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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1968 3
1974 4
1977 1
1982 1
1989 15
1990 46
1991 87
1992 132
1993 102
1994 129
1995 124
1996 124
1997 171
1998 224
1999 189
2000 253
2001 337
2002 339
2003 430
2004 499
2005 440
2006 448
2007 470
2008 433
2009 535
2010 519
2011 547
2012 529
2013 560
2014 572
2015 503
2016 443
2017 446
2018 413
2019 200
2020 3
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9,317 results
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Page 1
Regulation of cell proliferation by hypoxia-inducible factors.
Hubbi ME and Semenza GL. Am J Physiol Cell Physiol 2015 - Review. PMID 26491052 Free PMC article.
One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, hypoxia induces decreased cell proliferation, since an increased number of cells, with a consequent increase in O2 demand, would only exacerbate hypoxic stress. However, certain cell populations maintain cell proliferation in the face of hypoxia. This is a common pathological hallmark of cancers, but can also serve a physiological function, as in the maintenance of stem cell populations that reside in a hypoxic niche. ...
One of the key cell-autonomous effects of hypoxia is as a modulator of cell proliferation. For most cell types, hypoxia …
Otto Warburg's contributions to current concepts of cancer metabolism
Koppenol WH, et al. Nat Rev Cancer 2011 - Review. PMID 21508971
Otto Warburg pioneered quantitative investigations of cancer cell metabolism, as well as photosynthesis and respiration. Warburg and co-workers showed in the 1920s that, under aerobic conditions, tumour tissues metabolize approximately tenfold more glucose to lactate in a given time than normal tissues, a phenomenon known as the Warburg effect. However, this increase in aerobic glycolysis in cancer cells is often erroneously thought to occur instead of mitochondrial respiration and has been misinterpreted as evidence for damage to respiration instead of damage to the regulation of glycolysis. ...
Otto Warburg pioneered quantitative investigations of cancer cell metabolism, as well as photosynthesis and respiration. Warbu …
Variability of mitochondrial respiration in relation to sepsis-induced multiple organ dysfunction.
Kohoutová M, et al. Physiol Res 2018 - Review. PMID 30607965 Free article.
This review is primarily focused on mitochondrial oxygen consumption in various animal models of sepsis in relation to human disease and potential sources of variability in experimental results documenting decrease, increase or no change in mitochondrial respiration in various organs and species. To date, at least three possible explanations of sepsis-associated dysfunction of the mitochondrial respiratory system and consequently impaired energy production have been suggested: 1. ...
This review is primarily focused on mitochondrial oxygen consumption in various animal models of sepsis in relation to human disease and pot …
High-resolution Respirometry to Assess Mitochondrial Function in Permeabilized and Intact Cells.
Djafarzadeh S and Jakob SM. J Vis Exp 2017. PMID 28287504 Free PMC article.
The technique can be applied to measure respiration in a wide range of cell types and also provides information on mitochondrial quality and integrity, and maximal mitochondrial respiratory electron transport system capacity....
The technique can be applied to measure respiration in a wide range of cell types and also provides information on mitochondri …
Hypoxia-/HIF-1α-Driven Factors of the Tumor Microenvironment Impeding Antitumor Immune Responses and Promoting Malignant Progression
Vaupel P and Multhoff G. Adv Exp Med Biol 2018 - Review. PMID 30178341
., Treg, MDSC], secretion of immune-suppressive TH2-type cytokines), and (b) inhibition of antitumor immune responses (inhibition of immune cell actions [e.g., NK, NKT, CD4(+), CD8(+)], inhibition of antigen-presenting cells [e.g., DC], reduced production of immune-stimulatory TH1-type cytokines)....
., Treg, MDSC], secretion of immune-suppressive TH2-type cytokines), and (b) inhibition of antitumor immune responses (inhibition of immune …
Cell-Autonomous Metabolic Reprogramming in Hypoxia.
Schito L and Rey S. Trends Cell Biol 2018 - Review. PMID 29191366
Molecular oxygen (O(2)) is a universal electron acceptor that enables ATP synthesis through mitochondrial respiration in all metazoans. ...In this review we summarize current and emerging cell-autonomous molecular mechanisms that induce hypoxic metabolic reprogramming in health and disease....
Molecular oxygen (O(2)) is a universal electron acceptor that enables ATP synthesis through mitochondrial respiration in all metazoan …
High Altitude Pulmonary Hypertension
Bussotti M and Marchese G. Cardiovasc Hematol Disord Drug Targets 2018 - Review. PMID 29773069
The knowledge of the discrete mechanisms allowing the acclimatization both at genetic level or through the cell mediators production in addition to the macroscopic responses of the cardio-circulatory and ventilatory systems to a hypoxic environment has been progressively developed since the last century; moreover granting a safer stay in hypoxic conditions not only for the residents but also for the different cathegories of workers, sportsmen and tourists has been considered a worthy aim of the medical activity. ...
The knowledge of the discrete mechanisms allowing the acclimatization both at genetic level or through the cell mediators production …
Mitophagy: Link to cancer development and therapy
Kulikov AV, et al. Biochem Biophys Res Commun 2017 - Review. PMID 28212727
Pathways involved in the regulation of mitophagy, tumorigenesis, and cell death are overlapping in many cases and may be triggered by common upstream signals, which converge at the mitochondria. ...Thus, the analysis of crosstalk among the processes of mitophagy, cell death and tumorigenesis is important for the identification of targets responsible for the stimulation of cell death and selective elimination of cancer cells. ...
Pathways involved in the regulation of mitophagy, tumorigenesis, and cell death are overlapping in many cases and may be triggered by …
Adaptive regulation of glucose transport, glycolysis and respiration for cell proliferation.
Toyoda Y and Saitoh S. Biomol Concepts 2015 - Review. PMID 26418646
The cell must utilise nutrients to generate energy as a means of sustaining its life. As the environment is not necessarily abundant in nutrients and oxygen, the cell must be able to regulate energy metabolism to adapt to changes in extracellular and intracellular conditions. ...
The cell must utilise nutrients to generate energy as a means of sustaining its life. As the environment is not necessarily abundant …
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