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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1951 2
1952 1
1957 3
1958 5
1959 14
1960 8
1961 28
1962 13
1963 2
1964 20
1965 72
1966 261
1967 335
1968 414
1969 482
1970 506
1971 679
1972 816
1973 917
1974 1061
1975 1124
1976 1035
1977 993
1978 1008
1979 925
1980 903
1981 860
1982 895
1983 787
1984 837
1985 808
1986 711
1987 759
1988 678
1989 928
1990 1146
1991 853
1992 1011
1993 1289
1994 1354
1995 1470
1996 1528
1997 1590
1998 1820
1999 2223
2000 2652
2001 3288
2002 3349
2003 3670
2004 4006
2005 3880
2006 3834
2007 4041
2008 4174
2009 4239
2010 4462
2011 4786
2012 4803
2013 4642
2014 4205
2015 3955
2016 4067
2017 3861
2018 3533
2019 1587
2020 21
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Search Results

103,161 results
Results by year
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Page 1
Cellular senescence and its effector programs
Salama R, et al. Genes Dev 2014 - Review. PMID 24449267 Free PMC article.
Cellular senescence is a stress response that accompanies stable exit from the cell cycle. Classically, senescence, particularly in human cells, involves the p53 and p16/Rb pathways, and often both of these tumor suppressor pathways need to be abrogated to bypass senescence. ...These studies suggest that senescence is a collective phenotype of these multiple effectors, and their intensity and combination can be different depending on triggers and cell types, conferring a complex and diverse nature to senescence. ...
Cellular senescence is a stress response that accompanies stable exit from the cell cycle. Classically, senescence, particularly in h …
The dynamic lifecycle of mRNA in the nucleus.
Ben-Yishay R and Shav-Tal Y. Curr Opin Cell Biol 2019 - Review. PMID 30889416
The mRNA molecule roams through the nucleus on its way out to the cytoplasm. mRNA encounters and is bound by many protein factors, from the moment it begins to emerge from RNA polymerase II and during its travel in the nucleoplasm, where it will come upon chromatin and nuclear bodies. ...
The mRNA molecule roams through the nucleus on its way out to the cytoplasm. mRNA encounters and is bound by many protein factors, fr …
The Dynamic Nature of the Nuclear Envelope
De Magistris P and Antonin W. Curr Biol 2018 - Review. PMID 29689232 Free article.
Eukaryotes characteristically organize their genome in a separate compartment, the nucleus, which is surrounded by the nuclear envelope as a barrier. ...We discuss how the nuclear envelope is remodeled to insert nuclear pore complexes, the transport gates of the nucleus, into its double membrane structure. ...
Eukaryotes characteristically organize their genome in a separate compartment, the nucleus, which is surrounded by the nuclear envelo …
The Nuclear Lamina as an Organizer of Chromosome Architecture
Shevelyov YY and Ulianov SV. Cells 2019 - Review. PMID 30744037 Free PMC article.
In early embryonic cells, the NL mainly suppresses background transcription, whereas, in differentiated cell types, its disruption affects gene expression more severely. Normally, the NL serves as a backbone for multiple chromatin anchoring sites, thus shaping the spatial organization of chromosomes in the interphase nucleus. ...
In early embryonic cells, the NL mainly suppresses background transcription, whereas, in differentiated cell types, its disruption af …
On the origin of shape fluctuations of the cell nucleus.
Chu FY, et al. Proc Natl Acad Sci U S A 2017. PMID 28900009 Free PMC article.
NE defines the shape and size of the cell nucleus, which increases during the cell cycle, accommodating for chromosome decondensation followed by genome duplication. ...Our findings reveal that fluctuation amplitudes of both CGS and NE monotonously decrease during the cell cycle, serving as a reliable cell cycle stage indicator. ...
NE defines the shape and size of the cell nucleus, which increases during the cell cycle, accommodating for chromosome …
The nucleolus under stress
Boulon S, et al. Mol Cell 2010 - Review. PMID 20965417 Free PMC article.
Cells typically respond quickly to stress, altering their metabolism to compensate. In mammalian cells, stress signaling usually leads to either cell-cycle arrest or apoptosis, depending on the severity of the insult and the ability of the cell to recover. ...
Cells typically respond quickly to stress, altering their metabolism to compensate. In mammalian cells, stress signaling usually lead …
Fantastic nuclear envelope herniations and where to find them
Thaller DJ and Patrick Lusk C. Biochem Soc Trans 2018 - Review. PMID 30026368 Free PMC article.
Morphological abnormalities of the bounding membranes of the nucleus have long been associated with human diseases from cancer to premature aging to neurodegeneration. Studies over the past few decades support that there are both cell intrinsic and extrinsic factors (e.g. mechanical force) that can lead to nuclear envelope 'herniations', a broad catch-all term that reveals little about the underlying molecular mechanisms that contribute to these morphological defects. ...
Morphological abnormalities of the bounding membranes of the nucleus have long been associated with human diseases from cancer to pre …
Non-coding RNAs and chromatin domains
Yamamoto T and Saitoh N. Curr Opin Cell Biol 2019 - Review. PMID 30682683
Many of them are in the nucleus, where they associate with chromatin and regulate its structure and function. Interphase chromosomes are intricately folded into multiple layers and composed of domains. ...Some ncRNAs form RNA clouds in the nucleus and coordinate the transcription of multiple genes in a chromatin domain. In this review, we describe the emerging link between long ncRNAs and chromatin domains in the nucleus....
Many of them are in the nucleus, where they associate with chromatin and regulate its structure and function. Interphase chromosomes …
103,161 results
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