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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1995 1
1996 5
1997 15
1998 31
1999 30
2000 28
2001 41
2002 88
2003 72
2004 82
2005 137
2006 113
2007 130
2008 128
2009 125
2010 146
2011 141
2012 149
2013 189
2014 195
2015 208
2016 209
2017 157
2018 150
2019 65
2020 1
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2,430 results
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Page 1
Single-Cell Transcriptomics Meets Lineage Tracing.
Kester L and van Oudenaarden A. Cell Stem Cell 2018 - Review. PMID 29754780 Free article.
Currently, lineage trajectories can also be predicted using single-cell transcriptomics. Although single-cell transcriptomics provides detailed phenotypic information, the predicted lineage trajectories do not necessarily reflect genetic relationships. ...In this Review, we discuss transcriptome-based lineage trajectory prediction algorithms, single-cell genetic lineage tracing, and the promising combination of these techniques for stem cell and cancer research....
Currently, lineage trajectories can also be predicted using single-cell transcriptomics. Although single-cell transcrip …
Human haematopoietic stem cell lineage commitment is a continuous process.
Velten L, et al. Nat Cell Biol 2017. PMID 28319093 Free PMC article.
However, this model is based on the analysis of predefined flow-sorted cell populations. Here we integrated flow cytometric, transcriptomic and functional data at single-cell resolution to quantitatively map early differentiation of human HSCs towards lineage commitment. During homeostasis, individual HSCs gradually acquire lineage biases along multiple directions without passing through discrete hierarchically organized progenitor populations. ...
However, this model is based on the analysis of predefined flow-sorted cell populations. Here we integrated flow cytometric, transcri …
Single-cell analysis of progenitor cell dynamics and lineage specification in the human fetal kidney.
Menon R, et al. Development 2018. PMID 30166318 Free PMC article.
In order to shed light on human kidney development, we have used single-cell transcriptomics to characterize gene expression in different cell populations, and to study individual cell dynamics and lineage trajectories during development. Single-cell transcriptome analyses of 6414 cells from five individual specimens identified 11 initial clusters of specific renal cell types as defined by their gene expression profile. ...
In order to shed light on human kidney development, we have used single-cell transcriptomics to characterize gene expression in diffe …
Lineage dynamics of murine pancreatic development at single-cell resolution.
Byrnes LE, et al. Nat Commun 2018. PMID 30254276 Free PMC article.
Here, we profile the cell types within the epithelial and mesenchymal compartments of the murine pancreas across developmental time using a combination of single-cell RNA sequencing, immunofluorescence, in situ hybridization, and genetic lineage tracing. We identify previously underappreciated cellular heterogeneity of the developing mesenchyme and reconstruct potential lineage relationships among the pancreatic mesothelium and mesenchymal cell types. ...
Here, we profile the cell types within the epithelial and mesenchymal compartments of the murine pancreas across developmental time u …
Hematopoietic stem cell lineage specification.
Pouzolles M, et al. Curr Opin Hematol 2016 - Review. PMID 27135980
This review introduces recent advances in the roles played by the stem cell niche, regulatory transcriptional networks, and metabolic pathways in governing HSC self-renewal, commitment, and lineage differentiation. ...Once HSCs begin their lineage specification, single-cell analyses show that they do not become oligopotent but rather, differentiate directly into committed unipotent progenitors. ...
This review introduces recent advances in the roles played by the stem cell niche, regulatory transcriptional networks, and metabolic …
Mechanisms of radial glia progenitor cell lineage progression.
Beattie R and Hippenmeyer S. FEBS Lett 2017 - Review. PMID 29121403 Free PMC article.
Here, we discuss recent discoveries emerging from clonal lineage analysis at the single RGP cell level that provide us with an inaugural quantitative framework of RGP lineage progression. We further discuss the importance of the relative contribution of intrinsic gene functions and non-cell-autonomous or community effects in regulating RGP proliferation behavior and lineage progression....
Here, we discuss recent discoveries emerging from clonal lineage analysis at the single RGP cell level that provide us with an …
The Unfolded Protein Response and Cell Fate Control.
Hetz C and Papa FR. Mol Cell 2018 - Review. PMID 29107536 Free article.
The secretory capacity of a cell is constantly challenged by physiological demands and pathological perturbations. To adjust and match the protein-folding capacity of the endoplasmic reticulum (ER) to changing secretory needs, cells employ a dynamic intracellular signaling pathway known as the unfolded protein response (UPR). ...Here, we discuss recent advances into how the UPR integrates information about the intensity and duration of ER stress stimuli in order to control cell fate. ...
The secretory capacity of a cell is constantly challenged by physiological demands and pathological perturbations. To adjust and matc …
Building a lineage from single cells: genetic techniques for cell lineage tracking.
Woodworth MB, et al. Nat Rev Genet 2017 - Review. PMID 28111472 Free PMC article.
Although lineage tracking through the injection of retroviral libraries has long been the state of the art, a recent explosion of methodological advances in exogenous labelling and single-cell sequencing have enabled lineage tracking at larger scales, in more detail, and in a wider range of species than was previously considered possible. In this Review, we discuss these techniques for cell lineage tracking, with attention both to those that trace lineage forwards from experimental labelling, and those that trace backwards across the life history of an organism....
Although lineage tracking through the injection of retroviral libraries has long been the state of the art, a recent explosion of met …
Multiplex cell and lineage tracking with combinatorial labels.
Loulier K, et al. Neuron 2014. PMID 24507188 Free article.
We present a method to label and trace the lineage of multiple neural progenitors simultaneously in vertebrate animals via multiaddressable genome-integrative color (MAGIC) markers. ...Color labels delineate cytoarchitecture, resolve spatially intermixed clones, and specify the lineage of astroglial subtypes and adult neural stem cells. ...
We present a method to label and trace the lineage of multiple neural progenitors simultaneously in vertebrate animals via multiaddre …
Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging.
Wu SS, et al. Mol Cells 2019 - Review. PMID 30764600 Free PMC article.
In this review, we will introduce such novel computational methods, starting from single-cell RNA sequencing-based lineage analysis to DNA barcoding or genetic scar analysis. These novel approaches are complementary to conventional imaging-based approaches and enable us to study the lineage relationships of numerous cell types during vertebrate, and in particular human, development and disease....
In this review, we will introduce such novel computational methods, starting from single-cell RNA sequencing-based lineage ana …
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