNA sequencing studies of differentiating systems have raised fundamental questions regarding the discrete versus continuous nature of both differentiation and cell fate. Here we present Palantir, an algorithm that models trajectories of differentiating cells by treating cell fate as a probabilistic process and leverages entropy to measure cell plasticity along the trajectory. ...
Single-cell RNA sequencing studies of differentiating systems have raised fundamental questions regarding the discrete versus …
Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming.
Schiebinger G, et al. Cell 2019. PMID 30712874 Free PMC article.
Understanding the molecular programs that guide differentiation during development is a major challenge. Here, we introduce Waddington-OT, an approach for studying developmental time courses to infer ancestor-descendant fates and model the regulatory programs that underlie them. We apply the method to reconstruct the landscape of reprogramming from 315,000 single-cell RNA sequencing (scRNA-seq) profiles, collected at half-day intervals across 18 days. ...
Understanding the molecular programs that guide differentiation during development is a major challenge. Here, we introduce Waddingto …
DNA methylation: an epigenetic mark of cellular memory
Kim M and Costello J. Exp Mol Med 2017 - Review. PMID 28450738 Free PMC article.
DNA methylation is a stable epigenetic mark that can be inherited through multiple cell divisions. During development and cell differentiation, DNA methylation is dynamic, but some DNA methylation patterns may be retained as a form of epigenetic memory. ...
DNA methylation is a stable epigenetic mark that can be inherited through multiple cell divisions. During development and cell
Assessment of stem cell differentiation based on genome-wide expression profiles.
Godoy P, et al. Philos Trans R Soc Lond B Biol Sci 2018 - Review. PMID 29786556 Free PMC article.
In recent years, protocols have been established to differentiate stem and precursor cells into more mature cell types. However, progress in this field has been hampered by difficulties to assess the differentiation status of stem cell-derived cells in an unbiased manner. ...Finally, transcription factors responsible for incomplete and unwanted differentiation are identified. The proposed method is widely applicable and allows an unbiased and quantitative assessment of stem cell-derived cells.This article is part of the theme issue 'Designer human tissue: coming to a lab near you'....
In recent years, protocols have been established to differentiate stem and precursor cells into more mature cell types. Howeve …
Osteogenesis and aging: lessons from mesenchymal stem cells
Infante A and Rodríguez CI. Stem Cell Res Ther 2018 - Review. PMID 30257716 Free PMC article.
At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adipogenesis at the cost of osteogenesis. This differentiation shift leads to decreased bone formation, contributing to the etiology of osteoporosis. This review will focus on the most recent/relevant molecular findings driving this functional impairment of mesenchymal stem cells in the aging process....
At the cellular level, the mesenchymal stem cell pool in the bone marrow niche shows a biased differentiation into adipogenesi …
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