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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 1
1950 3
1951 3
1952 2
1954 3
1955 5
1956 5
1957 6
1958 8
1959 7
1960 17
1961 14
1962 11
1963 16
1964 42
1965 34
1966 35
1967 62
1968 57
1969 51
1970 39
1971 41
1972 38
1973 20
1974 22
1975 32
1976 28
1977 33
1978 44
1979 54
1980 58
1981 61
1982 76
1983 83
1984 59
1985 82
1986 58
1987 45
1988 60
1989 52
1990 44
1991 106
1992 94
1993 102
1994 78
1995 67
1996 89
1997 90
1998 117
1999 150
2000 207
2001 159
2002 220
2003 197
2004 254
2005 276
2006 329
2007 399
2008 440
2009 455
2010 555
2011 651
2012 663
2013 744
2014 740
2015 735
2016 769
2017 843
2018 822
2019 388
2020 8
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Search Results

11,046 results
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Page 1
Cellular Senescence: What, Why, and How.
Regulski MJ. Wounds 2017 - Review. PMID 28682291 Free article.
Cellular senescence is a process that results from a variety of stresses and leads to a state of irreversible growth arrest. ...Cellular senescence can be induced by various intrinsic and extrinsic factors. The pathways for the proteins p53/p21 and p16Ink4a/retinoblastoma protein are important for irreversible growth arrest and senescent cells. ...
Cellular senescence is a process that results from a variety of stresses and leads to a state of irreversible growth arrest. .
Cellular Senescence: A Translational Perspective.
Kirkland JL and Tchkonia T. EBioMedicine 2017 - Review. PMID 28416161 Free PMC article.
Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance, and frequently acquisition of a pro-inflammatory, tissue-destructive senescence-associated secretory phenotype (SASP). ...Delaying senescent cell accumulation or reducing senescent cell burden is associated with delay, prevention, or alleviation of multiple senescence-associated conditions. ...
Cellular senescence entails essentially irreversible replicative arrest, apoptosis resistance, and frequently acquisition of a
Aging, cellular senescence, and cancer.
Campisi J. Annu Rev Physiol 2013 - Review. PMID 23140366 Free PMC article.
This review discusses the idea that, despite seemingly opposite characteristics, the degenerative and hyperplastic pathologies of aging are at least partly linked by a common biological phenomenon: a cellular stress response known as cellular senescence. ...Thus, the senescence response may be the result of antagonistically pleiotropic gene action....
This review discusses the idea that, despite seemingly opposite characteristics, the degenerative and hyperplastic pathologies of aging are …
Cellular senescence: from physiology to pathology.
Muñoz-Espín D and Serrano M. Nat Rev Mol Cell Biol 2014 - Review. PMID 24954210
Recent discoveries are redefining our view of cellular senescence as a trigger of tissue remodelling that acts during normal embryonic development and upon tissue damage. ...This sequence of events - senescence, followed by clearance and then regeneration - may not be efficiently completed in aged tissues or in pathological contexts, thereby resulting in the accumulation of senescent cells. ...
Recent discoveries are redefining our view of cellular senescence as a trigger of tissue remodelling that acts during normal e …
Cellular senescence: a hitchhiker's guide.
Aravinthan A. Hum Cell 2015 - Review. PMID 25690721
Since its first description over 50 years ago, cellular senescence has gained increasing attention. The number of research publications on cellular senescence last year alone is more than the number of publications in the decade in 1990s. Laboratories solely studying senescence, scientific conferences and organisations dedicated to field of cellular senescence are also on the rise. ...
Since its first description over 50 years ago, cellular senescence has gained increasing attention. The number of research pub …
Cellular senescence and its effector programs.
Salama R, et al. Genes Dev 2014 - Review. PMID 24449267 Free PMC article.
Cellular senescence is a stress response that accompanies stable exit from the cell cycle. Classically, senescence, particularly in human cells, involves the p53 and p16/Rb pathways, and often both of these tumor suppressor pathways need to be abrogated to bypass senescence. In parallel, a number of effector mechanisms of senescence have been identified and characterized. These studies suggest that senescence is a collective phenotype of these multiple effectors, and their intensity and combination can be different depending on triggers and cell types, conferring a complex and diverse nature to senescence. ...
Cellular senescence is a stress response that accompanies stable exit from the cell cycle. Classically, senescence, par
Four faces of cellular senescence.
Rodier F and Campisi J. J Cell Biol 2011 - Review. PMID 21321098 Free PMC article.
In addition to suppressing tumorigenesis, cellular senescence might also promote tissue repair and fuel inflammation associated with aging and cancer progression. Thus, cellular senescence might participate in four complex biological processes (tumor suppression, tumor promotion, aging, and tissue repair), some of which have apparently opposing effects. ...
In addition to suppressing tumorigenesis, cellular senescence might also promote tissue repair and fuel inflammation associate …
cGAS is essential for cellular senescence.
Yang H, et al. Proc Natl Acad Sci U S A 2017. PMID 28533362 Free PMC article.
Cellular senescence is a natural barrier to tumorigenesis and it contributes to the antitumor effects of several therapies, including radiation and chemotherapeutic drugs. ...These results indicate that cGAS mediates cellular senescence and retards immortalization. This is distinct from, and complementary to, the role of cGAS in activating antitumor immunity....
Cellular senescence is a natural barrier to tumorigenesis and it contributes to the antitumor effects of several therapies, in
Cellular senescence and the senescent secretory phenotype: therapeutic opportunities.
Tchkonia T, et al. J Clin Invest 2013 - Review. PMID 23454759 Free PMC article.
One such mechanism is cellular senescence, which can cause chronic inflammation through the senescence-associated secretory phenotype (SASP). We review the mechanisms that induce senescence and the SASP, their associations with chronic disease and frailty, therapeutic opportunities based on targeting senescent cells and the SASP, and potential paths to developing clinical interventions....
One such mechanism is cellular senescence, which can cause chronic inflammation through the senescence-associated secre …
Cellular senescence: a view throughout organismal life.
von Kobbe C. Cell Mol Life Sci 2018 - Review. PMID 30030594
Cellular senescence is the final fate of most cells in response to specific stimuli, but is not the end. Indeed, it is the beginning of a singular life, with multiple side roads leading to diverse effects on the organism. ...Finally, we discuss the role of immune cells in keeping senescence burden below the threshold of disease....
Cellular senescence is the final fate of most cells in response to specific stimuli, but is not the end. Indeed, it is the beg
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