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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1956 1
1967 1
1968 3
1970 1
1974 9
1975 1
1988 2
1989 59
1990 128
1991 178
1992 265
1993 264
1994 310
1995 322
1996 342
1997 350
1998 400
1999 381
2000 450
2001 500
2002 487
2003 549
2004 686
2005 707
2006 759
2007 887
2008 853
2009 1015
2010 1015
2011 1127
2012 1262
2013 1285
2014 1401
2015 1421
2016 1429
2017 1283
2018 1249
2019 583
2020 14
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19,967 results
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Page 1
Regulation of cell proliferation by hypoxia-inducible factors.
Hubbi ME and Semenza GL. Am J Physiol Cell Physiol 2015 - Review. PMID 26491052 Free PMC article.
One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, hypoxia induces decreased cell proliferation, since an increased number of cells, with a consequent increase in O2 demand, would only exacerbate hypoxic stress. ...This review will discuss major molecular mechanisms by which hypoxia regulates cell proliferation in different cell populations, with a particular focus on the role of hypoxia-inducible factors....
One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, …
Cell-Autonomous Metabolic Reprogramming in Hypoxia.
Schito L and Rey S. Trends Cell Biol 2018 - Review. PMID 29191366
Consequently, hypoxia (low O(2)) has arisen as an organizing principle for cellular evolution, metabolism, and (patho)biology, eliciting a remarkable panoply of metabolic adaptations that trigger transcriptional, translational, post-translational, and epigenetic responses to determine cellular fitness. In this review we summarize current and emerging cell-autonomous molecular mechanisms that induce hypoxic metabolic reprogramming in health and disease....
Consequently, hypoxia (low O(2)) has arisen as an organizing principle for cellular evolution, metabolism, and (patho)biology, elicit …
Overcoming tumor hypoxia as a barrier to radiotherapy, chemotherapy and immunotherapy in cancer treatment.
Graham K and Unger E. Int J Nanomedicine 2018 - Review. PMID 30323592 Free PMC article.
Hypoxia is also a potent barrier to effective immunotherapy in cancer treatment. Because of the recognition of hypoxia as an important barrier to cancer treatment, a variety of approaches have been undertaken to overcome or reverse tumor hypoxia. ...Oxygen therapeutics, based on liquid FCs, can potentially increase the oxygen-carrying capacity of the blood to reverse tumor hypoxia. ...
Hypoxia is also a potent barrier to effective immunotherapy in cancer treatment. Because of the recognition of hypoxia as an i
Effects of Microvesicles on Cell Apoptosis under Hypoxia.
Guo Y, et al. Oxid Med Cell Longev 2019 - Review. PMID 31178970 Free PMC article.
Hypoxia, as one of the severe cellular stresses, can cause cellular injury and even cell death. Apoptosis is the main mechanism of regulating cell death and is closely related to the cell death caused by hypoxia. However, hypoxia-induced apoptosis is not entirely the result of direct hypoxic stimulus of cells. In recent years, it has been found that cells injured by hypoxia can shed a kind of membranous vesicles, which are called microvesicles (MVs). ...
Hypoxia, as one of the severe cellular stresses, can cause cellular injury and even cell death. Apoptosis is the main mechanis
CoCl(2) simulated hypoxia induce cell proliferation and alter the expression pattern of hypoxia associated genes involved in angiogenesis and apoptosis.
Rana NK, et al. Biol Res 2019. PMID 30876462 Free PMC article.
METHODS: Cell proliferation in MCF-7 and MDA-MB-231 cell lines treated with different concentration of CoCl(2) was analyzed by MTT assay. Flow cytometry was performed to check cell cycle distribution, whereas cell morphology was examined by phase contrast microscopy in both the cells during hypoxia induction. ...
METHODS: Cell proliferation in MCF-7 and MDA-MB-231 cell lines treated with different concentration of CoCl(2) was analyzed by …
Hypoxia and Metabolism in Metastasis.
Zhang T, et al. Adv Exp Med Biol 2019 - Review. PMID 31201718
As a response to hypoxia, a large number of target genes involved in cell growth, metabolism, metastasis and immunity are activated in cancer cells. ...Here, we focus on cancer cell metabolism and metastasis regulated by hypoxia....
As a response to hypoxia, a large number of target genes involved in cell growth, metabolism, metastasis and immunity are acti …
HIF-1 in cancer therapy: two decade long story of a transcription factor
Soni S and Padwad YS. Acta Oncol 2017 - Review. PMID 28358664
O(2) concentration in cellular milieu is defined as normoxia (∼21% O(2)), physoxia (∼1-13% O(2)) or hypoxia (∼0.1-1% O(2)). Hypoxia, a striking micro-environmental feature in tumorigenesis, is countered by tumor cells via induction of O(2) governed transcription factor, hypoxia inducible factor-1 (HIF-1). ...
O(2) concentration in cellular milieu is defined as normoxia (∼21% O(2)), physoxia (∼1-13% O(2)) or hypoxia (∼0.1-1% O(2)). Hypoxi
A method for the long-term cultivation of mammalian cells in the absence of oxygen: Characterization of cell replication, hypoxia-inducible factor expression and reactive oxygen species production.
Plotkin BJ, et al. Tissue Cell 2018. PMID 29429519
A novel methodology was developed that enabled anoxic cell cultivation (17d maximum time tested) and cell passage. In the absence of oxygen, cell morphology is significantly altered. ...Detection of ROS was inversely related to detection of hypoxia-inducible factor-1α (HIF1) mRNA and HIF-1 protein expression which cycled over a 10-day period. ...
A novel methodology was developed that enabled anoxic cell cultivation (17d maximum time tested) and cell passage. In the abse …
The stimulation of thrombosis by hypoxia.
Gupta N, et al. Thromb Res 2019 - Review. PMID 31376606
Thrombus formation is increased under conditions of hypoxia in animal models of thrombosis and in human populations, but current therapies for thrombosis do not directly target hypoxia-responsive signaling pathways. The vascular response to hypoxia is controlled primarily by the hypoxia-inducible transcription factors (HIFs), whose target genes include several factors that regulate thrombus formation. ...
Thrombus formation is increased under conditions of hypoxia in animal models of thrombosis and in human populations, but current ther …
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