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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 3
1949 1
1950 2
1951 3
1953 3
1954 1
1955 4
1956 7
1957 7
1958 5
1959 4
1960 2
1961 5
1962 12
1963 10
1964 13
1965 5
1966 2
1967 6
1968 21
1969 8
1970 79
1971 516
1972 824
1973 825
1974 1062
1975 1022
1976 908
1977 1090
1978 1043
1979 1144
1980 1245
1981 1187
1982 1450
1983 1436
1984 1710
1985 1801
1986 1887
1987 1732
1988 1868
1989 2158
1990 2439
1991 2259
1992 1699
1993 1877
1994 2063
1995 2015
1996 2178
1997 2309
1998 2418
1999 2693
2000 3169
2001 3569
2002 3855
2003 4319
2004 5034
2005 5599
2006 6098
2007 6850
2008 7363
2009 7924
2010 8834
2011 9798
2012 11338
2013 12183
2014 12213
2015 12543
2016 12753
2017 12575
2018 12260
2019 6791
2020 129
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191,529 results
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Page 1
Eukaryotic cell survival mechanisms: Disease relevance and therapeutic intervention.
Twayana KS and Ravanan P. Life Sci 2018 - Review. PMID 29730169
However, unresolved stresses exceeding the tolerance limit lead to cell death (apoptosis, autophagy etc.) that helps to get rid of damaged cells and protect cell integrity. ...Whereas pro-survival stress responses redirected to death signaling provokes excessive cell death in neurodegeneration. Clear understanding of such mechanistic link to disease progression is required in order to modulate these processes for new therapeutic targets. ...
However, unresolved stresses exceeding the tolerance limit lead to cell death (apoptosis, autophagy etc.) that helps to get rid of da …
Transcriptional and epigenetic regulation of autophagy in aging
Lapierre LR, et al. Autophagy 2015 - Review. PMID 25836756 Free PMC article.
Macroautophagy is a major intracellular degradation process recognized as playing a central role in cell survival and longevity. ...
Macroautophagy is a major intracellular degradation process recognized as playing a central role in cell survival and longevit …
Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy
Wu J and Waxman DJ. Cancer Lett 2018 - Review. PMID 29414305 Free PMC article.
However, certain cytotoxic cancer chemotherapeutic drugs, including doxorubicin, mitoxantrone, and cyclophosphamide, can kill tumor cells by an immunogenic cell death pathway, which activates robust innate and adaptive anti-tumor immune responses and has the potential to greatly increase the efficacy of chemotherapy. Here, we review studies on chemotherapeutic drug-induced immunogenic cell death, focusing on how the choice of a conventional cytotoxic agent and its dose and schedule impact anti-tumor immune responses. ...
However, certain cytotoxic cancer chemotherapeutic drugs, including doxorubicin, mitoxantrone, and cyclophosphamide, can kill tumor cells by …
Corrupting the DNA damage response: a critical role for Rad52 in tumor cell survival.
Lieberman R and You M. Aging (Albany NY) 2017 - Review. PMID 28722656 Free PMC article.
Upon sensing DNA damage, cells respond by activating this multi-faceted DNA damage response leading to restoration of the cell, senescence, programmed cell death, or genomic instability if the cell survives without proper repair. ...Thus, modulation of DNA repair pathways have important consequences for genomic instability within tumor cell biology and viability maintenance under high genotoxic stress. ...
Upon sensing DNA damage, cells respond by activating this multi-faceted DNA damage response leading to restoration of the cell, senes …
Regulating cell survival by controlling cellular energy production: novel functions for ancient signaling pathways?
Kuznetsov AV, et al. FEBS Lett 2004 - Review. PMID 15527752 Free article.
Cell survival is maintained by growth factors and critically depends on sufficient energy supply. New evidence suggests that a rise in cellular energy production is not merely a homeostatic response to increased demand but subject to regulation by extrinsic factors. ...Both, positive and negative regulators of cell survival impinge on the processes of cellular energy production to regulate growth and survival versus death....
Cell survival is maintained by growth factors and critically depends on sufficient energy supply. New evidence suggests that a
Glutathione-s-transferases as determinants of cell survival and death.
Tew KD and Townsend DM. Antioxid Redox Signal 2012 - Review. PMID 22540427 Free PMC article.
RECENT ADVANCES: More recent work indicates that in addition to the classic catalytic functions, specific GST isozymes have other characteristics that impact cell survival pathways in ways unrelated to detoxification. ...In addition, their role in regulating cell fate in signaling and cell death pathways has opened up a significant functional complexity that extends well beyond standard detoxification reactions....
RECENT ADVANCES: More recent work indicates that in addition to the classic catalytic functions, specific GST isozymes have other characteri …
Effect of the botanical formula LCS101 on the anti-cancer effects of radiation therapy
Cohen Z, et al. J Cancer Res Clin Oncol 2019. PMID 30523409
The present study examined the interaction between LCS101 and radiation therapy on cancer cell lines. METHODS: Incremental doses of LCS101 were added to breast adenocarcinoma (MCF7), prostate (DU145), transitional cell bladder carcinoma (T24), pancreatic epithelioid carcinoma (PANC-1), and osteosarcoma (U20S) cell lines 4 h after single-dose irradiation (range 0.5-4 Gy). Cell viability was tested using sulforhodamine B (SRB) assay after 1 week, with ROS activity examined using 1 mM of the ROS scavenger sodium pyruvate (ROS scavenger), testing cell viability with an SRB assay. ...
The present study examined the interaction between LCS101 and radiation therapy on cancer cell lines. METHODS: Incremental doses of L …
191,529 results
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