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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1945 14
1946 41
1947 44
1948 46
1949 37
1950 53
1951 124
1952 101
1953 109
1954 148
1955 97
1956 114
1957 119
1958 125
1959 134
1960 165
1961 210
1962 279
1963 463
1964 916
1965 912
1966 902
1967 840
1968 583
1969 782
1970 834
1971 1130
1972 1090
1973 1656
1974 2171
1975 2119
1976 1944
1977 2007
1978 1559
1979 1706
1980 2015
1981 1970
1982 2034
1983 2198
1984 2405
1985 2734
1986 2455
1987 2934
1988 3297
1989 3765
1990 4635
1991 4917
1992 5339
1993 5836
1994 6227
1995 6607
1996 6820
1997 6882
1998 7170
1999 7480
2000 8025
2001 8960
2002 9344
2003 10388
2004 11459
2005 12419
2006 12861
2007 13359
2008 14679
2009 15185
2010 16841
2011 17726
2012 19376
2013 21020
2014 21965
2015 22970
2016 22770
2017 22849
2018 23204
2019 11833
2020 317
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393,293 results
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Page 1
Cell Proliferation and Cytotoxicity Assays.
Adan A, et al. Curr Pharm Biotechnol 2016 - Review. PMID 27604355
Cell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for understanding the mechanisms in action of certain genes, proteins and pathways involved cell survival or death after exposing to toxic agents. Generally, methods used to determine viability are also common for the detection of cell proliferation. Cell cytotoxicity and proliferation assays are generally used for drug screening to detect whether the test molecules have effects on cell proliferation or display direct cytotoxic effects. ...
Cell viability is defined as the number of healthy cells in a sample and proliferation of cells is a vital indicator for under
Regulation of cell proliferation by hypoxia-inducible factors.
Hubbi ME and Semenza GL. Am J Physiol Cell Physiol 2015 - Review. PMID 26491052 Free PMC article.
One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, hypoxia induces decreased cell proliferation, since an increased number of cells, with a consequent increase in O2 demand, would only exacerbate hypoxic stress. ...This review will discuss major molecular mechanisms by which hypoxia regulates cell proliferation in different cell populations, with a particular focus on the role of hypoxia-inducible factors....
One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, …
Mathematical models of tumor cell proliferation: A review of the literature.
Jarrett AM, et al. Expert Rev Anticancer Ther 2018 - Review. PMID 30252552 Free PMC article.
Central to proliferation modeling is the incorporation of available biological data and validation with experimental data. Areas covered: We present an overview of past and current mathematical strategies directed at understanding tumor cell proliferation. ...We suggest areas for further investigation to establish mathematical models that more effectively utilize available data to make informed predictions on tumor cell proliferation....
Central to proliferation modeling is the incorporation of available biological data and validation with experimental data. Areas cove …
Clonogenic assay of cells in vitro
Franken NA, et al. Nat Protoc 2006. PMID 17406473
Clonogenic assay or colony formation assay is an in vitro cell survival assay based on the ability of a single cell to grow into a colony. ...The assay essentially tests every cell in the population for its ability to undergo "unlimited" division. Clonogenic assay is the method of choice to determine cell reproductive death after treatment with ionizing radiation, but can also be used to determine the effectiveness of other cytotoxic agents. ...
Clonogenic assay or colony formation assay is an in vitro cell survival assay based on the ability of a single cell to grow in …
Disproportionate feedback interactions govern cell-type specific proliferation in mammalian cells.
Sengupta D, et al. FEBS Lett 2018. PMID 30192983 Free article.
The model analysis reveals that the feedback motifs responsible for the G(1) -S transition act in a disparate fashion to organize the cell-type specific proliferation response. Importantly, the proposed model can be effectively tuned to gain insights into the proliferation commitment of diverse mammalian cell types and can find wide applicability....
The model analysis reveals that the feedback motifs responsible for the G(1) -S transition act in a disparate fashion to organize the cel
Research Techniques Made Simple: Techniques to Assess Cell Proliferation.
Romar GA, et al. J Invest Dermatol 2016. PMID 26763463 Free article.
Therefore, both researchers and clinicians should have a basic understanding of techniques used to assess cell proliferation. ...In this article, we identify four overarching categories of cell proliferation assays that signify various stages of the cell cycle: nucleoside-analog incorporation, cell cycle-associated protein detection, use of cytoplasmic proliferation dyes, and indirect measures of cell proliferation. ...
Therefore, both researchers and clinicians should have a basic understanding of techniques used to assess cell proliferation. …
Host tissue determinants of tumour immunity
Salmon H, et al. Nat Rev Cancer 2019 - Review. PMID 30867580
Recent studies have established that, in addition to cell-intrinsic effects, tumour growth regulation also depends on local cues driven by tissue environmental factors. ...
Recent studies have established that, in addition to cell-intrinsic effects, tumour growth regulation also depends on local cues driv …
Evaluating the Remote Control of Programmed Cell Death, with or without a Compensatory Cell Proliferation.
Dou X, et al. Int J Biol Sci 2018 - Review. PMID 30443184 Free PMC article.
Currently, it is still unclear whether a cell has only one death program or has several programs respectively controlling SD, apoptosis and SICD. ...In animals, apoptosis can occur only in those cell types that retain a lifelong ability of proliferation and never occurs in those cell types that can no longer replicate in adulthood. ...
Currently, it is still unclear whether a cell has only one death program or has several programs respectively controlling SD, apoptos …
Postnatal β-cell proliferation and mass expansion is dependent on the transcription factor Nkx6.1.
Taylor BL, et al. Diabetes 2015. PMID 25277396 Free PMC article.
In addition, Nkx6.1 has been proposed to control β-cell proliferation, but a role for Nkx6.1 in regulating β-cell mass has not been demonstrated. ...Identification of β-cell-intrinsic regulators that connect nutrient-sensing and proliferation suggests new therapeutic targets for expanding functional β-cell mass....
In addition, Nkx6.1 has been proposed to control β-cell proliferation, but a role for Nkx6.1 in regulating β-cell mass …
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