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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 14
1946 41
1947 44
1948 46
1949 37
1950 53
1951 124
1952 101
1953 109
1954 148
1955 97
1956 114
1957 119
1958 125
1959 134
1960 165
1961 210
1962 279
1963 460
1964 907
1965 764
1966 574
1967 438
1968 262
1969 339
1970 269
1971 338
1972 280
1973 389
1974 413
1975 398
1976 442
1977 347
1978 307
1979 304
1980 372
1981 248
1982 248
1983 222
1984 189
1985 198
1986 202
1987 239
1988 308
1989 332
1990 438
1991 498
1992 578
1993 523
1994 501
1995 559
1996 547
1997 528
1998 537
1999 589
2000 669
2001 861
2002 762
2003 851
2004 1185
2005 2029
2006 2403
2007 2653
2008 2751
2009 2825
2010 3054
2011 3164
2012 3257
2013 3366
2014 3920
2015 4408
2016 3956
2017 4126
2018 4089
2019 1857
2020 31
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63,313 results
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Page 1
Cell Proliferation and Cytotoxicity Assays.
Adan A, et al. Curr Pharm Biotechnol 2016 - Review. PMID 27604355
Cell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for understanding the mechanisms in action of certain genes, proteins and pathways involved cell survival or death after exposing to toxic agents. Generally, methods used to determine viability are also common for the detection of cell proliferation. Cell cytotoxicity and proliferation assays are generally used for drug screening to detect whether the test molecules have effects on cell proliferation or display direct cytotoxic effects. ...
Cell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for under
Regulation of cell proliferation by hypoxia-inducible factors.
Hubbi ME and Semenza GL. Am J Physiol Cell Physiol 2015 - Review. PMID 26491052 Free PMC article.
One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, hypoxia induces decreased cell proliferation, since an increased number of cells, with a consequent increase in O2 demand, would only exacerbate hypoxic stress. ...This review will discuss major molecular mechanisms by which hypoxia regulates cell proliferation in different cell populations, with a particular focus on the role of hypoxia-inducible factors....
One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, …
Quantification of epithelial cell proliferation, cell dynamics, and cell kinetics in vivo.
Goodlad RA. Wiley Interdiscip Rev Dev Biol 2017 - Review. PMID 28474479
The measurement of cell proliferation in vivo is usually carried out by the examination of static measures. These comprise the mitotic index or labeling indices using incorporation of DNA synthesis markers such as bromodeoxyuridine or tritiated thymidine, or intrinsic markers, such as Ki67 and proliferative cell nuclear antigen (PCNA). But static measures only provide a 'snapshot' of cell proliferation. Rate measures, including double labeling methods and the metaphase arrest method, can actually measure cell production rates but they are far less utilized at present. ...
The measurement of cell proliferation in vivo is usually carried out by the examination of static measures. These comprise the …
Mathematical models of tumor cell proliferation: A review of the literature.
Jarrett AM, et al. Expert Rev Anticancer Ther 2018 - Review. PMID 30252552 Free PMC article.
Central to proliferation modeling is the incorporation of available biological data and validation with experimental data. Areas covered: We present an overview of past and current mathematical strategies directed at understanding tumor cell proliferation. ...We suggest areas for further investigation to establish mathematical models that more effectively utilize available data to make informed predictions on tumor cell proliferation....
Central to proliferation modeling is the incorporation of available biological data and validation with experimental data. Areas cove …
Cell-Based High Content Analysis of Cell Proliferation and Apoptosis.
Mandavilli BS, et al. Methods Mol Biol 2018. PMID 29082486
High content imaging-based cell cycle analysis allows multiplexing of various parameters including DNA content, DNA synthesis, cell proliferation, and other cell cycle markers such as phosho-histone H3. 5'-Ethynyl-2'-deoxyuridine (EdU) incorporation is a thymidine analog that provides a sensitive method for the detection of DNA synthesis in proliferating cells that is a more convenient method than the traditional BrdU detection by antibody. ...Cell cycle and apoptosis are common parameters studied in the phenotypic analysis of compound toxicity and anti-cancer drugs. ...
High content imaging-based cell cycle analysis allows multiplexing of various parameters including DNA content, DNA synthesis, cel
Clonogenic assay of cells in vitro
Franken NA, et al. Nat Protoc 2006. PMID 17406473
Clonogenic assay or colony formation assay is an in vitro cell survival assay based on the ability of a single cell to grow into a colony. ...The assay essentially tests every cell in the population for its ability to undergo "unlimited" division. Clonogenic assay is the method of choice to determine cell reproductive death after treatment with ionizing radiation, but can also be used to determine the effectiveness of other cytotoxic agents. ...
Clonogenic assay or colony formation assay is an in vitro cell survival assay based on the ability of a single cell to grow in …
Cell competition: Emerging mechanisms to eliminate neighbors.
Nagata R and Igaki T. Dev Growth Differ 2018 - Review. PMID 30443922
Cell competition is a context-dependent cell elimination through short-range cell-cell interaction, in which cells with higher fitness eliminate neighboring less-fit or oncogenic cells within the growing tissue. ...The later type of cell competition includes tumor-suppressive cell competition triggered by loss of cell polarity genes such as scribble (scrib) or discs large (dlg). ...
Cell competition is a context-dependent cell elimination through short-range cell-cell interaction, in which cel
Satellite Cell Self-Renewal.
Giordani L, et al. Curr Top Dev Biol 2018 - Review. PMID 29304998
Upon acute injury or in pathological conditions, quiescent muscle-resident stem cells, called satellite cells, become activated and give rise to myogenic progenitors that massively proliferate, differentiate, and fuse to form new myofibers and restore tissue functionality. ...This process is controlled by cell-intrinsic transcription factors regulated by cell-extrinsic signals from the niche and the microenvironment. ...
Upon acute injury or in pathological conditions, quiescent muscle-resident stem cells, called satellite cells, become activated and give ris …
Simvastatin Inhibits Cell Proliferation and Migration in Human Anaplastic Thyroid Cancer.
Chen MC, et al. Int J Mol Sci 2017. PMID 29236027 Free PMC article.
Adding MEV and GGpp prevented the simvastatin-inhibited cell proliferation. Immunoblotting analysis illustrated that simvastatin diminished the activation of RhoA and Rac1 protein, and this effect was prevented by pre-treatment with MEV and GGpp. ...Introduction of Cyr61 siRNA into ATC cells prevented the epidermal growth factor (EGF)-enhanced cell migration. The EGF-induced increases of Cyr61 protein expression and cell migration were prevented by simvastatin. ...
Adding MEV and GGpp prevented the simvastatin-inhibited cell proliferation. Immunoblotting analysis illustrated that simvastat …
Drug with Neuroprotective Properties Noopept Does Not Stimulate Cell Proliferation.
Zainullina LF, et al. Bull Exp Biol Med 2019. PMID 30788746
Effects of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell cycle parameters were studied in HEK293 and SH-SY5Y cell lines. ...The possible mitogenic action of Noopept was estimated by its effect on cell proliferation. Noopept did not affect cell distribution over G1, S, G2 cell cycle phases and the relative level of proliferation marker Ki-67 in the cell lines under study. ...
Effects of Noopept (N-phenylacetyl-L-prolylglycine ethyl ester) on the relative level of proliferation marker Ki-67 and cell c …
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