Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1781 37
1782 18
1783 22
1784 27
1785 43
1786 60
1787 43
1788 33
1789 32
1790 44
1791 19
1792 33
1793 17
1794 18
1795 13
1796 14
1797 59
1798 15
1799 291
1800 377
1801 360
1802 283
1803 269
1804 289
1805 314
1806 282
1807 295
1808 289
1809 265
1810 267
1811 322
1812 238
1813 265
1814 285
1815 222
1816 315
1817 288
1818 303
1819 225
1820 213
1821 270
1822 247
1823 291
1824 269
1825 262
1826 385
1827 326
1828 467
1829 645
1830 569
1831 627
1832 313
1833 293
1834 287
1835 305
1836 271
1837 350
1838 484
1839 546
1840 695
1841 1154
1842 1488
1843 1118
1844 1248
1845 1277
1846 1406
1847 1367
1848 1203
1849 1207
1850 1126
1851 1228
1852 1310
1853 1558
1854 1306
1855 1586
1856 1587
1857 1488
1858 1542
1859 1562
1860 1632
1861 1275
1862 1112
1863 995
1864 1138
1865 1151
1866 1477
1867 1723
1868 1813
1869 1909
1870 1809
1871 2238
1872 2242
1873 2313
1874 2508
1875 2402
1876 2095
1877 2179
1878 2454
1879 2399
1880 2646
1881 3149
1882 2742
1883 3126
1884 3049
1885 3338
1886 3291
1887 3966
1888 4002
1889 4194
1890 4024
1891 3607
1892 4081
1893 4370
1894 3801
1895 4129
1896 4412
1897 4689
1898 4631
1899 4169
1900 3785
1901 3886
1902 3967
1903 3910
1904 4059
1905 4067
1906 3872
1907 4324
1908 4459
1909 4687
1910 4799
1911 5006
1912 4906
1913 5105
1914 5135
1915 4640
1916 4543
1917 4281
1918 4567
1919 4619
1920 4960
1921 4628
1922 4123
1923 4432
1924 4851
1925 4990
1926 5342
1927 5887
1928 5479
1929 5741
1930 5630
1931 5497
1932 5548
1933 5610
1934 5508
1935 5661
1936 5384
1937 5308
1938 5765
1939 5541
1940 4998
1941 4838
1942 4775
1943 4518
1944 4745
1945 20421
1946 53739
1947 64968
1948 70728
1949 62805
1950 85750
1951 103810
1952 108147
1953 108914
1954 105913
1955 108541
1956 107005
1957 111515
1958 109458
1959 109989
1960 112211
1961 120166
1962 125670
1963 141520
1964 162087
1965 176641
1966 179752
1967 191500
1968 207845
1969 215070
1970 218977
1971 222876
1972 227509
1973 230632
1974 234512
1975 248225
1976 250267
1977 249655
1978 257970
1979 265216
1980 266916
1981 271296
1982 282841
1983 294480
1984 302390
1985 318670
1986 331149
1987 347048
1988 363340
1989 377348
1990 382435
1991 380204
1992 381661
1993 389305
1994 400875
1995 410119
1996 420012
1997 417628
1998 435203
1999 452406
2000 488946
2001 501608
2002 519572
2003 547147
2004 590073
2005 648302
2006 693468
2007 731340
2008 778929
2009 818615
2010 881469
2011 957858
2012 1023858
2013 1074985
2014 1128744
2015 1171139
2016 1205209
2017 1228913
2018 1273007
2019 1334117
2020 1530532
2021 1675177
2022 1675817
2023 1588750
2024 1617572
2025 138379

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

36,026,629 results

Results by year

Filters applied: . Clear all
Page 1
Historical Perspective: Models of Parkinson's Disease.
Chia SJ, Tan EK, Chao YX. Chia SJ, et al. Int J Mol Sci. 2020 Apr 2;21(7):2464. doi: 10.3390/ijms21072464. Int J Mol Sci. 2020. PMID: 32252301 Free PMC article. Review.
Parkinson's disease (PD) is the most common movement disorder with motor and nonmotor signs. ...In neurotoxin-induced models, chemicals such as 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), rotenone, and paraquat are used to …
Parkinson's disease (PD) is the most common movement disorder with motor and nonmotor signs. ...In neurotoxin-induced m …
[Cell therapy for Parkinson's disease with induced pluripotent stem cells].
Morizane A. Morizane A. Rinsho Shinkeigaku. 2019 Mar 28;59(3):119-124. doi: 10.5692/clinicalneurol.cn-001235. Epub 2019 Feb 28. Rinsho Shinkeigaku. 2019. PMID: 30814448 Free article. Review. Japanese.
Cell therapy for Parkinson's disease has a history of being applied clinically with aborted embryos as donor source. ...This article discusses patient selection, procedure, and risk of the therapy. It also introduces the world's current situation of th …
Cell therapy for Parkinson's disease has a history of being applied clinically with aborted embryos as donor source. .. …
Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson's disease.
Kriks S, Shim JW, Piao J, Ganat YM, Wakeman DR, Xie Z, Carrillo-Reid L, Auyeung G, Antonacci C, Buch A, Yang L, Beal MF, Surmeier DJ, Kordower JH, Tabar V, Studer L. Kriks S, et al. Nature. 2011 Nov 6;480(7378):547-51. doi: 10.1038/nature10648. Nature. 2011. PMID: 22056989 Free PMC article.
However, the effective use of PSCs for cell therapy has lagged behind. Whereas mouse PSC-derived DA neurons have shown efficacy in models of Parkinson's disease, DA neurons from human PSCs generally show poor in vivo performance. ...In vivo survival an …
However, the effective use of PSCs for cell therapy has lagged behind. Whereas mouse PSC-derived DA neurons have shown efficacy in mo …
Embryonic stem cells go dopaminergic.
Hynes M, Rosenthal A. Hynes M, et al. Neuron. 2000 Oct;28(1):11-4. doi: 10.1016/s0896-6273(00)00079-9. Neuron. 2000. PMID: 11086977 Free article. Review. No abstract available.
Preclinical and dose-ranging assessment of hESC-derived dopaminergic progenitors for a clinical trial on Parkinson's disease.
Park S, Park CW, Eom JH, Jo MY, Hur HJ, Choi SK, Lee JS, Nam ST, Jo KS, Oh YW, Lee J, Kim S, Kim DH, Park CY, Kim SJ, Lee HY, Cho MS, Kim DS, Kim DW. Park S, et al. Cell Stem Cell. 2024 Jan 4;31(1):25-38.e8. doi: 10.1016/j.stem.2023.11.009. Epub 2023 Dec 11. Cell Stem Cell. 2024. PMID: 38086390 Free article.
Human embryonic stem cell (hESC)-derived midbrain dopaminergic (mDA) cell transplantation is a promising therapeutic strategy for Parkinson's disease (PD). ...
Human embryonic stem cell (hESC)-derived midbrain dopaminergic (mDA) cell transplantation is a promising therapeutic strategy …
Human iPSC-derived midbrain organoids functionally integrate into striatum circuits and restore motor function in a mouse model of Parkinson's disease.
Zheng X, Han D, Liu W, Wang X, Pan N, Wang Y, Chen Z. Zheng X, et al. Theranostics. 2023 Apr 29;13(8):2673-2692. doi: 10.7150/thno.80271. eCollection 2023. Theranostics. 2023. PMID: 37215566 Free PMC article.
Rationale: Parkinson's disease (PD) is a prevalent neurodegenerative disorder that is characterized by degeneration of dopaminergic neurons (DA) at the substantia nigra pas compacta (SNpc). ...Methods: 3-D hMOs were induced from three distinct hiPSC lines. hM …
Rationale: Parkinson's disease (PD) is a prevalent neurodegenerative disorder that is characterized by degeneration of …
Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model.
Xu P, He H, Gao Q, Zhou Y, Wu Z, Zhang X, Sun L, Hu G, Guan Q, You Z, Zhang X, Zheng W, Xiong M, Chen Y. Xu P, et al. J Clin Invest. 2022 Jul 15;132(14):e156768. doi: 10.1172/JCI156768. J Clin Invest. 2022. PMID: 35700056 Free PMC article.
Human pluripotent stem cell-based (hPSC-based) replacement therapy holds great promise for the treatment of Parkinson's disease (PD). However, the heterogeneity of hPSC-derived donor cells and the low yield of midbrain dopaminergic (mDA) neurons after transpl …
Human pluripotent stem cell-based (hPSC-based) replacement therapy holds great promise for the treatment of Parkinson's dis …
Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson's disease.
Tiklová K, Nolbrant S, Fiorenzano A, Björklund ÅK, Sharma Y, Heuer A, Gillberg L, Hoban DB, Cardoso T, Adler AF, Birtele M, Lundén-Miguel H, Volakakis N, Kirkeby A, Perlmann T, Parmar M. Tiklová K, et al. Nat Commun. 2020 May 15;11(1):2434. doi: 10.1038/s41467-020-16225-5. Nat Commun. 2020. PMID: 32415072 Free PMC article.
Cell replacement is a long-standing and realistic goal for the treatment of Parkinson's disease (PD). Cells for transplantation can be obtained from fetal brain tissue or from stem cells. ...Here, we report analysis by single-cell RNA sequencing (scRNA-seq) c …
Cell replacement is a long-standing and realistic goal for the treatment of Parkinson's disease (PD). Cells for transpl …
36,026,629 results
You have reached the last available page of results. Please see the User Guide for more information.