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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 3
1961 1
1962 1
1981 1
1987 3
1989 1
1993 2
1994 3
1995 98
1996 286
1997 291
1998 366
1999 459
2000 558
2001 721
2002 903
2003 852
2004 965
2005 1093
2006 1076
2007 1154
2008 1249
2009 1340
2010 1508
2011 1343
2012 1402
2013 1718
2014 1610
2015 1509
2016 1562
2017 1424
2018 1254
2019 469
2020 7
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23,142 results
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Page 1
Single-Cell Transcriptomics Meets Lineage Tracing.
Kester L and van Oudenaarden A. Cell Stem Cell 2018 - Review. PMID 29754780 Free article.
Currently, lineage trajectories can also be predicted using single-cell transcriptomics. Although single-cell transcriptomics provides detailed phenotypic information, the predicted lineage trajectories do not necessarily reflect genetic relationships. ...In this Review, we discuss transcriptome-based lineage trajectory prediction algorithms, single-cell genetic lineage tracing, and the promising combination of these techniques for stem cell and cancer research....
Currently, lineage trajectories can also be predicted using single-cell transcriptomics. Although single-cell transcrip …
Building a lineage from single cells: genetic techniques for cell lineage tracking.
Woodworth MB, et al. Nat Rev Genet 2017 - Review. PMID 28111472 Free PMC article.
Although lineage tracking through the injection of retroviral libraries has long been the state of the art, a recent explosion of methodological advances in exogenous labelling and single-cell sequencing have enabled lineage tracking at larger scales, in more detail, and in a wider range of species than was previously considered possible. In this Review, we discuss these techniques for cell lineage tracking, with attention both to those that trace lineage forwards from experimental labelling, and those that trace backwards across the life history of an organism....
Although lineage tracking through the injection of retroviral libraries has long been the state of the art, a recent explosion of met …
Tracing cell-lineage histories.
Burgess DJ. Nat Rev Genet 2018. PMID 29713013
Cell lineage tracing in the retina: Could material transfer distort conclusions?
Boudreau-Pinsonneault C and Cayouette M. Dev Dyn 2018 - Review. PMID 28643368 Free article.
While clearly impacting the interpretation of transplantation studies in the retina, the potential impact of material transfer in other experimental paradigms using cell-specific labels remains uncertain. Here, we briefly review the evidence supporting material transfer in transplantation studies and discuss whether it might influence retinal cell lineage tracing experiments in developmental and regeneration studies. ...
While clearly impacting the interpretation of transplantation studies in the retina, the potential impact of material transfer in other expe …
Single-cell transcriptomic analysis of oligodendrocyte lineage cells.
van Bruggen D, et al. Curr Opin Neurobiol 2017 - Review. PMID 29126015 Free article.
In this review, we focus on recent advances in single-cell transcriptomics suggesting that OLs are more heterogeneous than previously thought, with defined subpopulations and cell states that are associated with different stages of lineage progression and might also represent distinct functional states....
In this review, we focus on recent advances in single-cell transcriptomics suggesting that OLs are more heterogeneous than previously …
Single-nucleus and single-cell transcriptomes compared in matched cortical cell types.
Bakken TE, et al. PLoS One 2018. PMID 30586455 Free PMC article.
Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq) affords some advantages over single-cell RNA-sequencing (scRNA-seq). snRNA-seq provides less biased cellular coverage, does not appear to suffer cell isolation-based transcriptional artifacts, and can be applied to archived frozen specimens. We used well-matched snRNA-seq and scRNA-seq datasets from mouse visual cortex to compare cell type detection. Although more transcripts are detected in individual whole cells (~11,000 genes) than nuclei (~7,000 genes), we demonstrate that closely related neuronal cell types can be similarly discriminated with both methods if intronic sequences are included in snRNA-seq analysis. ...
Transcriptomic profiling of complex tissues by single-nucleus RNA-sequencing (snRNA-seq) affords some advantages over single-cell RNA …
Targeting the tumour stroma to improve cancer therapy
Valkenburg KC, et al. Nat Rev Clin Oncol 2018 - Review. PMID 29651130 Free PMC article.
Cancers are not composed merely of cancer cells alone; instead, they are complex 'ecosystems' comprising many different cell types and noncellular factors. ...Herein, we provide an overview of the advances in understanding the complex cancer cell-tumour stroma interactions and discuss how this knowledge can result in more effective therapeutic strategies, which might ultimately improve patient outcomes....
Cancers are not composed merely of cancer cells alone; instead, they are complex 'ecosystems' comprising many different cell types an …
Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging.
Wu SS, et al. Mol Cells 2019 - Review. PMID 30764600 Free PMC article.
In this review, we will introduce such novel computational methods, starting from single-cell RNA sequencing-based lineage analysis to DNA barcoding or genetic scar analysis. These novel approaches are complementary to conventional imaging-based approaches and enable us to study the lineage relationships of numerous cell types during vertebrate, and in particular human, development and disease....
In this review, we will introduce such novel computational methods, starting from single-cell RNA sequencing-based lineage ana …
Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast.
Stirparo GG, et al. Development 2018. PMID 29361568 Free PMC article.
We identify key transcriptional features over developmental time and elucidate lineage-specific regulatory networks. We resolve post-hoc cell-type assignment in the blastocyst, and define robust transcriptional prototypes that capture epiblast and primitive endoderm lineages. ...Our approach thus clarifies understanding both of lineage segregation in the early human embryo and of in vitro stem cell identity, and provides an analytical resource for comparative molecular embryology....
We identify key transcriptional features over developmental time and elucidate lineage-specific regulatory networks. We resolve post- …
Defining dendritic cells
Schraml BU and Reis e Sousa C. Curr Opin Immunol 2015 - Review. PMID 25553392 Free article.
Traditionally, DCs have been defined on the basis of cell morphology, expression of specific markers and select functional attributes such as the ability to migrate to T cell areas of secondary lymphoid organs and activate T lymphocytes. ...Phenotypic-based and function-based definitions can therefore lead to difficulties in cell identification. Here we review other approaches to try and solve questions of DC lineage attribution with an emphasis on recent insights arising from our increased understanding of DC ontogeny and differentiation....
Traditionally, DCs have been defined on the basis of cell morphology, expression of specific markers and select functional attributes …
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