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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1989 1
1990 13
1991 9
1992 10
1993 9
1994 10
1995 26
1996 35
1997 49
1998 46
1999 62
2000 84
2001 92
2002 98
2003 110
2004 136
2005 126
2006 146
2007 140
2008 166
2009 162
2010 153
2011 184
2012 175
2013 152
2014 133
2015 100
2016 85
2017 89
2018 83
2019 48
2020 1
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2,485 results
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Page 1
Aging of the Immune System. Mechanisms and Therapeutic Targets
Weyand CM and Goronzy JJ. Ann Am Thorac Soc 2016 - Review. PMID 28005419 Free PMC article.
Because of deficiency of the DNA repair kinase ataxia telangiectasia mutated, RA T cells carry a higher burden of DNA double-strand breaks, triggering cell-indigenous stress signals that shift the cell's survival potential and differentiation pattern. ...
Because of deficiency of the DNA repair kinase ataxia telangiectasia mutated, RA T cells carry a higher burden of DNA double-strand breaks, …
sRAGE prolonged stem cell survival and suppressed RAGE-related inflammatory cell and T lymphocyte accumulations in an Alzheimer's disease model.
Oh S, et al. Biochem Biophys Res Commun 2018. PMID 29127006
Fortunately, stem cell transplantation is emerging as a potential therapeutic candidate for AD, but the success of stem cell based therapy depends on the survival of transplanted cells. ...The survival of transplanted cell, the number of T lymphocytes and microglia, expression of RAGE and its ligands and neuronal cell death were determined, 4 weeks after sRAGE-MSC transplantation. ...
Fortunately, stem cell transplantation is emerging as a potential therapeutic candidate for AD, but the success of stem cell b …
Mechanism of NLRP3 inflammasome activation
Sutterwala FS, et al. Ann N Y Acad Sci 2014 - Review. PMID 24840700 Free PMC article.
This potent caspase-1-dependent process is capable of activating the innate immune system, initiating pyroptosis (an inflammatory form of programmed cell death), and shaping adaptive immunity. ...
This potent caspase-1-dependent process is capable of activating the innate immune system, initiating pyroptosis (an inflammatory form of pr …
Rasal3-mediated T cell survival is essential for inflammatory responses.
Muro R, et al. Biochem Biophys Res Commun 2018. PMID 29291408
Ras-activating protein-like 3 (Rasal3) is a T cell-specific Ras GTPase-activating protein that negatively regulates T cell receptor (TCR)-induced activation of Ras/MAPK pathway. ...Activated Rasal3-deficient T cells showed an increased cell death with reduced Bcl2 expression, suggesting that Rasal3 is required for the survival of not only naïve T cells but also activated T cells. ...
Ras-activating protein-like 3 (Rasal3) is a T cell-specific Ras GTPase-activating protein that negatively regulates T cell rec …
Immunogenic chemotherapy: Dose and schedule dependence and combination with immunotherapy
Wu J and Waxman DJ. Cancer Lett 2018 - Review. PMID 29414305 Free PMC article.
However, certain cytotoxic cancer chemotherapeutic drugs, including doxorubicin, mitoxantrone, and cyclophosphamide, can kill tumor cells by an immunogenic cell death pathway, which activates robust innate and adaptive anti-tumor immune responses and has the potential to greatly increase the efficacy of chemotherapy. Here, we review studies on chemotherapeutic drug-induced immunogenic cell death, focusing on how the choice of a conventional cytotoxic agent and its dose and schedule impact anti-tumor immune responses. ...
However, certain cytotoxic cancer chemotherapeutic drugs, including doxorubicin, mitoxantrone, and cyclophosphamide, can kill tumor cells by …
Immunological memories of the bone marrow
Chang HD, et al. Immunol Rev 2018 - Review. PMID 29664564 Free PMC article.
The lifestyle of memory plasma cells of the bone marrow may serve as a paradigm, showing that persistence of memory lymphocytes is not defined by intrinsic "half-lives", but rather conditional on distinct survival signals provided by dedicated niches. ...
The lifestyle of memory plasma cells of the bone marrow may serve as a paradigm, showing that persistence of memory lymphocytes is not defin …
Autophagy is essential for effector CD8(+) T cell survival and memory formation.
Xu X, et al. Nat Immunol 2014. PMID 25362489 Free PMC article.
Consistent with those findings, deletion of the gene encoding either of the autophagy-related molecules Atg5 or Atg7 had little to no effect on the proliferation and function of effector cells, but these autophagy-deficient effector cells had survival defects that resulted in compromised formation of memory T cells. Our studies define when autophagy is needed during effector and memory differentiation and warrant reexamination of the relationship between T cell activation and autophagy....
Consistent with those findings, deletion of the gene encoding either of the autophagy-related molecules Atg5 or Atg7 had little to no effect …
Bruton's Tyrosine Kinase Is Not Essential for B Cell Survival beyond Early Developmental Stages.
Nyhoff LE, et al. J Immunol 2018. PMID 29483358 Free PMC article.
Autoimmune-prone B1 cells also survived conditional Btk excision, contrasting their near absence in global Btk-deficient mice. ...Thus, B cells have nuanced signaling responses that are differentially regulated by Btk for development, survival, and function. ...
Autoimmune-prone B1 cells also survived conditional Btk excision, contrasting their near absence in global Btk-deficient mice. ...Thu …
TRAF3 as a Multifaceted Regulator of B Lymphocyte Survival and Activation.
Bishop GA, et al. Front Immunol 2018 - Review. PMID 30319624 Free PMC article.
Studies of B cell-specific TRAF3-deficient mice, complemented by investigations in normal and malignant mouse and human B cells, reveal that TRAF3 has powerful regulatory roles that are unique to this TRAF, as well as functions context-specific to the B cell. ...TRAF3 is also now known to function as a resident nuclear protein, and to impact B cell metabolism. Through these and additional mechanisms TRAF3 exerts powerful restraint upon B cell survival and activation. ...
Studies of B cell-specific TRAF3-deficient mice, complemented by investigations in normal and malignant mouse and human B cells, reve …
Programming plasma cell survival.
Klein U. J Exp Med 2014. PMID 24799529 Free PMC article.
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