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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1994 1
2004 1
2005 1
2006 5
2007 24
2008 71
2009 111
2010 278
2011 625
2012 813
2013 986
2014 1143
2015 1400
2016 1516
2017 1539
2018 1465
2019 739
2020 10
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9,296 results
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Page 1
Mechanisms of hepatic stellate cell activation.
Tsuchida T and Friedman SL. Nat Rev Gastroenterol Hepatol 2017 - Review. PMID 28487545
Activation of hepatic stellate cells (HSCs) - transdifferentiation of quiescent, vitamin-A-storing cells into proliferative, fibrogenic myofibroblasts - is now well established as a central driver of fibrosis in experimental and human liver injury. ...
Activation of hepatic stellate cells (HSCs) - transdifferentiation of quiescent, vitamin-A-storing cells into proliferative, fibrogen …
Molecular mechanisms of epithelial-mesenchymal transition.
Lamouille S, et al. Nat Rev Mol Cell Biol 2014 - Review. PMID 24556840 Free PMC article.
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial-mesenchymal transition (EMT), is integral in development, wound healing and stem cell behaviour, and contributes pathologically to fibrosis and cancer progression. This switch in cell differentiation and behaviour is mediated by key transcription factors, including SNAIL, zinc-finger E-box-binding (ZEB) and basic helix-loop-helix transcription factors, the functions of which are finely regulated at the transcriptional, translational and post-translational levels. ...
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial-mesenchymal transition
New insights into the mechanisms of epithelial-mesenchymal transition and implications for cancer.
Dongre A and Weinberg RA. Nat Rev Mol Cell Biol 2019 - Review. PMID 30459476
Epithelial-mesenchymal transition (EMT) is a cellular programme that is known to be crucial for embryogenesis, wound healing and malignant progression. During EMT, cell-cell and cell-extracellular matrix interactions are remodelled, which leads to the detachment of epithelial cells from each other and the underlying basement membrane, and a new transcriptional programme is activated to promote the mesenchymal fate. ...
Epithelial-mesenchymal transition (EMT) is a cellular programme that is known to be crucial for embryogenesis, wound healing and mali …
Signaling mechanisms of the epithelial-mesenchymal transition.
Gonzalez DM and Medici D. Sci Signal 2014 - Review. PMID 25249658 Free PMC article.
EMT, as well as a similar transition occurring in vascular endothelial cells called endothelial-mesenchymal transition (EndMT), results from the induction of transcription factors that alter gene expression to promote loss of cell-cell adhesion, leading to a shift in cytoskeletal dynamics and a change from epithelial morphology and physiology to the mesenchymal phenotype. Transcription program switching in EMT is induced by signaling pathways mediated by transforming growth factor β (TGF-β) and bone morphogenetic protein (BMP), Wnt-β-catenin, Notch, Hedgehog, and receptor tyrosine kinases. ...
EMT, as well as a similar transition occurring in vascular endothelial cells called endothelial-mesenchymal transition (EndMT) …
EMT in cancer
Brabletz T, et al. Nat Rev Cancer 2018. PMID 29326430
Similar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have been shown to play a role in the tumorigenic process. Although the first description of EMT in cancer was in cell cultures, evidence for its role in vivo is now widely reported but also actively debated. ...
Similar to embryonic development, changes in cell phenotypes defined as an epithelial to mesenchymal transition (EMT) have bee …
Cancer cell plasticity: Impact on tumor progression and therapy response.
da Silva-Diz V, et al. Semin Cancer Biol 2018 - Review. PMID 30130663
Cancer cell plasticity has been linked to the epithelial-to-mesenchymal transition program and relies not only on cell-autonomous mechanisms, but also on signals provided by the tumor microenvironment and/or induced in response to therapy. We provide an overview of the dynamic transition for cancer cell states, the mechanisms governing cell plasticity and their impact on tumor progression, metastasis and therapy response. ...
Cancer cell plasticity has been linked to the epithelial-to-mesenchymal transition program and relies not only on cell- …
EMT: Mechanisms and therapeutic implications
Singh M, et al. Pharmacol Ther 2018 - Review. PMID 28834698
The epithelial-mesenchymal transition (EMT) has been studied in normal mammalian development for decades, and it has been proposed as a critical mechanism during cancer progression and metastasis. ...In this review, we describe the sequence of events and defining mechanisms that take place during EMT, and how these interactions drive cancer cell progression into metastasis. ...
The epithelial-mesenchymal transition (EMT) has been studied in normal mammalian development for decades, and it has been proposed as …
Identification of the tumour transition states occurring during EMT.
Pastushenko I, et al. Nature 2018. PMID 29670281
Although all EMT subpopulations presented similar tumour-propagating cell capacity, they displayed differences in cellular plasticity, invasiveness and metastatic potential. Their transcriptional and epigenetic landscapes identify the underlying gene regulatory networks, transcription factors and signalling pathways that control these different EMT transition states. ...
Although all EMT subpopulations presented similar tumour-propagating cell capacity, they displayed differences in cellular plasticity …
Adult cell plasticity in vivo: de-differentiation and transdifferentiation are back in style.
Merrell AJ and Stanger BZ. Nat Rev Mol Cell Biol 2016 - Review. PMID 26979497 Free PMC article.
Specifically, certain adult cells retain the capacity to de-differentiate or transdifferentiate under physiological conditions, as part of an organ's normal injury response. Recent studies have highlighted the extent to which cell plasticity contributes to tissue homeostasis, findings that have implications for cell-based therapy....
Specifically, certain adult cells retain the capacity to de-differentiate or transdifferentiate under physiological conditions, as pa …
Plasticity of Cell Migration In Vivo and In Silico.
Te Boekhorst V, et al. Annu Rev Cell Dev Biol 2016 - Review. PMID 27576118
Cell migration results from stepwise mechanical and chemical interactions between cells and their extracellular environment. ...We here review the variability, decision making, and adaptation of cell migration approached by live-cell, in vivo, and in silico strategies, with a focus on cell movements in morphogenesis, repair, immune surveillance, and cancer metastasis....
Cell migration results from stepwise mechanical and chemical interactions between cells and their extracellular environment. ...We he
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