Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

MyNCBI Filters
Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 6
1968 3
1972 2
1980 1
1985 1
1987 3
1988 1
1989 18
1990 23
1991 53
1992 83
1993 133
1994 95
1995 103
1996 102
1997 153
1998 195
1999 191
2000 259
2001 213
2002 275
2003 249
2004 257
2005 264
2006 311
2007 381
2008 378
2009 419
2010 472
2011 472
2012 484
2013 544
2014 547
2015 474
2016 528
2017 521
2018 507
2019 232
2020 1
Text availability
Article attribute
Article type
Publication date

Search Results

8,093 results
Results by year
Filters applied: . Clear all
Page 1
Cellular Senescence: What, Why, and How.
Regulski MJ. Wounds 2017 - Review. PMID 28682291 Free article.
Cellular senescence is a process that results from a variety of stresses and leads to a state of irreversible growth arrest. ...Cellular senescence can be induced by various intrinsic and extrinsic factors. The pathways for the proteins p53/p21 and p16Ink4a/retinoblastoma protein are important for irreversible growth arrest and senescent cells. ...
Cellular senescence is a process that results from a variety of stresses and leads to a state of irreversible growth arrest. .
Aging, cellular senescence, and cancer.
Campisi J. Annu Rev Physiol 2013 - Review. PMID 23140366 Free PMC article.
This review discusses the idea that, despite seemingly opposite characteristics, the degenerative and hyperplastic pathologies of aging are at least partly linked by a common biological phenomenon: a cellular stress response known as cellular senescence. ...Thus, the senescence response may be the result of antagonistically pleiotropic gene action....
This review discusses the idea that, despite seemingly opposite characteristics, the degenerative and hyperplastic pathologies of aging are …
Cellular senescence in aging and osteoarthritis.
Toh WS, et al. Acta Orthop 2016 - Review. PMID 27658487 Free PMC article.
In this review, we discuss the causes and consequences of cellular senescence, and the associated biological challenges in cartilage repair. In addition, we present novel strategies for modulation of cellular senescence that may help to improve cartilage regeneration in an aging population....
In this review, we discuss the causes and consequences of cellular senescence, and the associated biological challenges in car …
Cellular senescence: a hitchhiker's guide.
Aravinthan A. Hum Cell 2015 - Review. PMID 25690721
Since its first description over 50 years ago, cellular senescence has gained increasing attention. The number of research publications on cellular senescence last year alone is more than the number of publications in the decade in 1990s. Laboratories solely studying senescence, scientific conferences and organisations dedicated to field of cellular senescence are also on the rise. ...
Since its first description over 50 years ago, cellular senescence has gained increasing attention. The number of research pub …
Cellular senescence and its effector programs.
Salama R, et al. Genes Dev 2014 - Review. PMID 24449267 Free PMC article.
Cellular senescence is a stress response that accompanies stable exit from the cell cycle. Classically, senescence, particularly in human cells, involves the p53 and p16/Rb pathways, and often both of these tumor suppressor pathways need to be abrogated to bypass senescence. In parallel, a number of effector mechanisms of senescence have been identified and characterized. These studies suggest that senescence is a collective phenotype of these multiple effectors, and their intensity and combination can be different depending on triggers and cell types, conferring a complex and diverse nature to senescence. ...
Cellular senescence is a stress response that accompanies stable exit from the cell cycle. Classically, senescence, par
Senescence and aging: Causes, consequences, and therapeutic avenues.
McHugh D and Gil J. J Cell Biol 2018 - Review. PMID 29114066 Free PMC article.
Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proinflammatory secretome. ...Here, we review the cellular and molecular links between cellular senescence and aging and discuss the novel therapeutic avenues that this connection opens....
Senescence is a cellular response characterized by a stable growth arrest and other phenotypic alterations that include a proi
Cellular senescence: when bad things happen to good cells.
Campisi J and d'Adda di Fagagna F. Nat Rev Mol Cell Biol 2007 - Review. PMID 17667954
Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular senescence. Understanding the causes and consequences of cellular senescence has provided novel insights into how cells react to stress, especially genotoxic stress, and how this cellular response can affect complex organismal processes such as the development of cancer and ageing....
Proliferating cells can initiate an additional response by adopting a state of permanent cell-cycle arrest that is termed cellular
Induction and Validation of Cellular Senescence in Primary Human Cells.
Hernandez-Segura A, et al. J Vis Exp 2018. PMID 29985363 Free PMC article.
Cellular senescence is a state of permanent cell cycle arrest activated in response to different damaging stimuli. Activation of cellular senescence is a hallmark of various pathophysiological conditions including tumor suppression, tissue remodeling and aging. The inducers of cellular senescence in vivo are still poorly characterized. However, a number of stimuli can be used to promote cellular senescence ex vivo. ...
Cellular senescence is a state of permanent cell cycle arrest activated in response to different damaging stimuli. Activation
The role of senescent cells in ageing
van Deursen JM. Nature 2014 - Review. PMID 24848057 Free PMC article.
Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against cancer, but recent discoveries have extended its known role to complex biological processes such as development, tissue repair, ageing and age-related disorders. New insights indicate that, unlike a static endpoint, senescence represents a series of progressive and phenotypically diverse cellular states acquired after the initial growth arrest. ...
Cellular senescence has historically been viewed as an irreversible cell-cycle arrest mechanism that acts to protect against c
Cellular senescence, aging, and age-related disease: Special issue of BMB Reports in 2019.
Lee JS. BMB Rep 2019. PMID 30638180 Free PMC article.
Cellular senescence is a state of permanent cell cycle arrest which exhibits large and flattened morphological characteristics. Cellular senescence might evolve to a beneficial process to suppress the accumulation of severely damaged cells. However, senescent cells are considered as the cause of age-related pathologies and diseases. ...
Cellular senescence is a state of permanent cell cycle arrest which exhibits large and flattened morphological characteristics
8,093 results
Jump to page
Feedback