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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 3
1961 1
1962 1
1987 2
1994 1
1995 6
1996 16
1997 37
1998 66
1999 62
2000 68
2001 98
2002 158
2003 136
2004 158
2005 229
2006 265
2007 272
2008 316
2009 358
2010 411
2011 367
2012 332
2013 444
2014 457
2015 444
2016 458
2017 409
2018 351
2019 153
2020 2
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5,549 results
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Page 1
Human haematopoietic stem cell lineage commitment is a continuous process.
Velten L, et al. Nat Cell Biol 2017. PMID 28319093 Free PMC article.
However, this model is based on the analysis of predefined flow-sorted cell populations. Here we integrated flow cytometric, transcriptomic and functional data at single-cell resolution to quantitatively map early differentiation of human HSCs towards lineage commitment. During homeostasis, individual HSCs gradually acquire lineage biases along multiple directions without passing through discrete hierarchically organized progenitor populations. ...
However, this model is based on the analysis of predefined flow-sorted cell populations. Here we integrated flow cytometric, transcri …
Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics.
Street K, et al. BMC Genomics 2018. PMID 29914354 Free PMC article.
RESULTS: We introduce Slingshot, a novel method for inferring cell lineages and pseudotimes from single-cell gene expression data. ...Accurate lineage inference is a critical step in the identification of dynamic temporal gene expression....
RESULTS: We introduce Slingshot, a novel method for inferring cell lineages and pseudotimes from single-cell gene expression d …
Lineage dynamics of murine pancreatic development at single-cell resolution.
Byrnes LE, et al. Nat Commun 2018. PMID 30254276 Free PMC article.
Here, we profile the cell types within the epithelial and mesenchymal compartments of the murine pancreas across developmental time using a combination of single-cell RNA sequencing, immunofluorescence, in situ hybridization, and genetic lineage tracing. We identify previously underappreciated cellular heterogeneity of the developing mesenchyme and reconstruct potential lineage relationships among the pancreatic mesothelium and mesenchymal cell types. ...
Here, we profile the cell types within the epithelial and mesenchymal compartments of the murine pancreas across developmental time u …
The Unfolded Protein Response and Cell Fate Control.
Hetz C and Papa FR. Mol Cell 2018 - Review. PMID 29107536 Free article.
The secretory capacity of a cell is constantly challenged by physiological demands and pathological perturbations. To adjust and match the protein-folding capacity of the endoplasmic reticulum (ER) to changing secretory needs, cells employ a dynamic intracellular signaling pathway known as the unfolded protein response (UPR). ...Here, we discuss recent advances into how the UPR integrates information about the intensity and duration of ER stress stimuli in order to control cell fate. ...
The secretory capacity of a cell is constantly challenged by physiological demands and pathological perturbations. To adjust and matc …
Cell lineage tracing in the retina: Could material transfer distort conclusions?
Boudreau-Pinsonneault C and Cayouette M. Dev Dyn 2018 - Review. PMID 28643368 Free article.
While clearly impacting the interpretation of transplantation studies in the retina, the potential impact of material transfer in other experimental paradigms using cell-specific labels remains uncertain. Here, we briefly review the evidence supporting material transfer in transplantation studies and discuss whether it might influence retinal cell lineage tracing experiments in developmental and regeneration studies. ...
While clearly impacting the interpretation of transplantation studies in the retina, the potential impact of material transfer in other expe …
Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging.
Wu SS, et al. Mol Cells 2019 - Review. PMID 30764600 Free PMC article.
In this review, we will introduce such novel computational methods, starting from single-cell RNA sequencing-based lineage analysis to DNA barcoding or genetic scar analysis. These novel approaches are complementary to conventional imaging-based approaches and enable us to study the lineage relationships of numerous cell types during vertebrate, and in particular human, development and disease....
In this review, we will introduce such novel computational methods, starting from single-cell RNA sequencing-based lineage ana …
Cell lineage branching as a strategy for proliferative control.
Buzi G, et al. BMC Biol 2015. PMID 25857410 Free PMC article.
Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understanding of what lineage feedback accomplishes is lacking. ...CONCLUSIONS: Regulated lineage branching is an effective strategy for dealing with disturbances in stem cell systems. The existence of this strategy provides a dynamics-based justification for feedback control of cell fate in vivo....
Experiments and mathematical modeling implicate feedback control of cell lineage progression, but a broad understanding of wha …
Robust lineage reconstruction from high-dimensional single-cell data.
Giecold G, et al. Nucleic Acids Res 2016. PMID 27207878 Free PMC article.
However, cell lineage reconstruction is still often associated with significant uncertainty due to technological constraints. ...We present ECLAIR (Ensemble Cell Lineage Analysis with Improved Robustness), a novel computational method for the statistical inference of cell lineage relationships from single-cell gene expression data. ...
However, cell lineage reconstruction is still often associated with significant uncertainty due to technological constraints. …
Transcriptional Convergence of Oligodendrocyte Lineage Progenitors during Development.
Marques S, et al. Dev Cell 2018. PMID 30078729 Free PMC article.
Here, we present bulk and single-cell transcriptomics resources providing insights on how transitions between these states occur. ...Single-cell RNA-seq and lineage tracing indicates that a subset of E13.5 Pdgfra+ cells originates cells of the pericyte lineage. ...
Here, we present bulk and single-cell transcriptomics resources providing insights on how transitions between these states occur. ... …
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