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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1953 7
1954 12
1955 22
1956 12
1957 5
1959 12
1960 15
1961 26
1962 20
1964 4
1965 12
1966 32
1967 49
1968 55
1969 1
1975 1
1979 2
1980 2
1982 4
1983 4
1985 2
1986 1
1987 1
1988 8
1989 65
1990 253
1991 352
1992 440
1993 401
1994 420
1995 443
1996 434
1997 434
1998 587
1999 527
2000 664
2001 854
2002 1361
2003 1374
2004 1638
2005 1942
2006 1996
2007 2117
2008 2268
2009 2424
2010 2699
2011 2788
2012 2696
2013 2757
2014 2820
2015 2852
2016 2675
2017 2651
2018 2397
2019 856
2020 7
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42,167 results
Results by year
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Page 1
Differentiation-based model of hematopoietic stem cell functions and lineage pathways.
Höfer T and Rodewald HR. Blood 2018 - Review. PMID 30042097 Free PMC article.
Thus, the new tools probing HSC differentiation in situ are progressing beyond assays for HSC activity based on proliferation measurements and fates of transplanted stem cells, and the data challenge lineage interpretations of single-cell gene expression snapshots. Linking in vivo fate analyses to gene expression and other molecular determinants of cell fate will aid in unraveling the mechanisms of lineage commitment and the architecture of physiological hematopoiesis....
Thus, the new tools probing HSC differentiation in situ are progressing beyond assays for HSC activity based on proliferation measure …
Adipogenesis and metabolic health
Ghaben AL and Scherer PE. Nat Rev Mol Cell Biol 2019 - Review. PMID 30610207
The expansion of adipose depots can be driven either by the increase in adipocyte size (hypertrophy) or by the formation of new adipocytes from precursor differentiation in the process of adipogenesis (hyperplasia). ...
The expansion of adipose depots can be driven either by the increase in adipocyte size (hypertrophy) or by the formation of new adipocytes f …
Diverse mechanisms for endogenous regeneration and repair in mammalian organs
Wells JM and Watt FM. Nature 2018 - Review. PMID 29769669
In many organs, injury reveals the plasticity of both resident stem cells and differentiated cells. The ability of resident cells to maintain and repair organs diminishes with age, whereas, paradoxically, the risk of cancer increases. New therapeutic approaches aim to harness cell plasticity for tissue repair and regeneration while avoiding the risk of malignant transformation of cells....
In many organs, injury reveals the plasticity of both resident stem cells and differentiated cells. The ability of resident cells to …
Adipogenesis
Sarjeant K and Stephens JM. Cold Spring Harb Perspect Biol 2012 - Review. PMID 22952395 Free PMC article.
Advances in understanding erythropoiesis: evolving perspectives
Nandakumar SK, et al. Br J Haematol 2016 - Review. PMID 26846448 Free PMC article.
Red blood cells (RBCs) are generated from haematopoietic stem and progenitor cells (HSPCs) through the step-wise process of differentiation known as erythropoiesis. ...Using recently defined cell surface markers, it is now possible to enrich for erythroid progenitors and precursors to a much greater extent than has been possible before. ...
Red blood cells (RBCs) are generated from haematopoietic stem and progenitor cells (HSPCs) through the step-wise process of differentiati
Spermatogonial stem cells and spermatogenesis in mice, monkeys and men
Fayomi AP and Orwig KE. Stem Cell Res 2018 - Review. PMID 29730571 Free PMC article.
Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial stem cells (SSCs), which balance self-renewing divisions that maintain stem cell pool with differentiating divisions that sustain continuous sperm production. ...This review will provide an overview of stem, progenitor and differentiating spermatogonia that support spermatogenesis; identifying parallels between rodents and primates where they exist as well as features unique to higher primates....
Continuous spermatogenesis in post-pubertal mammals is dependent on spermatogonial stem cells (SSCs), which balance self-renewing divisions …
The Physical and Biochemical Properties of the Extracellular Matrix Regulate Cell Fate.
Muncie JM and Weaver VM. Curr Top Dev Biol 2018 - Review. PMID 29853174 Free PMC article.
In this chapter, we review the composition of the extracellular matrix and summarize data illustrating its importance in embryogenesis, tissue-specific development, and stem cell differentiation. We discuss how the biophysical and biochemical properties of the extracellular matrix ligate specific transmembrane receptors to activate intracellular signaling that alter cell shape and cytoskeletal dynamics to modulate cell growth and viability, and direct cell migration and cell fate. ...
In this chapter, we review the composition of the extracellular matrix and summarize data illustrating its importance in embryogenesis, tiss …
Connections Between Metabolism and Epigenetics in Programming Cellular Differentiation.
Chisolm DA and Weinmann AS. Annu Rev Immunol 2018 - Review. PMID 29328786
Researchers are intensifying efforts to understand the mechanisms by which changes in metabolic states influence differentiation programs. ...We discuss this topic from the perspective of specialized CD4(+) T cells as well as effector and memory T cell differentiation programs. ...
Researchers are intensifying efforts to understand the mechanisms by which changes in metabolic states influence differentiation prog …
Cell differentiation.
Bennett V. Curr Opin Cell Biol 2008. PMID 18973808
Autophagy in stem cells: repair, remodelling and metabolic reprogramming
Boya P, et al. Development 2018 - Review. PMID 29483129 Free article.
Autophagy serves as a crucial intracellular quality control and repair mechanism but is also involved in cell remodelling during development and cell differentiation. In addition, mitophagy, the process by which damaged mitochondria undergo autophagy, has emerged as key regulator of cell metabolism. ...
Autophagy serves as a crucial intracellular quality control and repair mechanism but is also involved in cell remodelling during deve …
42,167 results
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