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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2006 1
2007 4
2008 16
2009 23
2010 91
2011 224
2012 317
2013 440
2014 517
2015 614
2016 734
2017 859
2018 874
2019 429
2020 8
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4,510 results
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Page 1
Mechanisms of hepatic stellate cell activation.
Tsuchida T and Friedman SL. Nat Rev Gastroenterol Hepatol 2017 - Review. PMID 28487545
Activation of hepatic stellate cells (HSCs) - transdifferentiation of quiescent, vitamin-A-storing cells into proliferative, fibrogenic myofibroblasts - is now well established as a central driver of fibrosis in experimental and human liver injury. ...
Activation of hepatic stellate cells (HSCs) - transdifferentiation of quiescent, vitamin-A-storing cells into proliferative, fibrogen …
Molecular mechanisms of epithelial-mesenchymal transition
Lamouille S, et al. Nat Rev Mol Cell Biol 2014 - Review. PMID 24556840 Free PMC article.
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial-mesenchymal transition (EMT), is integral in development, wound healing and stem cell behaviour, and contributes pathologically to fibrosis and cancer progression. This switch in cell differentiation and behaviour is mediated by key transcription factors, including SNAIL, zinc-finger E-box-binding (ZEB) and basic helix-loop-helix transcription factors, the functions of which are finely regulated at the transcriptional, translational and post-translational levels. ...
The transdifferentiation of epithelial cells into motile mesenchymal cells, a process known as epithelial-mesenchymal transition (EMT …
EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
Shibue T and Weinberg RA. Nat Rev Clin Oncol 2017 - Review. PMID 28397828 Free PMC article.
The introduction of the cancer stem cell (CSC) concept, which posits the presence of minor subpopulations of CSCs that are uniquely capable of seeding new tumours, has provided a framework for understanding one dimension of intratumoural heterogeneity. ...
The introduction of the cancer stem cell (CSC) concept, which posits the presence of minor subpopulations of CSCs that are uniquely c …
Chemical reprogramming and transdifferentiation.
Xie X, et al. Curr Opin Genet Dev 2017 - Review. PMID 28755566 Free article.
The revolutionizing somatic cell reprogramming/transdifferentiation technologies provide a new path for cell replacement therapies and drug screening. ...Many efforts have been taken to avoid genetic alteration in somatic cell reprogramming/transdifferentiation by using non-integrating gene delivery approaches, cell membrane permeable proteins, and small molecule compounds. ...
The revolutionizing somatic cell reprogramming/transdifferentiation technologies provide a new path for cell replacemen …
Cancer cell plasticity: Impact on tumor progression and therapy response.
da Silva-Diz V, et al. Semin Cancer Biol 2018 - Review. PMID 30130663
Cancer cell plasticity has been proposed as being an important mechanism that, along with genetic and epigenetic alterations, promotes cancer cell diversity and contributes to intra-tumor heterogeneity. ...We provide an overview of the dynamic transition for cancer cell states, the mechanisms governing cell plasticity and their impact on tumor progression, metastasis and therapy response. ...
Cancer cell plasticity has been proposed as being an important mechanism that, along with genetic and epigenetic alterations, promote …
Cancer stem cell heterogeneity: origin and new perspectives on CSC targeting.
Eun K, et al. BMB Rep 2017 - Review. PMID 27998397 Free PMC article.
CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation potential. ...
CSCs take charge of a cancer hierarchy, harboring stem cell-like properties involving self-renewal and aberrant differentiation poten …
Progression and metastasis of lung cancer
Popper HH. Cancer Metastasis Rev 2016 - Review. PMID 27018053 Free PMC article.
Metastasis requires cell migration toward higher oxygen tension, which is based on changing the structure of the cell (epithelial-mesenchymal transition), orientation within the stroma and stroma interaction, and communication with the immune system to avoid attack. ...
Metastasis requires cell migration toward higher oxygen tension, which is based on changing the structure of the cell (epithel …
On the origin of cancer metastasis
Seyfried TN and Huysentruyt LC. Crit Rev Oncog 2013 - Review. PMID 23237552 Free PMC article.
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