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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 62
1990 63
1991 69
1992 76
1993 79
1994 94
1995 90
1996 77
1997 76
1998 91
1999 103
2000 93
2001 103
2002 113
2003 115
2004 159
2005 273
2006 332
2007 335
2008 307
2009 268
2010 296
2011 340
2012 356
2013 380
2014 385
2015 306
2016 255
2017 277
2018 260
2019 301
2020 105
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5,058 results
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Page 1
GPCRs: Emerging anti-cancer drug targets
Nieto Gutierrez A and McDonald PH. Cell Signal 2018 - Review. PMID 28931490
They play critical roles in numerous cellular and physiological processes, including cell proliferation, differentiation, neurotransmission, development and apoptosis. ...
They play critical roles in numerous cellular and physiological processes, including cell proliferation, differentiation, neurotransm …
Smooth muscle cell-driven vascular diseases and molecular mechanisms of VSMC plasticity.
Frismantiene A, et al. Cell Signal 2018 - Review. PMID 30172025
Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike many other mature cell types in the adult body, VSMC do not terminally differentiate but retain a remarkable plasticity. ...
Vascular smooth muscle cells (VSMCs) are the major cell type in blood vessels. Unlike many other mature cell types in the adul …
Emerging role of non-coding RNA in oral cancer
Momen-Heravi F and Bala S. Cell Signal 2018 - Review. PMID 29056500
Oral squamous cell carcinoma (OSCC) is characterized by genomic and epigenomic alterations. However, the mechanisms underlying oral squamous cell carcinoma tumorigenesis and progression remain to be elucidated. ...In this review, we highlight the expression and functional roles of extracellular RNAs, lncRNAs, and circular RNAs in oral squamous cell carcinoma and discuss their potential clinical applications as diagnostic or prognostic biomarkers, and therapeutic targets....
Oral squamous cell carcinoma (OSCC) is characterized by genomic and epigenomic alterations. However, the mechanisms underlying oral s …
Dishevelled: A masterful conductor of complex Wnt signals
Sharma M, et al. Cell Signal 2018 - Review. PMID 29559363 Free PMC article.
Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell proliferation, survival, migration, differentiation, polarity and stem cell renewal. ...
Dishevelled functions as a principal component of Wnt signaling pathway and governs several cellular processes including cell prolife …
Protein neddylation and its alterations in human cancers for targeted therapy
Zhou L, et al. Cell Signal 2018 - Review. PMID 29331584 Free PMC article.
Indeed, neddylation inactivation by MLN4924 (also known as pevonedistat), a small molecule inhibitor of E1 NEDD8-activating enzyme currently in phase I/II clinical trials, exerts significant anticancer effects by inducing cell cycle arrest, apoptosis, senescence and autophagy in a cell-type and context dependent manner. ...
Indeed, neddylation inactivation by MLN4924 (also known as pevonedistat), a small molecule inhibitor of E1 NEDD8-activating enzyme currently …
Evolving complexity of MIF signaling
Jankauskas SS, et al. Cell Signal 2019 - Review. PMID 30682543
Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types, including hematopoietic, epithelial, endothelial, mesenchymal and neuronal cells. ...
Macrophage migration inhibitory factor (MIF) is a cytokine expressed in various cell types, including hematopoietic, epithelial, endo …
Role of cAMP and phosphodiesterase signaling in liver health and disease
Wahlang B, et al. Cell Signal 2018 - Review. PMID 29902522 Free PMC article.
Moreover, certain protective molecular pathways become repressed during liver injury including signaling pathways such as the cyclic adenosine monophosphate (cAMP) pathway. cAMP, a key second messenger molecule, regulates various cellular functions including lipid metabolism, inflammation, cell differentiation and injury by affecting gene/protein expression and function. ...
Moreover, certain protective molecular pathways become repressed during liver injury including signaling pathways such as the cyclic adenosi …
SLFN5 suppresses cancer cell migration and invasion by inhibiting MT1-MMP expression via AKT/GSK-3β/β-catenin pathway.
Wan G, et al. Cell Signal 2019. PMID 30844429
Here we show that SLFN5 expressions on both mRNA and protein levels are significantly higher in non/low-invasive cancer cell lines (breast cancer cell line MCF7, colorectal cancer cell line HCT116 and lung cancer cell line A549) than in highly-invasive cancer cell lines (fibrosarcoma cell line HT1080 and renal clear cell cancer cell line 786-0). SLFN5 knockdown in non/low-invasive cancer cell lines enhanced MT1-MMP expression and increased migration and invasion in vitro, and in vivo. ...
Here we show that SLFN5 expressions on both mRNA and protein levels are significantly higher in non/low-invasive cancer cell lines (b …
5,058 results
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